Simen Hyll Hansen

• Gelpi, M; Vestad, Beate; Raju, Sajan; Hansen, Simen Hyll; Høgh, J & Midttun, Øivind [Show all 13 contributors for this article] (2022). Association of the Kynurenine Pathway of Tryptophan Metabolism with Human Immunodeficiency Virus-Related Gut Microbiota Alterations and Visceral Adipose Tissue Accumulation. Journal of Infectious Diseases. ISSN 0022-1899. 225(11), p. 1948–1954. doi: 10.1093/infdis/jiac018.
• Larsen, Christopher Storm; Hande, Liv Nesse; Kummen, Martin; Thunhaug, Hilde; Vestad, Beate & Hansen, Simen Hyll [Show all 10 contributors for this article] (2022). Reduced gut microbial diversity in familial hypercholesterolemia with no effect of omega-3 polyunsaturated fatty acids intervention–a pilot trial. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 82(5), p. 363–370. doi: 10.1080/00365513.2022.2102540. Full text in Research Archive
• Valestrand, Laura Cecilie; Zheng, Fei; Hansen, Simen Hyll; Øgaard, Jonas; Hov, Johannes Espolin Roksund & Björkström, Niklas K. [Show all 9 contributors for this article] (2022). Bile from Patients with Primary Sclerosing Cholangitis Contains Mucosal-Associated Invariant T-Cell Antigens. American Journal of Pathology. ISSN 0002-9440. 192(4), p. 629–641. doi: 10.1016/j.ajpath.2021.12.008. Full text in Research Archive Show summary

  Primary sclerosing cholangitis (PSC) is associated with altered microbiota of the gut and bile. Mucosal-associated invariant T (MAIT) cells, enriched in human liver, uniquely recognize microbial-derived metabolites. This study aimed to determine whether bile from patients with PSC contains antigens activating MAIT cells. Bile was collected at the time of liver transplantation from patients with PSC (n = 28). The bile samples were either directly incubated with peripheral blood mononuclear cells from healthy donors or with antigen-presenting cells followed by co-culture with peripheral blood mononuclear cells. MAIT cell activation was assessed by flow cytometry. An anti-MR1 antibody was used to determine whether the activation was major histocompatibility complex class I–related protein (MR1) restricted. Biliary microbiota profiles were generated using 16S rRNA amplicon sequencing, and the abundance of the bacterial gene ribD was predicted. Eight of 28 bile samples could activate MAIT cells. This activation was partly MR1-dependent in five of eight bile samples. Microbial DNA was detected in 15 of 28 bile samples, including the five bile samples leading to MR1-dependent activation. A higher abundance of the ribD gene expression in the group of bile samples that could activate MAIT cells was predicted on the basis of the 16S sequencing. In co-culture experiments, cholangiocytes could take up and present biliary antigens to MAIT cells. These findings suggest a pathophysiological pathway in PSC connecting the immune system and the microbiome.

• Meyer-Myklestad, Malin Holm; Medhus, Asle Wilhelm; Stiksrud, Birgitte; Lorvik, Kristina Berg; Seljeflot, Ingebjørg & Hansen, Simen Hyll [Show all 13 contributors for this article] (2022). Probiotics to HIV-infected immunological nonresponders: Altered mucosal immunity and microbial diversity restricted to ileum. Journal of Acquired Immune Deficiency Syndromes. ISSN 1525-4135. 89(1), p. 77–86. doi: 10.1097/QAI.0000000000002817.
• Awoyemi, Ayodeji Olawale; Mayerhofer, Christiane Caroline; Felix, Alex S.; Hov, Johannes Espolin Roksund; Moscavitch, Samuel D. & Lappegård, Knut Tore [Show all 23 contributors for this article] (2021). Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial. EBioMedicine. ISSN 2352-3964. 70. doi: 10.1016/j.ebiom.2021.103511. Full text in Research Archive
• Skaarud, Kristin Aneta Joan; Hov, Johannes Espolin Roksund; Hansen, Simen Hyll; Kummen, Martin; Valeur, Jørgen & Seljeflot, Ingebjørg [Show all 12 contributors for this article] (2021). Mortality and microbial diversity after allogenic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial. Scientific Reports. ISSN 2045-2322. doi: 10.1038/s41598-021-90976-z. Full text in Research Archive
• Meyer-Myklestad, Malin Holm; Medhus, Asle Wilhelm; Lorvik, Kristina Berg; Seljeflot, Ingebjørg; Hansen, Simen Hyll & Holm, Kristian [Show all 13 contributors for this article] (2020). HIV-infected immunological non-responders have colon-restricted gut mucosal immune dysfunction. Journal of Infectious Diseases. ISSN 0022-1899. doi: 10.1093/infdis/jiaa714. Full text in Research Archive
• Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll & Moitinho-Silva, Lucas [Show all 22 contributors for this article] (2020). Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis. Gastroenterology. ISSN 0016-5085. doi: 10.1053/j.gastro.2020.12.058. Full text in Research Archive
• Valestrand, Laura Cecilie; Berntsen, Natalie Lie; Fei, Zheng; Schrumpf, Erik; Hansen, Simen Hyll & Karlsen, Tom Hemming [Show all 10 contributors for this article] (2020). Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells. Clinical and Experimental Immunology. ISSN 0009-9104. doi: 10.1111/cei.13541. Full text in Research Archive
• Sokolova, Marina; Yang, Kuan; Hansen, Simen Hyll; Louwe, Maria Cornelia; Kummen, Martin & Hov, Johannes Espolin Roksund [Show all 12 contributors for this article] (2020). NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet. Scientific Reports. ISSN 2045-2322. 10:21006, p. 1–16. doi: 10.1038/s41598-020-76497-1. Full text in Research Archive
• Gelpi, Marco; Vestad, Beate; Hansen, Simen Hyll; Holm, Kristian; Drivsholm, Ninna & Götz, Alexandra [Show all 17 contributors for this article] (2020). Impact of human immunodeficiency virus-related gut microbiota alterations on metabolic comorbid conditions. Clinical Infectious Diseases. ISSN 1058-4838. 71(8), p. e359–e367. doi: 10.1093/cid/ciz1235. Full text in Research Archive

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• Hansen, Simen Hyll; Gjerstad Maseng, M; Bjørkqvist, O; Halfvarsson, J; Bang, C & Detlie, Trond Espen [Show all 23 contributors for this article] (2023). Gut microbiota at diagnosis is associated with clinical features and future disease course in Inflammatory Bowel Disease: Data from IBSEN III, a new large Norwegian population-based inception cohort. Journal of Crohn's and Colitis. ISSN 1873-9946. 17, p. i1028–I2029. doi: 10.1093/ecco-jcc/jjac190.1050.
• Hansen, Simen Hyll; Kauserud, Håvard; Davey, Marie Louise; Thoen, Ella; Vik, Unni & Brysting, Anne Krag (2018). Climate and host identity structure fungal endophyte communities. Universitetet i Oslo.

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