Stephan Andreas Brackmann

• Senthakumaran, Thulasika; Moen, Aina Elisabeth Fossum; Tannæs, Tone Møller; Endres, Alexander; Brackmann, Stephan Andreas & Rounge, Trine Ballestad [Show all 8 contributors for this article] (2023). Microbial dynamics with CRC progression: a study of the mucosal microbiota at multiple sites in cancers, adenomatous polyps, and healthy controls. European Journal of Clinical Microbiology and Infectious Diseases. ISSN 0934-9723. 42, p. 305–322. doi: 10.1007/s10096-023-04551-7. Full text in Research Archive
• Vatn, Simen Svendsen; Lindstrøm, Jonas Christoffer; Moen, Aina Elisabeth Fossum; Brackmann, Stephan Andreas; Tannæs, Tone Møller & Olbjørn, Christine [Show all 19 contributors for this article] (2022). Mucosal Gene Transcript Signatures in Treatment Naïve Inflammatory Bowel Disease: A Comparative Analysis of Disease to Symptomatic and Healthy Controls in the European IBD-Character Cohort. Clinical and Experimental Gastroenterology. ISSN 1178-7023. 15, p. 5–25. doi: 10.2147/CEG.S343468. Full text in Research Archive
• Kristensen, Vendel Ailin; Opheim, Randi; Perminow, Gøri Margrete; Huppertz-Hauss, Gert; Detlie, Trond Espen & Lund, Charlotte [Show all 39 contributors for this article] (2021). Inflammatory bowel disease in South-Eastern Norway III (IBSEN III): a new population-based inception cohort study from South-Eastern Norway. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 56(8), p. 899–905. doi: 10.1080/00365521.2021.1922746. Full text in Research Archive Show summary

  Background and aim: Modern treatment strategies for inflammatory bowel disease (IBD) are postulated to change the natural disease course. Inception cohort studies are the gold standard for investigating such changes. We have initiated a new population-based inception cohort study; Inflammatory bowel disease in South Eastern Norway III (IBSEN III). In this article, we describe the study protocol and baseline characteristics of the cohort. Methods: IBSEN III is an ongoing, population-based observational inception cohort study with prospective follow-up. Adult and pediatric patients with suspected IBD in the South-Eastern Health Region of Norway (catchment area of 2.95 million inhabitants in 2017), during the 3-year period from 2017 to 2019, were eligible for inclusion. Comprehensive clinical, biochemical, endoscopic, demographic, and patient-reported data were collected at the time of diagnosis and throughout standardized follow-up. For a portion of the patients, extensive biological material was biobanked. Results: The study included 2168 patients, of whom 1779 were diagnosed with IBD (Crohn's disease: 626, ulcerative colitis: 1082, IBD unclassified: 71). In 124 patients, there were subtle findings indicative of, but not diagnostic for, IBD. The remaining 265 patients were classified as symptomatic non-IBD controls. Conclusion: We have included patients in a comprehensive population-based IBD cohort from a catchment population of 2.95 million, and a unique biobank with materials from newly diagnosed and treatment-naïve IBD patients and symptomatic non-IBD controls. We believe this cohort will add important knowledge about IBD in the years to come.

• Klepp, Pasquale Catherine; Brackmann, Stephan; Småstuen, Milada Cvancarova; Høivik, Marte Lie; Hovde, Øistein & Henriksen, Magne [Show all 15 contributors for this article] (2020). Risk of colorectal cancer in a population-based study 20 years after diagnosis of ulcerative colitis: results from the IBSEN study. BMJ open gastroenterology. ISSN 2054-4774. 7. doi: 10.1136/bmjgast-2019-000361. Full text in Research Archive Show summary

  Objective The association between ulcerative colitis (UC) and colorectal cancer (CRC) is widely accepted, although attenuated risk has been reported in recent years. Colonoscopic surveillance is recommended with intervals based on established clinical risk factors. Nevertheless, a significant number of patients develop interval cancers, indicating the need of improved individualised assessment. In the present study, we evaluated clinical risk factors associated with CRC during a prescheduled follow-up 20 years after diagnosis, the IBSEN study. Design A population-based inception cohort of patients diagnosed with inflammatory bowel disease from 1 January 1990 until 31 December 1993, prospectively followed at 1, 5, 10 and 20 years after diagnosis. A total of 517 patients with UC were included; 264 (51 %) men; median age at inclusion 37.4 years (4–88). Results The overall incidence of CRC was 1.6% (8/517) at a 20-year follow-up. The total lifetime risk of CRC prior to or after UC diagnosis was 2.3%. (12/517). Patients older than 70 years at diagnosis had a 15-fold higher risk of CRC compared with those diagnosed when younger than 40 years, with HR 15.68 (95% CI: 1.31 to 187.92). Neither sex, first-degree relative with CRC, extent of colitis nor primary sclerosing cholangitis affected the risk of CRC. Conclusion The risk of CRC in UC was low and comparable with the risk of CRC in the background population of Norway.

• Kristensen, Vendel Ailin; Valeur, Jørgen; Brackmann, Stephan; Jahnsen, Jørgen; Brunborg, Cathrine & Tveito, Kari (2019). Attention deficit and hyperactivity disorder symptoms respond to gluten-free diet in patients with coeliac disease. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 54(5), p. 571–576. doi: 10.1080/00365521.2019.1608467.
• Kisiel, John; Klepp, Pasquale Catherine; Allawi, Hatim T.; William, Taylor; Giakoumopoulos, Maria & Sander, Tamara [Show all 13 contributors for this article] (2019). Analysis of DNA Methylation at Specific Loci in Stool Samples Detects Colorectal Cancer and High-Grade Dysplasia in Patients With Inflammatory Bowel Disease. Clinical Gastroenterology and Hepatology. ISSN 1542-3565. 17(5), p. 914–921. doi: 10.1016/j.cgh.2018.05.004.
• Klepp, Pasquale Catherine; Tollisen, Anita; Røseth, Arne; Småstuen, Milada Cvancarova; Andersen, Solveig Norheim & Vatn, Morten H [Show all 8 contributors for this article] (2018). Real-life chromoendoscopy for dysplasia surveillance in ulcerative colitis. World Journal of Gastroenterology (WJG). ISSN 1007-9327. 24(35), p. 4069–4076. doi: 10.3748/wjg.v24.i35.4069. Full text in Research Archive
• Klepp, Pasquale Catherine; Kisiel, John; Allawi, Hatim T; Taylor, William R; Giakoumopoulos, Maria & sander, Tamara [Show all 13 contributors for this article] (2018). Analysis of DNA Methylation at Specific Loci in Stool Samples Detects Colorectal Cancer and High-grade Dysplasia in Patients with Inflammatory Bowel Disease. Clinical Gastroenterology and Hepatology. ISSN 1542-3565. doi: 10.1016/j.cgh.2018.05.004..
• Klepp, Pasquale Catherine; Kisiel, John; Småstuen, Milada Cvancarova; Røseth, Arne; Andersen, Solveig Norheim & Vatn, Morten H [Show all 9 contributors for this article] (2018). Multi-target stool DNA test in the surveillance of inflammatory bowel disease: a cross-sectional cohort study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 53(3), p. 273–278. doi: 10.1080/00365521.2018.1424935.
• Thorkildsen, Lill-Therese; Nwosu, Felix; Avershina, Ekaterina; Ricanek, Petr; Perminow, Gøri Margrete & Brackmann, Stephan [Show all 8 contributors for this article] (2013). Dominant Fecal Microbiota in Newly Diagnosed Untreated Inflammatory Bowel Disease Patients. Gastroenterology Research and Practice. ISSN 1687-6121. doi: 10.1155/2013/636785.
• Nwosu, Felix; Thorkildsen, Lill-Therese; Avershina, Ekaterina; Ricanek, Petr; Perminow, Gøri Margrete & Brackmann, Stephan [Show all 8 contributors for this article] (2013). Age-Dependent Fecal Bacterial Correlation to Inflammatory Bowel Disease for Newly Diagnosed Untreated Children. Gastroenterology Research and Practice. ISSN 1687-6121. doi: 10.1155/2013/302398. Full text in Research Archive
• Rudi, Knut; Ricanek, Petr; Tannæs, Tone; Perminov, G; Brackmann, Stephan & Vatn, Morten H (2012). Analysing tap-water from households of patients with inflammatory bowels disease in Norway. In Hoorfar, Jeffrey (Eds.), Case studies in food safety and authenticity. Woodhead Publishing Limited. ISSN 978-0-85709-412-4. p. 130–137.
• Sveen, Anita; Bakken, Anne Cathrine; Ågesen, Trude Holmeide; Lind, Guro Elisabeth; Nesbakken, Arild & Nordgård, Oddmund [Show all 10 contributors for this article] (2012). The exon-level biomarker SLC39A14 has organ-confined cancer-specificity in colorectal cancer. International Journal of Cancer. ISSN 0020-7136. 131(6), p. 1479–1485. doi: 10.1002/ijc.27399.
• Ricanek, Petr; Brackmann, Stephan; Perminow, Gøri Margrete; Lyckander, Lars Gustav; Sponheim, Jon & Holme, Øyvind [Show all 9 contributors for this article] (2011). Evaluation of disease activity in IBD at the time of diagnosis by the use of clinical, biochemical, and fecal markers. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 46(9), p. 1081–1091. doi: 10.3109/00365521.2011.584897.
• Ricanek, Petr; Lothe, Sheba Maria; Szpinda, Irena; Jorde, Anne Tomine; Brackmann, Stephan & Perminow, Gøri [Show all 10 contributors for this article] (2010). Paucity of mycobacteria in mucosal bowel biopsies from adults and children with early inflammatory bowel disease. Journal - Crohn's and Colitis Foundation of Canada. ISSN 1197-4982. 4(5), p. 561–566. doi: 10.1016/j.crohns.2010.05.003.
• Brackmann, Stephan; Aamodt, Geir; Andersen, Solveig Norheim; Roald, Borghild; Langmark, Frøydis & Clausen, Ole Petter Fraas [Show all 10 contributors for this article] (2010). Widespread But Not Localized Neoplasia in Inflammatory Bowel Disease Worsens the Prognosis of Colorectal Cancer. Inflammatory Bowel Diseases. ISSN 1078-0998. 16(3), p. 474–481. doi: 10.1002/ibd.21053.
• Brackmann, Stephan; Andersen, Solveig Norheim; Aamodt, Geir; Frøydis, Langmark; Clausen, Ole Petter Fraas & Aadland, Erling [Show all 9 contributors for this article] (2009). Relationship between clinical parameters and the colitis-colorectal cancer interval in a cohort of patients with colorectal cancer in inflammatory bowel disease. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 44(1), p. 46–55. doi: 10.1080/00365520801977568.
• Brackmann, Stephan; Andersen, Solveig Norheim; Aamodt, Geir; Roald, Borghild; Langmark, Frøydis & Clausen, Ole Petter Fraas [Show all 10 contributors for this article] (2009). Two distinct groups of colorectal cancer in inflammatory bowel disease. Inflammatory Bowel Diseases. ISSN 1078-0998. 15(1), p. 9–16. doi: 10.1002/ibd.20542.
• Finanger, Gøri Margrete; Perminow, Gøri; Brackmann, Stephan; Lyckander, Lars G; Franke, Andre & Borthne, Arne [Show all 10 contributors for this article] (2009). A characterization in childhood inflammatory bowel disease, a new population-based inception cohort from South-Eastern Norway, 2005-07, showing increased incidence in Crohn's disease. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 44(4), p. 446–456. doi: 10.1080/00365520802647434.
• Brackmann, Stephan; Aamodt, Geir; Andersen, Solveig Norheim; Roald, Borghild; Langmark, Frøydis & Clausen, Ole Petter Fraas [Show all 10 contributors for this article] (2009). Widespread but not localized neoplasia in inflammatory bowel disease worsens the prognosis of colorectal cancer. Inflammatory Bowel Diseases. ISSN 1078-0998. doi: 10.1002/ibd.21053.
• Perminow, Gøri; Brackmann, Stephan; Lyckander, Lars G.; Franke, Andre; Borthne, Arne Sigmund & Rydning, Andreas [Show all 9 contributors for this article] (2008). Characterization in childhood inflammatory bowel disease. A new population-based inception cohort from South-Eastern Norway, 2005-07, showing increased incidence in Crohn's disease. Scandinavian Journal of Gastroenterology. ISSN 0036-5521.

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• Kristensen, Vendel Ailin; Valeur, Jørgen; Brackmann, Stephan; Jahnsen, Jørgen & Tveito, Kari (2019). Kognitive symptomer hos pasienter med cøliaki før og etter glutenfri kost.
• Alsøe, Lene; Wennerström, Anna Berit; Liu, Yan; Esbensen, Qin Ying; Bjørset, Randi & Penz, Christine [Show all 10 contributors for this article] (2018). Do APOBEC proteins contribute to genomic instability in colitis-associated colorectal cancer? .
• Alsøe, Lene; Wennerstrøm, Anna; Liu, Yan; Esbensen, Qin Ying; Bjørseth, Randi & Penz, Christine [Show all 10 contributors for this article] (2017). Do APOBEC proteins contribute to genomic instability in colitis-associated colorectal cancer? .
• Alsøe, Lene; Wennerstrøm, Anna; Liu, Yan; Esbensen, Qin Ying; Bjørseth, Randi & Penz, Christine [Show all 10 contributors for this article] (2017). Do APOBEC proteins contribute to genomic instability in colitis-associated colorectal cancer?
• Detlie, Trond Espen; Smaastuen, Milada; Ricanek, Petr; Brackmann, Stephan; Rydning, Andreas & Vatn, Morten Harald [Show all 7 contributors for this article] (2016). Phenotype correlation in inflammatory bowel disease (IBD ) compared to serological antibody activity at diagnosis and after treatment. A prospective population based study.
• Brackmann, Stephan; Valeur, Jørgen; Raa, Jan & Berstad, Arnold (2016). Sauerkraut - mat, medisin og konserveringsmiddel i over 2000 år. NGF-nytt. ISSN 0809-6570. 23(4), p. 46–47.
• Brackmann, Stephan; Pretorius, Maria E.; Klepp, Pasquale Catherine; Clausen, Ole Petter Fraas; Andersen, Solveig Norheim & Vatn, Morten H [Show all 9 contributors for this article] (2013). The distribution of chromosomal and microsatellite instability in colorectal cancers related to inflammatory bowel disease. Journal of Clinical Oncology. ISSN 0732-183X. 31(15).
• Brackmann, Stephan; Pretorius, Maria E.; Andersen, Solveig Norheim; Langmark, Frøydis; Clausen, Ole Petter Fraas & Vatn, Morten [Show all 7 contributors for this article] (2011). Large scale genomic instability in patients with colorectal cancer in inflammatory bowel disease. Association with clinicohistological factors and survival.
• Brackmann, Stephan; Andersen, Solveig Norheim; Aamodt, Geir; Roald, Borghild Barth-H; Langmark, Frøydis & Clausen, Ole Petter Fraas [Show all 10 contributors for this article] (2008). Colorectal cancer in inflammatory bowel disease without distant dysplasia may be a specific entity. Gastroenterology. ISSN 0016-5085. 134(4), p. A292–A292.
• Brackmann, Stephan; Andersen, Solveig Norheim; Aamodt, Geir; Roald, Borghild Barth-H; Langmark, Frøydis & Clausen, Ole Petter Fraas [Show all 10 contributors for this article] (2008). Widespread but not localized neoplasia in IBD worsens the prognosis of CRC.
• Brackmann, Stephan (2008). Colorectal cancer in inflammatory bowel disease.
• Brackmann, Stephan; Andersen, Solveig Norheim; Aamodt, Geir; Roald, Borghild Barth-H; Langmark, Frøydis & Clausen, Ole Petter Fraas [Show all 10 contributors for this article] (2008). COLORECTAL CANCER IN INFLAMMATORY BOWEL DISEASE WITHOUT DISTANT DYSPLASIA MAY BE A SPECIFIC ENTITY.
• Brackmann, Stephan; Andersen, Solveig Norheim; Aamodt, Geir; Roald, Borghild Barth-H; Langmark, Frøydis & Clausen, Ole Petter Fraas [Show all 10 contributors for this article] (2008). Colorectal cancer in inflammatory bowel disease without distant dysplasia may be a specific entity.
• Brackmann, Stephan; Andersen, Solveig Norheim; Aamodt, Geir; Roald, Borghild Barth-H; Langmark, Frøydis & Clausen, Ole Petter Fraas [Show all 10 contributors for this article] (2008). Colorectal cancer in inflammatory bowel disease without distant dysplasia may be a specific entity.
• Brackmann, Stephan (2007). Time to CRC in IBD - Factors related to the colitis-CRC interval.
• Brackmann, Stephan; Andersen, Solveig Norheim; Aamodt, Geir; Langmark, Frøydis; Clausen, Ole Petter Fraas & Aadland, Erling [Show all 9 contributors for this article] (2007). IBD relatert colorectalcancer overlevelelse i forhold til cancer screening.
• Brackmann, Stephan; Andersen, Solveig Norheim; Aamodt, Geir; Langmark, Frøydis; Clausen, Ole Petter Fraas & Aadland, Erling [Show all 9 contributors for this article] (2007). Risk factors affecting duration of colitis-CRC interval in a cohort of CRC in IBD.
• Brackmann, Stephan; Andersen, Solveig Norheim; Aamodt, Geir; Fausa, Olav; Aadland, Erling & Rydning, Andreas [Show all 9 contributors for this article] (2006). Overlevelse ved Kronisk Inflammatorisk Tarmsydkom relatert Colorectal Cancer.
• Brackmann, Stephan; Andersen, Solveig Norheim; Aamodt, Geir; Langmark, Frøydis; Clausen, Ole Petter Fraas & Aadland, Erling [Show all 9 contributors for this article] (2006). RISKFACTORS AND SURVIVAL IN PATIENTS WITH IBD AND COLORECTAL CANCER.
• Brackmann, Stephan (2009). Colorectal cancer and IBD in Norway. A retrospective analysis. Unipub forlag. ISSN 978-82-8072-777-0.

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