Program
13:00 – 13:50 T cell function and specificity in human disease. Dr. Arnold Han. Columbia University, New York, US.
13:50 – 14:10 A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions. Dr. Lene S. Høydahl. KG Jebsen Coeliac Disease Research Centre, University of Oslo.
14:10 – 14:25 Coffee break
14:25 – 15:15 Innate-like recognition in the adaptive immune system. Dr. David Price. Cardiff University, UK.
15:15 – 15:35 Discriminative T-cell recognition of gluten epitopes despite similar peptide:MHC topologies. Dr. Shiva Dahal-Koirala, KG Jebsen Coeliac Disease Research Centre, University of Oslo.
More about the lecturers
Read more about Dr. Han's research at his website.
Abstract David Price:
Adaptive immunity is based on clonal selection from a vast repertoire of somatically rearranged antigen receptors, yet biased usage of germline-encoded segments is commonly observed among epitope-specific memory T-cell populations. In this talk, I will demonstrate that T-cell receptor (TCR) bias can arise as a consequence of innate-like recognition within the αβ TCR repertoire, dictating immune response profiles in mice and potentially impacting the outcome of a widespread viral infection in humans.