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Translational Neurodegeneration and Neuropathology

Our research focuses on applied research for daily neuropathological diagnostics (brain biopsies, muscle diseases, autopsy for adults, kids and fetuses) and basic and molecular neurodegeneration research, translational projects, and patient-related treatment. 

We provide daily diagnostic service for brain tumours, muscle disease diagnostics, routine autopsy diagnostics, and forensic neuropathology.

Our research focuses on basic and molecular neurodegeneration research, translational projects and patient-related treatment and diagnostic research.

This combined research and diagnostic lab is located at Rikshospitalet. We host several mouse lines at the Radium Hospital mouse facility, also inducible humanised mouse lines of ABC transporters C1 and A7. We are currently developing AI-assisted tools for diagnostic and research purposes.

Projects

  • PETABC JPND consortium (2021-2024, consortium leader): PET analyses of ABC transporter function for diagnostics and stratification of dementia patients (JPND / EU / NFR / BMBF/ ANR / FGG / VIAA / MSTS, SRC)
  • TARIMAD EEA grants & Norway grants consortium (2021-2024): Targeted and improved Alzheimer’s disease drug development
  • PROP-AD (2016-2021): Propagation behaviour of peripheral amyloid-β towards brain structures: effects of the blood-brain barrier (JPND / EU / NFR / MOST / BMBF / AKA)
  • PhytoAD (2016-2021): St. John’s wort as Alzheimer’s treatment – New ways of identification, exploitation and use of natural resources (SAW Leibniz Society Grant / EFRE)
  • ABC-HC (2019-2022): The importance of ABC transporters for the pathogenesis and treatment of Huntington’s disease (HSØ) 
  • ABC-S1P (2019-2022): S1P and ABC transporters – synergistic treatment targets for Alzheimer´s disease (HSØ) 
  • REPURPOSE-DMF(2019-2022): Dimethyl fumarate – Repurposing a MS drug to treat AD (Nationalforeningen)
  • ShortAbeta (2018-2021): Short Aβ-related peptides in the pathogenesis of Alzheimer’s disease – new avenues for treatment (FLPP Latvia)
  • Establishment of comprehensive molecular diagnostics for kids’ brain tumours in Norway (Barnekreftforeningen 2019-2021)

Pahnke Lab

Read more on our external pages

Published Aug. 14, 2017 3:47 PM - Last modified June 19, 2023 1:25 PM

Contact

Group leader

Participants

  • Jens Pahnke University of Oslo
  • Ivan Eiriz Delgado University of Oslo
  • Surya Prakash Rai University of Oslo
  • Chantelle Ninette Kronberg Nerdrum University of Oslo
  • Luisa Möhle
  • Mirjam Brackhan
  • Henning Leske
  • Stefanie Brendecke
  • Thomas Brüning
  • Jolanta Upite
  • Pablo Bascuñana
  • Sven Stefan
  • Katja Stefan
  • Peter Brust
Detailed list of participants