Una Ryg

• Reijnen, Jeroen Sebastiaan; Ryg, Una; Marthinsen, Jon Bache; Schönhardt, Irina; Seierstad, Therese & Hole, Knut Håkon (2023). Monoparametric high-resolution diffusion weighted MRI as a possible first step in an MRI-directed diagnostic pathway for men with suspicion of prostate cancer. Frontiers in Oncology. ISSN 2234-943X. 13, p. 1–11. doi: 10.3389/fonc.2023.1102860. Full text in Research Archive
• Ryg, Una; Seierstad, Therese; Nilsen, Line; Hellebust, Taran Annette Paulsen; Djupvik, Linda Holth & Gustafson, Hilde [Show all 10 contributors for this article] (2022). A prospective study of high dose-rate brachytherapy or stereotactic body radiotherapy of Intra-prostatic recurrence: Toxicity and long term clinical outcome. Frontiers in Oncology. ISSN 2234-943X. 12:861127, p. 1–10. doi: 10.3389/fonc.2022.861127. Full text in Research Archive
• Wang, Yun Yong; Ryg, Una; Dahle, Maria Krudtaa; Steffensen, Knut Rune; Thiemermann, Christoph & Chaudry, Irshad H. [Show all 12 contributors for this article] (2011). Liver X Receptor Protects against Liver Injury in Sepsis Caused by Rodent Cecal Ligation and Puncture. Surgical Infections. ISSN 1096-2964. 12(4), p. 283–289. doi: 10.1089/sur.2010.066.
• Risøe, Petter Kirkeby; Ryg, Una; Wang, Yun Yong; Rutkovskiy, Arkady; Smedsrød, Bård & Valen, Guro [Show all 7 contributors for this article] (2011). CECAL LIGATION AND PUNCTURE SEPSIS IS ASSOCIATED WITH ATTENUATED EXPRESSION OF ADENYLYL CYCLASE 9 AND INCREASED MIR142-3P. Shock. ISSN 1073-2322. 36(4), p. 390–395. doi: 10.1097/SHK.0b013e318228ec6f. Show summary

  The host inflammatory response in sepsis may be resolved by endogenous anti-inflammatory immune cell responses, avoiding fatal pathogenesis, organ injury, and death. The intracellular signaling mediator cyclic 3'5'-adenosine monophosphate is a potent modulator of inflammatory responses and initiates the polarization of immune cells in a direction that suppresses inflammatory activation. Cyclic 3'5'-adenosine monophosphate is enzymatically produced by adenylyl cyclases (ACs). The expression of ACs is previously shown to be reduced in rat organs after in vivo endotoxemia, concurrent with the progressing systemic inflammation. In the present study, tissue AC gene expression and regulation are explored in a rat model of cecal ligation and puncture (CLP) sepsis. Eighteen hours after CLP operation, expression of several AC isoforms in the liver, spleen, and kidney was reduced, significantly so for AC9 in all tissues. AC9 expression is regulated by the microRNA miR142-3p in T cells. When microRNA was extracted and amplified for miR142-3p expression, it was increasingly expressed 18 h after CLP. A correlation between increased miR142-3p and decreased AC9 expression was found in the liver, kidney, and spleen, and when hepatocytes, Kupffer cells (KCs), and liver sinusoidal endothelial cells were isolated after CLP, reduced AC expression and increased miR142-3p expression were found in KCs and liver sinusoidal endothelial cells. Transfecting a miR142-3p inhibitor probe in rat KCs abolished LPS-mediated AC9 inhibition in vitro. These results indicate that CLP leads to miR142-3pYmediated AC9 reduction in liver macrophages, which may further limit cyclic 3'5'-adenosine monophosphate signaling and the ability of macrophages to resolve the proinflammatory response

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• Ryg, Una; Lilleby, Wolfgang; Hole, Knut Håkon; Lund-Iversen, Marius & Switlyk, Marta Daniela (2020). Local Recurrence of Prostate Cancer to the Intersphincteric Space: A Case Report. Urology. ISSN 0090-4295. 140, p. 18–21. doi: 10.1016/j.urology.2020.03.009.
• Risøe, Petter Kirkeby; Ågren, Joanna; Ryg, Una; Valen, Guro & Dahle, Maria Krudtaa (2010). Gender-differences in lipopolysaccharide-mediated regulation of adenylyl cyclase expression in human monocytes.
• Risøe, Petter Kirkeby; Ryg, Una; Aasen, Ansgar Oddne; Wang, Jacob Edward & Dahle, Maria Krudtaa (2008). Lipopolysaccharide regulates adenylyl cyclase expression in human monocytes.
• Ryg, Una; Risøe, Petter Kirkeby; Wang, Yun Yong; Smedsrød, Bård; Christoffersen, Thoralf & Aasen, Ansgar Oddne [Show all 8 contributors for this article] (2008). Cecal ligation and puncture sepsis is associated with a shift in adenylyl cyclase expression in sinusoidal liver cells.
• Risøe, Petter Kirkeby; Ryg, Una & Dahle, Maria Krudtaa (2008). Lipopolysaccharide regulates adenylyl cyclase in human monocytes.
• Ryg, Una; Risøe, Petter Kirkeby; Wang, YY & Dahle, Maria Krudtaa (2007). Expression of adenylyl cyclase mRNA in CLP sepsis.
• Ryg, Una; Dahle, Maria Krudtaa & Wang, Jacob Edward (2009). The role of Liver X Receptors and Adenylyl Cyclases in experimental sepsis. Universitetet i Oslo.

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