Silvia Rollefstad

• Ikdahl, Eirik; Rollefstad, Silvia Christin Hellerud; Kazemi, Amirhossein; Provan, Sella Aarrestad; Larsen, Trine-Lise & Semb, Anne Grete (2023). Non-steroidal anti-inflammatory drugs and risk of pulmonary embolism in patients with inflammatory joint disease—results from the nationwide Norwegian Cardio-rheuma registry. European Heart Journal (EHJ) - Cardiovascular Pharmacotherapy. ISSN 2055-6837. 10(1), p. 27–34. doi: 10.1093/ehjcvp/pvad078. Full text in Research Archive Show summary

  Aims Patients with inflammatory joint diseases (IJD), including rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA) have increased rates of pulmonary embolism (PE). Non-steroidal anti-inflammatory drugs (NSAIDs) use is associated with PE in the general population. Our aim was to evaluate the association between NSAIDs use and PE in IJD patients. Methods and results Using individual-level registry data from the whole Norwegian population, including data from the Norwegian Patient Registry and the Norwegian Prescription Database, we: (1) evaluated PE risk in IJD compared to non-IJD individuals, (2) applied the self-controlled case series method to evaluate if PE risks were associated with use of traditional NSAIDs (tNSAIDs) and selective cox-2 inhibitors (coxibs). After a one-year wash-out period, we followed 4 660 475 adults, including 74 001 with IJD (RA: 39 050, PsA: 20 803, and axSpA: 18 591) for a median of 9.0 years. Crude PE incidence rates per 1000 patient years were 2.02 in IJD and 1.01 in non-IJD individuals. Age and sex adjusted hazard ratios for PE events were 1.57 for IJD patients compared to non-IJD. Incidence rate ratios (IRR) [95% confidence interval (CI)] for PE during tNSAIDs use were 0.78 (0.64–0.94, P = 0.010) in IJD and 1.68 (1.61–1.76, P < 0.001) in non-IJD. IRR (95% CI) for PE during coxibs use was 1.75 (1.10–2.79, P = 0.018) in IJD and 2.80 (2.47–3.18, P < 0.001) for non-IJD. Conclusion Pulmonary embolism rates appeared to be higher in IJD than among non-IJD subjects in our study. Traditional NSAIDs may protect against PE in IJD patients, while coxibs may associated with increased PE risk.

• Ullensvang, Gyda; Kringeland, Ester Anne; Ikdahl, Eirik; Provan, Sella Aarrestad; Berg, Inger Jorid & Rollefstad, Silvia Christin Hellerud [Show all 10 contributors for this article] (2023). Cardiovascular organ damage in relation to hypertension status in patients with ankylosing spondylitis. Blood Pressure. ISSN 0803-7051. 32(1). doi: 10.1080/08037051.2023.2205956. Full text in Research Archive Show summary

  Purpose Hypertension is a major cardiovascular (CV) risk factor in ankylosing spondylitis (AS) patients. Less is known about the prevalence of CV organ damage in relation to hypertension status in AS patients. Materials and Methods CV organ damage was assessed by echocardiography, carotid ultrasound and pulse wave velocity (PWV) by applanation tonometry in 126 AS patients (mean age 49 ± 12 years, 39% women) and 71 normotensive controls (mean age 47 ± 11 years, 52% women). CV organ damage was defined as presence of abnormal left ventricular (LV) geometry, LV diastolic dysfunction, left atrial (LA) dilatation, carotid plaque or high pulse wave velocity (PWV). Results Thirty-four percent of AS patients had hypertension. AS patients with hypertension were older and had higher C-reactive protein (CRP) levels compared to AS patients without hypertension and controls (p < 0.05). The prevalence of CV organ damage was 84% in AS patients with hypertension, 29% in AS patients without hypertension and 30% in controls (p < 0.001). In multivariable logistic regression analyses, having hypertension was associated with a fourfold increased risk of CV organ damage independent of age, presence of AS, gender, body mass index, CRP, and cholesterol (odds ratio (OR) 4.57, 95% confidence interval (CI) 1.53 to 13.61, p = 0.006). In AS patients, presence of hypertension was the only covariable significantly associated with presence of CV organ damage (OR 4.40, 95% CI 1.40 to 13.84, p = 0.011). Conclusions CV organ damage in AS was strongly associated with hypertension, pointing to the importance of guideline-based hypertension management in AS patients.

• Kerola, Anne Mirjam; Kazemi, Amirhossein; Rollefstad, Silvia Christin Hellerud; Lillegraven, Siri; Sexton, Joseph & Wibetoe, Grunde [Show all 9 contributors for this article] (2022). All-cause and cause-specific mortality in rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis: a nationwide registry study. Rheumatology. ISSN 1462-0324. 61(12), p. 4656–4666. doi: 10.1093/rheumatology/keac210. Full text in Research Archive Show summary

  Objectives To explore mortality and causes of death among Norwegian patients with RA, PsA and axial spondyloarthritis (axSpA) compared with the general population by conducting a nationwide registry-based cohort study. Methods Patients with RA, PsA and axSpA were identified from the Norwegian Patient Registry based on ICD-10 codes between 2008 and 2017. Using age as the time variable, all-cause and cause-specific mortality were estimated between 2010 and 2017 with the Kaplan–Meier estimator and the cumulative incidence competing risk method, respectively. Sex-, education level-, health region- and age group-adjusted hazard ratios (HRs) for mortality were estimated using Cox regression models. Results We identified 36 095 RA, 18 700 PsA and 16 524 axSpA patients (70%, 53% and 45% women, respectively). RA and axSpA were associated with increased all-cause mortality (HR 1.45 [95% CI: 1.41, 1.48] and HR 1.38 [95% CI: 1.28, 1.38], respectively). Women but not men with PsA had a slightly increased mortality rate (HR 1.10 [95% CI: 1.00, 1.21] among women and 1.02 [95% CI: 0.93, 1.11] among men). For all patient groups as well as for the general population, the three leading causes of death were cardiovascular diseases, neoplasms and respiratory diseases. RA patients had increased mortality from all of these causes, while axSpA patients had increased mortality from cardiovascular and respiratory diseases. Conclusion Even in the era of modern treatments for IJDs, patients with RA and axSpA still have shortened life expectancy. Our findings warrant further attention to the prevention and management of comorbidities.

• Semb, Anne Grete; Ikdahl, Eirik; Kerola, Anne M.; Wibetoe, Grunde; Sexton, Joseph & Crowson, Cynthia S. [Show all 10 contributors for this article] (2022). A Clinical Audit of Cardiovascular Risk Factors and Disease in Patients with Rheumatoid Arthritis - SURF-RA. Mediterranean Journal of Rheumatology. ISSN 2529-198X. 33(2), p. 201–217. doi: 10.31138/mjr.33.2.201.
• Semb, Anne Grete; Rollefstad, Silvia Christin Hellerud; Sexton, Joseph; Ikdahl, Eirik; Crowson, Cynthia S. & van Riel, Piet [Show all 9 contributors for this article] (2022). Oral anticoagulant treatment in rheumatoid arthritis patients with atrial fibrillation results of an international audit. International journal of cardiology: Heart and Vasculature (IJCHA). ISSN 2352-9067. 42. doi: 10.1016/j.ijcha.2022.101117.
• Rollefstad, Silvia Christin Hellerud; Ikdahl, Eirik; Wibetoe, Grunde; Sexton, Joseph; Crowson, Cynthia S. & van Riel, Piet [Show all 38 contributors for this article] (2022). An international audit of the management of dyslipidaemia and hypertension in patients with rheumatoid arthritis: results from 19 countries. European Heart Journal (EHJ) - Cardiovascular Pharmacotherapy. ISSN 2055-6837. 8(6), p. 539–548. doi: 10.1093/ehjcvp/pvab052.
• Hammer, Hilde Berner; Rollefstad, Silvia Christin Hellerud; Semb, Anne Grete; Jensen, Gro Elisabeth; Karoliussen, Lars Fridtjof & Terslev, L [Show all 9 contributors for this article] (2022). Urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout: results from the NOR-Gout study. RMD Open. ISSN 2056-5933. 8(2), p. 1–5. doi: 10.1136/rmdopen-2022-002348. Full text in Research Archive
• Kerola, A.M.; Rollefstad, Silvia Christin Hellerud; Kazemi, Amirhossein; Wibetoe, Grunde; Sexton, Joseph & Mars, N. [Show all 10 contributors for this article] (2022). Psoriatic arthritis, axial spondyloarthritis and rheumatoid arthritis in Norway: nationwide prevalence and use of biologic agents. Scandinavian Journal of Rheumatology. ISSN 0300-9742. p. 1–9. doi: 10.1080/03009742.2021.1997436. Full text in Research Archive
• Kerola, Anne Mirjam; Sexton, Joseph; Wibetoe, Grunde; Rollefstad, Silvia Christin Hellerud; Crowson, Cynthia Sue & Mars, Nina [Show all 10 contributors for this article] (2021). Incidence, sociodemographic factors and treatment penetration of rheumatoid arthritis and psoriatic arthritis in Norway. Seminars in Arthritis & Rheumatism. ISSN 0049-0172. 51(5), p. 1081–1088. doi: 10.1016/j.semarthrit.2021.08.006. Full text in Research Archive Show summary

  Objectives: To evaluate nationwide incidence, sociodemographic associations and treatment penetration of rheumatoid arthritis (RA) and psoriatic arthritis (PsA) in Norway. Methods: The study combined data from nationwide registries on the total Norwegian adult population (age ≥ 18). From the Norwegian Patient Registry, incident RA and PsA cases during 2011-2015 were identified with records of first and second healthcare episodes listing RA/PsA diagnostic codes, and ≥ 1 episode in an internal medicine or rheumatology unit with RA/PsA code during the two-year period after the first episode. Dispensed DMARD prescriptions were obtained from the Norwegian Prescription Database. Persons with dispensed DMARD prescriptions or biologic DMARDs given in hospitals > 12 months before the index date were excluded. Results: Incidence of RA/PsA in Norway was 42/26 per 100,000 person-years (55/28 among women and 28/23 among men). RA peak incidence was observed at ages 70-79 in both sexes, whereas the peak incidence of PsA occurred at ages 50-59. Age- and sex-standardized incidences of RA and PsA were lower among persons with higher education levels. Within a year from the index date, 82.4/57.4% of RA/PsA patients used synthetic DMARDs while 9.4/9.5% used biologic DMARDs. Conclusions: Register-based incidence estimates for RA and PsA in Norway are similar to other Nordic countries, but slightly higher than in previous Norwegian studies. Furthermore, we found that higher socioeconomic status was associated with lower incidence of both RA and PsA. Although conventional synthetic DMARDs were less often used in early PsA than RA, frequency of biologic DMARD prescriptions was comparable.

• Semb, Anne Grete; Rollefstad, Silvia Christin Hellerud; Ikdahl, Eirik; Wibetoe, Grunde; Sexton, Joseph & Crowson, Cindy [Show all 41 contributors for this article] (2021). Diabetes mellitus and cardiovascular risk management in patients with rheumatoid arthritis: an international audit. RMD Open. ISSN 2056-5933. 7(2). doi: 10.1136/rmdopen-2021-001724. Show summary

  Aim: The objective was to examine the prevalence of atherosclerotic cardiovascular disease (ASCVD) and its risk factors among patients with RA with diabetes mellitus (RA-DM) and patients with RA without diabetes mellitus (RAwoDM), and to evaluate lipid and blood pressure (BP) goal attainment in RA-DM and RAwoDM in primary and secondary prevention. Methods: The cohort was derived from the Survey of Cardiovascular Disease Risk Factors in Patients with Rheumatoid Arthritis from 53 centres/19 countries/3 continents during 2014-2019. We evaluated the prevalence of cardiovascular disease (CVD) among RA-DM and RAwoDM. The study population was divided into those with and without ASCVD, and within these groups we compared risk factors and CVD preventive treatment between RA-DM and RAwoDM. Results: The study population comprised of 10 543 patients with RA, of whom 1381 (13%) had DM. ASCVD was present in 26.7% in RA-DM compared with 11.6% RAwoDM (p<0.001). The proportion of patients with a diagnosis of hypertension, hyperlipidaemia and use of lipid-lowering or antihypertensive agents was higher among RA-DM than RAwoDM (p<0.001 for all). The majority of patients with ASCVD did not reach the lipid goal of low-density lipoprotein cholesterol <1.8 mmol/L. The lipid goal attainment was statistically and clinically significantly higher in RA-DM compared with RAwoDM both for patients with and without ASCVD. The systolic BP target of <140 mm Hg was reached by the majority of patients, and there were no statistically nor clinically significant differences in attainment of BP targets between RA-DM and RAwoDM. Conclusion: CVD preventive medication use and prevalence of ASCVD were higher in RA-DM than in RAwoDM, and lipid goals were also more frequently obtained in RA-DM. Lessons may be learnt from CVD prevention programmes in DM to clinically benefit patients with RA .

• Kerola, Anne Mirjam; Rollefstad, Silvia Christin Hellerud & Semb, Anne Grete (2021). Atherosclerotic cardiovascular disease in rheumatoid arthritis: Impact of inflammation and antirheumatic treatment. European Cardiology. ISSN 1758-3756. 16. doi: 10.15420/ECR.2020.44.
• Konstantin, Friedrich; Rollefstad, Silvia Christin Hellerud; Ikdahl, Eirik; Wibetoe, Grunde; Sexton, Joseph & Hisdal, Jonny [Show all 7 contributors for this article] (2021). Degree of arterial stiffness is comparable across inflammatory joint disease entities. Scandinavian Journal of Rheumatology. ISSN 0300-9742. doi: 10.1080/03009742.2021.1920169. Full text in Research Archive
• Weijers, Julia M.; Semb, Anne Grete; Rollefstad, Silvia Christin Hellerud; Kitas, George D. & van Riel, Piet L.C.M. (2020). Strategies for implementation of guideline recommended cardiovascular risk management for patients with rheumatoid arthritis: results from a questionnaire survey of expert rheumatology centers. Rheumatology International. ISSN 0172-8172. 40, p. 523–527. doi: 10.1007/s00296-020-04533-4.
• Wibetoe, Grunde; Sexton, Joseph; Ikdahl, Eirik; Rollefstad, Silvia Christin Hellerud; Kitas, George D. & van Riel, Piet [Show all 27 contributors for this article] (2020). Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models. Arthritis Research & Therapy. ISSN 1478-6354. 22(1). doi: 10.1186/s13075-020-02178-z.
• Os, Hanna Augedal; Rollefstad, Silvia Christin Hellerud; Gerdts, Eva; Kringeland, Ester Anne; Ikdahl, Eirik & Semb, Anne Grete [Show all 7 contributors for this article] (2020). Preclinical cardiac organ damage during statin treatment in patients with inflammatory joint diseases: the RORA-AS statin intervention study. Rheumatology. ISSN 1462-0324. 59(12), p. 3700–3708. doi: 10.1093/rheumatology/keaa190.
• Semb, Anne Grete; Ikdahl, Eirik; Wibetoe, Grunde; Crowson, Cynthia & Rollefstad, Silvia Christin Hellerud (2020). Atherosclerotic cardiovascular disease prevention in rheumatoid arthritis. Nature Reviews Rheumatology. ISSN 1759-4790. 16(7), p. 361–379. doi: 10.1038/s41584-020-0428-y.
• Roelsgaard, Ida Kristiane; Ikdahl, Eirik; Rollefstad, Silvia Christin Hellerud; Wibetoe, Grunde; Esbensen, Bente Appel & Kitas, George D. [Show all 23 contributors for this article] (2019). Smoking Cessation Is Associated With Lower Disease Activity and Predicts Cardiovascular Risk Reduction in Rheumatoid Arthritis Patients. Rheumatology. ISSN 1462-0324. 59(8), p. 1997–2004. doi: 10.1093/rheumatology/kez557.
• Svanteson, Mona; Rollefstad, Silvia Christin Hellerud; Kløw, Nils-Einar; Hisdal, Jonny; Ikdahl, Eirik & Sexton, Joseph [Show all 8 contributors for this article] (2019). Effects of long-term statin-treatment on coronary atherosclerosis in patients with inflammatory joint diseases. PLOS ONE. ISSN 1932-6203. 14(12), p. 1–15. doi: 10.1371/journal.pone.0226479. Full text in Research Archive
• Provan, Sella Aarrestad; Rollefstad, Silvia Christin Hellerud; Ikdahl, Eirik; Mathiessen, Alexander; Berg, Inger Jorid & Wilkinson, I. B. [Show all 12 contributors for this article] (2019). Biomarkers of cardiovascular risk across phenotypes of osteoarthritis. Biomed Central Rheumatology. ISSN 2520-1026. 3(33). doi: 10.1186/s41927-019-0081-8.
• Sveaas, Silje Halvorsen; Bilberg, Annelie; Berg, Inger Jorid; Provan, Sella Aarrestad; Rollefstad, Silvia Christin Hellerud & Semb, Anne Grete [Show all 10 contributors for this article] (2019). High intensity exercise for 3 months reduces disease activity in axial spondyloarthritis (axSpA): A multicentre randomised trial of 100 patients. British Journal of Sports Medicine. ISSN 0306-3674. doi: 10.1136/bjsports-2018-099943.
• Roelsgaard, Ida Kristiane; Esbensen, Bente Appel; Østergaard, Mikkel; Rollefstad, Silvia Christin Hellerud; Semb, Anne Grete & Christensen, Robin [Show all 7 contributors for this article] (2018). Smoking cessation intervention for reducing disease activity in chronic autoimmune inflammatory joint diseases. Cochrane Database of Systematic Reviews. ISSN 1469-493X. 2019(9). doi: 10.1002/14651858.CD012958.pub2.
• Midtbø, Helga Bergljot; Semb, Anne Grete; Matre, Knut; Rollefstad, Silvia Christin Hellerud; Berg, Inger Jorid & Gerdts, Eva (2018). Left Ventricular Systolic Myocardial Function in Ankylosing Spondylitis . Arthritis care & research. ISSN 2151-464X. 71(9), p. 1276–1283. doi: 10.1002/acr.23765.
• Semb, Anne Grete & Rollefstad, Silvia Christin Hellerud (2018). Optimization of CVD prevention in psoriatic arthritis. Nature Reviews Rheumatology. ISSN 1759-4790. 14, p. 323–324. doi: 10.1038/s41584-018-0002-z.
• Ikdahl, Eirik; Rollefstad, Silvia Christin Hellerud; Wibetoe, Grunde; Salberg, Anne; Krøll, Frode & Bergsmark, Kjetil [Show all 15 contributors for this article] (2018). Feasibility of cardiovascular disease risk assessments in rheumatology outpatient clinics: Experiences from the nationwide NOCAR project. RMD Open. ISSN 2056-5933. 4(2), p. 1–10. doi: 10.1136/rmdopen-2018-000737.
• Fagerhøi, Maria Grorud; Rollefstad, Silvia Christin Hellerud; Olsen, Sissel Urke & Semb, Anne Grete (2018). The effect of brief versus individually tailored dietary advice on change in diet, lipids and blood pressure in patients with inflammatory joint disease. Food & Nutrition Research (FNR). ISSN 1654-6628. 62. doi: 10.29219/fnr.v62.1512.
• Gulati, Agnete Malm; Salvesen, Øyvind; Thomsen, Ruth Stoklund; Kavanaugh, Arthur; Semb, Anne Grete & Rollefstad, Silvia Christin Hellerud [Show all 8 contributors for this article] (2018). Change in cardiovascular risk factors in patients who develop psoriatic arthritis: longitudinal data from the Nord-Trøndelag Health Study (HUNT). RMD Open. ISSN 2056-5933. 4(1), p. 1–6. doi: 10.1136/rmdopen-2017-000630. Full text in Research Archive
• Midtbø, Helga Bergljot; Gerdts, Eva; Berg, Inger Jorid; Rollefstad, Silvia Christin Hellerud; Jonsson, Roland & Semb, Anne Grete (2018). Ankylosing spondylitis is associated with increased prevalence of left ventricular hypertrophy. Journal of Rheumatology. ISSN 0315-162X. 45(9), p. 1249–1255. doi: 10.3899/jrheum.171124.
• Ikdahl, Eirik; Wibetoe, Grunde; Rollefstad, Silvia Christin Hellerud; Salberg, Anne; Bergsmark, Kjetil & Kvien, Tore Kristian [Show all 14 contributors for this article] (2018). Guideline recommended treatment to targets of cardiovascular risk is inadequate in patients with inflammatory joint diseases. International Journal of Cardiology. ISSN 0167-5273. In Press, Corrected Proof, p. 1–8. doi: 10.1016/j.ijcard.2018.06.111.
• Wibetoe, Grunde; Ikdahl, Eirik; Rollefstad, Silvia Christin Hellerud; Olsen, Inge Christoffer; Bergsmark, Kjetil & Kvien, Tore Kristian [Show all 14 contributors for this article] (2018). Discrepancies in risk age and relative risk estimations of cardiovascular disease in patients with inflammatory joint diseases. International Journal of Cardiology. ISSN 0167-5273. 252, p. 201–206. doi: 10.1016/j.ijcard.2017.10.038.
• Crowson, Cynthia Sue; Rollefstad, Silvia Christin Hellerud; Ikdahl, Eirik; Kitas, George D.; van Riel, Piet L. C. M. & Gabriel, Sherine E. [Show all 28 contributors for this article] (2018). Impact of risk factors associated with cardiovascular outcomes in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases. ISSN 0003-4967. 77(1), p. 48–54. doi: 10.1136/annrheumdis-2017-211735.
• Roelsgaard, Ida Kristiane; Thomsen, Thordis; Østergaard, Mikkel; Christensen, Robin; Hetland, Merete Lund & Jacobsen, Søren [Show all 11 contributors for this article] (2017). The effect of an intensive smoking cessation intervention on disease activity in patients with rheumatoid arthritis: Study protocol for a randomised controlled trial. Trials. ISSN 1745-6215. 18(1). doi: 10.1186/s13063-017-2309-5.
• Crowson, Cynthia Sue; Rollefstad, Silvia Christin Hellerud; Kitas, George D.; van Riel, Piet L.C.M.; Gabriel, Sherine E. & Semb, Anne Grete (2017). Challenges of developing a Cardiovascular risk calculator for patients with rheumatoid arthritis. PLOS ONE. ISSN 1932-6203. 12(3). doi: 10.1371/journal.pone.0174656.
• Svanteson, Mona; Rollefstad, Silvia Christin Hellerud; Kløw, Nils-Einar; Hisdal, Jonny; Ikdahl, Eirik & Semb, Anne Grete [Show all 7 contributors for this article] (2017). Associations between coronary and carotid artery atherosclerosis in patients with inflammatory joint diseases. RMD Open. ISSN 2056-5933. 3(2). doi: 10.1136/rmdopen-2017-000544.
• Wibetoe, Grunde; Ikdahl, Eirik; Rollefstad, Silvia Christin Hellerud; Olsen, Inge Christoffer; Bergsmark, Kjetil & Kvien, Tore Kristian [Show all 14 contributors for this article] (2017). Cardiovascular disease risk profiles in inflammatory joint disease entities. Arthritis Research & Therapy. ISSN 1478-6354. 19(153). doi: 10.1186/s13075-017-1358-1.
• Agca, R.; Heslinga, SC; Rollefstad, Silvia Christin Hellerud; Heslinga, M.; McInnes, Iain B. & Peters, Mike J.L. [Show all 26 contributors for this article] (2016). EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update. Annals of the Rheumatic Diseases. ISSN 0003-4967. 76, p. 17–28. doi: 10.1136/annrheumdis-2016-209775.
• Ikdahl, Eirik; Rollefstad, Silvia Christin Hellerud; Wibetoe, Grunde; Olsen, Inge Christoffer; Berg, Inger Jorid & Hisdal, Jonny [Show all 11 contributors for this article] (2016). Predictive value of arterial stiffness and subclinical carotid atherosclerosis for cardiovascular disease in patients with rheumatoid arthritis. Journal of Rheumatology. ISSN 0315-162X. 43(9), p. 1622–1630. doi: 10.3899/jrheum.160053.
• Semb, Anne Grete; Ikdahl, Eirik; Hisdal, Jonny; Olsen, Inge Christoffer & Rollefstad, Silvia Christin Hellerud (2016). Exploring cardiovascular disease risk evaluation in patients with inflammatory joint diseases. International Journal of Cardiology. ISSN 0167-5273. 223, p. 331–336. doi: 10.1016/j.ijcard.2016.08.129.
• Midtbø, Helga Bergljot; Gerdts, Eva; Kvien, Tore Kristian; Olsen, Inge Christoffer; Lønnebakken, Mai Tone & Davidsen, Einar Skulstad [Show all 8 contributors for this article] (2016). The association of hypertension with asymptomatic cardiovascular organ damage in rheumatoid arthritis. Blood Pressure. ISSN 0803-7051. 25(5), p. 298–304. doi: 10.3109/08037051.2016.1172867.
• Ikdahl, Eirik; Rollefstad, Silvia Christin Hellerud; Hisdal, Jonny; Olsen, Inge Christoffer; Pedersen, Terje Rolf & Kvien, Tore Kristian [Show all 7 contributors for this article] (2016). Sustained improvement of arterial stiffness and blood pressure after long-term rosuvastatin treatment in patients with inflammatory joint diseases: Results from the rora-as study. PLOS ONE. ISSN 1932-6203. 11(4). doi: 10.1371/journal.pone.0153440.
• Arts, Elke E.A.; Popa, Calin D.; den Broeder, AA; Donders, R; Sandoo, A & Toms, T [Show all 12 contributors for this article] (2016). Prediction of cardiovascular risk in rheumatoid arthritis: performance of original and adapted SCORE algorithms. Annals of the Rheumatic Diseases. ISSN 0003-4967. 75(4), p. 674–680. doi: 10.1136/annrheumdis-2014-206879.
• Gulati, Agnete Malm; Semb, Anne Grete; Rollefstad, Silvia ; Romundstad, Pål Richard; Kavanaugh, A. & Gulati, Sasha [Show all 8 contributors for this article] (2016). On the HUNT for cardiovascular risk factors and disease in patients with psoriatic arthritis: Population-based data from the Nord-Trøndelag Health Study. Annals of the Rheumatic Diseases. ISSN 0003-4967. 75(5), p. 819–824. doi: 10.1136/annrheumdis-2014-206824.
• Ikdahl, Eirik; Hisdal, Jonny; Rollefstad, Silvia Christin Hellerud; Olsen, Inge Christoffer; Kvien, Tore Kristian & Pedersen, Terje Rolf [Show all 7 contributors for this article] (2015). Rosuvastatin improves endothelial function in patients with inflammatory joint diseases, longitudinal associations with atherosclerosis and arteriosclerosis: Results from the RORA-AS statin intervention study. Arthritis Research & Therapy. ISSN 1478-6354. 17. doi: 10.1186/s13075-015-0795-y.
• Rollefstad, Silvia Christin Hellerud; Ikdahl, Eirik; Hisdal, Jonny; Kvien, Tore Kristian; Pedersen, Terje Rolf & Semb, Anne Grete (2015). Association of Chest Pain and Risk of Cardiovascular Disease with Coronary Atherosclerosis in Patients with Inflammatory Joint Diseases. Frontiers in medicine. ISSN 2296-858X. doi: 10.3389/fmed.2015.00080.
• Rollefstad, Silvia Christin Hellerud; Ikdahl, Eirik; Hisdal, Jonny; Olsen, Inge Christoffer; Holme, Ingar Morten K & Hammer, Hilde Berner [Show all 11 contributors for this article] (2015). Rosuvastatin-induced carotid plaque regression in patients with inflammatory joint diseases: The rosuvastatin in rheumatoid arthritis, ankylosing spondylitis and other inflammatory joint diseases study. Arthritis & Rheumatology. ISSN 2326-5191. doi: 10.1002/art.39114.
• Ikdahl, Eirik; Rollefstad, Silvia Christin Hellerud; Olsen, Inge Christoffer; Kvien, Tore Kristian; Hansen, Inger Johanne Widding & Soldal, Dag [Show all 8 contributors for this article] (2015). EULAR task force recommendations on annual cardiovascular risk assessment for patients with rheumatoid arthritis: An audit of the success of implementation in a rheumatology outpatient clinic. BioMed Research International. ISSN 2314-6133. 2015. doi: 10.1155/2015/515280.
• Rollefstad, Silvia Christin Hellerud; Ikdahl, Eirik; Hisdal, Jonny; Kvien, Tore Kristian; Pedersen, Terje Rolf & Holme, Ingar Morten K [Show all 7 contributors for this article] (2015). Systemic inflammation in patients with inflammatory joint diseases does not influence statin dose needed to obtain LDL cholesterol goal in cardiovascular prevention. Annals of the Rheumatic Diseases. ISSN 0003-4967. 74(8), p. 1544–1550. doi: 10.1136/annrheumdis-2013-204636.
• Semb, Anne Grete; Rollefstad, Silvia Christin Hellerud; van Riel, Piet; Kitas, George D.; Matteson, Eric L. & Gabriel, Sherine E. (2014). Cardiovascular disease assessment in rheumatoid arthritis: A guide to translating knowledge of cardiovascular risk into clinical practice. Annals of the Rheumatic Diseases. ISSN 0003-4967. 73(7), p. 1284–1289. doi: 10.1136/annrheumdis-2013-204792.
• Rollefstad, Silvia Christin Hellerud; Kvien, Tore Kristian; Holme, Ingar Morten K; Eirheim, Anne Stormyhr; Pedersen, Terje Rolf & Semb, Anne Grete (2013). Treatment to lipid targets in patients with inflammatory joint diseases in a preventive cardio-rheuma clinic. Annals of the Rheumatic Diseases. ISSN 0003-4967. 72(12), p. 1968–1974. doi: 10.1136/annrheumdis-2012-202789.
• Østerås, Nina; Risberg, May Arna; Kvien, Tore Kristian; Engebretsen, Lars; Nordsletten, Lars & Bruusgaard, Dag [Show all 22 contributors for this article] (2013). Hand, hip and knee osteoarthritis in a Norwegian population-based study - The MUST protocol. BMC Musculoskeletal Disorders. ISSN 1471-2474. doi: 10.1186/1471-2474-14-201. Show summary

  Abstract Background Knowledge about the prevalence and consequences of osteoarthritis (OA) in the Norwegian population is limited. This study has been designed to gain a greater understanding of musculoskeletal pain in the general population with a focus on clinically and radiologically confirmed OA, as well as risk factors, consequences, and management of OA. Methods/Design The Musculoskeletal pain in Ullensaker STudy (MUST) has been designed as an observational study comprising a population-based postal survey and a comprehensive clinical examination of a sub-sample with self-reported OA (MUST OA cohort). All inhabitants in Ullensaker municipality, Norway, aged 40 to 79 years receive the initial population-based postal survey questionnaire with questions about life style, general health, musculoskeletal pain, self-reported OA, comorbidities, health care utilisation, medication use, and functional ability. Participants who self-report OA in their hip, knee and/or hand joints are asked to attend a comprehensive clinical examination at Diakonhjemmet Hospital, Oslo, including a comprehensive medical examination, performance-based functional tests, different imaging modalities, cardiovascular assessment, blood and urine samples, and a number of patient-reported questionnaires including five OA disease specific instruments. Data will be merged with six national data registries. A subsample of those who receive the questionnaire has previously participated in postal surveys conducted in 1990, 1994, and 2004 with data on musculoskeletal pain and functional ability in addition to demographic characteristics and a number of health related factors. This subsample constitutes a population based cohort with 20 years follow-up. Discussion This protocol describes the design of an observational population-based study that will involve the collection of data from a postal survey on musculoskeletal pain, and a comprehensive clinical examination on those with self-reported hand, hip and/or knee OA. These data, in addition to data from national registries, will provide unique insights into clinically and radiologically confirmed OA with respect to risk factors, consequences, and management. Keywords: Osteoarthritis; Hand; Hip; Knee; Observational study; Study protocol

• Semb, Anne Grete; Rollefstad, Silvia Christin Hellerud; Provan, Sella Aarrestad; Kvien, Tore Kristian; Stranden, Einar & Olsen, Inge Christoffer [Show all 7 contributors for this article] (2013). Carotid Plaque Characteristics and Disease Activity in Rheumatoid Arthritis. Journal of Rheumatology. ISSN 0315-162X. 40(4), p. 359–368. doi: 10.3899/jrheum.120621. Show summary

  Objective. Carotid plaques (CP) are predictive of acute coronary syndrome in patients with rheumatoid arthritis (RA), suggesting that atherosclerotic plaques in these patients are vulnerable. The objective of our study was to characterize vulnerability of CP in patients with RA compared to a control population, and between RA patients with different levels of disease activity. Methods. Ultrasound examination of carotid arteries was performed in 152 patients with RA and 89 controls. CP echolucency was evaluated by the Gray-Scale Median (GSM) technique. Lower GSM values indicate higher vulnerability of plaques. CP characteristics were compared between RA patients with active disease and in remission, and between patients and controls. All analyses were performed with adjustment for confounding factors (sex, age, smoking, and blood pressure). Poisson regression analysis was used for count data, mixed modeling for GSM and area per plaque, and analysis of covariance for minimum GSM value per patient. Results. Patients with RA more frequently had CP (median 2, range 0, 4) compared with controls (median 1, range 0, 3; p < 0.001), after adjustment for age and sex. Patients with active RA disease according to the Clinical Disease Activity Index (CDAI) had lower median GSM (p = 0.03), minimum GSM (p = 0.03), and a larger CP area (although the latter finding was not significant; p = 0.27), compared with patients with RA in remission. These findings were not confirmed for other disease measures (Simplified Disease Activity Index, Disease Activity Score-28, C-reactive protein, erythrocyte sedimentation rate). Conclusion. Patients with RA had more CP compared with controls and patients in CDAI remission, and controls had more stable CP than patients with active disease; these findings point to the importance of achieving remission in RA.

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• Agca, Rabia; Heslinga, Sjoerd C.; Rollefstad, Silvia Christin Hellerud; Heslinga, S.; Södergren, Anna & Semb, Anne Grete [Show all 9 contributors for this article] (2020). Response to: "influence of changes in cholesterol levels and disease activity on the 10-year cardiovascular risk estimated with different algorithms in rheumatoid arthritis patients" by Fornaro et al. Annals of the Rheumatic Diseases. ISSN 0003-4967. 79(9). doi: 10.1136/annrheumdis-2019-215748.
• Ikdahl, Eirik; Rollefstad, Silvia Christin Hellerud; Wibetoe, Grunde & Semb, Anne Grete (2016). Chronic kidney disease reduces risk of cardiovascular disease in patients with rheumatoid arthritis according to the QRISK lifetime cardiovascular risk calculator. Rheumatology. ISSN 1462-0324. 55(8), p. 1528–1529. doi: 10.1093/rheumatology/kew002.
• Rollefstad, Silvia Christin Hellerud; Eeg, Ingvild Karsen; Haugen, Ida Kristin; Østerås, Nina; Kvien, Tore Kristian & Semb, Anne Grete (2014). Cardiovascular preventive medication and treatment targets in patients with osteoarthritis: results from the MUST-Heart Study.
• Eeg, Ingvild Karsen; Rollefstad, Silvia Christin Hellerud; Haugen, Ida Kristin; Olsen, Inge C.; Østerås, Nina & Christensen, Barbara Therese Slatkovsky [Show all 11 contributors for this article] (2014). Risk of cardiovascular disease in patients with osteoarthritis: results from the MUST Heart Study.
• Gulati, Agnete Malm; Haugeberg, Glenn; Semb, Anne Grete; Romundstad, Pål Richard; Kavanagh, Arthur & Gulati, Sasha [Show all 8 contributors for this article] (2014). ON THE HUNT FOR CARDIOVASCULAR RISK FACTORS AND DISEASE IN PATIENTS WITH PSORIATIC ARTHRITIS – RESULTS FROM THE NORWEGIAN HUNT STUDY.
• Rollefstad, Silvia Christin Hellerud; Ikdahl, Eirik; Kvien, Tore Kristian; Pedersen, Terje Rolf; Holme, Ingar Morten K & Semb, Anne Grete (2013). Systemic Inflammation In Patients With Inflammatory Joint Disease Does Not Influence Statin Dose Needed To Obtain Low Density Lipoprotein Cholesterol Goal In Cardiovascular Prevention. Arthritis and Rheumatism. ISSN 0004-3591. 65, p. S166–S167.
• Rollefstad, Silvia Christin Hellerud; Ikdahl, Eirik; Olsen, Inge Christoffer; Hisdal, Jonny; Kvien, Tore Kristian & Eirheim, Anne Stormyhr [Show all 8 contributors for this article] (2013). Chest Pain Is Not Associated With Coronary Atherosclerosis In Patients With Rheumatoid Arthritis and Ankylosing Spondylitis. Arthritis and Rheumatism. ISSN 0004-3591. 65, p. S173–S173.
• Semb, Anne Grete; Rollefstad, Silvia Christin Hellerud; Ikdahl, Eirik; Hisdal, Jonny; van der Heijde, Désirée & Stranden, Einar [Show all 8 contributors for this article] (2013). Impact of asymptomatic atherosclerosis on CV prevention in patients with rheumatic joint diseases. European Heart Journal. ISSN 0195-668X. 34, p. 798–798.
• Ikdahl, Eirik; Rollefstad, Silvia Christin Hellerud; Olsen, Inge Christoffer; Kvien, Tore Kristian; Hansen, Inger Johanne Widding & Soldal, Dag [Show all 8 contributors for this article] (2013). Focus on cardiovascular Risk Factor Recording In a Rheumatology Outpatient Clinic. Arthritis and Rheumatism. ISSN 0004-3591. 65, p. S84–S85.

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