Long life expectancy is resulting in aged societies and a remarkable increase in age-related diseases, including cancer.
Stem cells self-renew and provide the source for replenishing mature cells in the organism throughout its life. These fascinating abilities ensure tissue regeneration, but must be fine-tuned regulated as their imbalance may contribute to both, ageing and cancer.
Stem cell behaviour results from integration of cell-autonomous and extracellular signals received from the stem cell niche.
Our research interest focuses on the processes that control stem cell behaviour. Taking the hematopoietic system as the primary model, our group aims at understanding the mechanisms of stem cell malignant transformation using an integrative perspective that considers cell-autonomous alterations in the stem cell and remodelling of the stem cell niche.
Research vision
Our goal is the identification of novel and efficient therapeutic targets of clinical interest that will improve survival rates and quality of life in patients.
Cooperation
- Anders Vik - UiT, UNN
- Arne Klungland - UiO, OUH
- Emma Haapaniemi - UiO, NCMM
- Bjørn Tore Gjertsen - UiB, HUS
- Francisca Ferrer-Marin - Hospital Universitario Morales-Meseguer, Murcia, Spain
- Paloma Garcia - University of Birmingham, United Kingdom
- Caroline Heckman - Institute for Molecular Medicine, Finland
- Andres Hidalgo - Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
- Giacomo Volpe - IRCCS Istituto Tumori “Giovanni Paolo II”, Italy
Selected publications
- Villatoro A#, Cuminetti V#, Bernal A, Torroja C, Cossío I, Benguría A, Ferré M, Konieczny J, Vázquez E, Rubio A, Utnes P, Tello A, You X, Fenton CG, Paulssen RH, Zhang J, Sánchez-Cabo F, Dopazo A, Vik A, Anderssen E, Hidalgo A, Arranz L. “Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation”. Nat Commun 2023, 14: 12. #Equal contribution
doi: 10.1038/s41467-022-35700-9 - Bernal A, Arranz L. “Nestin-expressing progenitor cells: function, identity and therapeutic implications”. Cell Mol Life Sci 2018, 75: 2177-2195.
doi: 10.1007/s00018-018-2794-z - Grimolizzi F, Arranz L. “Multiple faces of succinate beyond metabolism in blood”. Haematologica 2018, 103: 1586-1592. doi: 10.3324/haematol.2018.196097
- Arranz L*, Arriero MM, Villatoro AE. “Interleukin-1β as emerging therapeutic target in hematological malignancies and potentially in their complications”. Blood Rev 2017, 31: 306-317. *Corresponding author doi: 10.1016/j.blre.2017.05.001
- Arranz L, Sánchez-Aguilera A, Martín-Pérez D, Isern J, Langa X, Tzankov A, Lundberg P, Muntión S, Tzeng Y-S, Lai D-M, Schwaller J, Skoda RC, Méndez-Ferrer S. “Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms”. Nature 2014, 512: 78-81. doi: 10.1038/nature13383