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Innate immunity and cancer

Our group studies innate lymphocytes, with a particular focus on basic biology of NK cells, how they are influenced in a tumor microenvironment, and how they can be utilized in therapy in context of allo-transplantation and hematological malignancies.

About the group

Our main research aim is to understand how NK cells interact with and kill cancer cells. We have a particular focus on how NK cells utilizes extracellular vesicles for this purpose, and cover discoveries of new mechanistic biological insights with pre-clinical tests to develop new therapies. 

Projects

  • Developing NK-cell derived extracellular vesicles for cancer therapy
  • Developmental and functional characterization of NK cell subsets and ILCs in different tissues in the rat, and their regulation of inflammation.
  • Understanding the complex crosstalk between microbiota and prebiotics, their metabolites, and the effects on the gut immune system.
  • Exploiting plasma-derived extracellular vesicles as biomarkers for disease.

Cooperation

  • Senior Researcher Rachel Crossland, Newcastle University, UK
  • Professor Martha Enger, University of Bergen
  • Professor Erik Dissen, IMB, University of Oslo
  • Førsteamanuensis Kari Tvete Inngjerdingen, University of Oslo
  • Professor Helle Wangensten, University of Oslo
  • Fridtjof Lund-Johansen, Dept of Immunology, Oslo University Hospital
  • Senior Researcher Jørgen Wesche, Oslo University Hospital
Published Dec. 14, 2018 12:12 PM - Last modified June 19, 2023 12:51 PM

Contact

Group leader

Participants

  • Marit Inngjerdingen University of Oslo
  • Amanda Robin Sudworth University of Oslo
  • Emilie Steinbakk Ulriksen University of Oslo
  • Miriam Aarsund Larsen University of Oslo
  • Inez Nygaard University of Oslo
  • Yunjie Wu University of Oslo
  • Tirill Marie Trøften Hagen
Detailed list of participants