Norwegian version of this page

StopAutoimmunity

The project's main research is the gut microbiota and its impact on chronic inflammatory diseases and autoimmunity.

About the project

In the ERC-funded project StopAutoimmunity we study primary sclerosing cholangitis, a disease of the liver and biliary tree, looking specifically at patients who get recurrent disease after liver transplantation.

The hypothesis is that byproducts of gut bacterial activity contributes to the disease process and that treatment targeting the gut may stop or reverse disease development.

This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement No 802544.

Selected publications

  • Awoniyi M, Wang J, Ngo B, Meadows V, Tam J, Viswanathan A, Lai Y, Montgomery S, Farmer M, Kummen M, Thingholm L, Schramm C, Bang C, Franke A, Lu K, Zhou H, Bajaj JS, Hylemon PB, Ting J, Popov YV, Hov JR, Francis HL, Sartor RB. Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in a murine model of PSC. Gut. 2023 Apr;72(4):671-685. doi: 10.1136/gutjnl-2021-326500. Epub 2022 Jun 15. PMID: 35705368; PMCID: PMC9751228.
  • Schneider KM, Kummen M, Trivedi PJ, Hov JR. Role of microbiome in autoimmune liver diseases. Hepatology. 2023 Jun 27. doi: 10.1097/HEP.0000000000000506. Epub ahead of print. PMID: 37369002.
  • Hole MJ, Jørgensen KK, Holm K, Braadland PR, Meyer-Myklestad MH, Medhus AW, Reikvam DH, Götz A, Grzyb K, Boberg KM, Karlsen TH, Kummen M, Hov JR. A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation. Hepatology. 2023 Mar 1;77(3):715-728. doi: 10.1002/hep.32773. Epub 2023 Feb 17. PMID: 36056902; PMCID: PMC9936983.
  • Braadland PR, Schneider KM, Bergquist A, Molinaro A, Lövgren-Sandblom A, Henricsson M, Karlsen TH, Vesterhus M, Trautwein C, Hov JR, Marschall HU. Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis. JHEP Rep. 2022 Aug 18;4(11):100561. doi: 10.1016/j.jhepr.2022.100561. PMID: 36176935; PMCID: PMC9513776.
  • Braadland PR, Bergquist A, Kummen M, Bossen L, Engesæter LK, Reims HM, Björk I, Grzyb K, Abildgaard A, Småstuen MC, Folseraas T, Trøseid M, Ulvik A, Ueland PM, Melum E, Line PD, Høivik ML, Grønbæk H, Karlsen TH, Vesterhus M, Hov JR. Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation. J Hepatol. 2023 Oct;79(4):955-966. doi: 10.1016/j.jhep.2023.05.038. Epub 2023 Jun 14. PMID: 37328069.
  • Kummen M, Thingholm LB, Rühlemann MC, Holm K, Hansen SH, Moitinho-Silva L, Liwinski T, Zenouzi R, Storm-Larsen C, Midttun Ø, McCann A, Ueland PM, Høivik ML, Vesterhus M, Trøseid M, Laudes M, Lieb W, Karlsen TH, Bang C, Schramm C, Franke A, Hov JR. Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis. Gastroenterology. 2021 Apr;160(5):1784-1798.e0. doi: 10.1053/j.gastro.2020.12.058. Epub 2020 Dec 31. PMID: 33387530; PMCID: PMC7611822.
Published May 3, 2019 11:06 AM - Last modified Oct. 10, 2023 1:58 PM

Contact

Project Leader

Participants

Detailed list of participants