Our group brings together researchers studying a spectrum of chronic neurological disorders causing impaired motor function. Our areas of interest range across different movement disorders and neurodegenerative diseases.
We examine the clinical expression of the disorders, response to various treatments and perform studies investigating causes and risk factors for disease (genetic predispositions, environmental factors and pathophysiological mechanisms).
Scientific approaches
Our scientific approaches span from translational studies, based largely on laboratory and bioinformatic methodologies, to observational studies and clinical trials recruiting patients from the Department of Neurology.
Clinical studies are performed within the Department of Neurology, Oslo University Hospital. Laboratory work is carried out in modern laboratory facilities at Domus Medica. We have a broad network of national and international collaborators and participate in multi-center studies.
The Movement disorders and neurodegeneration group is a thematically overarching research group - organized into four subgroups focused on specific diseases and methodologies.
Subgroups
Clinical studies of movement disorders
In currently ongoing projects we study parkinsonism after basal ganglia strokes and impulse control disorders in Parkinson’s disease.
Clinical studies of movement disorders
Deep brain stimulation and botulinumtoxin treatment
Ongoing projects study the treatment effects and side effects of deep brain stimulation in tremor disorders, dystonia and Parkinson’s disease. Long-term efficacy of botulinum toxin treatment is the topic of another current study.
Deep brain stimulation and botulinumtoxin treatment
Molecular studies of Parkinson's disease
We study genetic causes of familial movement disorders. In Parkinson’s disease we examine changes in gene expression in brain tissue and the role of epigenetic changes in disease pathogenesis. Using both molecular methods and advanced imaging techniques in patients we examine the role of the glymphatic system in Parkinson’s disease.
Molecular studies of Parkinson's disease
Myasthenia gravis and amyotrophic lateral sclerosis
The project group focuses on clinical studies of myasthenia gravis and amyotrophic lateral sclerosis, and participates in national and international projects related to genetic studies, imaging and clinical trials.