About the group
The work is aiming at optimized diagnosis, prediction models and targeted treatment strategies based on the patients’ clinical, personal, genetic and/or molecular profile.
Furthermore, we will describe the burden of the disease for the patients, their families and the society. This is achieved through ongoing and planned clinical trials, observational studies and translational biomedical research.
Long term goal
The group's long-term goal is optimized and personalized treatment of childhood rheumatological disease with the correct use of resource-intensive strategies, goal-directed treatment and early identification of individuals with different risks.
This will help to avoid under- or over-treatment and improve the long-term outcome of the disease.
Collaboration
We have ten national and three international partners.
National
- Department of Medical Genetics, OUS/ Professor Benedicte LieUnit for clinical research, Diakonhjemmet hospital and REMEDY – Center for treatment of Rheumatic and Musculoskeletal Diseases/ Professor Espen A. Haavardsholm and Siri Lillegraven
- Children's department St Olav's Hospital/ Professor Marite Rygg
- Children's department, University Hospital of Northern Norway/ Senior doctor Ellen Nordal
- Children's Department Health West, Bergen/ Senior doctor Karin Tylleskar
- Children's department, University Hospital in Stavanger/ Senior doctor Bjørn Barstad
- Department of Radiology, OUS/Eva Kirkhus and Lil-Sofie Ording Muller
- Research support OUS/ Inge Christoffer Olsen
- Department of Medical Biochemistry, OUS/Nils Bolstad
- BURG Norwegian Rheumatism Association/ Joachim Sagen
International
- Bristol Royal Hospital/ Professor Athimalaipet V Ramanan
- Printo, Gaslini Institute, Genoa/Professor Nicola Ruperto
- Rigshospitalet, University of Copenhagen/ Professor Mikkel Østergaard
Publications
- Sande NK, Lilleby V, Aga AB, Kirkhus E, Flatø B, Bøyesen P. Associations between power Doppler ultrasound findings and B-mode synovitis and clinical arthritis in juvenile idiopathic arthritis using a standardised scanning approach and scoring system. RMD Open. 2023 Mar;9(1):e002937.
- Tollisen A, Selvaag AM, Aasland A, Ingebrigtsen T, Sagen J, Lerdal A, Flatø B. Personally Generated Quality of Life Outcomes in Adults With Juvenile Idiopathic Arthritis. J Rheumatol. 2022 Oct;49(10):1138-1145. doi: 10.3899/jrheum.211245. Epub 2022 May 15. PMID: 35569834.
- Bardan I, Fagerli KM, Sexton J, Kvien TK, Bakland G, Mielnik P, Hu Y, Lien G, Flatø B, Molberg Ø, Kristianslund EK, Aga AB. Treatment response to tumor necrosis factor inhibitors and methotrexate monotherapy in adults with juvenile idiopathic arthritis: Data from NORDMARD. J Rheumatol. 2022 Nov 15:jrheum.220645. doi: 10.3899/jrheum.220645. Epub ahead of print. PMID: 36379571.
- Li J, Li YR, Glessner JT, Yang J, March ME, Kao C, Vaccaro CN, Bradfield JP, Li J, Mentch FD, Qu HQ, Qi X, Chang X, Hou C, Abrams DJ, Qiu H, Wei Z, Connolly JJ, Wang F, Snyder J, Flatø B, Thompson SD, Langefeld CD, Lie BA, Munro JE, Wise C, Sleiman PMA, Hakonarson H. Identification of Novel Loci Shared by Juvenile Idiopathic Arthritis Subtypes Through Integrative Genetic Analysis. Arthritis Rheumatol. 2022 Aug;74(8):1420-1429. doi: 10.1002/art.42129. Epub 2022 Jul 15. PMID: 35347896; PMCID: PMC9542075.
- Felbo SK, Wiell C, Østergaard M, Poggenborg RP, Bøyesen P, Hammer HB, Boonen A, Pedersen SJ, Sørensen IJ, Madsen OR, Slot O, Møller JM, Szkudlarek M, Terslev L. Do tender joints in active psoriatic arthritis reflect inflammation assessed by ultrasound and magnetic resonance imaging? Rheumatology (Oxford). 2022 Feb 2;61(2):723-733. doi: 10.1093/rheumatology/keab384. PMID: 33895799.