Pål Andre Holme

• Holme, Pål Andre; Poulsen, Lone Hvitfeldt; Tueckmantel, Claudia; Maas Enriquez, Monika; Alvarez Román, María Teresa & De Cristofaro, Raimondo (2024). Safety and efficacy of damoctocog alfa pegol prophylaxis in patients with severe haemophilia A: Results of an interventional, post-marketing study. Haemophilia. ISSN 1351-8216. doi: 10.1111/hae.14930.
• Ettingshausen, Carmen Escuriola; Hermans, Cedric; Holme, Pål Andre; Cid, Ana R; Khair, Kate & Oldenburg, Johannes [Show all 10 contributors for this article] (2023). Real-world data in patients with congenital hemophilia and inhibitors: final data from the FEIBA Global Outcome (FEIBA GO) study. Therapeutic Advances in Hematology (TAH). ISSN 2040-6207. doi: 10.1177/20406207231184323. Full text in Research Archive
• Jørgensen, Ole Jakob; Steineger, Johan Edvard; Hillarp, Andreas; Wåland, Erik Pareli; Holme, Pål Andre & Heimdal, Ketil Riddervold [Show all 7 contributors for this article] (2023). Elevated FVIII levels in hereditary hemorrhagic telangiectasia: Implications for clinical management. Laryngoscope Investigative Otolaryngology (LIO). ISSN 2378-8038. 9(1). doi: 10.1002/lio2.1196. Full text in Research Archive
• Måseide, Ragnhild Johanne; Berntorp, Erik; Astermark, Jan; Olsson, Anna; Bruzelius, Maria & Frisk, Tony [Show all 10 contributors for this article] (2023). Health-related quality of life and physical activity in Nordic patients with moderate haemophilia A and B (the MoHem study). Haemophilia. ISSN 1351-8216. doi: 10.1111/hae.14899.
• Astermark, Jan; Baghaei, Fariba; Strandberg, Karin; Toplican, Petra Gabric; Birkedal, Maj Friberg & Grahn, Emma Engman [Show all 12 contributors for this article] (2023). Infrastructural considerations of implementing gene therapy for hemophilia in the Nordic context. Therapeutic Advances in Hematology (TAH). ISSN 2040-6207. 14. doi: 10.1177/20406207231202306. Full text in Research Archive
• Hillarp, Andreas; Holme, Pål Andre; Wåland, Erik Pareli; Skogstad, Marie Jeanette; Henriksson, Carola Elisabeth & Tjønnfjord, Geir Erland [Show all 7 contributors for this article] (2023). Report on 4 cases with decreased recovery due to neutralizing antibodies specific for PEGylated recombinant factor VIII. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. 21(10), p. 2771–2775. doi: 10.1016/j.jtha.2023.07.019. Full text in Research Archive
• Reding, Mark T.; Pabinger, Ingrid; Holme, Pål Andre; Maas Enriquez, Monika; Mancuso, Maria Elisa & Lalezari, Shadan [Show all 10 contributors for this article] (2023). Efficacy and safety of damoctocog alfa pegol prophylaxis in patients ⩾40 years with severe haemophilia A and comorbidities: post hoc analysis from the PROTECT VIII study. Therapeutic Advances in Hematology (TAH). ISSN 2040-6207. 14. doi: 10.1177/20406207231166779. Full text in Research Archive
• Arvanitakis, Alexandros; Holme, Pål Andre; Berntorp, Erik & Astermark, Jan (2023). Impact of timing of prophylaxis commencement, F8 genotype and age on factor consumption and health-related quality of life in patients with severe haemophilia A. Haemophilia. ISSN 1351-8216. doi: 10.1111/hae.14806. Full text in Research Archive
• Warlo, Ellen Mathea Kirsch; Kalstad, Are; Myhre, Peder Langeland; Solheim, Svein; Arnesen, Harald & Tveit, Arnljot [Show all 9 contributors for this article] (2023). von Willebrand factor, ADAMTS-13, and thrombospondin 1 in relation to clinical outcomes in elderly patients with a recent myocardial infarction. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 7(4). doi: 10.1016/j.rpth.2023.100164. Full text in Research Archive
• Kihlberg, Kristina; Baghaei, Fariba; Bruzelius, Maria; Funding, Eva; Holme, Pål Andre & Lassila, Riitta [Show all 11 contributors for this article] (2023). No difference in quality of life between persons with severe haemophilia A and B. Haemophilia. ISSN 1351-8216. doi: 10.1111/hae.14759. Full text in Research Archive
• Matlary, Ruth Elise Dybvik; Grydeland, May; Glosli, Heidi; Rüegg, Corina Silvia & Holme, Pål Andre (2023). Factors associated with physical activity in young people with haemophilia A on prophylaxis. Haemophilia. ISSN 1351-8216. 29(3), p. 900–909. doi: 10.1111/hae.14776. Full text in Research Archive Show summary

  Introduction: Physical activity (PA) is influenced by numerous factors, and the literature describing why people with haemophilia (PWH) are physically active or not is inconclusive. Aims: To investigate factors associated with PA (mean min/day in light (LPA), moderate (MPA), vigorous (VPA) and total PA, and proportion meeting World Health Organization (WHO) weekly moderate-to-vigorous (MVPA) recommendations) among young PWH A. Methods: Forty PWH A on prophylaxis from the HemFitbit study were included. PA was measured using Fitbit devices and participant characteristics were collected. Potential factors associated with PA were investigated by univariable linear regression models for continuous PA outcomes, and descriptively for teenagers meeting/not meeting WHO MVPA recommendations only, because all except one adult met PA recommendations. Results: Mean age (n = 40) was 19.5 years (SD 5.7). Annual bleeding rate was nearly zero and joint scores were low. We found an increase of four min/day in LPA (95% confidence interval (CI) 1–7) per year increase in age. Participants with ‘Haemophilia Early Arthropathy Detection with Ultrasound’ (HEAD-US) score ≥1 engaged in mean 14 min/day less MPA (95% CI −23.2 to −3.8), and 8 min less VPA (95% CI −15.0 to −0.4) compared to participants with HEAD-US score 0. Teenagers who met PA recommendations had slightly better joint status compared to those who did not meet recommendations. Conclusion: These findings indicate that presence of mild arthropathy does not affect LPA but may have a negative impact on PA of higher intensities. Early start of prophylaxis may be an important determinant of PA.

• Matlary, Ruth Elise Dybvik; Grydeland, May; Glosli, Heidi; Rüegg, Corina Silvia & Holme, Pål Andre (2023). Physical activity in Norwegian teenagers and young adults with haemophilia A compared to general population peers. Haemophilia. ISSN 1351-8216. doi: 10.1111/hae.14752. Full text in Research Archive Show summary

  Introduction: Limited evidence exists on objectively measured habitual physical activity (PA) of young people with haemophilia (PWH). Aims: To compare different outcomes of objective PA between young PWH A and controls using a commercial activity tracker. Methods: We enrolled males aged 13–30 years with moderate and severe haemophilia A, without inhibitors on regular prophylaxis. PA was measured with the activity tracker Fitbit Charge 3 for 12 weeks. Control group data was obtained from ≈60,000 Fitbit users, matched on age, sex and measurement period. PA variables [steps, intensities, volume, activity types, exercise frequencies and proportion meeting the World Health Organization's moderate-to-vigorous PA (MVPA) recommendations] were compared between groups descriptively and using Welch's two-sample t-test and two-sample test of proportions. Results: Forty PWH A were enrolled (mean age 19.5 years, 50% teenagers, 50% adults, three (7.5%) with moderate and 37 (92.5%) with severe haemophilia). Mean daily steps and minutes MVPA were similar between PWH and controls. PWH spent more time in light PA (mean 227 vs. 192 min/day, P = .033) and exercised more frequently (mean 5.6 vs. 3.9 exercise sessions/week, P < .001). Among teenagers, 40% PWH and 8% controls reached MVPA recommendations, compared to 95% and 100% among adults. The most common type of PA was walking. Conclusion: This cohort of young PWH A on prophylactic treatment had PA levels comparable to controls. Still, a considerable proportion of teenagers did not meet the recommended weekly volume of MVPA, and we encourage clinicians to have a particular focus on promoting PA for this group.

• Schultz, Nina Haagenrud; Søraas, Arne Vasli; Sørvoll, Ingvild Hausberg; Akkøk, Cigdem Ahaein; Vetlesen, Annette & Jagjit, Bhamra Singh [Show all 13 contributors for this article] (2022). Vaccine associated benign headache and cutaneous hemorrhage after ChAdOx1 nCoV-19 vaccine: A cohort study. Journal of Stroke & Cerebrovascular Diseases. ISSN 1052-3057. 32(1). doi: 10.1016/j.jstrokecerebrovasdis.2022.106860. Full text in Research Archive
• Warlo, Ellen Mathea Kirsch; Bratset, Vibeke; Pettersen, Alf Åge Reistad; Holme, Pål Andre; Arnesen, Harald & Seljeflot, Ingebjørg [Show all 7 contributors for this article] (2022). Genetic variation in ADAMTS13 is related to VWF levels, atrial fibrillation and cerebral ischemic events. Clinical and applied thrombosis/hemostasis. ISSN 1076-0296. 28, p. 1–8. doi: 10.1177/10760296221141893. Full text in Research Archive
• Klamroth, Robert; Ay, Cihan; De Moerloose, Philippe; Fontana, Pierre; Windyga, Jerzy & Astermark, Jan [Show all 20 contributors for this article] (2022). Applicability of the European Society of Cardiology Guidelines on the management of acute coronary syndromes to older people with haemophilia A – A modified Delphi consensus by the ADVANCE Working Group. Haemophilia. ISSN 1351-8216. doi: 10.1111/hae.14674.
• Hetland, Geir; Fagerhol, Magne Kristoffer; Wiedmann, Markus; Søraas, Arne Vasli; Mirlashari, Mohammad Reza & Nissen-Meyer, Lise Sofie Haug [Show all 9 contributors for this article] (2022). Elevated NETs and Calprotectin Levels after ChAdOx1 nCoV-19 Vaccination Correlate with the Severity of Side Effects. Vaccines. ISSN 2076-393X. 10(8). doi: 10.3390/vaccines10081267. Full text in Research Archive
• Lehtinen, Anna-Elina; Baghaei, Fariba; Astermark, Jan & Holme, Pål Andre (2022). Surgical outcomes in patients with haemophilia A or B receiving extended half-life recombinant factor VIII and IX Fc fusion proteins: Real-world experience in the Nordic countries. Haemophilia. ISSN 1351-8216. 28(5), p. 713–719. doi: 10.1111/hae.14585. Full text in Research Archive
• Szanto, Timea; Zetterberg, Eva; Ramström, Sofia; Leinøe, Eva B.; Holme, Pål Andre & Antovic, Jovan P. [Show all 16 contributors for this article] (2022). Platelet function testing: Current practice among clinical centres in Northern Europe. Haemophilia. ISSN 1351-8216. 28(4), p. 642–648. doi: 10.1111/hae.14578. Full text in Research Archive
• Kihlberg, Kristina; Baghaei, Fariba; Bruzelius, Maria; Funding, Eva; Holme, Pål Andre & Lassila, Riitta [Show all 13 contributors for this article] (2022). Factor IX antibodies and tolerance in hemophilia B in the Nordic countries – The impact of F9 variants and complications. Thrombosis Research. ISSN 0049-3848. 217, p. 22–32. doi: 10.1016/j.thromres.2022.06.015. Full text in Research Archive
• Matlary, Ruth Elise Dybvik; Holme, Pål Andre; Glosli, Heidi; Rueegg, Corina Silvia & Grydeland, May (2022). Comparison of free-living physical activity measurements between ActiGraph GT3X-BT and Fitbit Charge 3 in young people with haemophilia. Haemophilia. ISSN 1351-8216. p. 1–9. doi: 10.1111/hae.14624. Full text in Research Archive Show summary

  Introduction: Measurement of physical activity (PA) using commercial activity trackers such as Fitbit devices has become increasingly popular, also for people with haemophilia (PWH). The accuracy of the Fitbit model Charge 3 has not yet been examined. Aims: To compare the Fitbit Charge 3 against the research-grade accelerometer ActiGraph GT3X-BT in measuring average daily steps and minutes spent in different PA intensities. Methods: Twenty-four young PWH wore a wrist-worn Fitbit Charge 3 and hip-worn ActiGraph GT3X-BT simultaneously for seven consecutive days in free-living conditions. Correlation of and differences between the devices for daily averages of PA parameters were assessed using Pearson's correlation coefficient and paired t-test, respectively. Agreement between devices was assessed using Bland-Altman plots. Results: Twenty participants (mean age 21.8) were included in the analyses. We found moderate to high correlations between Fitbit and ActiGraph measured daily averages for all PA variables, but statistically significant differences between devices for all variables except daily minutes of moderate PA. Fitbit overestimated average daily steps, minutes of light, vigorous and moderate-to-vigorous PA. Bland-Altman plots showed a measurement bias between devices for all parameters with increasing overestimation by the Fitbit for higher volumes of PA. Conclusion: The Fitbit Charge 3 overestimated steps and minutes of light, moderate and moderate-to-vigorous PA as compared to the ActiGraph GT3X-BT, and this bias increased with PA volume. The Fitbit should therefore be used with caution in research, and we advise users of the device to be cognizant of this overestimation.

• Ueland, Thor; Sørvoll, Ingvild Hausberg; Mørtberg, Trude Victoria; Dahl, Tuva Børresdatter; Lerum, Tøri Vigeland & Michelsen, Annika Elisabet [Show all 16 contributors for this article] (2022). Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology. Platelets. ISSN 0953-7104. 33(4), p. 640–644. doi: 10.1080/09537104.2022.2042238. Full text in Research Archive
• Arvanitakis, Alexandros; Holme, Pål Andre; Berntorp, Erik & Astermark, Jan (2022). Clinical outcome and adherence rate in Scandinavian patients with intermediate-intensity prophylaxis before and after the switch of standard half-life FVIII products to BAY 81–8973. Haemophilia. ISSN 1351-8216. 28(2), p. 223–229. doi: 10.1111/hae.14489. Full text in Research Archive
• Klintman, Jenny; Akesson, Kristina E; Holme, Pål Andre & Fischer, Kathelijn (2022). Bone mineral density in haemophilia – a multicentre study evaluating the impact of different replacement regimens. Haemophilia. ISSN 1351-8216. 28(2), p. 239–246. doi: 10.1111/hae.14487. Full text in Research Archive
• Kihlberg, Kristina; Baghaei, Fariba; Bruzelius, Maria; Funding, Eva; Holme, Pål Andre & Lassila, Riitta [Show all 11 contributors for this article] (2021). Treatment outcomes in persons with severe haemophilia B in the Nordic region: The B-NORD study. Haemophilia. ISSN 1351-8216. 27(3), p. 366–374. doi: 10.1111/hae.14299. Full text in Research Archive
• Holstein, Katharina; Le Quellec, Sandra; Klamroth, Robert; Batorova, A; Holme, Pål Andre & Jiménez-Yuste, Victor [Show all 7 contributors for this article] (2021). Immune tolerance induction in the era of emicizumab – still the first choice for patients with haemophilia A and inhibitors? Haemophilia. ISSN 1351-8216. doi: 10.1111/hae.14470. Full text in Research Archive
• Wiedmann, Markus; Skattør, Thor Håkon; Stray-Pedersen, Arne; Romundstad, Luis Georg; Antal, Ellen-Ann & Marthinsen, Pål Bache [Show all 16 contributors for this article] (2021). Vaccine Induced Immune Thrombotic Thrombocytopenia Causing a Severe Form of Cerebral Venous Thrombosis With High Fatality Rate: A Case Series . Frontiers in Neurology. ISSN 1664-2295. 12:721146, p. 1–7. doi: 10.3389/fneur.2021.721146. Full text in Research Archive
• Johansen, Silje; Lægreid, Ingvild Jenssen; Ernstsen, Siw Leiknes; Azrakhsh, Nessar Ahmad; Kittang, Astrid Marta Olsnes & Lindås, Roald [Show all 13 contributors for this article] (2021). Thrombosis and thrombocytopenia after HPV vaccination. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. doi: 10.1111/jth.15604. Full text in Research Archive
• Jiménez-Yuste, Victor; Rodríguez-Merchán, E. Carlos; Matsushita, Tadashi & Holme, Pål Andre (2021). Concomitant use of bypassing agents with emicizumab for people with haemophilia A and inhibitors undergoing surgery. Haemophilia. ISSN 1351-8216. 27(4), p. 519–530. doi: 10.1111/hae.14322.
• Astermark, Jan; Ay, Cihan; Carvalho, Manuela; D'Oiron, Roseline; Moerloose, Philippe De & Dolan, Gerard [Show all 18 contributors for this article] (2021). New Inhibitors in the Ageing Population: A Retrospective, Observational, Cohort Study of New Inhibitors in Older People with Hemophilia. Thrombosis and Haemostasis. ISSN 0340-6245. doi: 10.1055/a-1642-4067.
• Holm, Sverre; Kared, Hassen; Michelsen, Annika Elisabet; Kong, Xiang Yi; Dahl, Tuva Børresdatter & Schultz, Nina Haagenrud [Show all 21 contributors for this article] (2021). Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia. European Heart Journal. ISSN 0195-668X. 42(39), p. 4064–4072. doi: 10.1093/eurheartj/ehab506. Full text in Research Archive
• Reding, Mark T.; Pabinger, Ingrid; Holme, Pål Andre; Poulsen, Lone; Negrier, Claude & Chalasani, Pavani [Show all 11 contributors for this article] (2021). Confirmed long-term safety and efficacy of prophylactic treatment with BAY 94–9027 in severe haemophilia A: final results of the PROTECT VIII extension study. Haemophilia. ISSN 1351-8216. 27(3), p. e347–e356. doi: 10.1111/hae.14297. Full text in Research Archive
• Schultz, Nina Haagenrud; Glosli, Heidi; Bjørnsen, Stine & Holme, Pål Andre (2021). The effect of emicizumab and bypassing agents in patients with hemophilia – An in vitro study. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 5(5), p. 1–7. doi: 10.1002/rth2.12561. Full text in Research Archive
• Måseide, Ragnhild Johanne; Berntorp, Erik; Nummi, Vuokko; Lassila, Riitta; Tjønnfjord, Geir E. & Holme, Pål A. (2021). Bleeding phenotype of patients with moderate haemophilia A and B assessed by thromboelastometry and thrombin generation. Haemophilia. ISSN 1351-8216. p. 1–10. doi: 10.1111/hae.14355. Full text in Research Archive
• Schultz, Nina Haagenrud; Sørvoll, Ingvild Hausberg; Michelsen, Annika; Munthe, Ludvig Andre; Lund-Johansen, Fridtjof & Ahlen, Maria Therese [Show all 11 contributors for this article] (2021). Thrombosis and thrombocytopenia after CHADOX1 NCoV-19 vaccination. New England Journal of Medicine. ISSN 0028-4793. 384(22), p. 2124–2130. doi: 10.1056/NEJMoa2104882. Full text in Research Archive
• Schultz, Nina Haagenrud; Fareed, Jawed & Holme, Pål Andre (2021). Investigation of the Optimal Dose aPCC in Reversing the Effect of Factor Xa Inhibitors—An In Vitro Study. Clinical and applied thrombosis/hemostasis. ISSN 1076-0296. 27, p. 1–7. doi: 10.1177/10760296211021156. Full text in Research Archive
• Måseide, Ragnhild Johanne; Berntorp, Erik; Astermark, Jan; Hansen, Jessica; Olsson, Anna & Bruzelius, Maria [Show all 11 contributors for this article] (2021). Haemophilia early arthropathy detection with ultrasound and haemophilia joint health score in the moderate haemophilia (MoHem) study. Haemophilia. ISSN 1351-8216. 27(2), p. e253–e259. doi: 10.1111/hae.14245. Full text in Research Archive
• Qvigstad, Christian; Tait, R. Campbell; de Moerloose, Philippe & Holme, Pål Andre (2020). Hematuria in aging men with hemophilia: Association with factor prophylaxis. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 4(2), p. 309–317. doi: 10.1002/rth2.12298. Full text in Research Archive
• Kempton, Christine L.; Makris, Michael & Holme, Pål Andre (2020). Management of comorbidities in haemophilia. Haemophilia. ISSN 1351-8216. doi: 10.1111/hae.14013.
• Qvigstad, Christian; Sørensen, Lars A Q; Tait, R. Campbell; De Moerloose, Philippe & Holme, Pål Andre (2020). Macroscopic hematuria as a risk factor for hypertension in ageing people with hemophilia and a family history of hypertension. Medicine. ISSN 0025-7974. 99(9), p. 1–8. doi: 10.1097/MD.0000000000019339. Full text in Research Archive
• Måseide, Ragnhild Johanne; Berntorp, Erik; Astermark, Jan; Olsson, Anna; Bruzelius, Maria & Frisk, Tony [Show all 10 contributors for this article] (2020). Joint health and treatment modalities in Nordic patients with moderate haemophilia A and B – The MoHem study. Haemophilia. ISSN 1351-8216. 26(5), p. 891–897. doi: 10.1111/hae.14114. Full text in Research Archive
• Gorkom, Britta; Holme, Pål Andre; Joch, Christine; Rogosch, Tobias; Feussner, Annette & McKeand, William [Show all 8 contributors for this article] (2020). Pharmacokinetics and pharmacodynamics of a recombinant fusion protein linking activated coagulation factor VII with human albumin (rVIIa-FP) in patients with congenital FVII deficiency. Hematology. ISSN 1024-5332. 25(1), p. 17–25. doi: 10.1080/16078454.2019.1700329. Full text in Research Archive
• Tjønnfjord, Eirik; Holme, Pål Andre; Darne, Bernadette; Khelif, Abderrahim; Waage, Anders & Michel, Marc [Show all 8 contributors for this article] (2020). Long-term outcomes of patients treated with rituximab as second-line treatment for adult immune thrombocytopenia – Follow-up of the RITP study. British Journal of Haematology. ISSN 0007-1048. 191(3), p. 460–465. doi: 10.1111/bjh.16672. Full text in Research Archive
• Chowdary, Pratima; Carcao, Manuel; Holme, Pål Andre; Jiménez-Yuste, Victor; Lentz, Steven R. & Møss, Judi [Show all 11 contributors for this article] (2019). Fixed doses of N8-GP prophylaxis maintain moderate-to-mild factor VIII levels in the majority of patients with severe hemophilia A. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 3(3), p. 542–554. doi: 10.1002/rth2.12220. Full text in Research Archive
• Lalezari, Shadan; Reding, Mark T.; Pabinger, Ingrid; Holme, Pål Andre; Negrier, Claude & Chalasani, Pavani [Show all 10 contributors for this article] (2019). BAY 94-9027 prophylaxis is efficacious and well tolerated for up to &amp;gt;5 years with extended dosing intervals: PROTECT VIII extension interim results. Haemophilia. ISSN 1351-8216. 25(6), p. 1011–1019. doi: 10.1111/hae.13853. Full text in Research Archive
• Curry, Nicola; Albayrak, Canan; Escobar, Miguel; Holme, Pål Andre; Kearney, Susan & Klamroth, Robert [Show all 14 contributors for this article] (2019). Once-weekly prophylaxis with glycoPEGylated recombinant factor VIII (N8-GP) in severe haemophilia A: Safety and efficacy results from pathfinder 2 (randomized phase III trial). Haemophilia. ISSN 1351-8216. 25(3), p. 373–381. doi: 10.1111/hae.13712. Full text in Research Archive
• Andersen, May-Linn Fauske; Holme, Pål Andre & Tjønnfjord, Geir Erland (2019). Surgical intervention in patients with severe bleeding disorder 1997-2014. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 139(8), p. 709–712. doi: 10.4045/tidsskr.18.0592. Show summary

  BACKGROUND As a result of good medical treatment, the life expectancy of patients with severe haemophilia is now approaching normal. This implies a growing need for treatment of lifestyle- and age-related disease. This article describes surgery in patients with severe haemophilia in the period 1997–2014. MATERIAL AND METHOD Data were retrieved from the registry linked to the national treatment service for surgery, intervention and advanced diagnostics for haemophilia. The patients were categorised according to type of haemophilia and type of intervention in orthopaedic and non-orthopaedic surgical procedures. RESULTS A total of 825 surgical procedures were undertaken in 286 patients. The number of procedures increased from 21 in 1997 to 66 in 2014. This increase was associated with non-orthopaedic interventions: altogether 4 such procedures were undertaken in 1997 and 45 in 2014. The number of orthopaedic interventions varied somewhat from year to year, but no clear trend was evident. INTERPRETATION With increased life expectancy, we are seeing a growing need for treatment of diseases that are not causally related to haemophilia. Doctors with little experience of patients with severe haemophilia will need to deal with lifestyle- and age-related disease in this patient group.

• Ljungkvist, Marcus; Strandberg, Karin; Berntorp, Erik; Chaireti, Roza; Holme, Pål Andre & Larsen, Ole Halfdan [Show all 10 contributors for this article] (2019). Evaluation of a standardized protocol for thrombin generation using the calibrated automated thrombogram: A Nordic study. Haemophilia. ISSN 1351-8216. p. 1–9. doi: 10.1111/hae.13640. Full text in Research Archive
• Schultz, Nina Haagenrud; Holme, Pål Andre; Bjørnsen, Stine; Henriksson, Carola; Sandset, Per Morten & Jacobsen, Eva-Marie (2018). The impact of rivaroxaban on primary hemostasis in patients with venous thrombosis. Platelets. ISSN 0953-7104. doi: 10.1080/09537104.2018.1557618.
• Yaddehi Gamage, Thilini Hansamali Gamage; Gunnes, Gjermund; Lee, Robert Hugh; Louch, William Edward; Holmgren, Asbjørn & Bruton, Joseph D. [Show all 19 contributors for this article] (2018). STIM1 R304W causes muscle degeneration and impaired platelet activation in mice. Cell Calcium. ISSN 0143-4160. 76, p. 87–100. doi: 10.1016/j.ceca.2018.10.001. Full text in Research Archive Show summary

  STIM1 and ORAI1 regulate store-operated Ca2+ entry (SOCE) in most cell types, and mutations in these proteins have deleterious and diverse effects. We established a mouse line expressing the STIM1 R304 W gain-of-function mutation causing Stormorken syndrome to explore effects on organ and cell physiology. While STIM1 R304 W was lethal in the homozygous state, surviving mice presented with reduced growth, skeletal muscle degeneration, and reduced exercise endurance. Variable STIM1 expression levels between tissues directly impacted cellular SOCE capacity. In contrast to patients with Stormorken syndrome, STIM1 was downregulated in fibroblasts from Stim1R304W/R304W mice, which maintained SOCE despite constitutive protein activity. In studies using foetal liver chimeras, STIM1 protein was undetectable in homozygous megakaryocytes and platelets, resulting in impaired platelet activation and absent SOCE. These data indicate that downregulation of STIM1 R304 W effectively opposes the gain-of-function phenotype associated with this mutation, and highlight the importance of STIM1 in skeletal muscle development and integrity.

• Holme, Pål Andre & Tjønnfjord, Geir Erland (2018). Continuous infusion of simoctocog alfa in haemophilia A patients undergoing surgeries. Haemophilia. ISSN 1351-8216. p. 1–6. doi: 10.1111/hae.13625. Full text in Research Archive
• Qvigstad, Christian; Tait, Robert Cambell; Rauchensteiner, Stephan; Berntorp, Erik; de Moerloose, Philippe & Schutgens, Roger E. [Show all 7 contributors for this article] (2018). The elevated prevalence of risk factors for chronic liver disease among ageing people with hemophilia and implications for treatment. Medicine. ISSN 0025-7974. 97:e12551(39), p. 1–7. doi: 10.1097/MD.0000000000012551. Full text in Research Archive
• Schultz, Nina Haagenrud; Lundblad, Runar & Holme, Pål Andre (2018). Activated prothrombin complex concentrate to reverse the factor Xa inhibitor (apixaban) effect before emergency surgery: A case series. Journal of Medical Case Reports. ISSN 1752-1947. 12(138). doi: 10.1186/s13256-018-1660-9.
• Schultz, Nina Haagenrud; Tran, Hoa Thi Tuyet; Bjørnsen, Stine; Henriksson, Carola Elisabeth; Sandset, Per Morten & Holme, Pål Andre (2017). The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII in apixaban-treated patients in vitro. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 1(1), p. 49–56. doi: 10.1002/rth2.12015.
• Holme, Pål Andre; Tjønnfjord, Geir Erland & Batorova, A (2017). Continuous infusion of coagulation factor concentrates during intensive treatment. Haemophilia. ISSN 1351-8216. 24(1), p. 24–32. doi: 10.1111/hae.13331.
• Osooli, Mehdi; Carlsson, Katarina Steen; Baghaei, Fariba; Holmström, Margareta; Rauchensteiner, Stephan & Holme, Pål Andre [Show all 9 contributors for this article] (2017). The association between health utility and joint status among people with severe haemophilia A: findings from the KAPPA register. Haemophilia. ISSN 1351-8216. 23(3), p. e180–e187. doi: 10.1111/hae.13231.
• Berntorp, Erik; Dargaud, Yesim; Hart, Daniel; Lobet, Sébastien; Mancuso, Maria Elisa & d'Oiron, Roseline [Show all 26 contributors for this article] (2017). The second Team Haemophilia Education Meeting, 2016, Frankfurt, Germany. European Journal of Haematology. ISSN 0902-4441. 98, p. 1–15. doi: 10.1111/ejh.12828.
• Schultz, Nina Haagenrud; Tran, Hoa Thi Tuyet; Bjørnsen, Stine; Henriksson, Carola; Sandset, Per Morten & Holme, Pål Andre (2017). The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII against anticoagulation of Xa inhibitor. Thrombosis Journal. ISSN 1477-9560. 15(1). doi: 10.1186/s12959-017-0129-1.
• Holme, Pål Andre; Combescure, Christophe; Tait, Robert Cambell; Berntorp, Erik E.; Rauchensteiner, Stephan & de Moerloose, Philippe R. (2016). Hypertension, haematuria and renal functioning in haemophilia - a cross-sectional study in Europe. Haemophilia. ISSN 1351-8216. 22(2), p. 248–255. doi: 10.1111/hae.12847.
• Berger, Karin B.; Schopohl, Dorothee; Lowe, Gordon; Holme, Pål Andre; Tait, Robert Cambell & Combescure, Christophe [Show all 8 contributors for this article] (2016). How to compare cardiovascular disease and risk factors in elderly patients with haemophilia with the general population. Haemophilia. ISSN 1351-8216. 22(5), p. e406–e416. doi: 10.1111/hae.13069.
• Barratt-Due, Andreas; Fløisand, Yngvar; Lang, Hilde Elisabeth; Kvam, Ann Kristin; Holme, Pål Andre & Bergseth, Grete [Show all 8 contributors for this article] (2016). Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome. Rheumatology. ISSN 1462-0324. doi: 10.1093/rheumatology/kew040. Full text in Research Archive
• James, PD; Mahlangu, J; Bidlingmaier, C; Mingot-Castellano, María Eva; Chitlur, M & Fogarty, PF [Show all 13 contributors for this article] (2016). Evaluation of the utility of the ISTH-BAT in haemophilia carriers: a multinational study. Haemophilia. ISSN 1351-8216. 22(6), p. 912–918. doi: 10.1111/hae.13089.
• Holstein, K; Batorova, A; Carvalho, M.; Fijnvandraat, K.; Holme, Pål Andre & Kavakli, K [Show all 10 contributors for this article] (2016). Current view and outcome of ITI therapy - A change over time? Thrombosis Research. ISSN 0049-3848. 148, p. 38–44. doi: 10.1016/j.thromres.2016.10.015. Show summary

  Introduction Inhibitor development in people with haemophilia is a serious complication that may require intensive and costly interventions. The goal of inhibitor management should be permanent inhibitor eradication through immune tolerance induction (ITI), but well-designed studies are lacking and the management of patients is therefore defined by the experience and views of the clinician. Objectives To explore the current clinical practice and outcome of ITI therapy in Europe and how this may have changed over the last decade, as well as to provide consensus recommendations to guide clinicians in their clinical practice. Methods A survey was conducted among 16 European haemophilia comprehensive care centres to evaluate current ITI treatment regimens and success rates in severe and mild/moderate haemophilia A and haemophilia B. In addition, an updated literature review was performed as guidance for providing recommendations. Results We demonstrated successful inhibitor treatment in 86% of severe haemophilia A patients with low responding (LR) and 59% of patients with high responding (HR) inhibitors. Some new trends in the management of patients with inhibitors were identified, including a tendency to use low-dose regimens (< 50 IU/kg/d) in both children and adults with HR inhibitors possibly based on similar success rates demonstrated in the I-ITI study compared to a high-dose protocol. Data on ITI therapy in mild and moderate haemophilia as well as haemophilia B were limited. Conclusions The outcome of ITI therapy seems to be stable over time, and treatment regimens remain heterogeneous. The use of low dose regimens however is considered more frequently.

• HAIG, YLVA; Enden, Tone Rønnaug; Grøtta, Ole Jørgen; Kløw, Nils-Einar; Slagsvold, Carl Erik & Ghanima, Waleed Khalid [Show all 13 contributors for this article] (2016). Post-thrombotic syndrome after catheter-directed thrombolysis for deep vein thrombosis (CaVenT): 5-year follow-up results of an open-label, randomised controlled trial. The Lancet Haematology. ISSN 2352-3026. 3(2), p. e64–e71. doi: 10.1016/S2352-3026(15)00248-3.
• Valentino, Leonard A. & Holme, Pål Andre (2015). Should anti-inhibitor coagulant complex and tranexamic acid be used concomitantly? Haemophilia. ISSN 1351-8216. 21(6), p. 709–714. doi: 10.1111/hae.12723.
• Fogarty, Patrick F.; Mancuso, Maria Elisa; Kasthuri, Ram S.; Bidlingmaier, Christoph M.; Chitlur, Meera B. & Gomez, Keith [Show all 12 contributors for this article] (2015). Presentation and management of acute coronary syndromes among adult persons with haemophilia: Results of an international, retrospective, 10-year survey. Haemophilia. ISSN 1351-8216. 21(5), p. 589–597. doi: 10.1111/hae.12652.
• Ghanima, Waleed Khalid; Khelif, Abderrahim; Waage, Anders; Michel, Marc; Tjønnfjord, Geir Erland & Romdhan, Neila Ben [Show all 9 contributors for this article] (2015). Rituximab as second-line treatment for adult immune thrombocytopenia (the RITP trial): A multicentre, randomised, double-blind, placebo-controlled trial. The Lancet. ISSN 0140-6736. 385(9978), p. 1653–1661. doi: 10.1016/S0140-6736(14)61495-1.
• Tran, Hoa Thi Tuyet; Sørensen, B.; Bjørnsen, Stine; Pripp, Are Hugo; Tjønnfjord, Geir Erland & Holme, Pål Andre (2015). Monitoring bypassing agent therapy - a prospective crossover study comparing thromboelastometry and thrombin generation assay. Haemophilia. ISSN 1351-8216. 21(2), p. 275–283. doi: 10.1111/hae.12570.
• Tvedt, Tor Henrik Anderson; Holme, Pål Andre & Bruserud, Øystein (2014). En mann i 80-årene med muskelstivhet og hudblødninger 1058. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 134(10), p. 1058–1061. doi: 10.4045/tidsskr.13.0817.
• Kristiansen, Annette; Brandt, Linn; Agoritsas, Thomas; Akl, Elie A.; Berge, Eivind & Bondi, Johan Fridtjof [Show all 19 contributors for this article] (2014). Adaptation of trustworthy guidelines developed using the GRADE methodology: a novel five-step process. Chest. ISSN 0012-3692. 146(3), p. 727–734. doi: 10.1378/chest.13-2828. Show summary

  BACKGROUND: Adaptation of guidelines for use at the national or local level can facilitate their implementation. We developed and evaluated an adaptation process in adherence with standards for trustworthy guidelines and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, aiming for efficiency and transparency. This article is the first in a series describing our adaptation of Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines for a Norwegian setting. METHODS: Informed by the ADAPTE framework, we developed a five-step adaptation process customized to guidelines developed using GRADE: (1) planning, (2) initial assessment of the recommendations, (3) modification, (4) publication, and (5) evaluation. We developed a taxonomy for describing how and why recommendations from the parent guideline were modified and applied a mixed-methods case study design for evaluation of the process. RESULTS: We published the adapted guideline in November 2013 in a novel multilayered format. The taxonomy for adaptation facilitated transparency of the modification process for both the guideline developers and the end users. We excluded 30 and modified 131 of the 333 original recommendations according to the taxonomy and developed eight new recommendations. Unforeseen obstacles related to acquiring a licensing agreement and procuring a publisher resulted in a 9-month delay. We propose modifications of the adaptation process to overcome these obstacles in the future. CONCLUSIONS: This case study demonstrates the feasibility of a novel guideline adaptation process. Replication is needed to further validate the usefulness of the process in increasing the organizational and methodologic efficiency of guideline adaptation.

• Husøy, Magnus Andreas Rognlien; Brinch, Lorentz; Tjønnfjord, Geir Erland; Gedde-Dahl, Tobias Jr.; Heldal, Dag & Holme, Pål Andre [Show all 16 contributors for this article] (2014). Allogen stamcelletransplantasjon hos voksne 1985-2012. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 134(16), p. 1569–1575. doi: 10.4045/tidsskr.13.1415.
• WESTBERG, MARIANNE; Paus, Albert Collett; Holme, Pål Andre & Tjønnfjord, Geir Erland (2014). Haemophilic arthropathy: Long-term outcomes in 107 primary total knee arthroplasties. Knee (Oxford). ISSN 0968-0160. 21(1), p. 147–150. doi: 10.1016/j.knee.2013.09.010.
• Tran, Hoa Thi Tuyet; Sørensen, B.; Rea, C.J.; Bjørnsen, Stine; Ueland, Thor & Pripp, Are Hugo [Show all 8 contributors for this article] (2014). Tranexamic acid as adjunct therapy to bypassing agents in haemophilia A patients with inhibitors. Haemophilia. ISSN 1351-8216. 20(3), p. 369–375. doi: 10.1111/hae.12318.
• Misceo, Doriana; Holmgren, Asbjørn; Louch, William Edward; Holme, Pål Andre; Mizobuchi, Masahiro & Morales, Raul J. [Show all 14 contributors for this article] (2014). A Dominant STIM1 Mutation Causes Stormorken Syndrome. Human Mutation. ISSN 1059-7794. 35(5), p. 556–564. doi: 10.1002/humu.22544.
• Tran, Hoa Thi Tuyet; Tjønnfjord, Geir Erland & Holme, Pål Andre (2014). Use of thromboelastography and thrombin generation assay to predict clinical phenotype in patients with severe FVII deficiency. Haemophilia. ISSN 1351-8216. 20(1), p. 141–146. doi: 10.1111/hae.12256.
• Mathijssen, Natascha C.J.; Masereeuw, Roselinde; Holme, Pål Andre; van Kraaij, Marian G.J.; Laros-van Gorkom, Britta A.P. & Peyvandi, Flora [Show all 7 contributors for this article] (2013). Increased volume of distribution for recombinant activated factor VII and longer plasma-derived factor VII half-life may explain their long lasting prophylactic effect. Thrombosis Research. ISSN 0049-3848. 132(2), p. 256–262. doi: 10.1016/j.thromres.2013.05.027.
• van Geffen, Mark; Mathijssen, Natascha C.J.; Holme, Pål Andre; Laros-van Gorkom, Britta A.P.; van Kraaij, Marian G.J. & Masereeuw, Roselinde [Show all 8 contributors for this article] (2013). Pharmacodynamics of recombinant activated factor VII and plasma-derived factor VII in a cohort of severe FVII deficient patients. Thrombosis Research. ISSN 0049-3848. 132(1), p. 116–122. doi: 10.1016/j.thromres.2013.04.021.
• Vetlesen, Annette; Holme, Pål Andre; Lyberg, Torstein & Kjeldsen-Kragh, Jens (2012). Recovery, survival, and function of transfused platelets and detection of platelet engraftment after allogeneic stem cell transplantation. Transfusion. ISSN 0041-1132. 52(6), p. 1321–1332. doi: 10.1111/j.1537-2995.2011.03442.x.
• Holmström, M.; Tran, Hoa Thi Tuyet & Holme, Pål Andre (2012). Combined treatment with APCC (FEIBA (R)) and tranexamic acid in patients with haemophilia A with inhibitors and in patients with acquired haemophilia A - a two-centre experience. Haemophilia. ISSN 1351-8216. 18(4), p. 544–549. doi: 10.1111/j.1365-2516.2012.02748.x.
• Enden, Tone Rønnaug; HAIG, YLVA; Klow, Nils-Einar; Slagsvold, Carl Erik; Sandvik, Leiv & Ghanima, Waleed Khalid [Show all 12 contributors for this article] (2012). Long-term outcome after additional catheter-directed thrombolysis versus standard treatment for acute iliofemoral deep vein thrombosis (the CaVenT study): a randomised controlled trial. The Lancet. ISSN 0140-6736. 379(9810), p. 31–38. doi: 10.1016/S0140-6736(11)61753-4.
• Batorova, A; Holme, Pål Andre; Gringeri, A; Richards, M.; Hermans, C. & Altisent, C. [Show all 8 contributors for this article] (2012). Continuous infusion in haemophilia: current practice in Europe. Haemophilia. ISSN 1351-8216. 18(5), p. 753–759. doi: 10.1111/j.1365-2516.2012.02810.x.
• Lassila, Riita; Holme, Pål Andre; Landorph, Andrea; Petrini, Pia; Onundarson, Páll T. & Hillarp, Andreas (2011). Nordic Haemophilia Council's Practical Guidelines on Diagnosis and Management of von Willebrand Disease. Seminars in Thrombosis and Hemostasis. ISSN 0094-6176. 37(5), p. 495–502. doi: 10.1055/s-0031-1281034.
• Tran, Hoa Thi Tuyet; Tjønnfjord, Geir Erland; Paus, Albert Collett & Holme, Pål Andre (2011). rFVIIa administered by continuous infusion during surgery in patients with severe congenital FVII deficiency. Haemophilia. ISSN 1351-8216. 17(5), p. 764–770. doi: 10.1111/j.1365-2516.2011.02596.x.
• Lassila, R; Antovic, Jovan P; Armstrong, Elina; Baghaei, Fariba; Dalsgaard-Nielsen, Jørn & Hilllarp, Andreas [Show all 11 contributors for this article] (2011). Practical viewpoints on the diagnosis and management of heparin induced thrombocytopenia. Seminars in Thrombosis and Hemostasis. ISSN 0094-6176. 37(3), p. 328–335. doi: 10.1055/s-0031-1274516. Show summary

  Heparin-induced thrombocytopenia (HIT, type II) is an immune-mediated disorder due to antibodies formed against heparin-platelet factor 4 complexes, usually appearing at days 5 to 14 after initiation of heparin. It is important to recognize HIT because heparin prophylaxis or treatment paradoxically associates with new venous and/or arterial thrombosis. Early clinical suspicion and diagnosis together with proper pharmacotherapy and close laboratory monitoring are the cornerstones for successful management. This includes monitoring of Thrombocytopenia, its Timing to heparin administration, appearance of new Thrombosis or resistance to treatment, and differential diagnosis by exclusion of o Ther causes (the 4T's). Specific attention should be paid to the absence or presence of thrombosis and to tailoring thromboprophylaxis or anticoagulant therapy with a nonheparin alternative. Even in the absence of HIT-associated thrombosis, an active policy for prolonged thromboprophylaxis is demanded. Rapid and reliable assays should be developed for diagnosis and anticoagulation monitoring to secure safe management with nonheparins. Semiquantitative testing for on-call hours should be available and later confirmed as clinically needed. Alternative therapeutic options are available, but because their use is infrequent, experienced coagulation treatment centers should provide guidance in the treatment and in laboratory monitoring. Most of the evidence in HIT is grade IC, and thus the best evidence is provided by clinical experience. New anticoagulants and platelet inhibitors may offer future alternatives in the management of HIT, but the current treatment options provide the best experience and benefit. The joint clinical and laboratory guidelines provided in this article along with two practical case scenarios were prepared by a Nordic expert panel. They will be valuable for hematologists and colleagues who do not routinely encounter HIT.

• Ghanima, Waleed Khalid; Holme, Pål Andre & Tjønnfjord, Geir Erland (2010). Immunologisk trombocytopeni - patofysiologi og behandling :. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 130(21), p. 2120–2123.
• Perry, Dewayne; Berntorp, E; Tait, C; Dolan, G; Holme, Pål Andre & Laffan, M [Show all 12 contributors for this article] (2010). FEIBA prophylaxis in haemophilia patients: a clinical update and treatment recommendations. Haemophilia. ISSN 1351-8216. 16(1), p. 80–89. doi: 10.1111/j.1365-2516.2009.02104.x. Show summary

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• Astermark, J; Negrier, C; Hermans, C.; Holme, Pål Andre; Klamroth, R & Kotsi, P [Show all 12 contributors for this article] (2009). European curriculum for thrombosis and haemostasis. Haemophilia. ISSN 1351-8216. 15(1), p. 337–344. doi: 10.1111/j.1365-2516.2008.01836.x.
• Enden, Tone Rønnaug; Kløw, Nils-Einar; Sandvik, Leiv; Slagsvold, Carl Erik; Ghanima, Waleed & Hafsahl, Geir [Show all 11 contributors for this article] (2009). Catheter-directed thrombolysis versus anticoagulant therapy alone in deep vein thrombosis: Results of an open randomized, controlled trial reporting on short term patency. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. 7(8), p. 1268–1275. doi: 10.1111/j.1538-7836.2009.03464.x. Show summary

  Background: Approximately one in four patients with acute proximal deep vein thrombosis (DVT) given anticoagulation and compression therapy develop post-thrombotic syndrome (PTS). Accelerated removal of thrombus by thrombolytic agents may increase patency and prevent PTS. Objectives: To assess short-term efficacy of additional catheterdirected thrombolysis (CDT) compared with standard treatment alone. Patients and methods: Open, multicenter, randomized, controlled trial. Patients (18–75 years) with iliofemoral DVT and symptoms < 21 days were randomized to receive additional CDT or standard treatment alone. After 6 months, iliofemoral patency was investigated using duplex ultrasound and air-plethysmography assessed by an investigator blinded to previous treatment. Results: One hundred and three patients (64 men, mean age 52 years) were allocated additional CDT (n = 50) or standard treatment alone (n=53). After CDT, grade III (complete) lysis was achieved in 24 and grade II (50%–90%) lysis in 20 patients. One patient suffered major bleeding and two had clinically relevant bleeding related to the CDT procedure. After 6 months, iliofemoral patency was found in 32 (64.0%) in the CDT group vs. 19 (35.8%) controls, corresponding to an absolute risk reduction (RR) of 28.2% (95% CI: 9.7%–46.7%; P = 0.004). Venous obstruction was found in 10 (20.0%) in the CDT group vs. 26 (49.1%) controls; absoluteRR29.1%(95%CI: 20.0%–38.0%; P = 0.004). Femoral venous insufficiency did not differ between the two groups. Conclusions: After 6 months, additional CDT increased iliofemoral patency from 36% to 64%. The ongoing long-term follow-up of this study will document whether patency is related to improved functional outcome.

• Negaard, Helene Francisca Stigter; Iversen, Per Ole; Østenstad, Bjørn; Iversen, Nina; Holme, Pål Andre & Sandset, Per Morten (2008). Hypercoagulability in patients with haematological neoplasia: No apparent initiation by tissue factor. Thrombosis and Haemostasis. ISSN 0340-6245. 99, p. 1040–1048. doi: 10.1160/TH07-09-0541. Show summary

  Patients with haematological malignancies carry increased risk of venous thrombosis (VT). However, the mechanisms that link these malignancies to activated coagulation have not been fully identified. Since anti-haemostatic agents are studied in clinical trials for their potential to prolong survival in cancer patients, a detailed characterisation of haemostatic markers in cancer subtypes is needed. Hence, in this study, we measured the plasma concentrations and mRNA expression in blood mononuclear cells of haemostatic parameters in 93 patients with haematological neoplasias (acute myeloid leukaemia, chronic lymphatic leukaemia, multiple myeloma, and non-Hodgkin’s lymphoma) before start and after completion of cancer therapy. At diagnosis we found activation of coagulation and fibrinolysis, especially in patients with acute myeloid leukaemia. This hypercoagulation was not associated with increased levels of tissue factor (TF) or factor VII (fVII) antigen or mRNA, or levels of activated fVII. In conclusion we found a hypercoagulable state in patients with haematological malignancy that did not seem to be initiated by TF.

• Enden, Tone; Sandvik, Leiv; Kløw, Nils-Einar; Hafsahl, Geir; Holme, Pål Andre & Holmen, Lars Olaf [Show all 11 contributors for this article] (2007). Catheter-directed venous thrombolysis in acute iliofemoral vein thrombosis (CaVenT) study: Rationale and design of a multicenter, randomized, controlled, clinical trial (NCT00251771). American Heart Journal. ISSN 0002-8703. 154, p. 808–814. doi: 10.1016/j.ahj.2007.07.010. Show summary

  Background. The conventional treatment of acute deep vein thrombosis (DVT) is anticoagulation and compression therapy, as recommended in the international guidelines. Anticoagulation prevents recurrent venous thrombosis, pulmonary embolism, and death. Compression therapy reduces the risk of developing long-term sequelae, that is, postthrombotic syndrome (PTS). Evaluation of systemic thrombolysis has shown effective thrombolysis and a likely reduction in PTS but at the cost of increased risk of bleeding complications. Catheter-directed thrombolysis (CDT) was introduced for rapid removal of thrombi and salvage of venous valves with less systemic thrombolytic effect, and is being offered to selected patients with iliofemoral DVT to prevent development of PTS. Case series have shown technical and thrombolytic success; however, no randomized studies have evaluated the long-term clinical effects of venous CDT. The aim of the CaVenT study is to investigate the role of adjunctive CDT by evaluating its clinical efficacy and safety compared with conventional treatment alone in patients with acute iliofemoral DVT. Methods. The CaVenT study is an open, randomized, controlled, clinical trial. We plan to include 200 patients who will receive either CDT, in addition to conventional treatment, or conventional treatment alone. The primary outcome measures are patency at 6 months and prevalence of PTS at 2 years. Conclusion. Implementation of the CaVenT study will be a contribution toward evidence-based medicine in the treatment of acute proximal DVT of the leg. Any documentation of improved functional outcome will have a significant impact on clinical practice for this patient group and may lead to a modification of existing international guidelines.

• Holme, Pål Andre; Brosstad, Frank Roger & Tjønnfjord, Geir Erland (2005). Acquired haemophilia: management of bleeds and immune therapy to eradicate autoantibodies. Haemophilia. ISSN 1351-8216. 11(5), p. 510–515. doi: 10.1111/j.1365-2516.2005.01136.

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• Hermans, Cedric; Astermark, Jan; Carvalho, Manuela; Dolan, Gerry; d'Oiron, Roseline & Fontana, Pierre [Show all 20 contributors for this article] (2023). Prevalence of COVID-19 related hospitalizations and mortality in adults aged ≥40 years with haemophilia: A survey from Europe. Haemophilia. ISSN 1351-8216. 29(3), p. 913–916. doi: 10.1111/hae.14761.
• Holme, Pål Andre; Ghanima, Waleed; Wik, Hilde Skuterud; Jacobsen, Eva-Marie & Fløisand, Yngvar (2022). Koagulasjonsforstyrrelser. In Birkeland, Kåre Inge; Gullestad, Lars & Aabakken, Lars (Ed.), Indremedisin I. Fagbokforlaget. ISSN 9788245043365. p. 447–458.
• Schultz, Nina Haagenrud; Holme, Pål Andre; Henriksson, Carola; Mowinckel, Marie-Christine; Sandset, Per Morten & Bratseth, Vibeke [Show all 7 contributors for this article] (2019). The influence of rivaroxaban on markers of fibrinolysis and endothelial cell activation/injury in patients with venous thrombosis. Thrombosis Research. ISSN 0049-3848. 177, p. 154–156. doi: 10.1016/j.thromres.2019.03.010.
• Tran, Hoa Thi Tuyet; Holmström, M. & Holme, Pål Andre (2011). The combined treatment of APCC and tranexamic acid in patients with haemophilia a with inhibitors and in patients with acquired haemophilia a - a two-centre experience. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. 9, p. 219–219.
• Holme, Pål Andre; Berntorp, E; De Moerloose, P & Tait, R.C. (2011). Haematuria and hypertension in haemophilia - the H3 study. Haemophilia. ISSN 1351-8216. 17(2), p. 377–377.
• Heldal, Dag; Brinch, Lorentz; Fløisand, Yngvar; Dybedal, Ingunn; Gedde-Dahl, Thobias & Holme, Pål Andre [Show all 8 contributors for this article] (2010). Long-term (>= 5 years) follow-up of a randomized study of allogeneic stem cell transplantation with stem cells from blood or bone marrow. Bone Marrow Transplantation. ISSN 0268-3369. 45, p. S155–S156.
• Batorova, Angelika; Holme, Pål Andre; Gringeri, Alessandro; Fijnvandraat, K.; Richards, M. & Hermans, C. [Show all 8 contributors for this article] (2010). Inhibitor incidence in hemophilia A patients intensively treated with continuous infusion of factor VIII. Haemophilia. ISSN 1351-8216. 16, p. 67–67.
• Brinch, Lorentz; Fløisand, Yngvar; Tjønnfjord, Geir Erland; Gedde-Dahl, Thobias; Heldal, Dag & Holme, Pål Andre [Show all 7 contributors for this article] (2009). Allogeneic blood stem cell transplants for AML using the Bu4Cy2 regimen in AML: long term experience. Bone Marrow Transplantation. ISSN 0268-3369. 43, p. S98–S98.
• Holme, Pål Andre & Michelsen, Annika (2008). En 40 år gammel kvinne med svimmelhet og oppkast. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 128(1413).

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