Om gruppen
Gruppen infeksjonsimmunologi ble etablert ved Institutt for indremedisinsk forskning på slutten av 2022.
Vi gjennomfører både randomiserte studier og observasjonelle studier med biobanking, og gjør analyser av vertsimmunologi, betennelsesprofiler, metabolitter, bakterier og virus fra blant annet luftveier og tarmflora.
Mål for forskningen
Målet er å utvikle mer persontilpassede behandlingsstrategier for pasienter med infeksjonssykdommer og immunsvikt, inkludert COVID-19, HIV, andre virusinfeksjoner og primær immunsvikt.
Utvalgte publikasjoner
- Serrano-Villar S, Saenz S, Tincati C, Raju S, Moreno E, Bargiela R, Ubeda A, Sendagorta E, Benito A, Kurz A, Perez-Molina JA, Hov JE, Fernandez-Lopez F, Muriel A, del Campo R, Moreno S, Trøseid M*, Seifert J*, Ferrer M*. *Shared senior authorship. Microbiome-Derived Cobalamin and Succinyl-CoA are Powerful Biomarkers for Improved Screening of Anal Cancer. Nature Medicine 2023, in press.
- Trøseid M, Holter JC, Holm K, Vestad B, Sazonova T, Granerud BK, Dyrhol-Riise AM, Holten AR, Tonby K, Kildal AB, Heggelund L, Tveita A, Bøe S, Müller KE, Jenum S, Hov JR, Ueland T; Norwegian SARS-CoV-2 study group. Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19. Crit Care 2023 Feb 23;27(1):69. doi: 10.1186/s13054-023-04356-2.
- Trøseid M, Arribas J, Assomou l, Rygh Holten, Poissy J, Terzic V, …. EU SOlidAct study group. Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID-19 (Bari-SolidAct): a randomised, double-blind, placebo-controlled phase 3 trial. Crit Care 2023 Jan 10;27(1):9. doi: 10.1186/s13054-022-04205-8.
- Macpherson ME, Skarpengland T, Hov JR, …, Jørgensen SF . Increased plasma levels of triglyceride-enriched lipoproteins associate with systemic inflammation, lipopolysaccharides and gut dysbiosis in Common variable immunodeficiency. Journal of Clinical Immunology: 1-12. 2023
- Skarpengland T, Macpherson ME, Hov JR,… , Jørgensen SF. Altered plasma fatty acids associate with gut microbial composition in Common variable immunodeficiency. Journal of Clinical immunology. 2022
- Kaarbø M, Yang M, Hov JR, …, Jørgensen SF. Duodenal inflammation in Common variable immunodeficiency have altered transcriptional response to virus. Journal of Allergy and Clinical Immunology. 2022.
- Trøseid M, Dahl TB, Holter JC, Kildal AB, Murphy SL, Yang K, Quiles-Jiménez A, Heggelund L, Müller KE, Tveita A, Michelsen AE, Bøe S, Holten AR, Hoel H, Mathiessen A, Aaløkken TM, Fevang B, Granerud BK, Tonby K, Henriksen KN, Lerum TV, Müller F, Skjønsberg OH, Barratt-Due A, Dyrhol-Riise AM, Aukrust P, Halvorsen B, Ueland T; NOR-SOLIDARITY Consortium; Norwegian SARS-CoV-2 study group. Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies. J Intern Med. 2022 Aug 18.
- Barratt-Due A, Olsen IC, Nezvalova-Henriksen K, …, Trøseid M, Aukrust P; NOR-Solidarity trial. Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial. Ann Intern Med. 2021 Sep;174(9):1261-1269. doi: 10.7326/M21-0653. Epub 2021 Jul 13.