The research conducted by this group is multidisciplinary, where collaboration between genetic and intensive care medicine, neurosurgery, neuroradiology, neuropsychology and rehabilitation has been established over the last 18 years.
Main aims
- To better understand the mechanisms, course and consequences of TBI, aSAH and multiple trauma by using translational research
- To develop and implement cost-effective rehabilitation interventions to target TBI-related challenges in the short- and long-term
- To improve collaboration and knowledge transfer between primary and secondary health care services - to ensure seamless rehabilitation for trauma patients
- To strengthen existing and initiate new national and international multicenter research collaborations
Specific aims
We intend to generate research-based knowledge of:
- The organization of patient care and rehabilitation trajectories, including patients’ needs and use of health care services after trauma
- Effective rehabilitation interventions to target trauma-related challenges in the short- and long-term; both holistic and specific interventions
- Cost-effectiveness of rehabilitation interventions
- Build evidence-based efficient protocols for the implementation of new cost-effective rehabilitation interventions into existing guidelines and services
- Collaboration between primary and secondary health care services
- Long-term outcomes and recovery process after aSAH
- The biomarkers of TBI and the severity of injuries including morphological changes in the brain
Cooperation
This broad range of areas requires close collaboration with research groups in Norway and abroad.
National
- Oslo Traumatic Brain Injury Outcome and Rehabilitation Research Network; OBIOR- research network
- Sunnaas Rehabilitation Hospital HF
- University Hospital of North Norway HF
- St Olavs hospital HF
- The universities of Oslo, Tromsø, Bergen and Trondheim
- Oslo Metropolitan University; OsloMet
- Norwegian Labour and Welfare Administration; NAV
International
- Karolinska institute, Uppsala, Umeå and Salgrenska University Hospitals, Sweden
- Copenhagen University Hospital and Hammel Rehabilitation and Research Centre, Denmark
- Virginia Commonwealth University, Richmond, US
- BioCruces Health Research Institute, Spain
- University of California, San Diego, CA, USA
- University of Gottingen, Germany
- University of Salamanca, Spain
- Hannover Medical School, Germany
- Monash University, Victoria, Australia
- CENTER-TBI collaborators across the European hospitals/universities
Selected publications
- Borgen IMH, Løvstad M, Hauger SL, Forslund MV, Kleffelgård I, Andelic N, Sveen U, Søberg HL, Sigurdardottir S, Winter L, Lindstad MØ, Brunborg C, Røe C. Effect of an Individually Tailored and Home-Based Intervention in the Chronic Phase of Traumatic Brain Injury: A Randomized Clinical Trial. JAMA Netw Open. 2023 May 1;6(5):e2310821. doi: 10.1001/jamanetworkopen.2023.10821.
- Retel Helmrich IRA, van Klaveren D, Andelic N, Lingsma H, Maas A, Menon D, Polinder S, Røe C, Steyerberg EW, Van Veen E, Wilson L; CENTER-TBI participants and investigators. Discrepancy between disability and reported well-being after traumatic brain injury. J Neurol Neurosurg Psychiatry. 2022 May 10;93(7):785–96. doi: 10.1136/jnnp-2021-326615
- Howe EI, Andelic N, Fure SCR, Røe C, Søberg HL, Hellstrøm T, Spjelkavik Ø, Enehaug H, Lu J, Ugelstad H, Løvstad M, Aas E. Cost-effectiveness analysis of combined cognitive and vocational rehabilitation in patients with mild-to-moderate TBI: results from a randomized controlled trial. BMC Health Serv Res. 2022 Feb 12;22(1):185. doi: 10.1186/s12913-022-07585-3.
- Fure SCR, Howe EI, Andelic N, Brunborg C, Sveen U, Røe C, Rike PO, Olsen A, Spjelkavik Ø, Ugelstad H, Lu J, Ponsford J, Twamley EW, Hellstrøm T, Løvstad M. Cognitive and vocational rehabilitation after mild-to-moderate traumatic brain injury: A randomised controlled trial. Ann Phys Rehabil Med. 2021 Sep;64(5):101538. doi: 10.1016/j.rehab.2021.101538.
- Andelic N, Røe C, Tenovuo O, Azouvi P, Dawes H, Majdan M, Ranta J, Howe EI, Wiegers EJA, Tverdal C, Borgen I, Forslund MV, Kleffelgaard I, Dahl HM, Jacob L, Cogné M, Lu J, von Steinbuechel N, Zeldovich M. Unmet Rehabilitation Needs after Traumatic Brain Injury across Europe: Results from the CENTER-TBI Study. J Clin Med. 2021 Mar 3;10(5):1035. doi: 10.3390/jcm10051035.
- Andelic N, Røe C, Brunborg C, Zeldovich M, Løvstad M, Løke D, Borgen IM, Voormolen DC, Howe EI, Forslund MV, Dahl HM, von Steinbuechel N; CENTER-TBI participants investigators. “Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study” J Neurol. Epub 2020 Jul 16. doi: 10.1007/s00415-020-10022-2
- Sveen U, Guldager R, Soberg HL, Andreassen TA, Egerod I, Poulsen I. “Rehabilitation interventions after traumatic brain injury: a scoping review” Disabil Rehabil. 2020 Jun 13:1-8. doi: 10.1080/09638288.2020.1773940
- Rasmussen MS, Andelic N, Pripp AH, Nordenmark TH, Soberg HL. The effectiveness of a family-centred intervention after traumatic brain injury: A pragmatic randomised controlled trial. Clin Rehabil. 2021 Oct;35(10):1428-1441. doi: 10.1177/02692155211010369. Epub 2021 Apr 15.
- Holthe OO, Hellstrom T, Andelic N, Server A, Sigurdardottir S Improvement and Prediction of Memory and Executive Functions in Patients Admitted to a Neurosurgery Service With Complicated and Uncomplicated Mild Traumatic Brain Injury. J Head Trauma Rehabil, 2019. 34 (5), E45-E56
- Røe C, Tverdal C, Howe EI, Tenovuo O, Azouvi P, Andelic N Randomized Controlled Trials of Rehabilitation Services in the Post-acute Phase of Moderate and Severe Traumatic Brain Injury - A Systematic Review. Front Neurol, 2019. 10, 557
- Maas AIR, Menon DK, Adelson PD, Andelic N et al (InTBIR Participants and Investigators). Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol. 2017 Nov 6. pii: S1474-4422(17)30371-X
- Soberg HL, Bautz-Holter E, Finset A, Roise O, Andelic N. Physical and mental health 10 years after multiple trauma: A prospective cohort study. J Trauma Acute Care Surg. 2015 Mar;78(3):628-33
- Andelic N, Ye J, Tornas S, Roe C, Lu J, Bautz-Holter E, Moger T, Sigurdardottir S, Schanke AK, Aas E. Cost-effectiveness analysis of an early-initiated, continuous chain of rehabilitation after severe traumatic brain injury. J Neurotrauma 2014; 15; 31:1313-20