Maria Belland Olsen

• Olsen, Maria Belland; Kong, Xiang Yi; Louwe, Maria; Lauritzen, Knut Husø; Schanke, Ylva & Kaasbøll, Ole Jørgen [Show all 14 contributors for this article] (2024). SLAMF1-derived peptide exhibits cardio protection after permanent left anterior descending artery ligation in mice. Frontiers in Immunology. ISSN 1664-3224. 15. doi: 10.3389/fimmu.2024.1383505.
• Gregersen, Ida; Kong, Xiang Yi; Kooijman, Sander; Foyn, Håvard; Grannes, Helene & Olsen, Maria Belland [Show all 25 contributors for this article] (2024). T cells with increased responsiveness cause obesity in mice without diet intervention. iScience. ISSN 2589-0042. 27(4). doi: 10.1016/j.isci.2024.109471.
• Kong, Xiang Yi; Lauritzen, Knut Husø; Dahl, Tuva Børresdatter; Holm, Sverre; Olsen, Maria Belland & Skjelland, Mona [Show all 12 contributors for this article] (2024). CD38 deficient mice are not protected from atherosclerosis. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 705. doi: 10.1016/j.bbrc.2024.149734.
• Vistnes, Maria; Murugan Erusappan, Pugazendhi; Sasi, Athiramol; Nordén, Einar Sjaastad; Bergo, Kaja Knudsen & Romaine, Andreas [Show all 22 contributors for this article] (2023). Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction. Cardiovascular Research (CVR). ISSN 0008-6363. 119(10), p. 1915–1927. doi: 10.1093/cvr/cvad078. Full text in Research Archive
• Jacobsen, Daniel Pitz; Fjeldstad, Heidi Elisabeth Storebø; Sugulle, Meryam; Johnsen, Guro Mørk; Olsen, Maria Belland & Kanaan, Sami B. [Show all 7 contributors for this article] (2023). Fetal microchimerism and the two-stage model of preeclampsia. Journal of Reproductive Immunology. ISSN 0165-0378. 159. doi: 10.1016/j.jri.2023.104124. Full text in Research Archive
• Olsen, Maria Belland; Huse, Camilla; Sousa, Mirta; Murphy, Sarah Louise Mikalsen; Sarno, Antonio & Obermann, Tobias Sebastian [Show all 20 contributors for this article] (2022). DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients. Journal of Inflammation Research. ISSN 1178-7031. 15, p. 6629–6644. doi: 10.2147/JIR.S379331. Full text in Research Archive
• Olsen, Maria Belland; Sannes, Ann-Christin; Yang, Kuan; Nielsen, Morten Birkeland; Einarsen, Ståle Valvatne & Christensen, Jan Olav [Show all 9 contributors for this article] (2022). Mapping of pituitary stress-induced gene regulation connects Nrcam to negative emotions. iScience. ISSN 2589-0042. 25(9). doi: 10.1016/j.isci.2022.104953. Full text in Research Archive Show summary

  Environmental stressors such as repeated social defeat may initiate powerful activation of subconscious parts of the brain. Here, we examine the consequences of such stress (induced by resident-intruder paradigm) on the pituitary gland. In male stressed vs. control rats, by RNA- and bisulfite DNA sequencing, we found regulation of genes involved in neuron morphogenesis and communication. Among these, Neuronal cell adhesion molecule (Nrcam) showed reduced transcription and reduced DNA methylation in a region corresponding to intron 1 in human NRCAM. Also, genetic variability in this area was associated with altered stress response in male humans exposed to repeated social defeat in the form of abusive supervision. Thus, our data show that the pituitary gene expression may be affected by social stress and that genetic variability in NRCAM intron 1 region influences stress-induced negative emotions. We hope our shared datasets will facilitate further exploration of the motions triggered by social stressors.

• Karlsen, Tom Rune; Olsen, Maria Belland; Kong, Xiang Yi; Yang, Kuan; Quiles-Jiménez, Ana M T & Kroustallaki, Pinelopi [Show all 15 contributors for this article] (2022). NEIL3-deficient bone marrow displays decreased hematopoietic capacity and reduced telomere length. Biochemistry and Biophysics Reports. ISSN 2405-5808. 29. doi: 10.1016/j.bbrep.2022.101211. Full text in Research Archive
• Karlsen, Tom Rune; Kong, Xiang Yi; Holm, Sverre; Quiles-Jiménez, Ana M T; Dahl, Tuva Børresdatter & Yang, Kuan [Show all 17 contributors for this article] (2021). NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype. Scientific Reports. ISSN 2045-2322. 11(1). doi: 10.1038/s41598-021-98820-0. Full text in Research Archive
• Olsen, Maria Belland; Gregersen, Ida; Sandanger, Øystein; Yang, Kuan; Sokolova, Marina & Halvorsen, Bente E. [Show all 10 contributors for this article] (2021). Targeting the Inflammasome in Cardiovascular Disease. JACC: Basic to Translational Science. ISSN 2452-302X. 7(1), p. 84–98. doi: 10.1016/j.jacbts.2021.08.006. Full text in Research Archive
• Quiles-Jiménez, Ana M T; Gregersen, Ida; Segers, Filip; Skarpengland, Tonje; Kroustallaki, Pinelopi & Yang, Kuan [Show all 30 contributors for this article] (2021). DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development. Atherosclerosis. ISSN 0021-9150. 324, p. 123–132. doi: 10.1016/j.atherosclerosis.2021.02.023. Full text in Research Archive
• Lauritzen, Knut H.; Olsen, Maria Belland; Ahmed, Mohammed Shakil; Yang, Kuan; Rinholm, Johanne Egge & Bergersen, Linda H. [Show all 13 contributors for this article] (2021). Instability in nad+ metabolism leads to impaired cardiac mitochondrial function and communication. eLIFE. ISSN 2050-084X. 10, p. 1–23. doi: 10.7554/ELIFE.59828. Full text in Research Archive
• Olsen, Maria Belland & Gregersen, Ida (2020). Immunsystemets rolle i alvorlig covid-19. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(18), p. 1–3. doi: 10.4045/tidsskr.20.0860.
• Louwe, Maria Cornelia; Olsen, Maria Belland; Kaasbøll, Ole Jørgen; Yang, Kuan; Fosshaug, Linn Elisabeth Lillerud & Alfsnes, Katrine [Show all 25 contributors for this article] (2020). Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction. JACC: Basic to Translational Science. ISSN 2452-302X. 5(12), p. 1210–1224. doi: 10.1016/j.jacbts.2020.09.013. Full text in Research Archive
• Holt, Margrethe Flesvig; Seim, Bjørn Edvard; Øgaard, Jonas; Olsen, Maria Belland; Woldbæk, Per R & Kvitting, John Peder Escobar [Show all 12 contributors for this article] (2019). Selective and marked decrease of complement receptor C5aR2 in human thoracic aortic aneurysms: A dysregulation with potential inflammatory effects. Open heart. ISSN 2053-3624. 6.e001098(2), p. 1–8. doi: 10.1136/openhrt-2019-001098. Full text in Research Archive
• Yang, Kuan; Lauritzen, Knut Husø; Olsen, Maria Belland; Dahl, Tuva Børresdatter; Ranheim, Trine & Ahmed, Muhammad Shakil [Show all 12 contributors for this article] (2019). Low cellular NAD+ compromises lipopolysaccharide-induced inflammatory responses via inhibiting TLR4 signal transduction in human monocytes. Journal of Immunology. ISSN 0022-1767. 203(6), p. 1598–1608. doi: 10.4049/jimmunol.1801382.
• Norum, Hilde Margrethe; Michelsen, Annika; Lekva, Tove; Arora, Satish; Otterdal, Kari & Olsen, Maria Belland [Show all 15 contributors for this article] (2018). Circulating delta-like Notch ligand 1 is correlated with cardiac allograft vasculopathy and suppressed in heart transplant recipients on everolimus-based immunosuppression. American Journal of Transplantation. ISSN 1600-6135. p. 1–11. doi: 10.1111/ajt.15141. Full text in Research Archive Show summary

  Cardiac allograft vasculopathy (CAV) causes heart failure after heart transplantation (HTx), but its pathogenesis is incompletely understood. Notch signaling, possibly modulated by everolimus (EVR), is essential for processes involved in CAV. We hypothesized that circulating Notch ligands would be dysregulated after HTx. We studied circulating delta‐like Notch ligand 1 (DLL1) and periostin (POSTN) and CAV in de novo HTx recipients (n = 70) randomized to standard or EVR‐based, calcineurin inhibitor‐free immunosuppression and in maintenance HTx recipients (n = 41). Compared to healthy controls, plasma DLL1 and POSTN were elevated in de novo (P < .01; P < .001) and maintenance HTx recipients (P < .001; P < .01). Use of EVR was associated with a treatment effect for DLL1. For de novo HTx recipients, a change in DLL1 correlated with a change in CAV at 1 (P = .021) and 3 years (P = .005). In vitro, activation of T cells increased DLL1 secretion, attenuated by EVR. In vitro data suggest that also endothelial cells and vascular smooth muscle cells (VSMCs) could contribute to circulating DLL1. Immunostaining of myocardial specimens showed colocalization of DLL1 with T cells, endothelial cells, and VSMCs. Our findings suggest a role of DLL1 in CAV progression, and that the beneficial effect of EVR on CAV could reflect a suppressive effect on DLL1.

• Sokolova, Marina; Vinge, Leif Erik; Alfsnes, Katrine; Olsen, Maria Belland; Eide, Lars & Kaasbøll, Ole Jørgen [Show all 16 contributors for this article] (2017). Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. ISSN 1388-1981. 1862(2), p. 234–245. doi: 10.1016/j.bbalip.2016.11.003.
• Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine & Palibrk, Vuk [Show all 29 contributors for this article] (2017). NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. Cell reports. ISSN 2211-1247. 18, p. 82–92. doi: 10.1016/j.celrep.2016.12.009. Full text in Research Archive
• Fadila, Cero; Hillestad, Vigdis; Sjaastad, Ivar; Yndestad, Arne; Aukrust, Pål & Ranheim, Trine [Show all 15 contributors for this article] (2015). Absence of the inflammasone adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice. American Journal of Physiology - Lung cellular and Molecular Physiology. ISSN 1040-0605. 309, p. L378–L387. doi: 10.1152/ajplung.00342.2014.
• Fadila, Cero; Hillestad, Vigdis; Sjaastad, Ivar; Yndestad, Arne; Aukrust, Pål & Ranheim, Trine [Show all 15 contributors for this article] (2015). Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice. American Journal of Physiology - Lung cellular and Molecular Physiology. ISSN 1040-0605. 309(4), p. L378–L387. doi: 10.1152/ajplung.00342.2014.
• Ohm, Ingrid Kristine; Gao, Erhe; Olsen, Maria Belland; Alfsnes, Katrine; Bliksøen, Marte & Øgaard, Jonas [Show all 12 contributors for this article] (2014). Toll-like receptor 9-activation during onset of myocardial ischemia does not influence infarct extension. PLOS ONE. ISSN 1932-6203. 9(8). doi: 10.1371/journal.pone.0104407.
• Ohm, Ingrid Kristine; Alfsnes, Katrine; Olsen, Maria Belland; Ranheim, Trine; Sandanger, Øystein & Dahl, Tuva Børresdatter [Show all 10 contributors for this article] (2014). Toll-like receptor 9 mediated responses in cardiac fibroblasts. PLOS ONE. ISSN 1932-6203. 9:e0104398(8). doi: 10.1371/journal.pone.0104398.
• Matre, Dagfinn; Olsen, Maria Belland; Jacobsen, Line Melå; Klein, Thomas & Gjerstad, Johannes (2013). Induction of the perceptual correlate of human long-term potentiation (LTP) is associated with the 5-HTT genotype. Brain Research. ISSN 0006-8993. 1491, p. 54–59. doi: 10.1016/j.brainres.2012.10.045. Show summary

  The purpose of the present study was to examine how genetic variability in the promoter of the SLC6A4 gene encoding the serotonin transporter (5-HTT) may influence induction of long-term potentiation (LTP). The genotyping of the 53 healthy volunteers was performed by a combination of TaqMan assay and gel electrophoresis. Based on the transcription rates, the subjects were divided in 3 groups; 5-HTT SS, 5-HTT SLG/LALG/SLA and 5-HTT LALA. The intensity of pain to test stimuli was rated on a visual analog scale (VAS). High frequency stimulation (HFS) conditioning applied to one arm was used to induce LTP. Only a minor change in pain was observed following the HFS conditioning evoked by electrical test stimuli delivered through the conditioning electrode. Moreover, the change in pain evoked by test stimuli delivered through the conditioning electrode was not related to the 5-HTT genotype. However, we observed a clear increase in pain following the HFS conditioning evoked by mechanical pin-prick test stimuli delivered at the skin adjacent to the conditioning. Also, the 9 individuals with the 5-HTT SS genotype reported more pain than individuals with 5-HTT SLG/LALG/SLA genotype following HFS conditioning on mechanical pin-prick test stimuli. Thus, the present data show that induction of the perceptual correlate of human LTP is associated with the genetic variability in the gene encoding the 5-HTT. Taken together, this suggests that the expression of 5-HTT, may be important for induction of LTP in humans.

• Olsen, Maria Belland; Jacobsen, Line Melå; Iordanova, Ellina; Pedersen, Linda Margareth; Rygh, Lars Jørgen & Røe, Cecilie [Show all 7 contributors for this article] (2012). Pain intensity the first year after lumbar disc herniation is associated with the A118G polymorphism in the opioid receptor Mu 1 gene: evidence of a sex and genotype interaction. Journal of Neuroscience. ISSN 0270-6474. 32(29), p. 9831–9834. doi: 10.1523/JNEUROSCI.1742-12.2012. Show summary

  Earlier studies have shown that the single nucleotide polymorphism (SNP) A118G (rs1799971) in the opioid receptor mu 1 (OPRM1) gene may affect pain sensitivity. In the present study we investigated whether the A118G SNP could predict clinical outcome regarding progression of pain intensity and disability in patients with low back pain and sciatica after lumbar disc herniation. Patients (n = 258) with lumbar disc herniation and sciatic pain, all European-Caucasian, were recruited from two hospitals in Norway. Pain and disability were rated on a visual analog scale (VAS), by McGill Sensory Questionnaire and by Oswestry Disability Index (ODI) over a 12 months period. The data revealed a significant interaction between sex and A118G genotype regarding the pain intensity during the 12 months (VAS, p = 0.002; McGill, p = 0.021; ODI, p = 0.205, repeated-measures ANOVA). We found that */G women had a slower recovery rate than the */G men. Actually, the */G women had 2.3 times as much pain as the */G men 12 months after the disc herniation (VAS, p = 0.043, one-way ANOVA; p = 0.035, Tukey HSD). In contrast, the A/A women and A/A men seemed to have almost exactly the same recovery rate. The present data suggest that OPRM1 G allele increases the pain intensity in women, but has a protective effect in men the first year after disc herniation.

View all works in Cristin

• Ueland, Thor; Äikäs, Lauri A.O.; Dahl, Tuva Børresdatter; Gregersen, Ida; Olsen, Maria Belland & Michelsen, Annika Elisabet [Show all 20 contributors for this article] (2023). Low-density lipoprotein particles carrying proinflammatory proteins with altered aggregation pattern detected in COVID-19 patients 3 months after hospitalization. Journal of Infection. ISSN 0163-4453. 86(5), p. 489–492. doi: 10.1016/j.jinf.2023.02.024.
• Gregersen, Ida; Ueland, Thor; Holter, Jan Cato; Olsen, Maria Belland; Michelsen, Annika Elisabet & Murphy, Sarah L [Show all 22 contributors for this article] (2022). CXCL16 associates with adverse outcome and cardiac involvement in hospitalized patients with Covid-19. Journal of Infection. ISSN 0163-4453. 85(6), p. 735–738. doi: 10.1016/j.jinf.2022.09.029.
• Olsen, Maria Belland (2020). Downs syndrom og covid-19 -en oversett risikogruppe? Tidsskrift for Den norske legeforening. ISSN 0029-2001. doi: 10.4045/tidsskr.20.0754.
• Cero, Fadila; Larsen, Karl-Otto; Hillestad, Vigdis; Olsen, Maria Belland; Udjus, Camilla & Sjaastad, Ivar [Show all 11 contributors for this article] (2015). The inflammasome adaptor ASC mediates pulmonary artery remodelling.
• Cero, Fadila; Larsen, Karl-Otto; Hillestad, Vigdis; Olsen, Maria Belland; Udjus, Camilla & Yndestad, Arne [Show all 10 contributors for this article] (2015). Hypoxic pulmonary hypertension; a role for the inflammasome.

View all works in Cristin