1) Metakaryotic biology: stem cells of organogenesis and carcinogenesis
Time: 11 A.M.
The stem cells of human organ development and tumor growth are not eukaryotic cells! They are "metakaryotic" cells with hollow bell shaped nuclei appended to rather than enclosed in the cytoplasm.They divide by both symmetric and asymmetric amitoses creating the eukaryotic (mitotic) cells of tissue and tumor parenchyma. Their "chromosomes" appear to be continuous, joined at telomeres.
They create a double stranded RNA/DNA replicative intermediate prior to and during cytokinesis. They are strongly resistant to x-rays and chemo-"therapeutic" agents.
Multiple agents that kill them in cell culture have been found.
2) Metakaryotic biology: stem cell mutation and age-specific cancer mortality rates
Time: 1 P.M.
Fetal/juvenile organogenic stem cells appear to have very high mutation rates."Initiation" is presented as blockage of maturation of organogenic stem cells resulting in a slowly growing mutator/hypermutable preneoplastic stem cell population.
A modified Armitage-Doll two stage cancer model is offered and discussed in terms of colorectal cancer mortality rates, heritable cancer risk and immigrant cancer pattern shifts.