Ulla Randen

• Helland, Åslaug; Steinskog, Eli Sihn Samdal; Blix, Egil St⊘re; Flobak, Åsmund; Brabrand, Sigmund & Puco, Katarina [Show all 20 contributors for this article] (2024). Hever kvaliteten på behandling av kreft. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 144(1), p. 1–5. doi: 10.4045/tidsskr.23.0740.
• Berentsen, Sigbjørn; D'Sa, Shirley; Randen, Ulla; Malecka, Agnieszka Maria & Vos, Josephine M.I. (2022). Cold Agglutinin Disease: Improved Understanding of Pathogenesis Helps Define Targets for Therapy. Hemato. ISSN 2673-6357. 3(4), p. 574–594. doi: 10.3390/hemato3040040. Full text in Research Archive
• Berentsen, Sigbjørn; Malecka, Agnieszka Maria; Randen, Ulla & Tjønnfjord, Geir Erland (2020). Cold agglutinin disease: where do we stand, and where are we going? Clinical Advances in Hematology & Oncology (CAH&O). ISSN 1543-0790. 18(1), p. 35–44.
• Berentsen, Sigbjørn; Barcellini, Wilma; D'Sa, Shirley; Randen, Ulla; Tvedt, Tor Henrik Anderson & Fattizzo, Bruno [Show all 23 contributors for this article] (2020). Cold agglutinin disease revisited: a multinational, observational study of 232 patients. Blood. ISSN 0006-4971. 136(4), p. 480–488. doi: 10.1182/blood.2020005674.
• Berentsen, Sigbjørn; Roth, Alexandra; Randen, Ulla; Jilma, Bernd & Tjønnfjord, Geir Erland (2019). Cold agglutinin disease: Current challenges and future prospects. Journal of Blood Medicine. ISSN 1179-2736. 10, p. 93–103. doi: 10.2147/JBM.S177621. Full text in Research Archive
• Lenartova, Andrea; Randen, Ulla; Johannessen, Tom Børge & Tjønnfjord, Geir Erland (2019). Richter syndrome epidemiology in a large population based chronic lymphocytic leukemia cohort from Norway. Cancer Epidemiology. ISSN 1877-7821. 60, p. 128–133. doi: 10.1016/j.canep.2019.04.002.
• Habberstad, Andreas Hanssønn; Tran, Hoa Thi Tuyet; Randen, Ulla; Spetalen, Signe; Dybedal, Ingunn & Tjønnfjord, Geir Erland [Show all 7 contributors for this article] (2018). Neutropenia caused by hairy cell leukemia in a patient with myelofibrosis secondary to polycythemia vera: A case report. Journal of Medical Case Reports. ISSN 1752-1947. 12(1). doi: 10.1186/s13256-018-1663-6. Full text in Research Archive
• Malecka, Agnieszka Maria; Trøen, Gunhild; Tierens, Anne; Østlie, Ingunn; Malecki, Jedrzej Mieczyslaw & Randen, Ulla [Show all 10 contributors for this article] (2017). Frequent somatic mutations of KMT2D (MLL2) and CARD11 genes in primary cold agglutinin disease. British Journal of Haematology. ISSN 0007-1048. 183(5), p. 838–842. doi: 10.1111/bjh.15063.
• Berentsen, Sigbjørn; Randen, Ulla; Oksman, Markku; Birgens, Henrik; Tvedt, Tor Henrik Anderson & Dalgaard, Jakob [Show all 13 contributors for this article] (2017). Bendamustine plus rituximab for chronic cold agglutinin disease: Results of a Nordic prospective multicenter trial. Blood. ISSN 0006-4971. 130(4), p. 537–541. doi: 10.1182/blood-2017-04-778175.
• Berentsen, Sigbjørn; Randen, Ulla & Tjønnfjord, Geir Erland (2015). Cold Agglutinin-Mediated Autoimmune Hemolytic Anemia. Hematology/Oncology Clinics of North America. ISSN 0889-8588. 29(3), p. 455–471. doi: 10.1016/j.hoc.2015.01.002.
• Randen, Ulla; Trøen, Gunhild; Tierens, Anne; Steen, Chloe Beate; Warsam, Abdirashid Ali & Beiske, Klaus [Show all 9 contributors for this article] (2014). Primary cold agglutinin associated lymphoproliferative disease: a B-cell lymphoma of the bone marrow distinct from lymphoplasmacytic lymphoma. Haematologica. ISSN 0390-6078. 99(3), p. 497–504. doi: 10.3324/haematol.2013.091702.
• Randen, Ulla; Tierens, Anne; Tjønnfjord, Geir Erland & Delabie, Jan (2013). Bone Marrow Histology in Monoclonal B-Cell Lymphocytosis Shows Various B-Cell Infiltration Patterns. American Journal of Clinical Pathology. ISSN 0002-9173. 139(3), p. 390–395. doi: 10.1309/AJCPPHSUQM8XBJH7.
• Warsame, Abdirashid Ali; Åsheim, Hans-Christian; Nustad, Kjell Johannes; Trøen, Gunhild; Tierens, Anne & Wang, Chia-Wei Vivian [Show all 11 contributors for this article] (2011). Splenic marginal zone lymphoma with VH1-02 gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity. Blood. ISSN 0006-4971. 118(12), p. 3331–3339. doi: 10.1182/blood-2011-03-341651.
• Berentsen, Sigbjørn; Randen, Ulla; Vågan, Anna Marita; Hjort-Hansen, Henrik; Vik, Anders & Dalgaard, Jakob [Show all 10 contributors for this article] (2010). High response rate and durable remissions following fludarabine and rituximab combination therapy for chronic cold agglutinin disease. Blood. ISSN 0006-4971. 116(17), p. 3180–3184. doi: 10.1182/blood-2010-06-288647. Show summary

  Most patients diagnosed with primary chronic cold agglutinin disease (CAD) have a clonal lymphoproliferative bone marrow disorder. Treatment with rituximab is the only well-documented effective therapy, leading to 45%-60% partial responses (PR). Complete responses (CR) are rare, and median response duration is only 11 months. In a prospective multicenter trial, 29 patients received rituximab 375 mg/m(2) on days 1, 29, 57 and 85; and fludarabine orally, 40 mg/m(2) on days 1-5, 29-34, 57-61 and 85-89. Twenty-two patients (76%) responded, 6 (21%) achieving CR and 16 (55%) PR. Among 10 patients nonresponsive to rituximab monotherapy, 1 achieved CR and 6 PR. Median increase in hemoglobin level was 3.1 g/dL among the responders and 4.0 g/dL in those who achieved CR. Lower quartile of response duration was not reached after 33 months. Estimated median response duration was more than 66 months. Grade 3-4 hematologic toxicity occurred in 12 patients (41%). In conclusion, fludarabine and rituximab combination therapy is very efficient in patients with CAD. Toxicity may be a concern, and benefits should be carefully weighed against risks in very old and comorbid patients. It remains to be established whether the combination should be first-line or an efficient second-line therapy in CAD patients requiring treatment.

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• Alaggio, Rita; Amador, Catalina; Anagnostopoulos, Ioannis; Attygalle, Ayoma D.; de Oliveira Araujo, Iguaracyra Barreto & Berti, Emilio [Show all 310 contributors for this article] (2023). Correction: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia. 2022 Jul;36(7):1720–1748 (Leukemia, (2022), 36, 7, (1720-1748), 10.1038/s41375-022-01620-2). Leukemia. ISSN 0887-6924. 37, p. 1944–1951. doi: 10.1038/s41375-023-01962-5.
• Tasken, Kjetil; Russnes, Hege Elisabeth Giercksky; Aas, Eline; Bjørge, Line; Blix, Egil Støre & Ahlquist, Terje C. [Show all 116 contributors for this article] (2022). A national precision cancer medicine implementation initiative for Norway. Nature Medicine. ISSN 1078-8956. 28(5), p. 885–887. doi: 10.1038/s41591-022-01777-4.
• Malecka, Agnieszka Maria; Trøen, Gunhild; Delabie, Jan; Malecki, Jedrzej Mieczyslaw; Østlie, Ingunn & Tierens, Anne [Show all 9 contributors for this article] (2021). The mutational landscape of cold agglutinin disease: CARD11 and CXCR4 mutations are correlated with lower hemoglobin levels. American Journal of Hematology. ISSN 0361-8609. doi: 10.1002/ajh.26205.
• Malecka, Agnieszka Maria; Delabie, Jan; Østlie, Ingunn; Tierens, Anne; Randen, Ulla & Berentsen, Sigbjørn [Show all 8 contributors for this article] (2020). Cold agglutinin-associated B-cell lymphoproliferative disease shows highly recurrent gains of chromosome 3 and 12 or 18. Blood Advances. ISSN 2473-9529. 4(6), p. 993–996. doi: 10.1182/bloodadvances.2020001608.
• Malecka, Agnieszka Maria; Trøen, Gunhild; Tierens, Anne; Østlie, Ingunn; Malecki, Jedrzej Mieczyslaw & Randen, Ulla [Show all 9 contributors for this article] (2016). Immunoglobulin heavy and light chain gene features are correlated with primary cold agglutinin disease onset and activity. Haematologica. ISSN 0390-6078. 101(9), p. e361–e364. doi: 10.3324/haematol.2016.146126.

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