Olav Sundnes

• Alfonso, Jose Hernan; Bassarova, Assia Vassileva; Endre, Kim Magnus Advocaat; Sundnes, Olav & Lossius, Astrid Haaskjold (2024). Generalised pustular psoriasis triggered by monkeypox vaccination successfully treated with spesolimab. JEADV Clinical Practice. ISSN 2768-6566. doi: 10.1002/jvc2.493.
• Stabell, Siri Hansen; Renzi, Anastasia; Nilsen, Hogne Røed; Antonsen, Olaf Harald; Fosse, Johanna Hol & Haraldsen, Guttorm [Show all 7 contributors for this article] (2023). Detection of native, activated Notch receptors in normal human apocrine-bearing skin and in hidradenitis suppurativa. Experimental Dermatology. ISSN 0906-6705. 33(1). doi: 10.1111/exd.14977. Full text in Research Archive
• Nast, A.; Smith, Catherine H.; Spuls, P; Avila Valle, Valle; Bata-Csörgö, Z. & Boonen, H. [Show all 27 contributors for this article] (2021). EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris – Part 2: specific clinical and comorbid situations. Journal of the European Academy of Dermatology and Venereology. ISSN 0926-9959. 35(2), p. 281–317. doi: 10.1111/jdv.16926.
• Fjær, Roar; Marciniak, Katarzyna; Sundnes, Olav; Hjorthaug, Hanne; Sheng, Ying & Hammarström, Clara Louise [Show all 18 contributors for this article] (2021). A novel somatic mutation in GNB2 provides new insights to the pathogenesis of Sturge-Weber syndrome. Human Molecular Genetics. ISSN 0964-6906. 30(21), p. 1919–1931. doi: 10.1093/hmg/ddab144. Full text in Research Archive Show summary

  Sturge–Weber syndrome (SWS) is a neurocutaneous disorder characterized by vascular malformations affecting skin, eyes and leptomeninges of the brain, which can lead to glaucoma, seizures and intellectual disability. The discovery of a disease-causing somatic missense mutation in the GNAQ gene, encoding an alpha chain of heterotrimeric G-proteins, has initiated efforts to understand how G-proteins contribute to SWS pathogenesis. The mutation is predominantly detected in endothelial cells and is currently believed to affect downstream MAPK signalling. In this study of six Norwegian patients with classical SWS, we aimed to identify somatic mutations through deep sequencing of DNA from skin biopsies. Surprisingly, one patient was negative for the GNAQ mutation, but instead harbored a somatic mutation in GNB2 (NM_005273.3:c.232A>G, p.Lys78Glu), which encodes a beta chain of the same G-protein complex. The positions of the mutant amino acids in the G-protein are essential for complex reassembly. Therefore, failure of reassembly and continuous signalling is a likely consequence of both mutations. Ectopic expression of mutant proteins in endothelial cells revealed that expression of either mutant reduced cellular proliferation, yet regulated MAPK signalling differently, suggesting that dysregulated MAPK signalling cannot fully explain the SWS phenotype. Instead, both mutants reduced synthesis of Yes-associated protein (YAP), a transcriptional co-activator of the Hippo signalling pathway, suggesting a key role for this pathway in the vascular pathogenesis of SWS. The discovery of the GNB2 mutation sheds novel light on the pathogenesis of SWS and suggests that future research on targets of treatment should be directed towards the YAP, rather than the MAPK, signalling pathway.

• Lossius, Astrid Haaskjold; Sundnes, Olav; Ingham, Anna Cäcilia; Edslev, Sofie Marie; Bjørnholt, Jørgen Vildershøj & Lilje, Berit [Show all 12 contributors for this article] (2021). Shifts in the Skin Microbiota after UVB Treatment in Adult Atopic Dermatitis. Dermatology. ISSN 1018-8665. 238(1), p. 109–120. doi: 10.1159/000515236. Full text in Research Archive
• Sundnes, Olav; Ottestad, William Arne; Schjalm, Camilla; Lundbäck, Peter; La Cour Poulsen, Lars & Mollnes, Tom Eirik [Show all 8 contributors for this article] (2021). Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study. Molecular medicine (Cambridge, Mass. Print). ISSN 1076-1551. 27:29, p. 1–10. doi: 10.1186/s10020-021-00288-1. Full text in Research Archive
• Gatti, Francesca; Mia, Sobuj; Hammarström, Clara Louise; Frerker, Nadine; Fosby, Bjarte & Wang, Junbai [Show all 11 contributors for this article] (2021). Nuclear IL-33 restrains the early conversion of fibroblasts to an extracellular matrix-secreting phenotype. Scientific Reports. ISSN 2045-2322. 11:108(1), p. 1–13. doi: 10.1038/s41598-020-80509-5. Full text in Research Archive
• Nast, A.; Smith, C.; Spuls, P.I.; Avila Valle, Valle; Bata-Csörgö, Z. & Boonen, H. [Show all 27 contributors for this article] (2020). EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris – Part 1: treatment and monitoring recommendations. Journal of the European Academy of Dermatology and Venereology. ISSN 0926-9959. 34(11), p. 2461–2498. doi: 10.1111/jdv.16915.
• Lossius, Astrid Haaskjold; Berents, Teresa Løvold; Sætre, Frank Ove; Nilsen, Hogne Røed; Bradley, Maria & Asad, Samina [Show all 9 contributors for this article] (2020). Early transcriptional changes after UVB treatment in atopic dermatitis includes inverse regulation of IL‐36γ and IL‐37. Experimental Dermatology. ISSN 0906-6705. 30(2), p. 249–261. doi: 10.1111/exd.14217. Full text in Research Archive
• Pietka, Wojciech; Sundnes, Olav; Hammarström, Clara Louise; Zucknick, Manuela; Khnykin, Denis & Haraldsen, Guttorm (2020). Lack of interleukin-33 and its receptor does not prevent calcipotriol-induced atopic dermatitis-like inflammation in mice. Scientific Reports. ISSN 2045-2322. 10:6451, p. 1–8. doi: 10.1038/s41598-020-63410-z. Full text in Research Archive
• Pietka, Wojciech; Khnykin, Denis; Bertelsen, Vibeke; Lossius, Astrid Haaskjold; Stav-Noraas, Tor Espen & Hol, Johanna [Show all 9 contributors for this article] (2018). Hypo-osmotic stress drives IL-33 production in human keratinocytes - An epidermal homeostatic response. Journal of Investigative Dermatology. ISSN 0022-202X. 139(1), p. 81–90. doi: 10.1016/j.jid.2018.07.023. Full text in Research Archive
• La Cour Poulsen, Lars; Edelmann, Reidunn Jetne; Krüger, Stig; Diéguez-Hurtado, Rodrigo; Shah, Akshay & Stav-Noraas, Tor Espen [Show all 22 contributors for this article] (2018). Inhibition of endothelial NOTCH1 signaling attenuates inflammation by reducing cytokine-mediated histone acetylation at inflammatory enhancers . Arteriosclerosis, Thrombosis and Vascular Biology. ISSN 1079-5642. 38(4), p. 854–869. doi: 10.1161/ATVBAHA.117.310388. Full text in Research Archive
• Stav-Noraas, Tor Espen; Edelmann, Reidunn Jetne; La Cour Poulsen, Lars; Sundnes, Olav; Phung, Danh & Kuchler, Axel Matthias [Show all 11 contributors for this article] (2017). Endothelial IL-33 expression is augmented by adenoviral activation of the DNA damage machinery. Journal of Immunology. ISSN 0022-1767. 198(8), p. 3318–3325. doi: 10.4049/jimmunol.1600054. Full text in Research Archive
• Ngcungcu, Thandiswa; Oti, Martin; Sitek, Jan Cezary; Haukanes, Bjørn Ivar; Linghu, Bolan & Bruccoleri, Robert [Show all 29 contributors for this article] (2017). Duplicated enhancer region increases expression of CTSB and segregates with keratolytic winter erythema in South African and Norwegian families. American Journal of Human Genetics. ISSN 0002-9297. 100(5), p. 737–750. doi: 10.1016/j.ajhg.2017.03.012.
• Gundersen, Mona Dixon; Goll, Rasmus; Hol, Johanna; Olsen, Trine; Rismo, Renathe & Sørbye, Sveinung Wergeland [Show all 9 contributors for this article] (2016). Loss of interleukin 33 expression in colonic crypts - a potential marker for disease remission in ulcerative colitis. Scientific Reports. ISSN 2045-2322. 6. doi: 10.1038/srep35403. Full text in Research Archive
• Schrumpf, Elisabeth; Tan, Corey; Karlsen, Tom Hemming; Sponheim, Jon; Björkström, Niklas K. & Sundnes, Olav [Show all 16 contributors for this article] (2015). The biliary epithelium presents antigens to and activates natural killer T cells. Hepatology. ISSN 0270-9139. 62(4), p. 1249–1259. doi: 10.1002/hep.27840.
• Sundnes, Olav; Pietka, Wojciech; Loos, Tamara; Sponheim, Jon; Rankin, Andrew L. & Pflanz, Stefan [Show all 11 contributors for this article] (2015). Epidermal expression and regulation of interleukin-33 during homeostasis and inflammation: Strong species differences. Journal of Investigative Dermatology. ISSN 0022-202X. 135(7), p. 1771–1780. doi: 10.1038/jid.2015.85.
• Tveita, Anders; Schjesvold, Fredrik Hellem; Sundnes, Olav; Haabeth, Ole Audun; Haraldsen, Guttorm & Bogen, Bjarne (2014). Indirect CD4+ T-cell-mediated elimination of MHC II(NEG) tumor cells is spatiallyrestricted and fails to prevent escape of antigen-negative cells. European Journal of Immunology. ISSN 0014-2980. 44(9), p. 2625–2637. doi: 10.1002/eji.201444659.
• Pollheimer, Jürgen; Bodin, Johanna; Sundnes, Olav; Bekkeheien, Reidunn C; Skånland, Sigrid Strand & Sponheim, Jon [Show all 16 contributors for this article] (2013). Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells. Arteriosclerosis, Thrombosis and Vascular Biology. ISSN 1079-5642. 33(2), p. e47–e55. doi: 10.1161/ATVBAHA.112.253427.

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• Gjersvik, Petter & Sundnes, Olav (2021). Slik får biologiske legemidler navn. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(3), p. 1–3. doi: 10.4045/tidsskr.20.0995.
• Schjesvold, Fredrik Hellem; Tveita, Anders; Sundnes, Olav; Haraldsen, Guttorm & Bogen, Bjarne (2013). CD4+T cell-mediated protection against tumors: no bystander killing. Journal of Immunology. ISSN 0022-1767. 190.
• Sundnes, Olav; Khnykin, Denis & Haraldsen, Guttorm (2013). Cellular expression of the alarmin IL-33 in acute skin inflammation. Journal of Investigative Dermatology. ISSN 0022-202X. 133, p. S52–S52.

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