Meryam Sugulle

• Værnesbranden, Caren Magdalena Rydland; Staff, Anne Cathrine; Wiik, Johanna; Sjøborg, Katrine Dønvold; Rüegg, Corina Silvia & Sugulle, Meryam [Show all 21 contributors for this article] (2024). Placental human papillomavirus infections and adverse pregnancy outcomes. Placenta. ISSN 0143-4004. 152, p. 23–30. doi: 10.1016/j.placenta.2024.05.126.
• Staff, Anne Cathrine; Costa, Maria Laura; Dechend, Ralf; Jacobsen, Daniel Pitz & Sugulle, Meryam (2024). Hypertensive disorders of pregnancy and long-term maternal cardiovascular risk: Bridging epidemiological knowledge into personalized postpartum care and follow-up. Pregnancy Hypertension. ISSN 2210-7789. 36. doi: 10.1016/j.preghy.2024.101127.
• Hoel, Sissel; Moe, Kjartan; Sugulle, Meryam; Petrovski, Goran; Veiby, Nina & Staff, Anne Cathrine (2024). Retinal oximetry and microvascular assessment after hypertensive pregnancy complications. Acta Ophthalmologica. ISSN 1755-375X. doi: 10.1111/aos.16651.
• Fjeldstad, Heidi; Jacobsen, Daniel Pitz; Johnsen, Guro Mørk; Sugulle, Meryam; Chae, Angel & Kanaan, Sami B. [Show all 8 contributors for this article] (2024). Fetal-origin cells in maternal circulation correlate with placental dysfunction, fetal sex, and severe hypertension during pregnancy. Journal of Reproductive Immunology. ISSN 0165-0378. 162. doi: 10.1016/j.jri.2024.104206.
• Fiskå, Bendik Seth; Pay, Aase Serine Devold; Staff, Anne Cathrine & Sugulle, Meryam (2023). Gestational diabetes mellitus, follow-up of future maternal risk of cardiovascular disease and the use of eHealth technologies—a scoping review. Systematic Reviews. ISSN 2046-4053. 12. doi: 10.1186/s13643-023-02343-w. Full text in Research Archive
• Jacobsen, Daniel Pitz; Fjeldstad, Heidi Elisabeth Storebø; Sugulle, Meryam; Johnsen, Guro Mørk; Olsen, Maria Belland & Kanaan, Sami B. [Show all 7 contributors for this article] (2023). Fetal microchimerism and the two-stage model of preeclampsia. Journal of Reproductive Immunology. ISSN 0165-0378. 159. doi: 10.1016/j.jri.2023.104124. Full text in Research Archive
• Fjeldstad, Heidi Elisabeth Storebø; Jacobsen, Daniel Pitz; Johnsen, Guro Mørk; Sugulle, Meryam; Chae, Angel & Kanaan, Sami B. [Show all 8 contributors for this article] (2023). Poor glucose control and markers of placental dysfunction correlate with increased circulating fetal microchimerism in diabetic pregnancies. Journal of Reproductive Immunology. ISSN 0165-0378. 159, p. 1–9. doi: 10.1016/j.jri.2023.104114. Full text in Research Archive
• Fjeldstad, Heidi Elisabeth Storebø; Jacobsen, Daniel Pitz; Johnsen, Guro Mørk; Sugulle, Meryam; Chae, Angel & Kanaan, Sami B. [Show all 8 contributors for this article] (2023). Markers of placental function correlate with prevalence and quantity of nucleated fetal cells in maternal circulation in normotensive term pregnancies. Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. 102(6), p. 690–698. doi: 10.1111/aogs.14547. Full text in Research Archive
• Linge, Lydia Lande; Sugulle, Meryam; Wallukat, Gerd; Dechend, Ralf & Staff, Anne Cathrine (2022). Circulating angiotensin II type I receptor – autoantibodies in diabetic pregnancies. Journal of Reproductive Immunology. ISSN 0165-0378. 155. doi: 10.1016/j.jri.2022.103777. Full text in Research Archive
• Bowe, Sophie; Mitlid-Mork, Birgitte; Gran, Jon Michael; Distante, Sonia; Redman, Christopher W.G. & Staff, Anne Cathrine [Show all 8 contributors for this article] (2022). Predelivery placenta-associated biomarkers and computerized intrapartum fetal heart rate patterns. AJOG Global Reports. 3(1). doi: 10.1016/j.xagr.2022.100149. Full text in Research Archive Show summary

  Background Increasing syncytiotrophoblast stress in term and postdate placentas is reflected by increasing antiangiogenic dysregulation in the maternal circulation, with low “proangiogenic” placental growth factor concentrations and increased “antiangiogenic” soluble fms-like tyrosine kinase-1 concentrations. Imbalances in these placenta-associated proteins are associated with intrapartum fetal compromise and adverse pregnancy and delivery outcome. Cardiotocography is widely used to assess fetal well-being during labor, but it is insufficient on its own for predicting adverse neonatal outcome. Development of improved surveillance tools to detect intrapartum fetal stress are needed to prevent neonatal adverse outcome. Objective This study aimed to assess whether predelivery circulating maternal angiogenic protein concentrations are associated with intrapartum computerized fetal heart rate patterns, as calculated by the Oxford System for computerized intrapartum monitoring (OxSys) 1.7 prototype. We hypothesized that in pregnancies with low “proangiogenic” placental growth factor levels, increased “antiangiogenic” soluble fms-like tyrosine kinase-1 levels, and increased soluble fms-like tyrosine kinase-1–placental growth factor ratio, the OxSys 1.7 prototype will generate more automated alerts, indicating fetal compromise. Our secondary objective was to investigate the relationship between maternal circulating placenta-associated biomarkers and rates of automated alerts in pregnancies with and without adverse neonatal outcome. Study Design This was an observational prospective cohort study conducted at a single tertiary center from September 2016 to March 2020. Of 1107 singleton pregnancies (gestational week ≥37+0), 956 had available prelabor and predelivery placental growth factor and soluble fms-like tyrosine kinase-1 concentrations and intrapartum cardiotocography recordings. All neonatal and delivery outcomes were externally reviewed and categorized into 2 groups—the “complicated” group (n=32) and the “uncomplicated” group (n=924)—according to predefined adverse neonatal outcome. Eight different cardiotocography features were calculated by OxSys 1.7: baseline at start of cardiotocography, baseline at end of cardiotocography, short-term variation at start, short-term variation at end, nonreactive initial trace, and throughout the entire cardiotocography, maximum decelerative capacity, total number of prolonged decelerations, and OxSys 1.7 alert. OxSys 1.7 triggered an alert if the initial trace was nonreactive or if decelerative capacity and/or the number of prolonged decelerations exceeded a predefined threshold. Included women and attending clinicians were blinded to both biomarker and OxSys 1.7 results. Results Mean maternal placental growth factor concentration was lower in the group with OxSys 1.7 alert compared with the group without the alert (151 vs 169 pg/mL; P=.04). There was a weak negative correlation between predelivery high soluble fms-like tyrosine kinase-1 and low short-term variation start (rs=−0.068; 95% confidence interval, −0.131 to −0.004; P=.036), predelivery high soluble fms-like tyrosine kinase-1 and low short-term variation end (rs=−0.068; 95% confidence interval, −0.131 to −0.005; P=.036), and high soluble fms-like tyrosine kinase-1–placental growth factor ratio and low short-term variation end (rs=−0.071; 95% confidence interval, −0.134 to −0.008; P=.027). The rate of decelerative capacity alerts increased more rapidly as placental growth factor decreased in the “complicated” compared with the “uncomplicated” group (0% to 17% vs 4% to 8%). Conclusion More automated alerts indicative of fetal distress were generated by OxSys 1.7 in pregnancies with low maternal predelivery placental growth factor level, in line with likely increasing placental stress toward the end of the pregnancy. An antiangiogenic predelivery profile...

• Fosheim, Ingrid Knutsdotter; Jacobsen, Daniel Pitz; Sugulle, Meryam; Alnæs-Katjavivi, Patji; Fjeldstad, Heidi & Ueland, Thor [Show all 8 contributors for this article] (2022). Serum amyloid A1 and pregnancy zone protein in pregnancy complications and correlation with markers of placental dysfunction. American Journal of Obstetrics & Gynecology MFM (AJOG MFM). ISSN 2589-9333. 5(1). doi: 10.1016/j.ajogmf.2022.100794. Full text in Research Archive
• Kedziora, Sarah M.; Obermayer, Benedikt; Sugulle, Meryam; Herse, Florian; Kräker, Kristin & Haase, Nadine [Show all 11 contributors for this article] (2022). Placental transcriptome profiling in subtypes of diabetic pregnancies Is strongly confounded by fetal sex. International Journal of Molecular Sciences. ISSN 1661-6596. 23:15388(23), p. 1–16. doi: 10.3390/ijms232315388. Full text in Research Archive Show summary

  The placenta is a temporary organ with a unique structure and function to ensure healthy fetal development. Placental dysfunction is involved in pre-eclampsia (PE), fetal growth restriction, preterm birth, and gestational diabetes mellitus (GDM). A diabetic state affects maternal and fetal health and may lead to functional alterations of placental metabolism, inflammation, hypoxia, and weight, amplifying the fetal stress. The placental molecular adaptations to the diabetic environment and the adaptive spatio–temporal consequences to elevated glucose or insulin are largely unknown (2). We aimed to identify gene expression signatures related to the diabetic placental pathology of placentas from women with diabetes mellitus. Human placenta samples (n = 77) consisting of healthy controls, women with either gestational diabetes mellitus (GDM), type 1 or type 2 diabetes, and women with GDM, type 1 or type 2 diabetes and superimposed PE were collected. Interestingly, gene expression differences quantified by total RNA sequencing were mainly driven by fetal sex rather than clinical diagnosis. Association of the principal components with a full set of clinical patient data identified fetal sex as the single main explanatory variable. Accordingly, placentas complicated by type 1 and type 2 diabetes showed only few differentially expressed genes, while possible effects of GDM and diabetic pregnancy complicated by PE were not identifiable in this cohort. We conclude that fetal sex has a prominent effect on the placental transcriptome, dominating and confounding gene expression signatures resulting from diabetes mellitus in settings of well-controlled diabetic disease. Our results support the notion of placenta as a sexual dimorphic organ. Keywords: diabetes mellitus; human; placenta; pregnancy; RNA sequencing

• Tingleff, Tiril; Räisänen, Sari; Vikanes, Åse Vigdis; Sandvik, Leiv; Sugulle, Meryam & Lahmami, Gulim [Show all 7 contributors for this article] (2022). Different pathways for preterm birth between singleton and twin pregnancies: a population-based registry study of 481 176 nulliparous women. BJOG: An International Journal of Obstetrics and Gynaecology. ISSN 1470-0328. p. 1–9. doi: 10.1111/1471-0528.17344. Full text in Research Archive
• Jacobsen, Daniel Pitz; Røysland, Ragnhild; Strand, Heidi; Moe, Kjartan; Sugulle, Meryam & Omland, Torbjørn [Show all 7 contributors for this article] (2022). Circulating cardiovascular biomarkers during and after preeclampsia: Crosstalk with placental function? Pregnancy Hypertension. ISSN 2210-7789. 30, p. 103–109. doi: 10.1016/j.preghy.2022.09.003. Full text in Research Archive
• Mitlid-Mork, Birgitte; Bowe, Sophie; Staff, Anne Cathrine & Sugulle, Meryam (2022). Alterations in maternal sFlt-1 and PlGF: Time to labor onset in term-/late-term pregnancies with and without placental dysfunction. Pregnancy Hypertension. ISSN 2210-7789. 30, p. 148–153. doi: 10.1016/j.preghy.2022.10.004. Full text in Research Archive
• Jacobsen, Daniel Pitz; Røysland, Ragnhild; Strand, Heidi; Moe, Kjartan; Sugulle, Meryam & Omland, Torbjørn [Show all 7 contributors for this article] (2022). Cardiovascular biomarkers in pregnancy with diabetes and associations to glucose control. Acta Diabetologica. ISSN 0940-5429. 59(9), p. 1229–1236. doi: 10.1007/s00592-022-01916-w. Full text in Research Archive
• Kordt Sundet, Birgitte; Kreyberg, Ina; Staff, Anne Cathrine; Carlsen, Karin Cecilie Lødrup; Bains, Karen Eline Stensby & Berg, Jens Petter [Show all 20 contributors for this article] (2022). The effect of nicotine-containing products and fetal sex on placenta-associated circulating midpregnancy biomarkers. Biology of Sex Differences. ISSN 2042-6410. 13(1). doi: 10.1186/s13293-022-00443-1. Full text in Research Archive Show summary

  In utero exposure to nicotine, largely assessed by smoking, is a risk factor for impaired offspring health, while potential effects of non-combustible nicotine use such as snus (oral moist tobacco), are less well-known. Maternal serum concentrations of placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) may be viewed as “placenta health markers”, known to differ by fetal sex. Maternal smoking during pregnancy has been associated with lower levels of circulating sFlt-1, while the effect of snus on placenta-associated angiogenic factors is unknown. Our aim was to explore if snus and/or smoking exposure was associated with midpregnancy maternal levels of sFlt-1, PlGF and sFlt-1/PlGF ratio if these associations were modified by fetal sex. Methods Midpregnancy (16–22 gestational weeks) serum from 2603 Scandinavian women enrolled in the population-based multi-center PreventADALL (Preventing Atopic Dermatitis and ALLergies in children) study was analysed for sFlt-1 and PlGF concentrations by electrochemiluminescence, deriving the sFlt-1/PGF ratio. Nicotine use was assessed by electronic questionnaires at enrollment in 2278 of the women. Univariable and multivariable linear regression models on log transformed outcomes were used to assess the association between nicotine use and biomarker levels. Interaction terms were included to identify whether the associations were modified by fetal sex. Results Median sFlt-1, PlGF and sFlt-1/PlGF ratios among women with nicotine exposure information were similar to those of all included women and differed by fetal sex. Current snus use was significantly associated with reduced maternal circulating PlGF levels in adjusted analyses [β − 0.12, (95% CI − 0.20; 0.00) compared to never use, p = 0.020]. A significant interaction between fetal sex and snus exposure was observed for PIGF (p = 0.031). Prior or periconceptional snus use was significantly associated with PIGF in male fetus pregnancies [β − 0.05 (95% CI − 0.09 to (− 0.02)) and β − 0.07 (95% CI − 0.12 to (− 0.02)) compared to never use, p = 0.002]. Smoking was not significantly associated with any circulating biomarkers levels. Conclusions Midpregnancy maternal angiogenic profile differed by periconceptional snus use and fetal sex. Snus exposure, perceived as “safe” by users, before or during pregnancy seems to affect midpregnancy placental health in a sex dimorphic manner.

• Jacobsen, Daniel Pitz; Fjeldstad, Heidi Elisabeth Storebø; Johnsen, Guro Mørk; Fosheim, Ingrid Knutsdotter; Moe, Kjartan & Alnæs-Katjavivi, Patji [Show all 9 contributors for this article] (2021). Acute Atherosis Lesions at the Fetal-Maternal Border: Current Knowledge and Implications for Maternal Cardiovascular Health. Frontiers in Immunology. ISSN 1664-3224. 12, p. 1–16. doi: 10.3389/fimmu.2021.791606. Full text in Research Archive
• Sugulle, Meryam; Halldórsdóttir, Erna; Kvile, Janne; Berntzen, Line Dahlgaard & Jacobsen, Anne Flem (2021). Prospective assessment of vacuum deliveries from midpelvic station in a tertiary care university hospital: Frequency, failure rates, labor characteristics and maternal and neonatal complications. PLOS ONE. ISSN 1932-6203. 16(11), p. 1–12. doi: 10.1371/journal.pone.0259926. Full text in Research Archive
• Kedziora, Sarah M.; Kräker, Kristin; Markó, Lajos; Binder, Julia; Sugulle, Meryam & Gauster, Martin [Show all 10 contributors for this article] (2021). Kidney Injury Caused by Preeclamptic Pregnancy Recovers Postpartum in a Transgenic Rat Model . International Journal of Molecular Sciences. ISSN 1661-6596. 22(7), p. 1–13. doi: 10.3390/ijms22073762.
• Nonn, Olivia; Fischer, Cornelius; Geisberger, Sabrina; El-Heliebi, Amin; Kroneis, Thomas & Forstner, Désirée [Show all 20 contributors for this article] (2021). Maternal Angiotensin Increases Placental Leptin in Early Gestation via an Alternative Renin-Angiotensin System Pathway: Suggesting a Link to Preeclampsia. Hypertension. ISSN 0194-911X. 77(5), p. 1723–1736. doi: 10.1161/HYPERTENSIONAHA.120.16425.
• Bowe, Sophie; Mitlid-Mork, Birgitte; Georgieva, Antoniya; Gran, Jon M.; Redman, Christopher W.G. & Staff, Anne Cathrine [Show all 7 contributors for this article] (2021). The association between placenta-associated circulating biomarkers and composite adverse delivery outcome of a likely placental cause in healthy post-date pregnancies. Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. 100(10), p. 1893–1901. doi: 10.1111/aogs.14223. Full text in Research Archive
• Ziesler, Charlotte Philippa Øxnevad; Staff, Anne Cathrine; Sugulle, Meryam & Moe, Kjartan (2021). Low physical activity levels 1 year after pregnancy complications. Pregnancy Hypertension. ISSN 2210-7789. 25, p. 136–142. doi: 10.1016/j.preghy.2021.05.022.
• Fosheim, Ingrid Knutsdotter; Johnsen, G.M.; Alnaes-Katjavivi, P.; Turowski, Gitta Erika; Sugulle, M. & Staff, A.C. (2021). Decidua basalis and acute atherosis: Expression of atherosclerotic foam cell associated proteins. Placenta. ISSN 0143-4004. 107, p. 1–7. doi: 10.1016/j.placenta.2021.03.001. Full text in Research Archive
• Mitlid-Mork, Birgitte; Turowski, Gitta Erika; Bowe, Sophie; Staff, Anne Cathrine & Sugulle, Meryam (2021). Circulating angiogenic profiles and histo-morphological placental characteristics of uncomplicated post-date pregnancies. Placenta. ISSN 0143-4004. 109, p. 55–63. doi: 10.1016/j.placenta.2021.04.017. Full text in Research Archive
• Jacobsen, Daniel Pitz; Lekva, Tove; Moe, Kjartan; Fjeldstad, Heidi Elisabeth; Johnsen, Guro Mørk & Sugulle, Meryam [Show all 7 contributors for this article] (2020). Pregnancy and postpartum levels of circulating maternal sHLA-G in preeclampsia. Journal of Reproductive Immunology. ISSN 0165-0378. 143. doi: 10.1016/j.jri.2020.103249. Full text in Research Archive
• Lekva, Tove; Sugulle, Meryam; Moe, Kjartan; Redman, Christopher W.G.; Dechend, Ralf & Staff, Anne Cathrine (2020). Multiplex Analysis of Circulating Maternal Cardiovascular Biomarkers Comparing Preeclampsia Subtypes. Hypertension. ISSN 0194-911X. 75(6), p. 1513–1522. doi: 10.1161/HYPERTENSIONAHA.119.14580. Full text in Research Archive
• Mitlid-Mork, Birgitte; Bowe, Sophie; Gran, Jon Michael; Bolstad, Nils; Berg, Jens Petter & Redman, Christopher W.G. [Show all 8 contributors for this article] (2020). Maternal placental growth factor and soluble fms-like tyrosine kinase-1 reference ranges in post-term pregnancies: A prospective observational study. PLOS ONE. ISSN 1932-6203. 15:e0240473(10), p. 1–14. doi: 10.1371/journal.pone.0240473. Full text in Research Archive
• Staff, Anne Cathrine; Fjeldstad, Heidi Elisabeth; Fosheim, Ingrid Knutsdotter; Moe, Kjartan; Turowski, Gitta Erika & Johnsen, Guro Mørk [Show all 8 contributors for this article] (2020). Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia. American Journal of Obstetrics and Gynecology. ISSN 0002-9378. p. 1–12. doi: 10.1016/j.ajog.2020.09.026. Full text in Research Archive
• Moe, Kjartan; Sugulle, Meryam; Dechend, Ralf; Angel, Kristin & Staff, Anne Cathrine (2020). Functional and structural vascular biomarkers in women 1 year after a hypertensive disorder of pregnancy. Pregnancy Hypertension. ISSN 2210-7789. 21, p. 23–29. doi: 10.1016/j.preghy.2020.04.008.
• Thorsteinsdottir, Hjørdis; Salvador, Cathrin Lytomt; Mjøen, Geir; Lie, Anine; Sugulle, Meryam & Tøndel, Camilla [Show all 9 contributors for this article] (2020). Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation. Disease Markers. ISSN 0278-0240. 2020:6162892, p. 1–8. doi: 10.1155/2020/6162892. Full text in Research Archive
• Moe, Kjartan; Sugulle, Meryam; Dechend, Ralf & Staff, Anne Cathrine (2019). Risk prediction of maternal cardiovascular disease one year after hypertensive pregnancy complications or gestational diabetes mellitus . European Journal of Preventive Cardiology (EJPC). ISSN 2047-4873. p. 1–11. doi: 10.1177/2047487319879791.
• Moe, Kjartan; Alnæs-Katjavivi, Patji; Størvold, Gro Leite; Sugulle, Meryam; Johnsen, Guro Mørk & Redman, Christopher W.G. [Show all 8 contributors for this article] (2018). Classical cardiovascular risk markers in pregnancy and associations to uteroplacental acute atherosis. Hypertension. ISSN 0194-911X. 72(3), p. 695–702. doi: 10.1161/HYPERTENSIONAHA.118.10964. Full text in Research Archive
• Rieber-Mohn, Amalie; Sugulle, Meryam; Wallukat, Gerd; Alnæs-Katjavivi, Patji; Størvold, Gro Leite & Bolstad, Nils [Show all 9 contributors for this article] (2018). Auto-antibodies against the angiotensin II type I receptor in women with uteroplacental acute atherosis and preeclampsia at delivery and several years postpartum. Journal of Reproductive Immunology. ISSN 0165-0378. 128, p. 23–29. doi: 10.1016/j.jri.2018.05.008. Full text in Research Archive
• Sugulle, Meryam; Heidecke, Harald; Maschke, Ulrike; Herse, Florian; Danser, A.H. Jan & Mueller, Dominik [Show all 8 contributors for this article] (2017). Soluble (pro)renin receptor in preeclampsia and diabetic pregnancies. Journal of the American Society of Hypertension : JASH. ISSN 1933-1711. 11(10), p. 644–652. doi: 10.1016/j.jash.2017.08.001.
• Weedon-Fekjær, Mina Susanne; Sheng, Ying; Sugulle, Meryam; Johnsen, Guro Mørk; Herse, F & Redman, Christopher W.G. [Show all 9 contributors for this article] (2014). Placental miR-1301 is dysregulated in early-onset preeclampsia and inversely correlated with maternal circulating leptin. Placenta. ISSN 0143-4004. 35(9), p. 709–717. doi: 10.1016/j.placenta.2014.07.002.
• Goldman-Wohl, D.; Cesla, T.; Smith, Y; Greenfield, C.; Dechend, R. & Staff, Anne Cathrine [Show all 11 contributors for this article] (2013). Expression profiling of autophagy associated genes in placentas of preeclampsia. Placenta. ISSN 0143-4004. 34(10), p. 959–962. doi: 10.1016/j.placenta.2013.07.069.
• Herse, Florian; LaMarca, Babbette; Hubel, Carl A; Kaartokallio, Tea; Lokki, A Inkeri & Ekholm, Eeva [Show all 24 contributors for this article] (2012). Cytochrome P450 Subfamily 2J Polypeptide 2 Expression and Circulating Epoxyeicosatrienoic Metabolites in Preeclampsia. Circulation. ISSN 0009-7322. 126(25), p. 2990–2999. doi: 10.1161/CIRCULATIONAHA.112.127340.
• Sugulle, Meryam; Herse, Florian; Hering, Lydia; Möckel, Martin; Dechend, Ralf & Staff, Anne Cathrine (2012). Cardiovascular Biomarker Midregional Proatrial Natriuretic Peptide During and After Preeclamptic Pregnancies. Hypertension. ISSN 0194-911X. 59(2), p. 395–401. doi: 10.1161/HYPERTENSIONAHA.111.185264.
• Weedon-Fekjær, Mina Susanne; Johnsen, Guro Mørk; Anthonisen, Elin Holter; Sugulle, Meryam; Nebb, Hilde Irene & Duttaroy, Asim K. [Show all 7 contributors for this article] (2010). Expression of Liver X Receptors in Pregnancies Complicated by Preeclampsia. Placenta. ISSN 0143-4004. 31(9), p. 818–824. doi: 10.1016/j.placenta.2010.06.015. Show summary

  Preeclampsia is a pregnancy-specific disorder associated with hyperlipidemia. Liver X receptor (LXR) alpha and LXRbeta are key regulators of lipid homeostasis. In the current study, we investigated expression of LXRalpha, LXRbeta and their target genes in human term placenta, decidua and subcutaneous adipose tissue from pregnancies complicated by preeclampsia. Furthermore, we analyzed the protein levels of LXRalpha and LXRbeta in placenta. We also analyzed lipid concentrations in term placental tissue. Gene expression of LXRalpha, LXRbeta and fatty acid transporter CD36 was significantly decreased in placental tissues, while increased expression was observed for LXRalpha in adipose tissue, from pregnancies complicated by preeclampsia. The placental protein level of LXRbeta was reduced, and there was a positive correlation between placental LXRbeta mRNA expression and placental free fatty acids in preeclampsia. Our results suggest a possible role for LXRbeta as a transcriptional regulator in preeclampsia.

• Sugulle, Meryam; Dechend, R; Herse, F; Weedon, Mina Susanne; Johnsen, Guro Mørk & Broshnihan, KB [Show all 10 contributors for this article] (2009). Circulating and Placental Growth-Differentiation Factor 15 in Preeclampsia and in Pregnancy Complicated by Diabetes Mellitus. Hypertension. ISSN 0194-911X. 54(1), p. 106–112. doi: 10.1161/HYPERTENSIONAHA.109.130583.

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• Yakub, Sheraz; Bjørk, Ida; Sugulle, Meryam & Folseraas, Trine (2023). Biopsy helpful in diagnosing a liver mass in pregnancy: focal nodular hyperplasia. The Lancet. ISSN 0140-6736. doi: 10.1016/S0140-6736(23)01606-9..
• Fiskå, Bendik Seth; Pay, Aase Serine Devold; Staff, Anne Cathrine & Sugulle, Meryam (2023). Correction: Gestational diabetes mellitus, follow-up of future maternal risk of cardiovascular disease and the use of eHealth technologies – a scoping review (Systematic Reviews, (2023), 12, 1, (178), 10.1186/s13643-023-02343-w). Systematic Reviews. ISSN 2046-4053. 12(1). doi: 10.1186/s13643-023-02383-2.
• Ziesler, Charlotte P.Ø.; Staff, Anne Cathrine; Sugulle, Meryam & Moe, Kjartan (2023). Corrigendum to “Low physical activity levels 1 year after pregnancy complications” [Pregnancy Hyperten. 25 (2021) 136–142, (S221077892100060X), (10.1016/j.preghy.2021.05.022)]. Pregnancy Hypertension. ISSN 2210-7789. 33, p. 30–31. doi: 10.1016/j.preghy.2023.06.003.
• Palmrich, Pilar; Haase, Nadine; Sugulle, Meryam; Kalafat, Erkan; Khalil, Asma & Binder, Julia (2023). Maternal haemodynamics in Hypertensive Disorders of Pregnancy under antihypertensive therapy (HyperDiP): study protocol for a prospective observational case-control study. BMJ Open. ISSN 2044-6055. 13(6). doi: 10.1136/bmjopen-2022-065444. Full text in Research Archive
• Fosheim, Ingrid; Johnsen, Guro Mørk; Alnæs-Katjavivi, Patji Haakon; Turowski, Gitta Erika; Sugulle, Meryam & Staff, Anne Cathrine (2021). Corrigendum to "Decidua basalis and acute atherosis: Expression of atherosclerotic foam cell associated proteins" [Placenta 107 (2021) 1-7]. Placenta. ISSN 0143-4004. doi: 10.1016/j.placenta.2021.10.014.
• Lekva, Tove; Jacobsen, Daniel Pitz; Sugulle, Meryam; Moe, Kjartan; Fjeldstad, Heidi E. & Dechend, Ralf [Show all 7 contributors for this article] (2021). Circulating HLA-G and its association with cardiovascular markers in pregnancy. Journal of Reproductive Immunology. ISSN 0165-0378. 146. doi: 10.1016/j.jri.2021.103331.
• Weedon-Fekjær, Mina Susanne; Sheng, Ying; Herse, Florian; Lyle, Robert; Sugulle, Meryam & Dechend, Ralf [Show all 7 contributors for this article] (2012). DIFFERENTIAL EXPRESSION OF MIRNAS IN PLACENTA FROM EARLY AND LATE ONSET PREECLAMPSIA VERSES CONTROLS. Placenta. ISSN 0143-4004. 33(9), p. A78–A78.
• Sugulle, Meryam; Herse, Florian; Kvehaugen, Anne Stine; Mueller, Dominik; Dechend, Ralf & Staff, Anne Cathrine (2011). Atrial Natriuretic Peptide Reflects The Cardiovascular Alterations in Preeclampsia. Hypertension. ISSN 0194-911X. 58(5), p. E172–E173.
• Johnsen, GM; Weedon-Fekjaer, MS; Sugulle, Meryam; Kliman, HJ & Staff, Anne Cathrine (2010). ADRP IS ASSOCIATED WITH FOAM CELLS AND ACUTE ATHEROSIS IN DECIDUAL TISSUE. Placenta. ISSN 0143-4004. 31(9), p. A124–A124.
• Weedon-Fekjaer, MS; Johnsen, Guro Mørk; Sugulle, Meryam; Duttaroy, Asim K.; Nebb, Hilde Irene & Staff, Anne Cathrine (2008). Regulation of liver X receptor and target genes in primary trophoblasts, placenta, dfcidua and fat tissue. Placenta. ISSN 0143-4004. 29, p. A44–A44.
• Herse, F; Hering, L; Verlohren, S; Sugulle, Meryam; Luft, F & Müller, Daniel [Show all 8 contributors for this article] (2008). Adipocytes Produce their Own Endogenous Inhibitor for Angiogenesis (Sflt): Implications for Preeclampsia and Fat Cell Proliferation. Hypertension in Pregnancy. ISSN 1064-1955. 27(4), p. 461–461.

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