The group mainly focus on:
- Hypoxia
Experimental and clinical research focused on effects of alveolar hypoxia on the organism, and mechanisms involved in hypoxia-related conditions. Cell-, animal-, and clinical studies. Evaluation and treatment of patients suffering from hypoventilation. - Training and respiratory physiology
Training of patients suffering from various diseases, with special emphasis on patients surgically treated for lung cancer, and effect of various diseases and treatment strategies on cardio-respiratory Fitness. - Allergy
Clinical and biochemical effects of specific immunotherapy. - Ultrasound
Can ultrasound be used to monitor the respiration through continuously monitoring the movements of the diaphragm?
Cooperation
- The Institute for Experimental Medical Research (IEMR), OUH/UiO
- Research Institute for Internal Medicine, OUH/UiO
- Department of Cardiothoracic Surgery, OUH
- Division of Pulmonary Diseases, Geneva, Switzerland
- Department of Informatics, UiO
- Norwegian School of Sport Sciences
Projects
- The role of inflammasomes and related cytokines in the development of pulmonary hypertension cardiac dysfunction
- Long-term effects of intensive training after lung cancer operation
- Penicillin allergy de-labeling of patients with false diagnosis of penicillin allergy. A tool for choosing the correct antimicrobial treatment and reducing antimicrobial resistance
- Monitoring non-invasive ventilation; what should be the basic tools?
- Information to children with one parent with cystic fibrosis
- A double-blind, randomised, placebo-controlled cross over study of inhaled alginate oligosaccharide (OligoG) administered for 28 days in subjects with Cystic Fibrosis
- Responsible Explainable Machine Learning for Sleep-related Respiratory Disorders (RESPIRE)
Selected publications
- Dyspnoea, lung function and CT findings 3 months after hospital admission for COVID-19.
Lerum TV, Aaløkken TM, Brønstad E, Aarli B, Ikdahl E, Lund KMA, Durheim MT, Rodriguez JR, Meltzer C, Tonby K, Stavem K, Skjønsberg OH, Ashraf H, Einvik G.Eur Respir J. 2021 Apr 29;57(4):2003448. doi: 10.1183/13993003.03448-2020. Print 2021 Apr.PMID: 33303540 - Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension.
Udjus C, Cero FT, Halvorsen B, Behmen D, Carlson CR, Bendiksen BA, Espe EKS, Sjaastad I, Løberg EM, Yndestad A, Aukrust P, Christensen G, Skjønsberg OH, Larsen KO.Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L999-L1012. doi: 10.1152/ajplung.00322.2018. Epub 2019 Mar 25.PMID: 30908936 - Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9.
Lerum TV, Maltzahn NN, Aukrust P, Trøseid M, Henriksen KN, Kåsine T, Dyrhol-Riise AM, Stiksrud B, Haugli M, Blomberg B, Kittang BR, Johannessen A, Hannula R, Aballi S, Kildal AB, Eiken R, Dahl TB, Lund-Johansen F, Müller F, Rodriguez JR, Meltzer C, Einvik G, Ueland T, Olsen IC; NOR-SOLIDARITY Consortium; Barratt-Due A, Aaløkken TM, Skjønsberg OH. Sci Rep. 2021 Dec 1;11(1):23205. doi: 10.1038/s41598-021-02547-x.PMID: 34853380 - Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice.
Cero FT, Hillestad V, Sjaastad I, Yndestad A, Aukrust P, Ranheim T, Lunde IG, Olsen MB, Lien E, Zhang L, Haugstad SB, Løberg EM, Christensen G, Larsen KO, Skjønsberg OH.Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15;309(4):L378-87. doi: 10.1152/ajplung.00342.2014. Epub 2015 Jun 12.PMID: 26071556 - High-intensity training following lung cancer surgery: a randomised controlled trial. Edvardsen E, Skjønsberg OH, Holme I, Nordsletten L, Borchsenius F, Anderssen SA.Thorax. 2015 Mar;70(3):244-50. doi: 10.1136/thoraxjnl-2014-205944. Epub 2014 Oct 16.PMID: 25323620