Current Projects
- Importance of genome stability in maintaining in healthy aging
- Genome instability as a driver of tumorigenesis and as a determinant of cancer therapy response
- DNA repair dependent chromatin dynamics as a basis of gene regulation
- Crosstalk between RNA- and DNA-quality control mechanisms
Techniques
We use biochemistry, molecular biology, cell biology, classical and reverse genetic techniques, imaging, FACS and bioinformatics in our research. We use three model systems for these experiments:
- Caenorhabditis elegans
- Transgenic mice
- Mammalian cells/iPSCs and tissue