Marton König

• Wolf, Asia-Sophia Fumika Michaela; Ravussin, Anthony; König, Marton; Øverås, Mathias Herstad; Solum, Guri & Kjønstad, Ingrid Fadum [Show all 18 contributors for this article] (2023). T cell responses to SARS-CoV-2 vaccination differ by disease-modifying therapy for multiple sclerosis. JCI Insight. ISSN 2379-3708. 8(12), p. 1–14. doi: 10.1172/jci.insight.165111. Full text in Research Archive
• Frič, Radek; König, Marton; Due-Tønnessen, Bernt Johan; Ramm-Pettersen, Jon-Terje & Berg-Johnsen, Jon (2023). Long-term outcome of patients treated for craniopharyngioma: a single center experience. British Journal of Neurosurgery. ISSN 0268-8697. doi: 10.1080/02688697.2023.2179600. Full text in Research Archive
• Tran, Trung; Vaage, Eline Benno; Mehta, Adi; Chopra, Adity; Tietze, Lisa & Kolderup, Heidi Anette [Show all 40 contributors for this article] (2022). Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants. npj Vaccines. ISSN 2059-0105. 7(1). doi: 10.1038/s41541-022-00586-7. Full text in Research Archive
• König, Marton; Torgauten, Hilde Marie; Tran, Trung; Holmøy, Trygve; Vaage, John T. & Lund-Johansen, Fridtjof [Show all 7 contributors for this article] (2022). Immunogenicity and Safety of a Third SARS-CoV-2 Vaccine Dose in Patients with Multiple Sclerosis and Weak Immune Response after COVID-19 Vaccination. JAMA Neurology. ISSN 2168-6149. 79(3), p. 307–309. doi: 10.1001/jamaneurol.2021.5109.
• Riise, Jon; Meyer, Saskia; Blaas, Isaac; Chopra, Adity; Tran, Trung & Delic-Sarac, Marina [Show all 22 contributors for this article] (2022). Rituximab-treated patients with lymphoma develop strong CD8 T-cell responses following COVID-19 vaccination. British Journal of Haematology. ISSN 0007-1048. 197(6), p. 697–708. doi: 10.1111/bjh.18149. Full text in Research Archive Show summary

  B-cell depletion induced by anti-cluster of differentiation 20 (CD20) monoclonal antibody (mAb) therapy of patients with lymphoma is expected to impair humoral responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination, but effects on CD8 T-cell responses are unknown. Here, we investigated humoral and CD8 T-cell responses following two vaccinations in patients with lymphoma undergoing anti-CD20-mAb therapy as single agent or in combination with chemotherapy or other anti-neoplastic agents during the last 9 months prior to inclusion, and in healthy age-matched blood donors. Antibody measurements showed that seven of 110 patients had antibodies to the receptor-binding domain of the SARS-CoV-2 Spike protein 3–6 weeks after the second dose of vaccination. Peripheral blood CD8 T-cell responses against prevalent human leucocyte antigen (HLA) class I SARS-CoV-2 epitopes were determined by peptide-HLA multimer analysis. Strong CD8 T-cell responses were observed in samples from 20/29 patients (69%) and 12/16 (75%) controls, with similar median response magnitudes in the groups and some of the strongest responses observed in patients. We conclude that despite the absence of humoral immune responses in fully SARS-CoV-2-vaccinated, anti-CD20-treated patients with lymphoma, their CD8 T-cell responses reach similar frequencies and magnitudes as for controls. Patients with lymphoma on B-cell depleting therapies are thus likely to benefit from current coronavirus disease 2019 (COVID-19) vaccines, and development of vaccines aimed at eliciting T-cell responses to non-Spike epitopes might provide improved protection.

• König, Marton; Lorentzen, Åslaug Rudjord; Torgauten, Hilde Marie; Tran, Trung; Schikora-Rustad, Stine & Vaage, Eline Benno [Show all 22 contributors for this article] (2021). Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations. Journal of Neurology, Neurosurgery and Psychiatry. ISSN 0022-3050. doi: 10.1136/jnnp-2021-327612. Full text in Research Archive
• König, Marton & Koht, Jeanette (2021). Unilateral erythema or unilateral pallor? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(12), p. 1–3. doi: 10.4045/tidsskr.21.0319.
• Corniola, Marco Vincenzo; König, Marton & Meling, Torstein Ragnar (2021). STA-MCA Bypass in Carotid Stenosis after Radiosurgery for Cavernous Sinus Meningioma. Cancers. ISSN 2072-6694. 13. doi: 10.3390/cancers13102420.
• König, Marton; Osnes, Terje; Bruland, Øyvind; Hall, Kirsten Sundby; Bratland, Åse & Meling, Torstein Ragnar (2020). The role of adjuvant treatment in craniofacial malignancy: A critical review . Frontiers in Oncology. ISSN 2234-943X. 10. doi: 10.3389/fonc.2020.01402. Full text in Research Archive
• König, Marton; Osnes, Terje; Bratland, Åse & Meling, Torstein Ragnar (2019). Squamous Cell Carcinoma of the Paranasal Sinuses: A Single Center Experience. Journal of Neurological Surgery. Part B: Skull Base: an interdisciplinary approach. ISSN 2193-6331. 81(6), p. 664–672. doi: 10.1055/s-0039-1694967. Full text in Research Archive
• König, Marton; Osnes, Terje; Bratland, Åse; Jebsen, Peter Wilhelm & Meling, Torstein Ragnar (2019). Treatment of sinonasal adenocarcinoma: A population-based prospective cohort study. Journal of Neurological Surgery. Part B: Skull Base: an interdisciplinary approach. ISSN 2193-6331. 61(8), p. 627–637. doi: 10.1055/s-0039-1694050. Full text in Research Archive
• König, Marton; Osnes, Terje; Jebsen, Peter Wilhelm & Meling, Torstein Ragnar (2018). Craniofacial resection of malignant tumors of the anterior skull base: a case series and a systematic review. Acta Neurochirurgica. ISSN 0001-6268. 160(12), p. 2339–2348. doi: 10.1007/s00701-018-3716-4. Full text in Research Archive
• König, Marton; Osnes, Terje; Jebsen, Peter Wilhelm; Evensen, Jan Folkvard & Meling, Torstein Ragnar (2017). Olfactory neuroblastoma: a single-center experience. Neurosurgical review. ISSN 0344-5607. 41, p. 323–331. doi: 10.1007/s10143-017-0859-3.
• König, Marton Skog Steinberger; Osnes, Terje; Lobmaier, Ingvild Victoria Koren; Bjerkehagen, Bodil; Bruland, Øyvind & Hall, Kirsten Sundby [Show all 7 contributors for this article] (2016). Multimodal treatment of craniofacial osteosarcoma with high-grade histology. A single-center experience over 35 years. Neurosurgical review. ISSN 0344-5607. p. 1–12. doi: 10.1007/s10143-016-0802-z. Show summary

  High-grade craniofacial osteosarcoma (CFOS) is an aggressive malignancy with a poor prognosis. Our goals were to evaluate treatment outcomes in those treated at a single referral institution over 35 years and to compare our results to the available literature. A retrospective analysis of all 42 patients treated between 1980 and 2015 at Oslo University Hospital, Norway, identified in a prospectively collected database, was conducted. Mean follow-up was 79.6 months. Overall survival at 2 and 5 years was 70.5 and 44.7%, respectively. The corresponding disease-specific survival rates were 73.0 and 49.8%. Treatment was surgery only in eight cases. Additional therapy was administered in 34 patients: chemotherapy in nine, radiotherapy in seven, and a combination of these in 18 cases. Stratified analysis by resection margins demonstrated significantly better survival at 2 and 5 years after radical surgical treatment. Neoadjuvant chemotherapy and subsequent adequate surgery resulted in better survival than surgery alone. Half of the patients either had a primary or familial cancer predisposition. This is the largest single-center study conducted on high-grade CFOS to date. Our experience indicates that neoadjuvant chemotherapy with complete surgical resection significantly improved survival, compared to surgery alone.

• König, Marton Steinberger; Osnes, Terje & Meling, Torstein (2014). Treatment of esthesioneuroblastomas. Neuro-chirurgie. ISSN 0028-3770. 60(4), p. 151–157. doi: 10.1016/j.neuchi.2014.03.007.
• König, Marton Steinberger; Bakke, Jacob; Scheie, David; Sorteberg, Wilhelm & Meling, Torstein (2011). Reactive Expansive Intracerebral Process as a Complication of Endovascular Coil Treatment of an Unruptured Intracranial Aneurysm: Case Report. Neurosurgery. ISSN 0148-396X. 68(5), p. E1468–E1473. doi: 10.1227/NEU.0b013e318210c7c0.
• König, Marton; Due-Tønnessen, Bernt Johan; Osnes, Terje ; Haugstvedt, Jan-Ragnar & Meling, Torstein (2010). Median facial cleft with a frontoethmoidal encephalocele treated with craniofacial bipartition and free radial forearm flap: a case report. Skull base surgery. ISSN 1052-1453. 20(2), p. 119–123. doi: 10.1055/s-0029-1238216.
• König, Marton; Mork, Jon; Hall, Kirsten Sundby; Osnes, Terje & Meling, Torstein (2010). Multimodal Treatment of Osteogenic Sarcoma of the Jaw. Skull base surgery. ISSN 1052-1453. 20(3), p. 207–212. doi: 10.1055/s-0029-1246221.
• König, Marton Skog Steinberger; Due-Tønnessen, Bernt Johan; Osnes, Terje; Haugstvedt, Jan-Ragnar & Meling, Torstein (2010). Median facial cleft with a frontoethmoidal encephalocele treated with craniofacial bipartition and free radial forearm flap. Journal of Neurological Surgery. Part B: Skull Base: an interdisciplinary approach. ISSN 2193-6331. 2(20), p. 119–123. doi: 10.1055/s-0029-1238216.

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• Tran, Trung; Vaage, Eline Benno; Mehta, Adi; Chopra, Adity; Tietze, Lisa & Kolderup, Heidi Anette [Show all 40 contributors for this article] (2023). Author Correction: Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants (npj Vaccines, (2022), 7, 1, (174), 10.1038/s41541-022-00586-7). npj Vaccines. ISSN 2059-0105. 8(1). doi: 10.1038/s41541-023-00600-6.
• Hermansen, My Vuong; Kleggetveit, Inge Petter; Ulvin, Line Bédos; Chawla, Maninder Singh & König, Marton (2023). En mann i 20-årene med svakhet og nummenhet i beina. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(1). doi: 10.4045/tidsskr.22.0642.
• Rasmussen, Tilde; König, Marton; Lorentzen, Åslaug Rudjord; Schikora-Rustad, Stine; Berge, Tone & Holmøy, Trygve [Show all 17 contributors for this article] (2022). Safety of a third SARS CoV 2 mRNA vaccine dose in people with multiple sclerosis.
• König, Marton; Wolf, Asia-Sophia Fumika Michaela; Ravussin, Anthony; Chopra, Adity; Tran, Trung & Torgauten, Hilde Marie [Show all 28 contributors for this article] (2022). Immunogenicity and efficacy of mRNA-COVID-19 vaccines in people with multiple sclerosis.
• Ghali, Michael G.Z.; Ghali, George Zaki; Lima, Adriana; McDermott, Michael; Glover, Emma & Voglis, Stefanos [Show all 12 contributors for this article] (2021). Retraction: Mechanisms underlying the generation of autonomorespiratory coupling amongst the respiratory central pattern generator, sympathetic oscillators, and cardiovagal premotoneurons (Journal of Integrative Neuroscience (2020) 19 (521-560) DOI: 10.31083/j.jin.2020.03.0196). Journal of Integrative Neuroscience (JIN). ISSN 0219-6352. 20(2). doi: 10.31083/j.jin.2020.03.0196R.
• Nygaard, Gro Owren; Schikora-Rustad, Stine; Lie, Ingeborg Haugesag; Aase, Audun; Leiknes, Ingvild Jullum & König, Marton [Show all 15 contributors for this article] (2021). Humoral immune response to the influenza vaccine in multiple sclerosis patients treated with cladribine or rituximab.
• König, Marton; Lorentzen, Åslaug Rudjord; Torgauten, Hilde Marie; Tran, The Trung; Schikora-Rustad, Stine & Vaage, Eline Benno [Show all 22 contributors for this article] (2021). Humoral Immunity to SARS-CoV-2 mRNA Vaccination in People with Multiple Sclerosis using High-Efficacy Disease Modifying Therapies.
• König, Marton (2020). Hidden treasures. Tidsskrift for Den norske legeforening. ISSN 0029-2001. doi: 10.4045/tidsskr.20.0622.
• König, Marton (2020). Skjulte skatter. Tidsskrift for Den norske legeforening. ISSN 0029-2001. doi: 10.4045/tidsskr.20.0622.
• König, Marton (2019). Hva ville Ole Brumm sagt? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 139(16). doi: 10.4045/tidsskr.19.0679.
• Meling, Torstein Ragnar & König, Marton (2019). Bifrontal craniotomy. In Raabe, Andreas (Eds.), The Craniotomy Atlas. Thieme Medical Publishers. ISSN 9783132057913. p. 112–118. Show summary

  Given that the great majority of brain surgeries are preceded by a craniotomy, mastering the procedure is essential for junior residents. Choosing the appropriate craniotomy and executing it safely is the difference between a straightforward case with good access to the target and a procedure where access to the target is needlessly traumatic and may even be impossible. Professor Raabe's The Craniotomy Atlas provides precise instructions for performing all common neurosurgical cranial exposures, including: convexity approaches, midline approaches, skull base approaches, transsphenoidal approaches and more. Instructions for each craniotomy include positioning, head fixation, aesthetic considerations, and protecting the dura mater.

• König, Marton (2019). Hodepine hos barn.
• Rutherford, Ole-Christian Walter; König, Marton; Risnes, Klaus; Raouf, Nezar; Atar, Dan & Ghanima, Waleed Khalid (2018). O-C.W. Rutherford og medarbeidere svarer. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(7), p. 621–621. doi: 10.4045/tidsskr.18.0238.
• König, Marton; Osnes, Terje; Jebsen, Peter Wilhelm; Bratland, Åse & Meling, Torstein Ragnar (2018). Squamous cell carcinoma of the paranasal sinuses: a single center experience.
• König, Marton; Osnes, Terje; Jebsen, Peter Wilhelm & Meling, Torstein Ragnar (2018). Craniofacial resection of malignant tumors of the anterior skull base.
• König, Marton; Osnes, Terje; Jebsen, Peter Wilhelm; Evensen, Jan Folkvard & Meling, Torstein Ragnar (2018). Olfactory neuroblastoma: a single-center experience.
• Rutherford, Ole-Christian Walter; König, Marton; Risnes, Klaus; Raouf, Nezar; Atar, Dan & Ghanima, Waleed Khalid (2018). Antidotbehandling ved bruk av direktevirkende antikoagulasjonsmidler. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(3), p. 244–247. doi: 10.4045/tidsskr.17.0190.
• König, Marton (2017). M. Konig svarer:. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(4), p. 260–261. doi: 10.4045/tidsskr.17.0103.
• König, Marton (2017). M. König svarer. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(4), p. 260–261. doi: 10.4045/tidsskr.17.0103.
• Meling, Torstein Ragnar; König, Marton; Jebsen, Peter Wilhelm; Evensen, Jan Folkvard & Osnes, Terje (2017). Olfactory neuroblastoma: a single-center experience.
• König, Marton (2016). Akutte nevrologer. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(23), p. 2031–2031. doi: 10.4045/tidsskr.16.0762.
• König, Marton Skog Steinberger; Osnes, Terje; Lobmaier, Ingvild Victoria Koren; Bjerkehagen, Bodil; Bruland, Øyvind & Sundby Hall, Kirsten [Show all 7 contributors for this article] (2016). Treatment of Craniofacial Osteosarcoma: a Multidisciplinary Approach.
• König, Marton Skog Steinberger; Osnes, Terje; Lobmaier, Ingvild Victoria Koren; Bjerkehagen, Bodil; Bruland, Øyvind & Sundby Hall, Kirsten [Show all 7 contributors for this article] (2016). Craniofacial Osteosarcoma: A Single-Institution Experience.
• König, Marton; Osnes, Terje & Meling, Torstein R. (2012). Treatment of Esthesioneuroblastomas: a Single Institution Experience .
• König, Marton; Mork, Jon; Sundby Hall, Kirsten; Osnes, Terje & Meling, Torstein R. (2009). Treatment of Osteogenic Sarcoma of the Jaw: a Case Report.

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