Terje Osnes

• Huynh, Thuy-Tien Maria; Aass, Hans Christian Dalsbotten; Falk, Ragnhild Sørum; Astrup, Guro Lindviksmoen; Helland, Åslaug & Bjøro, Trine [Show all 14 contributors for this article] (2022). Associations between patient-reported late effects and systemic cytokines in long-term survivors of head and neck cancer treated with radiotherapy. Journal of cancer survivorship. ISSN 1932-2259. doi: 10.1007/s11764-022-01273-1. Full text in Research Archive Show summary

  Purpose Head and neck cancer (HNC) treatment may lead to late effects and impaired health-related quality of life of survivors. Knowledge on long-term late effects after radiotherapy (RT) and potential underlying biological mechanisms is lacking. We assessed the prevalence of xerostomia, dysphagia, and chronic fatigue (CF) in HNC survivors ≥ 5 years post-RT, and examined associations between pro-inflammatory cytokines and late effects. Methods In a cross-sectional study, 263 HNC survivors treated between 2007 and 2013 were enrolled. They completed validated questionnaires assessing xerostomia and dysphagia (the EORTC QLQ-H&N35), and CF (the Fatigue Questionnaire), and underwent blood sampling and clinical examination. Pro-inflammatory cytokines were analyzed in 262 survivors and 100 healthy age- and gender-matched controls. Results Median time since treatment was 8.5 years. The proportions of survivors reporting xerostomia, dysphagia, and CF were 58%, 31%, and 33%, respectively, with a preponderance of females. We found no significant associations between IL-6, IL-8, IP-10, TARC, TNF, or ENA-78 and the three late effects. The odds of having elevated levels of IL-6 and IP-10 were significantly higher in the survivors compared to the controls. Conclusions More than one-third of long-term HNC survivors experienced xerostomia, dysphagia, and CF. Persistent inflammation, with elevated systemic cytokines, was not associated with these late effects, although HNC survivors had higher levels of some cytokines than the controls. Implications for Cancer Survivors This study provides new knowledge on late effects that can serve as grounds for informing patients with HNC about risk of late effects more than 5 years after RT.

• Skalleberg, Jakob Rasmussen; Myhrum, M.; Småstuen, M.C.; Osnes, Terje; Fosså, Sophie Dorothea & Bunne, M. (2021). Speech perception 30 years after cisplatin-based chemotherapy in adults: limited clinical relevance of long-term ototoxicity? Acta Oncologica. ISSN 0284-186X. 60(4), p. 426–433. doi: 10.1080/0284186X.2021.1887514.
• Hui, David; Johansen, Edvard; Akre, Harriet; Osnes, Terje & Dheyauldeen, Sinan (2020). Øre-nese-hals-leger og sars-CoV-2-viruset. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(10). doi: 10.4045/tidsskr.20.0423.
• Skalleberg, Jakob Rasmussen; Småstuen, Milada Cvancarova; Oldenburg, Jan; Osnes, Terje; Fosså, Sophie Dorothea & Bunne, Bodil Iris Marie (2020). The relationship between cisplatin-related and age-related hearing loss during an extended follow-up. The Laryngoscope. ISSN 0023-852X. 130(9), p. E515–E521. doi: 10.1002/lary.28543.
• Rana, Mohammad Usman; Østhus, Arild Andre; Heimdal, Ketil Riddervold; Jebsen, Peter Wilhelm; Rootwelt-Revheim, Mona-Elisabeth & Osnes, Terje (2020). Head and neck paragangliomas in Norway, importance of genetics, updated diagnostic workup and treatment. Acta Oto-Laryngologica. ISSN 0001-6489. p. 1–7. doi: 10.1080/00016489.2020.1845397. Full text in Research Archive
• Lorntzsen, Bianca M.R.; Brøndbo, Kjell & Osnes, Terje Andreas (2020). From the clavicle to the windpipe: Tracheal window resections reconstructed with calcifying periosteum in thyroid cancer. Laryngoscope Investigative Otolaryngology (LIO). ISSN 2378-8038. 5, p. 961–968. doi: 10.1002/lio2.463. Full text in Research Archive
• Lorntzsen, Bianca M.R.; Jacobsen, Anne-birgitte; Kotanska-Grøholt, Krystyna; Sigstad, Eva & Osnes, Terje Andreas (2020). Survival and Surgical Complications in Anaplastic Thyroid Cancer Patients After Completed Multimodal Treatment. Anticancer Research. ISSN 0250-7005. 40(12), p. 6979–6985. doi: 10.21873/anticanres.14722. Full text in Research Archive
• König, Marton; Osnes, Terje; Bruland, Øyvind; Hall, Kirsten Sundby; Bratland, Åse & Meling, Torstein Ragnar (2020). The role of adjuvant treatment in craniofacial malignancy: A critical review . Frontiers in Oncology. ISSN 2234-943X. 10. doi: 10.3389/fonc.2020.01402. Full text in Research Archive
• Steineger, Johan Edvard; Geirdal, Amy Østertun; Osnes, Terje; Heimdal, Ketil Riddervold & Dheyauldeen, Sinan (2019). Intranasal bevacizumab injections improve quality of life in HHT patients. The Laryngoscope. ISSN 0023-852X. p. 1–5. doi: 10.1002/lary.28179.
• König, Marton; Osnes, Terje; Bratland, Åse & Meling, Torstein Ragnar (2019). Squamous Cell Carcinoma of the Paranasal Sinuses: A Single Center Experience. Journal of Neurological Surgery. Part B: Skull Base: an interdisciplinary approach. ISSN 2193-6331. 81(6), p. 664–672. doi: 10.1055/s-0039-1694967. Full text in Research Archive
• König, Marton; Osnes, Terje; Bratland, Åse; Jebsen, Peter Wilhelm & Meling, Torstein Ragnar (2019). Treatment of sinonasal adenocarcinoma: A population-based prospective cohort study. Journal of Neurological Surgery. Part B: Skull Base: an interdisciplinary approach. ISSN 2193-6331. 61(8), p. 627–637. doi: 10.1055/s-0039-1694050. Full text in Research Archive
• Steineger, Johan Edvard; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Osnes, Terje & Heimdal, Ketil Riddervold [Show all 7 contributors for this article] (2018). Pentraxin 3 level is elevated in hereditary hemorrhagic telangiectasia and reflects the severity of disease-associated epistaxis. The Laryngoscope. ISSN 0023-852X. 129(1), p. E44–E49. doi: 10.1002/lary.27548.
• Steineger, Johan Edvard; Osnes, Terje; Heimdal, Ketil Riddervold & Dheyauldeen, Sinan (2018). Long-term experience with intranasal bevacizumab therapy. The Laryngoscope. ISSN 0023-852X. 128(10), p. 2237–2244. doi: 10.1002/lary.27147.
• König, Marton; Osnes, Terje; Jebsen, Peter Wilhelm & Meling, Torstein Ragnar (2018). Craniofacial resection of malignant tumors of the anterior skull base: a case series and a systematic review. Acta Neurochirurgica. ISSN 0001-6268. 160(12), p. 2339–2348. doi: 10.1007/s00701-018-3716-4. Full text in Research Archive
• Jacobsen, Anne-Birgitte; Kotanska-Grøholt, Krystyna; Lorntzsen, Bianca M.R.; Osnes, Terje; Falk, Ragnhild Sørum & Sigstad, Eva (2017). Anaplastic thyroid cancer and hyperfractionated accelerated radiotherapy (HART) with and without surgery. European Archives of Oto-Rhino-Laryngology. ISSN 0937-4477. 274(12), p. 4203–4209. doi: 10.1007/s00405-017-4764-8.
• Skalleberg, Jakob Rasmussen; Popova, Olesya; Fosså, Sophie Dorothea; Småstuen, Milada C; Osnes, Terje & Gundersen, Per Ole Mobråten [Show all 7 contributors for this article] (2017). Long-term ototoxicity in women after cisplatin treatment for ovarian germ cell cancer. Gynecologic Oncology. ISSN 0090-8258. 145(1), p. 148–153. doi: 10.1016/j.ygyno.2017.02.006.
• König, Marton; Osnes, Terje; Jebsen, Peter Wilhelm; Evensen, Jan Folkvard & Meling, Torstein Ragnar (2017). Olfactory neuroblastoma: a single-center experience. Neurosurgical review. ISSN 0344-5607. 41, p. 323–331. doi: 10.1007/s10143-017-0859-3.
• Dale, Einar; Moan, Jon Magne; Osnes, Terje & Bogsrud, Trond (2016). Cervical lymph node metastases of squamous cell carcinoma of unknown origin: the diagnostic value of FDG PET/CT and clinical outcome. European Archives of Oto-Rhino-Laryngology. ISSN 0937-4477. 274(2), p. 1015–1019. doi: 10.1007/s00405-016-4318-5.
• König, Marton Skog Steinberger; Osnes, Terje; Lobmaier, Ingvild Victoria Koren; Bjerkehagen, Bodil; Bruland, Øyvind & Hall, Kirsten Sundby [Show all 7 contributors for this article] (2016). Multimodal treatment of craniofacial osteosarcoma with high-grade histology. A single-center experience over 35 years. Neurosurgical review. ISSN 0344-5607. p. 1–12. doi: 10.1007/s10143-016-0802-z. Show summary

  High-grade craniofacial osteosarcoma (CFOS) is an aggressive malignancy with a poor prognosis. Our goals were to evaluate treatment outcomes in those treated at a single referral institution over 35 years and to compare our results to the available literature. A retrospective analysis of all 42 patients treated between 1980 and 2015 at Oslo University Hospital, Norway, identified in a prospectively collected database, was conducted. Mean follow-up was 79.6 months. Overall survival at 2 and 5 years was 70.5 and 44.7%, respectively. The corresponding disease-specific survival rates were 73.0 and 49.8%. Treatment was surgery only in eight cases. Additional therapy was administered in 34 patients: chemotherapy in nine, radiotherapy in seven, and a combination of these in 18 cases. Stratified analysis by resection margins demonstrated significantly better survival at 2 and 5 years after radical surgical treatment. Neoadjuvant chemotherapy and subsequent adequate surgery resulted in better survival than surgery alone. Half of the patients either had a primary or familial cancer predisposition. This is the largest single-center study conducted on high-grade CFOS to date. Our experience indicates that neoadjuvant chemotherapy with complete surgical resection significantly improved survival, compared to surgery alone.

• König, Marton Steinberger; Osnes, Terje & Meling, Torstein (2014). Treatment of esthesioneuroblastomas. Neuro-chirurgie. ISSN 0028-3770. 60(4), p. 151–157. doi: 10.1016/j.neuchi.2014.03.007.
• Dollner, Ralph; Taraldsrud, Eli; Iversen, Kristin; Osnes, Terje ; Kristensen, B. & Kramer, Matthias F. (2013). Non-allergic, mastocytosis-associated rhinitis. Clinical and Experimental Allergy. ISSN 0954-7894. 43(4), p. 406–412. doi: 10.1111/cea.12053.
• Strøm-Roum, Henrik; Rødvik, Arne K; Osnes, Terje ; Fagerland, Morten & Wie, Ona Bø (2012). Sound localising ability in children with bilateral sequential cochlear implants. International Journal of Pediatric Otorhinolaryngology. ISSN 0165-5876. 76(9), p. 1245–1248. doi: 10.1016/j.ijporl.2012.05.013.
• Dheyauldeen, Sinan Ahmed Dheyauldeen; Geirdal, Amy Østertun; Osnes, Terje ; Vartdal, Liv Sofie & Dollner, Ralph (2012). Bevacizumab in hereditary hemorrhagic telangiectasia-associated epistaxis: Effectiveness of an injection protocol based on the vascular anatomy of the nose. The Laryngoscope. ISSN 0023-852X. 122(6), p. 1210–1214. doi: 10.1002/lary.23303.
• Wie, Ona Bø; Falkenberg, Eva-Signe; Tvete, Ole; Bunne, Marie & Osnes, Terje (2011). Cochleaimplantat til døve barn - hørsel- og talespråkutvikling. Spesialpedagogikk. ISSN 0332-8457. 76(5), p. 39–49. Show summary

  Bruk av cochleaimplantat har gitt førspråklig døve barn økt mulighet til å høre og til å tilegne seg talespråk. I artikkelen presenteres resultater fra tre studier utført i tidsrommet 200-2010. Barnas hørsel, deres taleoppfattelse, talespråkutvikling og habiliteringssituasjon er undersøkt. En stor del (50%) av variasjonen i taleoppfattelse kunne forklares med variasjon i alder ved implantering, intelligens, daglig bruk, valg av opplæringssituasjon, språk og språkkommunikasjonsform. Blant barna som fikk tosidig simultan implantasjon fra 5 til 18 måneder, hadde henholdsvis 81% og 57% oppnådd aldersakdekvate reseptive og ekspressive talespråkferdigheter 12-48 måneder etter implantasjon. Andelen barn med aldersadekvate talespråkferdigheter økte med alder og implantatbrukstid.

• König, Marton; Due-Tønnessen, Bernt Johan; Osnes, Terje ; Haugstvedt, Jan-Ragnar & Meling, Torstein (2010). Median facial cleft with a frontoethmoidal encephalocele treated with craniofacial bipartition and free radial forearm flap: a case report. Skull base surgery. ISSN 1052-1453. 20(2), p. 119–123. doi: 10.1055/s-0029-1238216.
• König, Marton; Mork, Jon; Hall, Kirsten Sundby; Osnes, Terje & Meling, Torstein (2010). Multimodal Treatment of Osteogenic Sarcoma of the Jaw. Skull base surgery. ISSN 1052-1453. 20(3), p. 207–212. doi: 10.1055/s-0029-1246221.
• König, Marton Skog Steinberger; Due-Tønnessen, Bernt Johan; Osnes, Terje; Haugstvedt, Jan-Ragnar & Meling, Torstein (2010). Median facial cleft with a frontoethmoidal encephalocele treated with craniofacial bipartition and free radial forearm flap. Journal of Neurological Surgery. Part B: Skull Base: an interdisciplinary approach. ISSN 2193-6331. 2(20), p. 119–123. doi: 10.1055/s-0029-1238216.
• Osnes, Terje Andreas & Rollheim, Jan (2002). Effect of UPPP with respect to site of pharyngeal obstruction in sleep apnoea: follow-up at 18 months by overnight recording of airway pressure and flow. Clinical Otolaryngology. ISSN 1749-4478. 27, p. 38–43.
• Sandstad, Olav.; Osnes, Terje Andreas; Urdal, Petter; Skar, V. & Osnes, Magne (2000). Brown pigment stones in the common bile duct: reduced bilirubinate diconjugate in bile. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 35(2), p. 198–203.
• Sandstad, Olav.; Osnes, Terje Andreas; Skar, V.; Urdal, Petter & Osnes, Magne (2000). Structure and Composition of Common Bile Duct Stones in Relation to Duodenal Diverticula, Gastric Resection, Cholecystectomy and Infection. Digestion. ISSN 0012-2823. 61, p. 181–188.
• Rollheim, Jan; Dingsør, B. & Osnes, Terje Andreas (2000). The distribution of hypopnoeic events in relation to apnoeic events in patients with sleep-induced upper airway narrowing. Clinical Otolaryngology. ISSN 1749-4478. 25, p. 361–362.
• Rollheim, Jan; Miljeteig, Harald & Osnes, Terje Andreas (1999). Body mass index less than 28 kg/m2 is a predictor of subjective improvement after laser-assisted uvulopalatoplasty for snoring. The Laryngoscope. ISSN 0023-852X. 109(3), p. 411–414.
• Rollheim, Jan; Osnes, Terje Andreas & Miljeteig, Harald (1999). The sites of obstruction in OSA, identified by continuous measurements of airway pressure and flow during sleep: mbulatory versus in hospital recordings. Clinical Otolaryngology. ISSN 1749-4478. 24, p. 502–506.
• Osnes, Terje Andreas; Sandstad, Olav.; Skar, V. & Osnes, Magne (1997). Lipopolysaccharides and Beta-Glucuronidase Activity in Choledochal Bile in Relation to Choledocholithiasis. Digestion. ISSN 0012-2823. 58 (5), p. 437–443.
• Osnes, Terje Andreas; Sandstad, Olav.; Skar, V. & Osnes, Magne (1997). beta,Glucuronidase in common duct bile, methodological aspects, variation of pH optima and relation to gallstones. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 57 (4), p. 307–315.

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• König, Marton; Osnes, Terje; Jebsen, Peter Wilhelm; Bratland, Åse & Meling, Torstein Ragnar (2018). Squamous cell carcinoma of the paranasal sinuses: a single center experience.
• König, Marton; Osnes, Terje; Jebsen, Peter Wilhelm & Meling, Torstein Ragnar (2018). Craniofacial resection of malignant tumors of the anterior skull base.
• König, Marton; Osnes, Terje; Jebsen, Peter Wilhelm; Evensen, Jan Folkvard & Meling, Torstein Ragnar (2018). Olfactory neuroblastoma: a single-center experience.
• Meling, Torstein Ragnar; König, Marton; Jebsen, Peter Wilhelm; Evensen, Jan Folkvard & Osnes, Terje (2017). Olfactory neuroblastoma: a single-center experience.
• König, Marton Skog Steinberger; Osnes, Terje; Lobmaier, Ingvild Victoria Koren; Bjerkehagen, Bodil; Bruland, Øyvind & Sundby Hall, Kirsten [Show all 7 contributors for this article] (2016). Treatment of Craniofacial Osteosarcoma: a Multidisciplinary Approach.
• König, Marton Skog Steinberger; Osnes, Terje; Lobmaier, Ingvild Victoria Koren; Bjerkehagen, Bodil; Bruland, Øyvind & Sundby Hall, Kirsten [Show all 7 contributors for this article] (2016). Craniofacial Osteosarcoma: A Single-Institution Experience.
• König, Marton; Osnes, Terje & Meling, Torstein R. (2012). Treatment of Esthesioneuroblastomas: a Single Institution Experience .
• Strøm-Roum, Henrik; Rødvik, Arne K; Osnes, Terje & Wie, Ona Bø (2011). Optimal sound level- a comparison between children with CI and normal hearing children.
• König, Marton; Mork, Jon; Sundby Hall, Kirsten; Osnes, Terje & Meling, Torstein R. (2009). Treatment of Osteogenic Sarcoma of the Jaw: a Case Report.
• Meling, T.R; Osnes, Terje Andreas & Kragerud, Beate (2007). Craniofacial Resection of Sinonasal Anterior Skull Base Tumors. Skull base. ISSN 1531-5010. 17, p. 107–107.
• Osnes, Terje Andreas (2007). Everyday clinical use of US in oncological H&N Surgery.
• Osnes, Terje Andreas (2007). Diagnostikk og behandling av lokalt invasiv cancer thyroidea.
• Osnes, Terje Andreas (2007). Head and Neck multidicipilinary team.
• Meling, Torstein Ragnar; Kragerud, Beate & Osnes, Terje (2007). Craniofacial resection of sinonasal anterior skull base tumours.
• Moen, Anne; Smørdal, Ole; Kristiansen, Tove; Refseth, Yngve; Mortensen, Berit Marie & Osnes, Terje Andreas (2004). Information Sharing in Interdisciplinary Mobile Health Teams.
• Smørdal, Ole; Moen, Anne; Refseth, Yngve; Kristiansen, Tove; Mortensen, Berit Marie & Osnes, Terje Andreas (2004). Participatory design and infrastructures for coordination and communication in interdisciplinary mobile health teams.
• Osnes, Terje Andreas; Aaløkken, Trond Mogens & Siem, Geir (2001). Atlantoaksial subluksasjon.
• Rollheim, Jan; Osnes, Terje Andreas & Miljeteig, Harald (1999). Forholdet mellom obstruktiv søvn apnea og body mass index.
• Rollheim, Jan; Miljeteig, Harald & Osnes, Terje Andreas (1999). Body mass index under 28 kg/m2 predikerer subjektiv bedring etter laser assistert uvulopalatoplastikk for snorking.
• Osnes, Terje Andreas (1998). A study of common duct gallstone disease, with special reference to brown pigment calculi. Methodological aspects and studies of endoscopically obtained bile and calculi. Oslo universitetssykehus HF.

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