The public defence will be held as a video conference over Zoom.
The digital trial lecture will follow regular procedure as far as possible, hence it will be open to the public and the audience can ask ex auditorio questions when invited to do so.
Click here to participate in the public defence
Due to copyright reasons, an electronic copy of the thesis must be ordered from the faculty. In order for the faculty to have time to process the order, it must be received by the faculty no later than 2 days prior to the public defence. Orders received later than 2 days before the defence will not be processed. Inquiries regarding the thesis after the public defence must be addressed to the candidate.
Digital Trial Lecture – time and place
Adjudication committee
- First opponent: Senior Consultant Britt-Marie Karlson, Akademiska sjukhuset, Uppsala
- Second opponent: Senior Consultant Jon-Helge Angelsen, Haukeland University hospital
- Third member and chair of the evaluation committee: Professor II John Terje Geitung, University of Oslo
Chair of the Defence
Professor II Lars Nordsletten, University of Oslo
Principal Supervisor
Professor II Trond A. Buanes, University of Oslo
Summary
The present PhD-thesis investigates opportunities for improving management of surgically treated pancreatic cancer patients by incorporating patients’ experience. The aim was to explore the putative prognostic value of patient reported outcome (PRO), the effects of complications on longitudinal PRO, and the value of PACADI, a short, patient-derived and disease-specific PRO measure.
Preoperative cognitive function was independently associated with survival, with 10 months median survival for patients with self-reported cognitive impairment and 21 months for patients reporting normal cognition (p<.001).
No significant difference in PRO was found at 3 and 6 months after surgery between patients with or without complications, suggesting limited negative long-term effect of complications.
The PACADI score has prognostic value and shows better psychometric performance compared with two widely used generic questionnaires.
PRO has prognostic value and should be part of preoperative assessment. PRO also enables monitoring of treatment effects, potentially improving outcome. Because of its feasibility and good psychometric scores, PACADI should be used in patients with pancreatic cancer.
Additional information
Contact the research support staff.