Mari Nerhus

• Johansen, Ingrid Torp; Steen, Nils Eiel; Rødevand, Linn ; Lunding, Synve Hoffart; Hjell, Gabriela & Ormerod, Monica Bettina E. Greenwood [Show all 11 contributors for this article] (2024). Sex differences in autonomic adverse effects related to antipsychotic treatment and associated hormone profiles. Nature NPJ Schizophrenia. ISSN 2334-265X. 10(1). doi: 10.1038/s41537-023-00430-4.
• Jaholkowski, Piotr Pawel; Hindley, Guy; Shadrin, Alexey; Tesfaye, Markos ; Bahrami, Shahram & Nerhus, Mari [Show all 19 contributors for this article] (2023). Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci. Schizophrenia Bulletin. ISSN 0586-7614. 49(6), p. 1654–1664. doi: 10.1093/schbul/sbad063. Full text in Research Archive
• Bjella, Thomas; Høegh, Margrethe Collier; Olsen, Stine Holmstul; Aminoff, Sofie Ragnhild; Barrett, Elizabeth Ann & Ueland, Torill [Show all 14 contributors for this article] (2022). Developing "MinDag" - an app to capture symptom variation and illness mechanisms in bipolar disorder. Frontiers in Medical Technology. 4. doi: 10.3389/fmedt.2022.910533. Full text in Research Archive Show summary

  Introduction: The illness course of bipolar disorder (BD) is highly heterogeneous with substantial variation between individuals with the same BD subtype and within individuals over time. This heterogeneity is not well-delineated and hampers the development of more targeted treatment. Furthermore, although lifestyle-related behaviors are believed to play a role in the illness course, such mechanisms are poorly understood. To address some of these knowledge gaps, we aimed to develop an app for collection of multi-dimensional longitudinal data on BD-relevant symptoms and lifestyle-related behaviors. Methods: An app named MinDag was developed at the Norwegian Center for Mental Disorders Research in Oslo, Norway. The app was designed to tap into selected areas: mood, sleep, functioning/activities (social, occupational, physical exercise, leisure), substance use, emotional reactivity, and psychotic experiences. Ethical, security and usability issues were highly prioritized throughout the development and for the final app solution. We conducted beta- and pilot testing to eliminate technical problems and enhance usability and acceptability. Results: The final version of MinDag comprises six modules; three which are presented for the user once daily (the Sleep module in the morning and the Mood and Functoning/Activities modules in the evening) and three which are presented once weekly (Substance Use, Emotional Reactivity, and Psychotic Experiences modules). In general, MinDag was well received in both in the beta-testing and the pilot study, and the participants provided valuable feedback that was taken into account in the final development. MinDag is now in use as part of the research protocol at the NORMENT center and in a specialized treatment unit for BD at Oslo University Hospital in Norway. Discussion: We believe that MinDag will generate unique longitudinal data well suited for capturing the heterogeneity of BD and clarifying important unresolved issues such as how life-style related behavior may influence BD symptoms. Also, the experiences and knowledge derived from the development of MinDag may contribute to improving the security, acceptability, and benefit of digital tools in mental health.

• Johansen, Ingrid Torp; Steen, Nils Eiel; Rødevand, Linn ; Werner, Maren Caroline Frogner; Lunding, Synve Hoffart & Hjell, Gabriela [Show all 12 contributors for this article] (2022). Sex-specific associations between metabolic hormones, severe mental disorders and antipsychotic treatment. Psychoneuroendocrinology. ISSN 0306-4530. 146. doi: 10.1016/j.psyneuen.2022.105927.
• Johansen, Ingrid Torp; Steen, Nils Eiel; Haram, Marit; Rødevand, Linn ; Werner, Maren Caroline Frogner & Lunding, Synve Hoffart [Show all 12 contributors for this article] (2022). Sex differences in antipsychotic-related triglyceride levels are associated with metabolic hormone differences in patients with severe mental disorders. Schizophrenia Research. ISSN 0920-9964. 243, p. 55–63. doi: 10.1016/j.schres.2022.02.015. Full text in Research Archive
• Takizawa, Naomi; Melle, Ingrid; Barrett, Elizabeth Ann; Nerhus, Mari & Ottesen, Akiah (2021). The Influence of Mental Health Literacy, Migration, and Education on the Duration of Untreated Psychosis. Frontiers in Public Health. ISSN 2296-2565. 9, p. 1–9. doi: 10.3389/fpubh.2021.705397. Full text in Research Archive
• Lagerberg, Trine Vik; Icick, Romain; Aminoff, Sofie Ragnhild; Nerhus, Mari; Barrett, Elizabeth Ann & Bjella, Thomas [Show all 9 contributors for this article] (2021). Substance Misuse Trajectories and Risk of Relapse in the Early Course of Bipolar Disorder. Frontiers in Psychiatry. ISSN 1664-0640. 12, p. 1–9. doi: 10.3389/fpsyt.2021.656912. Full text in Research Archive
• Hope, Sigrun; Nærland, Terje; Høyland, Anne Lise; Torske, Tonje; Malt, Eva & Abrahamsen, Tore G [Show all 16 contributors for this article] (2020). Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia A comparison among participants between 2 and 53 years. The FASEB Journal. ISSN 0892-6638. 34(6), p. 8114–8124. doi: 10.1096/fj.201900855RRR. Full text in Research Archive
• Berg, Akiah Ottesen; Jørgensen, Kjetil Nordbø; Nerhus, Mari; Athanasiu, Lavinia; Popejoy, Alice & Bettella, Francesco [Show all 13 contributors for this article] (2018). Vitamin D levels, brain volume, and genetic architecture in patients with psychosis. PLOS ONE. ISSN 1932-6203. 13(8). doi: 10.1371/journal.pone.0200250. Full text in Research Archive
• Gurholt, Tiril Pedersen; Osnes, Kåre; Nerhus, Mari; Jørgensen, Kjetil Nordbø; Lonning, Vera Louise Hiorth & Berg, Akiah Ottesen [Show all 9 contributors for this article] (2018). Vitamin D, Folate and the Intracranial Volume in Schizophrenia and Bipolar Disorder and Healthy Controls. Scientific Reports. ISSN 2045-2322. 8. doi: 10.1038/s41598-018-29141-y. Full text in Research Archive
• Nerhus, Mari; Berg, Akiah Ottesen; Simonsen, Carmen Elisabeth; Haram, Marit; Haatveit, Beathe Christin & Dahl, Sandra Rinne [Show all 11 contributors for this article] (2017). Vitamin D deficiency associated with cognitive functioning in psychotic disorders. Journal of Clinical Psychiatry. ISSN 0160-6689. 78(7), p. e750–e757. doi: 10.4088/JCP.16m10880.
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Hope, Sigrun; Aas, Monica & Nerhus, Mari [Show all 17 contributors for this article] (2017). Persistent increase in TNF and IL-1 markers in severe mental disorders suggests trait-related inflammation: a one year follow-up study. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 136(4), p. 400–408. doi: 10.1111/acps.12783.
• Berg, Akiah Ottesen; Melle, Ingrid; Zuber, Verena; Simonsen, Carmen Elisabeth; Nerhus, Mari & Ueland, Torill [Show all 9 contributors for this article] (2017). Modelling difficulties in abstract thinking in psychosis: the importance of socio-developmental background. Cognitive Neuropsychiatry. ISSN 1354-6805. 22(1), p. 39–52. doi: 10.1080/13546805.2016.1259998.
• Melle, Ingrid; Ottesen, Akiah; Leopold, K.; Zarafonitis-Möller, S.; Nerhus, Mari & Stouten, L.H. [Show all 7 contributors for this article] (2016). Improving outcomes: Factors influencing help-seeking behaviors in immigrants and ethnic minorities with first-episode psychosis. Psychiatrie. ISSN 1614-4864. 13(3), p. 152–157. doi: 10.1055/s-0038-1672286.
• Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen & Nerhus, Mari [Show all 13 contributors for this article] (2016). Serum levels of second-generation antipsychotics are associated with cognitive function in psychotic disorders. World Journal of Biological Psychiatry. ISSN 1562-2975. 18(6), p. 471–482. doi: 10.1080/15622975.2016.1245441.
• Haram, Marit; Bettella, Francesco; Brandt, Christine Lycke; Quintana, Daniel; Nerhus, Mari & Bjella, Thomas [Show all 11 contributors for this article] (2016). Contribution of oxytocin receptor polymorphisms to amygdala activation in schizophrenia spectrum disorders. BJPsych Open. ISSN 2056-4724. 2(6), p. 353–358. doi: 10.1192/bjpo.bp.116.003376.
• Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen & Nerhus, Mari [Show all 13 contributors for this article] (2016). Serum concentrations of mood stabilizers are associated with memory, but not other cognitive domains in psychosis spectrum disorders; explorative analyses in a naturalistic setting. International journal of bipolar disorders. ISSN 2194-7511. 4(24). doi: 10.1186/s40345-016-0067-z. Full text in Research Archive
• Quintana, Daniel; Elstad, Maja; Kaufmann, Tobias; Brandt, Christine Lycke; Haatveit, Beathe Christin & Haram, Marit [Show all 9 contributors for this article] (2016). Resting-state heart rate variability is related to respiratory frequency in individuals with severe mental illness but not healthy controls. Scientific Reports. ISSN 2045-2322. 6:37212, p. 1–8. doi: 10.1038/srep37212. Full text in Research Archive
• Tesli, Martin Steen; Wirgenes, Katrine Verena; Hughes, Timothy; Bettella, Francesco; Athanasiu, Lavinia & Hoseth, Eva Zsuzsanna [Show all 14 contributors for this article] (2016). VRK2 gene expression in schizophrenia, bipolar disorder and healthy controls. British Journal of Psychiatry. ISSN 0007-1250. 209(2), p. 114–120. doi: 10.1192/bjp.bp.115.161950.
• Nerhus, Mari; Berg, Akiah Ottesen; Kvitland, Levi Røstad; Dieset, Ingrid; Hope, Sigrun & Dahl, Sandra Rinne [Show all 11 contributors for this article] (2016). Low vitamin D is associated with negative and depressive symptoms in psychotic disorders. Schizophrenia Research. ISSN 0920-9964. 178(1-3), p. 44–49. doi: 10.1016/j.schres.2016.08.024. Full text in Research Archive Show summary

  BACKGROUND: There are indications that low S-25(OH)D is associated with increased disease severity in psychotic disorder. Our first aim was to investigate the relations between low S-25(OH)D and positive, negative and depressive symptoms. Our second aim was to explore if associations between S-25(OH)D and symptoms were influenced by levels of inflammatory markers. METHODS: Participants (N=358) with a medical history of one or more psychotic episodes were recruited. Current symptomatology was assessed by The Structured Interview for the Positive and Negative Syndrome Scaleanalyzed by a five-factor model. The Calgary Depression Scale for Schizophrenia was used to assess depression and suicidal ideation. Blood samples were analyzed for S-25(OH)D, CRP, sTNF-R1, IL-Ra and OPG. We performed bivariate correlations and multiple regression models to evaluate the effect of S-25(OH)D on the outcomes. RESULTS: Low S-25(OH)D was significantly associated with negative symptoms (adjusted R2=0.113, F(6,357)=8.58, p<0.001) and with depression (adjusted R2=0.045, F(4,357)=5.233, p<0.001) when adjusting for possible confounding factors (i.e. gender, education, diagnose, hospitalization status, ethnicity, season and thyroid status). CRP was correlated with both S-25(OH)D (rho=-0.13, p=0.02) and negative symptoms (rho=0.14, p=0.01), but did not act as a mediator. The correlations between S-25(OH)D and the inflammatory markers sTNF-R1, IL-Ra and OPG were not significant. CONCLUSION: There is a strong association between low S-25(OH)D and higher negative and depressive symptoms in psychotic disorders. Randomized controlled trials should be performed to investigate the effect of vitamin D supplementation as adjuvant treatment strategy in patients with prominent negative or depressive symptoms.

• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Hope, Sigrun; Aas, Monica & Nerhus, Mari [Show all 15 contributors for this article] (2016). Inflammatory evidence for the psychosis continuum model. Psychoneuroendocrinology. ISSN 0306-4530. 67, p. 189–197. doi: 10.1016/j.psyneuen.2016.02.011.
• Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen & Nerhus, Mari [Show all 13 contributors for this article] (2015). Serum level of venlafaxine is associated with better memory in psychotic disorders. Schizophrenia Research. ISSN 0920-9964. 169(1-3), p. 386–392. doi: 10.1016/j.schres.2015.10.021.
• Nerhus, Mari; Berg, Akiah Ottesen; Dahl, Sandra Rinne; Holvik, Kristin; Gardsjord, Erlend Strand & Weibell, Melissa Anne E.a [Show all 9 contributors for this article] (2015). Vitamin D status in psychotic disorder patients and healthy controls - The influence of ethnic background. Psychiatry Research. ISSN 0165-1781. 230(2), p. 616–621. doi: 10.1016/j.psychres.2015.10.015. Full text in Research Archive Show summary

  Vitamin D deficiency is common among patients with psychotic disorders and could be due to unknown disease mechanisms or contingent factors. However most studies are performed in chronic patients and have often failed to address the influence of ethnicity on vitamin D levels in clinical samples. We investigated serum concentrations of 25-hydroxy vitamin D (S-25 OH D) in first episode patients compared to patients with multi episodes and healthy controls; with a specific focus on differences between visible ethnic minorities and participants from the majority population. A total of 284 participants were included in this cross-sectional study. First episode patients with a DSM-IV psychotic disorder were matched on age, gender and ethnicity to participants from a multi episode patient sample (1:1) and healthy controls (1:2). We did not find any differences between either patient groups or the healthy controls, but participants from visible ethnic minorities had significantly lower S-25 OH D than participants from the majority population. This implies that S-25 OH D should be routinely measured in persons from visible ethnic minorities since low levels are associated with higher levels of depressive symptoms

• Berg, Akiah Ottesen; Barrett, Elizabeth Ann; Nerhus, Mari; Buchmann, Camilla Bakkalia; Simonsen, Carmen Elisabeth & Færden, Ann [Show all 8 contributors for this article] (2015). Psychosis: clinical insight and beliefs in immigrants in their first episode. Early Intervention in Psychiatry. ISSN 1751-7885. 12(2), p. 185–192. doi: 10.1111/eip.12297. Show summary

  Aim: Lack of insight into illness is frequent in psychotic disorders and seen as part of their primary pathology. The recognition of symptoms as psychotic, and beliefs about treatment alternatives, is also influenced by socio-cultural factors. Here we examined clinical insight into illness and beliefs about psychosis in immigrants in their first episode of psychosis compared to a reference group. Methods: 277 first episode psychosis participants were recruited to this cross-sectional study; 40 first- and 40 second-generation immigrants from Europe, Americas and Oceania (n=37), Asia including Turkey (n=28), or Africa (n=15). The Birchwood Insight Scale was used to measure clinical insight and “The Attitudes and Beliefs about Mental Health Problems”, schizophrenia version to assess socio-cultural beliefs. Results: Immigrants did not differ from the reference sample in clinical insight. After controlling for education level first generation immigrants were less likely to recognize psychotic symptoms (OR 2.9; Wald = 8.977, df 1, p =.003) and viewed hospitalization (OR 5.2; Wald = 20.388, df 1, p =.001) and treatment by a psychiatrist (OR 4.9; Wald = 6.609, df 1, p =.01)) as less beneficial than the reference group. Immigrants from Asia held more alternative explanations (OR 0.3; Wald = 6.567, df 1, p=.010). There were significantly stronger associations between clinical insight and socio-cultural beliefs in the reference group. Conclusions: Socio-cultural beliefs about psychosis in immigrants in first episode psychosis calls for more tailored information to this group, and emphasize the importance of treatment interventions involving both a cultural and personal perspective of insight.

• Berg, Akiah Ottesen; Aas, Monica; Larsson, Sara; Nerhus, Mari; Hauff, Edvard & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2015). Childhood trauma mediates the association between ethnic minority status and more severe hallucinations in psychotic disorder. Psychological Medicine. ISSN 0033-2917. 45(01), p. 133–142. doi: 10.1017/S0033291714001135. Full text in Research Archive
• Steen, Nils Eiel; Methlie, Paal; Lorentzen, Steinar; Dieset, Ingrid; Aas, Monica & Nerhus, Mari [Show all 11 contributors for this article] (2014). Altered systemic cortisol metabolism in bipolar disorder and schizophrenia spectrum disorders. Journal of Psychiatric Research. ISSN 0022-3956. 52(1), p. 57–62. doi: 10.1016/j.jpsychires.2014.01.017.
• Nerhus, Mari; Berg, Akiah Ottesen; Haram, Marit; Kvitland, Levi Røstad; Andreassen, Ole Andreas & Melle, Ingrid (2013). Migrant background and ethnic minority status as predictors for duration of untreated psychosis. Early Intervention in Psychiatry. ISSN 1751-7885. doi: 10.1111/eip.12106. Show summary

  AIM: The aim of the study was to explore if patients with migration and/or ethnic minority background have longer duration of untreated psychosis (DUP) than patients from the reference population, and in case to what extent this was best explained by ethnic minority status or migration background, including age at migration. METHODS: Four hundred sixty-two first-episode patients were included. The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Axis I Disorders was used for diagnostic purposes. Patients were interviewed about migration history and ethnicity using structured questionnaires. RESULTS: Being part of an ethnic minority group had a trend-level significance, and migration after the age of 6 had a statistically significant association with prolonged DUP. CONCLUSIONS: Age at migration has a moderate, but statistically significant effect on DUP. The findings indicate migrating after school start is associated with a longer DUP in immigrant populations.

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• Dønnum, Monica Stolen; Nag, Heidi Elisabeth; Nerhus, Mari & Nærland, Terje (2024). Psychiatric symptoms in Smith-Magenis syndrome and Potocki-Lupski syndrome.
• Nerhus, Mari (2018). Vitamin D and psychotic disorders -clinical and cognitive correlates.
• Berg, Akiah Ottesen; Melle, Ingrid & Nerhus, Mari (2018). ENVIRONAMNETAL RISK FACTORS AND SYMPTOMS IN IMMIGRANTS WITH PSYCHOTIC DISORDER .
• Gurholt, Tiril Pedersen; Nerhus, Mari; Osnes, Kåre; Berg, Akiah Ottesen; Andreassen, Ole Andreas & Melle, Ingrid [Show all 7 contributors for this article] (2018). Hippocampus volume reduction in psychosis spectrum could be ameliorated by vitamin D. Schizophrenia Research. ISSN 0920-9964. 199, p. 433–435. doi: 10.1016/j.schres.2018.03.011.
• Gurholt, Tiril Pedersen; Nerhus, Mari; Osnes, Kåre; Jørgensen, Kjetil Nordbø; Berg, Akiah Ottesen & Andreassen, Ole Andreas [Show all 8 contributors for this article] (2017). Age-Related Effect of Vitamin D on Hippocampus Volume in Schizophrenia and Bipolar Disorder.
• Nerhus, Mari; Berg, Akiah Ottesen; Melle, Ingrid & Andreassen, Ole Andreas (2015). Vitamin D status in psychotic disorder patients and healthy controls -The influence of ethnic background.
• Nerhus, Mari (2015). Blir vi glade av lys? Årstider og vitamin D ved psykiske lidelser.
• Nerhus, Mari; Berg, Akiah Ottesen & Melle, Ingrid (2015). Migrant background and visible ethnic minority status as predictors for duration of untreated psychosis.
• Melle, Ingrid; Nerhus, Mari & Barrett, Elizabeth Ann (2015). Clinical and socio-cultural measures of insight in immigrants in their first episode of psychosis.
• Berg, Akiah Ottesen & Nerhus, Mari (2015). Tran og D-Vitamin: Enda sunnere enn du tror? [Internet]. Forskningsrådet.
• Berg, Akiah Ottesen; Aas, Monica; Andreassen, Ole Andreas; Hauff, Edvard; Larsson, Sara & Melle, Ingrid [Show all 7 contributors for this article] (2014). Childhood Trauma Mediates the Association Between Ethnic Minority Status and More Severe Hallucinations in Psychotic Disorder.
• Berg, Akiah Ottesen; Aas, Monica; Larsson, Sara; Nerhus, Mari; Hauff, Edvard & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2014). Childhood Trauma Mediates the Association Between Ethnic Minority Status and More Severe Hallucinations in Psychotic Disorder .
• Kvitland, Levi Røstad; Ringen, Petter Andreas; Aminoff, Sofie Ragnhild; Haram, Marit; Hellvin, Tone & Lagerberg, Trine Vik [Show all 9 contributors for this article] (2013). Cannabis use in the early phase of bipolar disorder: clinical characteristics in a cross-sectional sample. Bipolar Disorders. ISSN 1398-5647. 15, p. 118–118.

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