Endocrine and metabolic diseases such as diabetes, thyroid diseases, adrenal diseases and osteoporosis are major causes of morbidity and mortality. The challenges are to identify persons at risk, implement therapeutic and preventive measures and monitor effects of these actions. Adequate diagnostics and follow-up of treatment depend heavily on biomarkers in blood, urine, tears and saliva.
We use transcriptomic, proteomic and metabolomic approaches in close collaboration with the Dept of Endocrinology, Oslo University Hospital(OUS).
Projects
Finding new biomarkers
Diabetes
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Proteomic / metabolomic profiling of human insulin producing cells aiming at discovering biomarkers for cell mas / function
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Posttranslational modification of albumin in diabetes and late complications of diabetes
Thyroid disease
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Prospective evaluation of biomarkers of tear fluid in Graves ophtalmopathy
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Metabolomic profiling of tear fluid in Graves ophtalmopathy
Basal studies
- Functional studies of genetic modifications in thyroid hormone resistance
- Proteomic / metabolomic profiling of human fat tissue
- Gene expression of vitamin D stimulated insulin producing cells
- Metabolomic profiling of hyperglycemic clamp in humans
- Proteomic profiling of CSF in narcolepsy
Other Projects
- Influence of estrogen supplementations on cortisol measurements in humans
- Steroid profiling in congenital adrenal hyperplasia