Academic interest
Placental function, interaction between mother, placenta and fetus, placental nutrient transport and how the placenta contributes to the maternal metabolome in pregnancy.
In addition, we run clinical studies with particular focus on high risk obstetrics and management of labor.
Prizes and articles
Publications
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Gaudernack, Lise Christine; Einarsen, Angeline Elisabeth Styve; Sørbye, Ingvil Krarup; Lukasse, Mirjam; Gunnes, Nina & Michelsen, Trond Melbye
(2024).
The effect of intravenous hyoscine butylbromide on slow progress in labor (BUSCLAB): A double-blind randomized placebo-controlled trial.
Nature Methods.
ISSN 1548-7091.
21(3).
doi:
10.1371/journal.pmed.1004352.
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Henriksen, Tore; Sajjad, Muhammad Umar; Haugen, Guttorm Nils & Michelsen, Trond Melbye
(2024).
Placental energy metabolism: Evidence for a placental-maternal lactate-ketone trade in the human.
Placenta.
ISSN 0143-4004.
148,
p. 31–37.
doi:
10.1016/j.placenta.2024.01.020.
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Øyri, Linn K. L.; Christensen, Jacob J.; Sebert, Sylvain; Thoresen, Magne; Michelsen, Trond M. & Ulven, Stine M.
[Show all 12 contributors for this article]
(2023).
Maternal prenatal cholesterol levels predict offspring weight trajectories during childhood in the Norwegian Mother, Father and Child Cohort Study.
BMC Medicine.
ISSN 1741-7015.
21.
doi:
10.1186/s12916-023-02742-9.
Full text in Research Archive
Show summary
Background
Numerous intrauterine factors may affect the offspring’s growth during childhood. We aimed to explore if maternal and paternal prenatal lipid, apolipoprotein (apo)B and apoA1 levels are associated with offspring weight, length, and body mass index from 6 weeks to eight years of age. This has previously been studied to a limited extent.
Methods
This parental negative control study is based on the Norwegian Mother, Father and Child Cohort Study and uses data from the Medical Birth Registry of Norway. We included 713 mothers and fathers with or without self-reported hypercholesterolemia and their offspring. Seven parental metabolites were measured by nuclear magnetic resonance spectroscopy, and offspring weight and length were measured at 12 time points. Data were analyzed by linear spline mixed models, and the results are presented as the interaction between parental metabolite levels and offspring spline (age).
Results
Higher maternal total cholesterol (TC) level was associated with a larger increase in offspring body weight up to 8 years of age (0.03 ≤ Pinteraction ≤ 0.04). Paternal TC level was not associated with change in offspring body weight (0.17 ≤ Pinteraction ≤ 0.25). Higher maternal high-density lipoprotein cholesterol (HDL-C) and apoA1 levels were associated with a lower increase in offspring body weight up to 8 years of age (0.001 ≤ Pinteraction ≤ 0.005). Higher paternal HDL-C and apoA1 levels were associated with a lower increase in offspring body weight up to 5 years of age but a larger increase in offspring body weight from 5 to 8 years of age (0.01 ≤ Pinteraction ≤ 0.03). Parental metabolites were not associated with change in offspring height or body mass index up to 8 years of age (0.07 ≤ Pinteraction ≤ 0.99).
Conclusions
Maternal compared to paternal TC, HDL-C, and apoA1 levels were more strongly and consistently associated with offspring body weight during childhood, supporting a direct intrauterine effect.
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Henriksen, Tore; Roland, Marie Cecilie; Sajjad, Muhammad Umar; Haugen, Guttorm Nils & Michelsen, Trond Melbye
(2022).
Uteroplacental versus fetal use of glucose in healthy pregnancies at term. A human in vivo study.
Placenta.
ISSN 0143-4004.
128,
p. 116–122.
doi:
10.1016/j.placenta.2022.09.001.
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Kristiansen, Oddrun; Roland, Marie Cecilie; Zucknick, Manuela; Reine, Trine M.; Kolset, Svein Olav & Henriksen, Tore
[Show all 8 contributors for this article]
(2022).
Maternal body mass index and placental weight: a role for fetal insulin, maternal insulin and leptin.
Journal of Endocrinological Investigation.
ISSN 0391-4097.
45,
p. 2105–2121.
doi:
10.1007/s40618-022-01842-2.
Show summary
Purpose
Placental weight (PW) has been found to mediate the main effect of maternal BMI on fetal size. Still, the BMI–PW association is poorly understood. Therefore, we aimed to explore potential explanatory variables, including gestational weight gain (GWG), early- and late-pregnancy circulating levels of maternal glucose, insulin, leptin, adiponectin, triglycerides, LDL-C, and HDL-C, and fetal insulin.
Methods
We included two studies of pregnant women from Oslo University Hospital, Norway: the prospective STORK (n = 263) and the cross-sectional 4-vessel method study (4-vessel; n = 165). We used multiple linear regression for data analyses. A non-linear BMI-PW association was observed, which leveled off from BMI25. Therefore, BMI <25 and ≥25 were analyzed separately (n = 170/122 and 93/43 for STORK/4-vessel). Confounding variables included maternal age, parity, and gestational age.
Results
PW increased significantly per kg m−2 only among BMI <25 (univariate model’s std.β[p] = 0.233 [0.002] vs. 0.074[0.48]/0.296[0.001] vs. −0.030[0.85] for BMI <25 vs. ≥25 in STORK/4-vessel). Maternal early- but not late-pregnancy insulin and term fetal insulin were associated with PW. The estimated effect of early pregnancy insulin was similar between the BMI groups but statistically significant only among BMI <25 (std.β[p] = 0.182[0.016] vs. 0.203[0.07] for BMI <25 vs. ≥25). Late pregnancy leptin was inversely associated with PW with a 1.3/1.7-fold greater effect among BMI ≥25 than BMI <25 in the STORK/4-vessel.
Conclusions
The BMI–PW association was non-linear: an association was observed for BMI <25 but not for BMI ≥25. Leptin may be involved in the non-linear association through a placental–adipose tissue interplay. Maternal early pregnancy insulin and fetal insulin at term were associated with PW.
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Degnes, Maren-Helene Langeland; Westerberg, Ane Cecilie; Zucknick, Manuela; Powell, Theresa L.; Jansson, Thomas & Henriksen, Tore
[Show all 8 contributors for this article]
(2022).
Placenta-derived proteins across gestation in healthy pregnancies—a novel approach to assess placental function?
BMC Medicine.
ISSN 1741-7015.
20.
doi:
10.1186/s12916-022-02415-z.
Full text in Research Archive
Show summary
ackground
Placenta-derived proteins in the systemic maternal circulation are suggested as potential biomarkers for placental function. However, the identity and longitudinal patterns of such proteins are largely unknown due to the inaccessibility of the human placenta and limitations in assay technologies. We aimed to identify proteins derived from and taken up by the placenta in the maternal circulation. Furthermore, we aimed to describe the longitudinal patterns across gestation of placenta-derived proteins as well as identify placenta-derived proteins that can serve as reference curves for placental function.
Methods
We analyzed proteins in plasma samples collected in two cohorts using the Somalogic 5000-plex platform. Antecubital vein samples were collected at three time points (gestational weeks 14–16, 22–24, and 30–32) across gestation in 70 healthy pregnancies in the longitudinal STORK cohort. In the cross sectional 4-vessel cohort, blood samples were collected simultaneously from the maternal antecubital vein (AV), radial artery (RA), and uterine vein (UV) during cesarean section in 75 healthy pregnancies. Placenta-derived proteins and proteins taken up by the placenta were identified using venoarterial differences (UV-RA). Placenta-derived proteins were defined as placenta-specific by comparison to the venoarterial difference in the antecubital vein-radial artery (AV-RA). These proteins were described longitudinally based on the STORK cohort samples using a linear mixed effects model per protein. Using a machine learning algorithm, we identified placenta-derived proteins that could predict gestational age, meaning that they closely tracked gestation, and were potential read-outs of placental function.
Results
Among the nearly 5000 measured proteins, we identified 256 placenta-derived proteins and 101 proteins taken up by the placenta (FDR < 0.05). Among the 256 placenta-derived proteins released to maternal circulation, 101 proteins were defined as placenta-specific. These proteins formed two clusters with distinct developmental patterns across gestation. We identified five placenta-derived proteins that closely tracked gestational age when measured in the systemic maternal circulation, termed a “placental proteomic clock.”
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Zahid, Saba Muneer; Opheim, Gun Lisbeth; Henriksen, Tore; Michelsen, Trond Melbye & Haugen, Guttorm Nils
(2022).
Effect of a standardized maternal meal on fetal middle cerebral artery Doppler indices: A single-blinded crossover study.
PLOS ONE.
ISSN 1932-6203.
17(8),
p. 1–12.
doi:
10.1371/journal.pone.0272062.
Full text in Research Archive
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Øyri, Linn Kristin Lie; Bogsrud, Martin Prøven; Christensen, Jacob J.; Ulven, Stine Marie; Brantsæter, Anne Lise & Retterstøl, Kjetil
[Show all 13 contributors for this article]
(2021).
Novel associations between parental and newborn cord blood metabolic profiles in the Norwegian Mother, Father and Child Cohort Study.
BMC Medicine.
ISSN 1741-7015.
19.
doi:
10.1186/s12916-021-01959-w.
Full text in Research Archive
Show summary
Background:More than one third of Norwegian women and men between 20 and 40 years of age have elevated cholesterol concentration. Parental metabolic health around conception or during pregnancy may affect the offspring’s cardiovascular disease risk. Lipids are important for fetal development, but the determinants of cord blood lipids have scarcely been studied. We therefore aimed to describe the associations between maternal andpaternal peri-pregnancy lipid and metabolic profile and newborn cord blood lipid and metabolic profile.
Methods:This study is based on 710 mother–father–newborn trios from the Norwegian Mother, Father and ChildCohort Study (MoBa) and uses data from the Medical Birth Registry of Norway (MBRN). The sample included in thisstudy consisted of parents with and without self-reported hypercholesterolemia the last 6 months before pregnancy and their partners and newborns. Sixty-four cord blood metabolites detected by nuclear magnetic resonance spectroscopy were analyzed by linear mixed model analyses. The false discovery rate procedure wasused to correct for multiple testing.
Results:Among mothers with hypercholesterolemia, maternal and newborn plasma high-density lipoproteincholesterol, apolipoprotein A1, linoleic acid, docosahexaenoic acid, alanine, glutamine, isoleucine, leucine, valine,creatinine, and particle concentration of medium high-density lipoprotein were significantly positively associated(0.001≤q≤0.09). Among mothers without hypercholesterolemia, maternal and newborn linoleic acid, valine,tyrosine, citrate, creatinine, high-density lipoprotein size, and particle concentration of small high-density lipoproteinwere significantly positively associated (0.02≤q≤0.08). Among fathers with hypercholesterolemia, paternal andnewborn ratio of apolipoprotein B to apolipoprotein A1 were significantly positively associated (q= 0.04). Amongfathers without hypercholesterolemia, no significant associations were found between paternal and newbornmetabolites. Sex differences were found for many cord blood lipids.
Conclusions:Maternal and paternal metabolites and newborn sex were associated with several cord bloodmetabolites. This may potentially affect the offspring’s long-term cardiovascular disease risk.Keywords:MoBa, the Norwegian Mother, Father and Child Cohort Study, MBRN, Medical Birth Registry of Norway,Cholesterol, Metabolic profiling, Cord blood, Sex differences
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Michelsen, Trond Melbye; Tronstad, Christian & Rosseland, Leiv Arne
(2021).
Blood pressure and cardiac output during caesarean delivery under spinal anaesthesia: A prospective cohort study.
BMJ Open.
ISSN 2044-6055.
11(6),
p. 1–9.
doi:
10.1136/bmjopen-2020-046102.
Full text in Research Archive
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Gaudernack, Lise Christine; Michelsen, Trond Melbye; Egeland, Thore; Voldner, Nanna & Lukasse, Mirjam
(2020).
Does prolonged labor affect the birth experience and subsequent wish for cesarean section among first-time mothers? A quantitative and qualitative analysis of a survey from Norway.
BMC Pregnancy and Childbirth.
ISSN 1471-2393.
20:605,
p. 1–13.
doi:
10.1186/s12884-020-03196-0.
Full text in Research Archive
Show summary
Background
Prolonged labor might contribute to a negative birth experience and influence first-time mothers’ attitudes towards future pregnancies. Previous studies have not adjusted for possible confounding factors, such as operative delivery, induction and postpartum hemorrhage. We aimed to determine the impact of prolonged labor on birth experience and a wish for cesarean section in subsequent pregnancies.
Methods
A survey including the validated “Childbirth Experience Questionnaire”. First-time mothers giving birth between 2012 and 2014 at a Norwegian university hospital participated. Data from deliveries were collected. Regression analysis and thematic content analysis were performed.
Results
459 (71%) women responded. Women with labor duration > 12 h had significantly lower scores on two out of four sub-items of the questionnaire: own capacity (p = 0.040) and perceived safety (p = 0.023).
Other factors contributing to a negative experience were:
Cesarean section vs vaginal birth: own capacity (p = 0.001) and perceived safety (p = 0.007). Operative vaginal vs spontaneous birth: own capacity (p = 0.001), perceived safety (p < 0.001) and participation (p = 0.047).
Induced vs spontaneous start: own capacity (p = 0.039) and participation (p = 0.050). Postpartum hemorrhage ≥500 ml vs < 500 ml: perceived safety (p = 0.002) and participation (p = 0.031).
In the unadjusted analysis, prolonged labor more than doubled the risk (odds ratio (OR) 2.66, 95%CI 1.42–4.99) of a subsequent wish for cesarean delivery. However, when adjustments were made for mode of delivery and induction, emergency cesarean section (OR 8.86,95%CI 3.85–20.41) and operative vaginal delivery (OR 3.05, 95%CI 1.46–6.38) remained the only factors significantly increasing the probability of wanting a cesarean section in subsequent pregnancies.
The written comments on prolonged labor (n = 46) indicated four main themes:
Difficulties gaining access to the labor ward.
Being left alone during the unexpectedly long, painful early stage of labor.
Stressful operative deliveries and worse pain than imagined.
Lack of support and too little or contradictory information from the staff.
Conclusions
Women with prolonged labors are at risk of a negative birth experience. Prolonged labor per se did not predict a wish for a cesarean section in a subsequent pregnancy. However, women with long labors more often experience operative delivery, which is a risk factor of a later wish for a cesarean section.
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Johansen, Nora; Tonstad, Serena; Liavaag, Astrid Helene; Selmer, Randi Marie; Tanbo, Tom Gunnar & Michelsen, Trond Melbye
(2020).
Risk of cardiovascular disease after preventive salpingo-oophorectomy.
International Journal of Gynecological Cancer.
ISSN 1048-891X.
30(5),
p. 575–582.
doi:
10.1136/ijgc-2019-000856.
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Michelsen, Trond Melbye; Holme, Ane Moe; Holm, Maia Blomhoff; Roland, Marie Cecilie; Haugen, Guttorm & Powell, Theresa L.
[Show all 8 contributors for this article]
(2019).
Uteroplacental glucose uptake and fetal glucose consumption: A quantitative study in human pregnancies.
Journal of Clinical Endocrinology and Metabolism (JCEM).
ISSN 0021-972X.
104(3),
p. 873–882.
doi:
10.1210/jc.2018-01154.
Show summary
Context
Maternal glucose levels and body mass index (BMI) are determinants of fetal overgrowth, but their relation to fetal glucose consumption is not well characterized in human pregnancy.
Objectives
To quantify uteroplacental glucose uptake and the allocation of glucose between the placenta and fetus and to identify factors that affect fetal glucose consumption.
Design
Human in vivo study in term pregnancies.
Setting
Oslo University Hospital, Norway.
Participants
One hundred seventy-nine healthy women with elective cesarean section.
Interventions
Uterine and umbilical blood flow was determined using Doppler ultrasonography. Glucose and insulin were measured in the maternal radial artery and uterine vein and the umbilical artery and vein. In a subcohort (n = 33), GLUT1 expression was determined in isolated syncytiotrophoblast basal and microvillous plasma membranes.
Main Outcome Measures
Uteroplacental glucose uptake and placental and fetal glucose consumption quantified by the Fick principle.
Results
Median (Q1, Q3) uteroplacental glucose uptake was 117.1 (59.1, 224.9) μmol⋅min−1, and fetal and placental glucose consumptions were 28.9 (15.4, 41.8) µmol⋅min−1⋅kg fetus−1 and 51.4 (−65.8, 185.4) µmol⋅min−1⋅kg placenta−1, respectively. Fetal glucose consumption correlated with birth weight (ρ: 0.34; P < 0.001) and maternal–fetal glucose gradient (ρ: 0.60; P < 0.001), but not with maternal BMI or uteroplacental glucose uptake. Uteroplacental glucose uptake was correlated to placental glucose consumption (ρ: 0.77; P < 0.001). Fetal and placental glucose consumptions were inversely correlated (ρ: −0.47; P < 0.001), but neither was correlated with placental GLUT1 expression.
Conclusion
These findings suggest that fetal glucose consumption is balanced against the placental needs for glucose and that placental glucose consumption is a key modulator of maternal–fetal glucose transfer in women.
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Michelsen, Trond Melbye; Henriksen, Tore; Reinhold, Dominik; Powell, Theresa L & Jansson, Thomas
(2019).
The human placental proteome secreted into the maternal and fetal circulations in normal pregnancy based on 4-vessel sampling.
The FASEB Journal.
ISSN 0892-6638.
33(2),
p. 2944–2956.
doi:
10.1096/fj.201801193R.
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Johansen, Nora; Liavaag, Astrid Helene; Mørkrid, Lars & Michelsen, Trond Melbye
(2018).
Hormone Levels and Sexual Functioning After Risk-Reducing Salpingo-Oophorectomy.
Sexual Medicine - Open Access.
ISSN 2050-1161.
6(2),
p. 143–153.
doi:
10.1016/j.esxm.2018.02.002.
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Majak, Guri Bårdstu; Reisæter, Anna Varberg; Weedon-Fekjær, Harald; Henriksen, Tore & Michelsen, Trond Melbye
(2018).
The effect of pregnancy on the long-term risk of graft loss, cardiovascular disease, and death in kidney transplanted women in Norway: A retrospective cohort study.
Transplantation.
ISSN 0041-1337.
102(9),
p. e391–e396.
doi:
10.1097/TP.0000000000002167.
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Waage, Christin; Mdala, Ibrahimu; Jenum, Anne Karen; Michelsen, Trond Melbye; Birkeland, Kåre I. & Sletner, Line
(2016).
Ethnic differences in blood pressure from early pregnancy to postpartum: A Norwegian cohort study.
Journal of Hypertension.
ISSN 0263-6352.
34(6),
p. 1151–1159.
doi:
10.1097/HJH.0000000000000918.
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Johansen, Nora; Liavaag, Astrid Helene; Tanbo, Tom Gunnar; Dahl, Alv A; Pripp, Are Hugo & Michelsen, Trond Melbye
(2016).
Sexual activity and functioning after risk-reducing salpingo-oophorectomy: Impact of hormone replacement therapy.
Gynecologic Oncology.
ISSN 0090-8258.
140(1),
p. 101–106.
doi:
10.1016/j.ygyno.2015.11.016.
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Michelsen, Trond Melbye; Dørum, Anne; Småstuen, Milada C; Liavaag, Astrid Helene & Dahl, Alv A
(2013).
Association between Hysterectomy with Ovarian Preservation and Cardiovascular Disease in a Norwegian Population-Based Sample.
Gynecologic and Obstetric Investigation.
ISSN 0378-7346.
75(1),
p. 61–67.
doi:
10.1159/000345072.
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Michelsen, Trond Melbye & Iversen, Ole-Erik
(2011).
Masseundersøkelser mot gynekologisk kreft - status og fremtid.
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
131(16),
p. 1550–1553.
doi:
10.4045/tidsskr.11.0026.
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Gultekin, Murat; Dursun, Polat; Vranes, Boris; Laky, Rene; Bossart, Michaela & Grabowski, Jacep P.
[Show all 40 contributors for this article]
(2011).
Gynecologic Oncology Training Systems in Europe A Report From the European Network of Young Gynaecological Oncologists.
International Journal of Gynecological Cancer.
ISSN 1048-891X.
21(8),
p. 1500–1506.
doi:
10.1097/IGC.0b013e3182202d17.
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Erichsen, Eva Martina Moter; Husebye, Eystein Sverre; Michelsen, Trond Melbye; Dahl, Alv A & Løvås, Kristian
(2010).
Sexuality and Fertility in Women with Addison's Disease.
Journal of Clinical Endocrinology and Metabolism (JCEM).
ISSN 0021-972X.
95(9),
p. 4354–4360.
doi:
10.1210/jc.2010-0445.
Show summary
Martina M Erichsen har oppgitt Department of Medicine , Haukeland University Hospital, og Institute of Medicine, University of Bergen, N-5007 Bergen, Norway; i artikkelen/aa
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Michelsen, Trond Melbye; Tonstad, Serena; Pripp, Are Hugo; Tropé, Claes Gøran & Dørum, Anne
(2010).
Coronary Heart Disease Risk Profile in Women Who Underwent Salpingo-Oophorectomy to Prevent Hereditary Breast Ovarian Cancer.
International Journal of Gynecological Cancer.
ISSN 1048-891X.
20(2),
p. 233–239.
doi:
10.1111/IGC.0b013e3181ca5ff4.
Show summary
(ikke adgang til e-versjonen)
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Michelsen, Trond Melbye; Dørum, Anne & Dahl, Alv A
(2009).
A controlled study of mental distress and somatic complaints after risk-reducing salpingo-oophorectomy in women at risk for hereditary breast ovarian cancer.
Gynecologic Oncology.
ISSN 0090-8258.
113(1),
p. 128–133.
doi:
10.1016/j.ygyno.2008.12.024.
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Michelsen, Trond Melbye; Dorum, Anne; Tropé, Claes Gøran; Fosså, Sophie Dorothea & Dahl, Alv A
(2009).
Fatigue and Quality of Life After Risk-Reducing Salpingo-Oophorectomy in Women at Increased Risk for Hereditary Breast-Ovarian Cancer.
International Journal of Gynecological Cancer.
ISSN 1048-891X.
19(6),
p. 1029–1036.
doi:
10.1111/IGC.0b013e3181a83cd5.
View all works in Cristin
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Andresen, Ina Jungersen; Degnes, Maren-Helene Langeland; Zucknick, Manuela; Powell, Theresa L; Jansson, Thomas & Henriksen, Tore
[Show all 8 contributors for this article]
(2022).
Protein biomarkers of late-onset preeclampsia.
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Degnes, Maren-Helene Langeland; Westerberg, AC; Andresen, Ina Jungersen; Zucknick, Manuela; Powell, Theresa L & Jansson, Thomas
[Show all 9 contributors for this article]
(2022).
Six placenta-derived proteins as markers of placental function.
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Westerberg, AC; Degnes, Maren-Helene Langeland; Andresen, Ina Jungersen; Zucknick, Manuela; Powell, Theresa L & Jansson, Thomas
[Show all 9 contributors for this article]
(2022).
Pleiotrophin and Fatty-acid Amide Hydrolase 2 – Placenta-derived Biomarkers of Preeclampsia?
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Sørbye, Ingvil; Gaudernack, Lise Christine; Einarsen, Angeline Elisabeth Styve; Rosseland, Leiv Arne; Lukasse, Mirjam & Gunnes, Nina
[Show all 7 contributors for this article]
(2022).
Study protocol for the BUSCopan in LABor (BUSCLAB) study: A randomized placebocontrolled trial investigating the effect of butylscopolamine bromide to prevent prolonged labor.
PLOS ONE.
ISSN 1932-6203.
17(11).
doi:
10.1371/journal.pone.0276613.
Full text in Research Archive
Show summary
Background
First-time mothers are prone to prolonged labor, defined as the crossing of partograph alert or action lines. Prolonged labor may occur among as many as one out of five women, and is associated with a range of adverse birth outcomes. Oxytocin is the standard treatment for prolonged labor, but has a narrow therapeutic window, several adverse effects and limited efficacy. Despite poor evidence, labor wards often use antispasmodic agents to treat prolonged labor. The antispasmodic drug butylscopolamine bromide (Buscopan®) may shorten duration of labor, but studies on prevention of prolonged labor are lacking. In this randomized double-blind placebo-controlled clinical trial, we aim to evaluate the effect of butylscopolamine bromide on duration of labor in first-time mothers showing first signs of slow labor progress by crossing the World Health Organization partograph alert line.
Methods and analysis
The study is a single center study at Oslo University Hospital, Oslo, Norway. We will recruit 250 primiparous women with spontaneous labor start at term. Women are included in the first stage of labor if they show signs of slow labor progress, defined as the crossing of the partograph alert line with a cervical dilation between 3–9 cm. Participants are randomized 1:1 to either 20 mg intravenous butylscopolamine bromide or intravenous placebo (1 mL sodium chlorine 9 mg/mL). We considered a mean difference of 60 minutes in labor duration clinically relevant. The primary outcome is duration of labor from the provision of the investigational medicinal product to vaginal delivery. The secondary outcomes include change in labor pain, use of oxytocin augmentation, delivery mode, and maternal birth experience. The primary data for the statistical analysis will be the full analysis set and will occur on completion of the study as per the prespecified statistical analysis plan. The primary outcome will be analyzed using Weibull regression, and we will treat cesarean delivery as a censoring event.
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Bekkenes, Maria Egeland; Stubhaug, Audun; Reme, Silje Endresen; Fagerland, Morten Wang; Michelsen, Trond Melbye & Rosseland, Leiv Arne
(2022).
Effects of 2.5 IU oxytocin or 100 μg carbetocin on pain intensity and opioid consumption
after planned cesarean delivery; a randomized controlled trial.
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Øyri, Linn Kristin Lie; Bogsrud, Martin Prøven; Christensen, Jacob J.; Ulven, Stine Marie; Brantsæter, Anne Lise & Retterstøl, Kjetil
[Show all 12 contributors for this article]
(2019).
Novel and comprehensive metabolite profiling in cord blood reveal sex differences: A sub-study from the Norwegian Mother, Father and Child Cohort study.
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Gaudernack, Lise Christine; Frøslie, Katrine Frey; Michelsen, Trond Melbye; Voldner, Nanna & Lukasse, Mirjam
(2019).
De-medicalization of birth by reducing the use of oxytocin for augmentation among first-time mothers - a prospective intervention study.
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Staff, Anne Cathrine; Henriksen, Tore; Langesæter, Eldrid; Magnussen, Elisabeth Balstad; Michelsen, Trond Melbye & Thomsen, Liv Cecilie Vestrheim
[Show all 7 contributors for this article]
(2014).
Hypertensive svangerskapskomplikasjoner og eklampsi.
In Øian, Pål; Jacobsen, Anne Flem & Kessler, Jørg (Ed.),
Veileder i fødselshjelp 2014.
Den norske legeforening.
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Roland, Marie Cecilie Paasche; Holme, Ane Moe; Lorentzen, Bjørg; Michelsen, Trond Melbye & Henriksen, Tore
(2013).
IN VIVO STUDIES OF GLUCOSE TRANSPORT OVER THE HUMAN PLACENTA.
Pediatric Research.
ISSN 0031-3998.
74(4),
p. 483–483.
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Michelsen, Trond Melbye; Dørum, Anne; Tropé, Claes Gøran; Liavaag, Astrid Helene; Fosså, Sophie Dorothea & Fiane, Bent
[Show all 7 contributors for this article]
(2007).
Factors associated with fatigue in women who had prophylactic bilateral salpingo-oophorectomy for hereditary breast ovarian cancer.
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Michelsen, Trond Melbye; Dørum, Anne & Tropé, Claes Gøran
(2010).
Long term somatic and psychosocial morbidity after risk-reducing salpingo-oophorectomy in women at risk for hereditary breast ovarian cancer.
Unipub forlag.
ISSN 978-82-8072-379-6.
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Liavaag, Astrid Helene; Dørum, Anne; Dahl, Alv A; Tropé, Claes Gøran; Fosså, Sophie Dorothea & Michelsen, Trond Melbye
(2009).
Epithelial ovarian cancer survivors. Somatic and mental health sexualtiy and quality of life studies.
Unipub forlag.
ISSN 978-82-8072-334-5.
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Published
Feb. 7, 2020 12:36 PM
- Last modified
July 13, 2023 12:33 PM