Michael Thomas Durheim

• Lærum, Dan; Strand, Trond-Eirik; Brustugun, Odd Terje; Gallefoss, Frode; Falk, Ragnhild Sørum & Durheim, Michael Thomas [Show all 7 contributors for this article] (2024). Evaluation of sex inequity in lung-cancer-specific survival. Acta Oncologica. ISSN 0284-186X. 63, p. 343–350. doi: 10.2340/1651-226X.2024.27572.
• Øvrebotten, Tarjei; Mecinaj, Albulena; Stavem, Knut; Ghanima, Waleed; Brønstad, Eivind & Durheim, Michael Thomas [Show all 14 contributors for this article] (2024). Trajectory of cardiac troponin T following moderate-to-severe COVID-19 and the association with cardiac abnormalities. BMC Cardiovascular Disorders. ISSN 1471-2261. 24(1). doi: 10.1186/s12872-024-03854-7.
• Sikkeland, Liv Ingunn Bjoner; Ueland, Thor; Samersaw-Lund, May Brit; Durheim, Michael Thomas & Mollnes, Tom Eirik (2023). A role for the terminal C5-C9 complement pathway in idiopathic pulmonary fibrosis. Frontiers in medicine. ISSN 2296-858X. 10. doi: 10.3389/fmed.2023.1236495. Full text in Research Archive
• Mangseth, Henrik; Sikkeland, Liv Ingunn Bjoner; Durheim, Michael Thomas; Ulvestad, Mariann; Myrdal, Ole Henrik & Kongerud, Johny Steinar [Show all 7 contributors for this article] (2023). Comparison of different reference values for lung function: implications of inconsistent use among centers. BMC Pulmonary Medicine. ISSN 1471-2466. 23. doi: 10.1186/s12890-023-02430-7. Full text in Research Archive
• Lerum, Tøri Vigeland; Meltzer, Carin; Rivero, Jezabel Rodriguez; Aaløkken, Trond Mogens; Brønstad, Eivind & Aarli, Bernt Bøgvald [Show all 12 contributors for this article] (2023). A prospective study of pulmonary outcomes and chest computed tomography in the first year after COVID-19. European Respiratory Journal Open Research (ERJ Open Research). ISSN 2312-0541. 9(2). doi: 10.1183/23120541.00575-2022. Full text in Research Archive
• Stavem, Knut; Heir, Trond; Dammen, Toril; Brønstad, Eivind; Lerum, Tøri Vigeland & Durheim, Michael Thomas [Show all 9 contributors for this article] (2022). The course and determinants of post-traumatic stress over 12 months after hospitalization for COVID-19. Frontiers in Psychiatry. ISSN 1664-0640. 13. doi: 10.3389/fpsyt.2022.931349. Full text in Research Archive Show summary

  Objective: To assess the trajectory of symptoms and symptom-defined post-traumatic stress disorder (PTSD) from 1.5 to 12 months after hospitalization for COVID-19 and determine risk factors for persistent symptoms and PTSD. Methods: This was a prospective cohort study of consecutive patients discharged after hospitalization for COVID-19 before 1 June 2020 in six hospitals in Southern Norway. Symptom-defined PTSD was assessed by the post-traumatic stress disorder (PTSD) checklist for DSM-5 (PCL-5) at 1.5, 3 and/or 12 months after hospitalization, using DSM-5 criteria. Changes in PCL-5 symptom score and the prevalence of PTSD were analyzed with multivariable mixed models. Results: In total, 388 patients were discharged alive, and 251 (65%) participated. Respondents had a mean (SD) age of 58.4 (14.2) years, and 142 (57%) were males. The prevalence of symptom-defined PTSD was 14, 8, and 9% at 1.5, 3, and 12 months, respectively. WHO disease severity for COVID-19 was not associated with PCL-5 scores. Female sex, lower age and non-Norwegian origin were associated with higher PCL-5 scores. The odds ratio (OR) (95%CI) for PTSD was 0.32 (0.12 to 0.83, p = 0.019) at 3 months and 0.38 (0.15 to 0.95, p = 0.039) at 12 months compared to 1.5 months. There was no association between PTSD and WHO severity rating. Conclusions: The level of PTSD symptoms decreased from 1.5 to 3 months after hospitalization, but did not decrease further to 12 months, and there was no association between PTSD symptoms and COVID-19 disease severity.

• Martinez, Fernando J.; Yow, Eric; Flaherty, Kevin R.; Snyder, Laurie D.; Durheim, Michael Thomas & Wisniewski, Stephen R. [Show all 18 contributors for this article] (2021). Effect of Antimicrobial Therapy on Respiratory Hospitalization or Death in Adults with Idiopathic Pulmonary Fibrosis: The CleanUP-IPF Randomized Clinical Trial. Journal of the American Medical Association (JAMA). ISSN 0098-7484. 325(18), p. 1841–1851. doi: 10.1001/jama.2021.4956.
• Durheim, Michael Thomas; Bendstrup, Elisabeth; Carlson, Lisa; Sutinen, Eva M.; Hyldgaard, Charlotte & Kalafatis, Dimitrios [Show all 9 contributors for this article] (2021). Outcomes of patients with advanced idiopathic pulmonary fibrosis treated with nintedanib or pirfenidone in a real-world multicentre cohort. Respirology (Carlton South. Print). ISSN 1323-7799. 26(10), p. 982–988. doi: 10.1111/resp.14116. Full text in Research Archive
• Ulvestad, Mariann; Godang, Kristin; Durheim, Michael; Kongerud, Johny S.; Lund, May-Brith & Bollerslev, Jens [Show all 7 contributors for this article] (2021). Effect of high-intensity training on bone health and body composition in lung transplant recipients: A secondary analysis of a randomized controlled trial. Clinical Transplantation. ISSN 0902-0063. p. 1–9. doi: 10.1111/ctr.14375. Full text in Research Archive Show summary

  Background: Loss of bone mineral and skeletal muscle mass is common after lung transplantation (LTx), and physical activity (PA) may prevent further deterioration. We aimed to assess the effects of 20-week high-intensity training (HIT) on body composition, bone health, and PA in LTx recipients, 6–60 months after surgery. Methods: In a randomized controlled trial, 51 LTx recipients underwent Dual-energy X-ray absorptiometry (DXA), and PA level and sedentary time were objectively recorded by accelerometers for seven consecutive days. Of these, 39 participants completed the study, including 19 participants in the HIT group and 20 participants in the standard care group. Results: Following the intervention, ANCOVA models revealed a nonsignificant between-group difference for change in lean body mass (LBM) and bone mineral density (BMD) of the lumbar spine of 0.4% (95% CI = −3.2, 1.5) (p = .464) and 1.0% (95% CI=−1.3, 3.4) (p = .373), respectively. Trabecular bone score (TBS) of the lumbar spine (L1-L4), however, increased by 2.2 ± 5.0% in the exercise group and decreased by −1.6 ± 5.9% in the control group, giving a between-group difference of 3.8% (95% CI=0.1, 7.5) (p = .043). There were no between-group differences in PA or sedentary time. Conclusion: High-intensity training after LTx improved TBS significantly, but not PA, LBM or BMD.

• Fraz, Mai Sasaki Aanensen; Moe, Natasha; Rootwelt-Revheim, Mona-Elisabeth; Stavrinou, Maria; Durheim, Michael & Nordøy, Ingvild [Show all 11 contributors for this article] (2021). Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency—Features of CT and 18F-FDG Positron Emission Tomography/CT in Clinically Progressive Disease. Frontiers in Immunology. ISSN 1664-3224. 11. doi: 10.3389/fimmu.2020.617985. Full text in Research Archive
• Sikkeland, Liv Ingunn Bjoner; Durheim, Michael Thomas; Riste, Tonje Bøyum; Kongerud, Johny; Alexis, Neil E. & Holm, Are Martin (2020). Relation of sputum neutrophilia to the development of chronic lung allograft dysfunction after lung transplantation. Clinical Transplantation. ISSN 0902-0063. doi: 10.1111/ctr.14188.
• Durheim, Michael; Judy, Jennifer; Bender, Shaun; Neely, Megan L.; Baumer, Dorothy & Robinson, Scott [Show all 10 contributors for this article] (2020). A retrospective study of in-hospital mortality in patients with idiopathic pulmonary fibrosis between 2015 and 2018. Medicine. ISSN 0025-7974. doi: 10.1097/MD.0000000000023143.
• Anstrom, Kevin J.; Noth, Imre; Flaherty, Kevin; Edwards, Rex H.; Albright, Joan & Baucom, Amanda [Show all 18 contributors for this article] (2020). Design and rationale of a multi-center, pragmatic, open-label randomized trial of antimicrobial therapy-the study of clinical efficacy of antimicrobial therapy strategy using pragmatic design in Idiopathic Pulmonary Fibrosis (CleanUP-IPF) clinical trial. Respiratory Research. ISSN 1465-9921. 21(1), p. 1–13. doi: 10.1186/s12931-020-1326-1.
• Olsen, Jul Eirik; Auråen, Henrik; Durheim, Michael; Fiane, Arnt E & Holm, Are Martin (2020). Predictors of long intensive care need after lung transplantation. Clinical Transplantation. ISSN 0902-0063. doi: 10.1111/ctr.14152.
• Lerum, Tøri Vigeland; Aaløkken, Trond M; Brønstad, Eivind; Aarli, Bernt Bøgvald; Ikdahl, Eirik & Lund, Kristine Marie Aarberg [Show all 14 contributors for this article] (2020). Dyspnoea, lung function and CT findings three months after hospital admission for COVID-19. European Respiratory Journal. ISSN 0903-1936. doi: 10.1183/13993003.03448-2020. Full text in Research Archive
• Ulvestad, Mariann; Durheim, Michael; Kongerud, Johny; Hansen, Bjørge Herman; Samersaw-Lund, May Brit & Edvardsen, Elisabeth (2020). Cardiorespiratory Fitness and Physical Activity following Lung Transplantation: A National Cohort Study. Respiration. ISSN 0025-7931. 99(4), p. 316–324. doi: 10.1159/000506883. Full text in Research Archive Show summary

  Background: Low cardiorespiratory fitness and inactivity are common after lung transplantation (LTx). The causes of exercise intolerance are incompletely understood. Objectives: The aim of this study was to objectively assess cardiorespiratory fitness and physical activity, evaluate causes of exercise intolerance, and explore clinical factors associated with cardiorespiratory fitness after bilateral LTx (BLTx). Materials and Methods: Peak oxygen uptake (V∙O2peak) and exercise-limiting factors were evaluated by a treadmill cardiopulmonary exercise test (CPET) 6–60 months after BLTx. Physical activity was measured with accelerometers, and results were compared with Norwegian normative data and the World Health Organization’s (WHO) recommendations for physical activity. Results: In 54 included BLTx recipients (mean age 50 ± 15 years, 50% females), V∙O2peak (mL × kg–1 × min–1) was 21.8 ± 7.7 for men and 22.4 ± 6.2 for women, corresponding to 57 ± 17 and 70 ± 12% of predicted, respectively. Three patients (6%) met criteria for normal V∙O2peak. Deconditioning limited V∙O2peak in 22 patients (41%), while ventilatory limitation and abnormal gas exchange were observed in 14 (26%) and 20 (37%) patients, respectively (some had more than 1 finding). Forty-three patients (86%) did not meet the WHO physical activity recommendations. There was a moderate correlation between V∙O2peak and physical activity (r = 0.642, p < 0.01). Body mass index, physical activity, forced expiratory volume after 1 second, sex, and hemoglobin together accounted for 73% of the variability in V∙O2peak. Conclusions: Low cardiorespiratory fitness was observed in the majority of BLTx recipients. Both deconditioning and cardiopulmonary limitations were common findings. Nearly 90% were classified as being inactive according to physical activity recommendations. CPET appears to identify a deconditioned subgroup of BLTx recipients for whom exercise training may be especially beneficial.

• Durheim, Michael; Hoffmann-Vold, Anna-Maria; Eagan, Tomas Mikal; Hovden, Arnt-Ove; Samersaw-Lund, May Brit & Bjerke, Gisle [Show all 10 contributors for this article] (2020). ILD-specific health-related quality of life in systemic sclerosis-associated ILD compared with IPF. BMJ Open Respiratory Research. ISSN 2052-4439. 7(1). doi: 10.1136/bmjresp-2020-000598. Full text in Research Archive
• Ulvestad, Mariann; Durheim, Michael; Kongerud, Johny; Samersaw-Lund, May Brit & Edvardsen, Elisabeth (2020). Effect of high-intensity training on peak oxygen uptake and muscular strength after lung transplantation: A randomized controlled trial. The Journal of Heart and Lung Transplantation. ISSN 1053-2498. p. 1–9. doi: 10.1016/j.healun.2020.06.006. Full text in Research Archive
• Durheim, Michael; Judy, Jennifer; Bender, Shaun; Baumer, Dorothy; Lucas, Joseph & Robinson, Scott B [Show all 11 contributors for this article] (2019). In-Hospital Mortality in Patients with Idiopathic Pulmonary Fibrosis: A US Cohort Study. Lung. ISSN 0341-2040. 197(6), p. 699–707. doi: 10.1007/s00408-019-00270-z.
• Auråen, Henrik; Durheim, Michael; Dellgren, Gøran; Hämmäinen, Pekka; Larsson, H & Geiran, Odd [Show all 11 contributors for this article] (2019). Effect of Donor Age on Outcome of Lung Transplantation Stratified by Recipient Diagnosis: A Nordic Multicenter Study. Transplantation. ISSN 0041-1337. 103(4), p. 807–814. doi: 10.1097/TP.0000000000002402. Full text in Research Archive
• Durheim, Michael; Holmes, Dajuanicia N; Blanco, Rosalia G; Allen, Larry A; Chan, Paul & Freeman, James V [Show all 15 contributors for this article] (2018). Characteristics and outcomes of adults with chronic obstructive pulmonary disease and atrial fibrillation. Heart. ISSN 1355-6037. 104(22), p. 1850–1858. doi: 10.1136/heartjnl-2017-312735.
• Burroughs Peña, Melissa S.; Dunning, Allison; Schulte, Phillip J.; Durheim, Michael; Kussin, Peter & Checkley, William [Show all 7 contributors for this article] (2016). Pulmonary function and adverse cardiovascular outcomes: Can cardiac function explain the link? Respiratory Medicine. ISSN 0954-6111. 121, p. 4–12. doi: 10.1016/j.rmed.2016.10.009.

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• Lynn, Evelyn; Forde, Sarah H.; Franciosi, Alessandro N.; Bendstrup, Elisabeth; Veltkamp, Marcel & Wind, Anne E. [Show all 12 contributors for this article] (2024). Updated Prevalence of Lymphangioleiomyomatosis in Europe. American Journal of Respiratory and Critical Care Medicine. ISSN 1073-449X. 209(4), p. 456–459. doi: 10.1164/rccm.202310-1736LE.
• Sikkeland, Liv Ingunn Bjoner; Durheim, Michael; Riste, Tonje Bøyum; Kongerud, Johny; Alexis, Neil E. & Holm, Are Martin (2021). Relation of sputum neutrophilia to the development of chronic lung allograft dysfunction after lung transplantation. Clinical Transplantation. ISSN 0902-0063. 35(3), p. 1–5. doi: 10.1111/ctr.14188.
• Durheim, Michael Thomas (2020). Toward realizing the full potential of registries in interstitial lung disease. Annals of the American Thoracic Society. ISSN 2329-6933. 17(12), p. 1534–1535. doi: 10.1513/AnnalsATS.202008-1077ED.

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