Anders M. Dale

• Frei, Oleksandr; Hindley, Guy; Shadrin, Alexey; van der Meer, Dennis; Akdeniz, Bayram Cevdet & Hagen, Espen [Vis alle 16 forfattere av denne artikkelen] (2024). Improved functional mapping of complex trait heritability with GSA-MiXeR implicates biologically specific gene sets. Nature Genetics. ISSN 1061-4036. 56(6), s. 1310–1318. doi: 10.1038/s41588-024-01771-1.
• Nievergelt, Caroline M.; Maihofer, Adam X.; Atkinson, Elizabeth G.; Chen, Chia-Yen; Choi, Karmel W. & Coleman, Jonathan R. I. [Vis alle 235 forfattere av denne artikkelen] (2024). Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. Nature Genetics. ISSN 1061-4036. doi: 10.1038/s41588-024-01707-9.
• Tissink, E.P.; Shadrin, Alexey; van der Meer, Dennis; Parker, Nadine; Hindley, Guy & Roelfs, Daniel [Vis alle 18 forfattere av denne artikkelen] (2024). Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study. Nature Communications. ISSN 2041-1723. 15(1). doi: 10.1038/s41467-024-46817-4.
• He, Qiang; Wang, Wenjing; Xu, Dingkang; Xiong, Yang; Tao, Chuanyuan & You, Chao [Vis alle 185 forfattere av denne artikkelen] (2024). Potential causal association between gut microbiome and posttraumatic stress disorder. Translational Psychiatry. ISSN 2158-3188. 14(1). doi: 10.1038/s41398-024-02765-7.
• Andreassen, Maren Marie Sjaastad; Loubrie, Stephane; Tong, Michelle W.; Fang, Lauren; Seibert, Tyler & Wallace, Anne M. [Vis alle 15 forfattere av denne artikkelen] (2023). Restriction spectrum imaging with elastic image registration for automated evaluation of response to neoadjuvant therapy in breast cancer. Frontiers in Oncology. ISSN 2234-943X. 13. doi: 10.3389/fonc.2023.1237720. Fulltekst i vitenarkiv
• Parker, Nadine; Cheng, Weiqiu; Hindley, Guy; O'Connell, Kevin Sean; Karthikeyan, Sandeep & Holen, Børge [Vis alle 19 forfattere av denne artikkelen] (2023). Genetic Overlap Between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts. Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2023.06.008. Fulltekst i vitenarkiv
• Wang, Lu; Heffner, Caleb; Vong, Keng loi; Barrows, Chelsea; Ha, Yoo-Jin & Lee, Sangmoon [Vis alle 20 forfattere av denne artikkelen] (2023). TMEM161B modulates radial glial scaffolding in neocortical development. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 120(4). doi: 10.1073/pnas.2209983120. Fulltekst i vitenarkiv
• Akdeniz, Bayram Cevdet ; Frei, Oleksandr; Shadrin, Alexey; Vetrov, Dmitry; Kropotov, Dmitry & Dale, Anders [Vis alle 8 forfattere av denne artikkelen] (2022). Finemap-MiXeR: A variational Bayesian approach for genetic finemapping. bioRxiv. ISSN 2692-8205.
• Huynh-Le, Minh-Phuong; Karunamuni, Roshan; Fan, Chun Chieh; Asona, Lui; Thompson, Wesley Kurt & Martinez, Maria Elena [Vis alle 75 forfattere av denne artikkelen] (2022). Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score. Prostate Cancer and Prostatic Diseases. ISSN 1365-7852. 25(4), s. 755–761. doi: 10.1038/s41391-022-00497-7. Fulltekst i vitenarkiv
• Loughnan, Robert J.; Shadrin, Alexey; Frei, Oleksandr; van der Meer, Dennis; Zhao, Weiqi & Palmer, Clare E. [Vis alle 12 forfattere av denne artikkelen] (2022). Generalization of cortical MOSTest genome-wide associations within and across samples. NeuroImage. ISSN 1053-8119. 263. doi: 10.1016/j.neuroimage.2022.119632. Fulltekst i vitenarkiv
• Loughnan, Robert; Ahern, Jonathan; Tompkins, Cherisse; Palmer, Clare E.; Iversen, John & Thompson, Wesley Kurt [Vis alle 12 forfattere av denne artikkelen] (2022). Association of Genetic Variant Linked to Hemochromatosis with Brain Magnetic Resonance Imaging Measures of Iron and Movement Disorders. JAMA Neurology. ISSN 2168-6149. 79(9), s. 919–928. doi: 10.1001/jamaneurol.2022.2030.
• Hindley, Guy Frederick Lanyon; O'Connell, Kevin Sean; Rahman, Zillur; Frei, Oleksandr; Bahrami, Shahram & Shadrin, Alexey [Vis alle 17 forfattere av denne artikkelen] (2022). The shared genetic basis of mood instability and psychiatric disorders: A cross-trait genome-wide association analysis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. ISSN 1552-4841. 189(6), s. 207–218. doi: 10.1002/ajmg.b.32907. Fulltekst i vitenarkiv
• Cheng, Weiqiu; van der Meer, Dennis; Parker, Nadine; Hindley, Guy Frederick Lanyon; O'Connell, Kevin Sean & Wang, Yunpeng [Vis alle 20 forfattere av denne artikkelen] (2022). Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood. Molecular Psychiatry. ISSN 1359-4184. doi: 10.1038/s41380-022-01751-z. Fulltekst i vitenarkiv
• Besser, Alexandra H.; Fang, Lauren K.; Tong, Michelle W.; Andreassen, Maren Marie Sjaastad; Ojeda-Fournier, Haydee & Conlin, Christopher C. [Vis alle 14 forfattere av denne artikkelen] (2022). Tri-Compartmental Restriction Spectrum Imaging Breast Model Distinguishes Malignant Lesions from Benign Lesions and Healthy Tissue on Diffusion-Weighted Imaging. Cancers. ISSN 2072-6694. 14(13). doi: 10.3390/cancers14133200. Fulltekst i vitenarkiv
• Bahrami, Shahram; Nordengen, Kaja; Shadrin, Alexey; Frei, Oleksandr; van der Meer, Dennis & Dale, Anders [Vis alle 9 forfattere av denne artikkelen] (2022). Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders. Nature Communications. ISSN 2041-1723. 13(1). doi: 10.1038/s41467-022-31086-w. Fulltekst i vitenarkiv
• Hindley, Guy; Frei, Oleksandr; Shadrin, Alexey; Cheng, Weiqiu; O'Connell, Kevin Sean & Icick, Romain [Vis alle 17 forfattere av denne artikkelen] (2022). Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation. American Journal of Psychiatry. ISSN 0002-953X. 179(11), s. 833–843. doi: 10.1176/appi.ajp.21101051.
• Icick, Romain; Shadrin, Alexey; Holen, Børge; Karadag, Naz; Lin, Aihua & Hindley, Guy [Vis alle 17 forfattere av denne artikkelen] (2022). Genetic overlap between mood instability and alcohol-related phenotypes suggests shared biological underpinnings. Neuropsychopharmacology. ISSN 0893-133X. 47, s. 1883–1891. doi: 10.1038/s41386-022-01401-6.
• Makowski, Carolina; van der Meer, Dennis; Dong, Weixiu; Wang, Hao; Wu, Yan & Zou, Jingjing [Vis alle 18 forfattere av denne artikkelen] (2022). Discovery of genomic loci of the human cerebral cortex using genetically informed brain atlases. Science. ISSN 0036-8075. 375(6580). doi: 10.1126/science.abe8457.
• Chaarani, B.; Hahn, S.; Allgaier, N.; Adise, S.; Owens, M.M. & Juliano, A.C. [Vis alle 193 forfattere av denne artikkelen] (2021). Baseline brain function in the preadolescents of the ABCD Study. Nature Neuroscience. ISSN 1097-6256. 24(8), s. 1176–1186. doi: 10.1038/s41593-021-00867-9.
• Huynh-Le, Minh-Phuong; Fan, Chun Chieh; Karunamuni, Roshan A.; Thompson, Wesley K.; Martinez, Maria Elena & Eeles, Rosalind A. [Vis alle 78 forfattere av denne artikkelen] (2021). Polygenic hazard score is associated with prostate cancer in multi-ethnic populations. Nature Communications. ISSN 2041-1723. 12(1). doi: 10.1038/s41467-021-21287-0.
• Karunamuni, Roshan A.; Huynh-Le, Minh-Phuong; Fan, Chun Chieh; Thompson, Wesley K.; Lui, Asona & Martinez, Maria Elena [Vis alle 48 forfattere av denne artikkelen] (2021). Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24. Prostate Cancer and Prostatic Diseases. ISSN 1365-7852. doi: 10.1038/s41391-021-00403-7.
• Huynh-Le, Minh-Phuong; Karunamuni, Roshan; Fan, Chun-Chieh; Thompson, Wesley K; Muir, Kenneth & Lophatananon, Artitaya [Vis alle 13 forfattere av denne artikkelen] (2021). Common genetic and clinical risk factors: association with fatal prostate cancer in the Cohort of Swedish Men. Prostate Cancer and Prostatic Diseases. ISSN 1365-7852. doi: 10.1038/s41391-021-00341-4.
• Andlauer, Till F.M.; Guzman-Parra, José; Streit, Fabian; Strohmaier, Jana; González, Maria José & Flores, Susana Gil [Vis alle 50 forfattere av denne artikkelen] (2021). Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders. Molecular Psychiatry. ISSN 1359-4184. 26, s. 1286–1298. doi: 10.1038/s41380-019-0558-2. Fulltekst i vitenarkiv
• Shadrin, Alexey A.; Kaufmann, Tobias; van der Meer, Dennis; Palmer, Clare E.; Makowski, Carolina & Loughnan, Robert [Vis alle 22 forfattere av denne artikkelen] (2021). Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology. NeuroImage. ISSN 1053-8119. 244, s. 1–8. doi: 10.1016/j.neuroimage.2021.118603. Fulltekst i vitenarkiv
• Pihlstrøm, Lasse; Fan, Chun Chieh; Frei, Oleksandr; Tan, Manuela; Karunamuni, Roshan A. & Blauwendraat, Cornelis [Vis alle 12 forfattere av denne artikkelen] (2021). Genetic Stratification of Age-Dependent Parkinson's Disease Risk by Polygenic Hazard Score. Movement Disorders. ISSN 0885-3185. doi: 10.1002/mds.28808. Fulltekst i vitenarkiv
• Hindley, Guy Frederick Lanyon; Bahrami, Shahram; Steen, Nils Eiel; O'Connell, Kevin Sean; Frei, Oleksandr & Shadrin, Alexey [Vis alle 13 forfattere av denne artikkelen] (2021). Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking. Translational Psychiatry. ISSN 2158-3188. 11:466, s. 1–10. doi: 10.1038/s41398-021-01576-4. Fulltekst i vitenarkiv
• Rødevand, Linn ; Bahrami, Shahram; Frei, Oleksandr; Chu, Yunhan; Shadrin, Alexey A. & O'Connell, Kevin Sean [Vis alle 14 forfattere av denne artikkelen] (2021). Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes. Translational Psychiatry. ISSN 2158-3188. 11. doi: 10.1038/s41398-021-01527-z. Fulltekst i vitenarkiv
• Bahrami, Shahram; Shadrin, Alexey A.; Frei, Oleksandr; O`Connell, Kevin; Bettella, Francesco & Krull, Florian [Vis alle 15 forfattere av denne artikkelen] (2021). Genetic loci shared between major depression and intelligence with mixed directions of effect. Nature Human Behaviour. ISSN 2397-3374. s. 1–9. doi: 10.1038/s41562-020-01031-2.
• Shadrin, Alexey A.; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Bettella, Francesco; O`Connell, Kevin & Gani, Osman [Vis alle 12 forfattere av denne artikkelen] (2020). Phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories revealed by AI-MiXeR. Bioinformatics. ISSN 1367-4803. doi: 10.1093/bioinformatics/btaa568. Fulltekst i vitenarkiv
• van der Meer, Dennis; Frei, Oleksandr; Kaufmann, Tobias; Shadrin, Alexey A.; Devor, Anna & Smeland, Olav Bjerkehagen [Vis alle 12 forfattere av denne artikkelen] (2020). Understanding the genetic determinants of the brain with MOSTest. Nature Communications. ISSN 2041-1723. 11:3512, s. 1–9. doi: 10.1038/s41467-020-17368-1.
• Fan, Chun Chieh; Banks, Sarah J.; Thompson, Wesley K.; Chen, Chi-Hua; McEvoy, Linda K. & Tan, Chin Hong [Vis alle 14 forfattere av denne artikkelen] (2020). Sex-dependent autosomal effects on clinical progression of Alzheimer's disease. Brain. ISSN 0006-8950. 143(7), s. 2272–2280. doi: 10.1093/brain/awaa164.
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Dale, Anders & Andreassen, Ole Andreas (2020). The polygenic architecture of schizophrenia — rethinking pathogenesis and nosology. Nature Reviews Neurology. ISSN 1759-4758. s. 1–14. doi: 10.1038/s41582-020-0364-0.
• Bahrami, Shahram; Steen, Nils Eiel; Shadrin, Alexey A.; O`Connell, Kevin; Frei, Oleksandr & Bettella, Francesco [Vis alle 13 forfattere av denne artikkelen] (2020). Shared genetic loci between body mass index and major psychiatric disorders: A genome-wide association study. JAMA psychiatry. ISSN 2168-6238. 77(5), s. 503–512. doi: 10.1001/jamapsychiatry.2019.4188. Vis sammendrag

  IMPORTANCE People with major psychiatric disorders (MPDs) have a 10- to 20-year shorter life span than the rest of the population, and this difference is mainly due to comorbid cardiovascular diseases. Genome-wide association studies have identified common variants involved in schizophrenia (SCZ), bipolar disorder (BIP), and major depression (MD) and body mass index (BMI), a key cardiometabolic risk factor. However, genetic variants jointly influencing MPD and BMI remain largely unknown. OBJECTIVE To assess the extent of the overlap between the genetic architectures of MPDs and BMI and identify genetic loci shared between them. DESIGN, SETTING, AND PARTICIPANTS Using a conditional false discovery rate statistical framework, independent genome-wide association study data on individuals with SCZ (n = 82 315), BIP (n = 51 710), MD (n = 480 359), and BMI (n = 795 640) were analyzed. The UK Biobank cohort (n = 29 740) was excluded from the MD data set to avoid sample overlap. Data were collected from August 2017 to May 2018, and analysis began July 2018. MAIN OUTCOMES AND MEASURES The primary outcomes were a list of genetic loci shared between BMI and MPDs and their functional pathways. RESULTS Genome-wide association study data from 1 380 284 participants were analyzed, and the genetic correlation between BMI and MPDs varied (SCZ: r for genetic = −0.11, P = 2.1 × 10−10; BIP: r for genetic = −0.06, P = .0103; MD: r for genetic = 0.12, P = 6.7 × 10−10). Overall, 63, 17, and 32 loci shared between BMI and SCZ, BIP, and MD, respectively, were analyzed at conjunctional false discovery rate less than 0.01. Of the shared loci, 34% (73 of 213) in SCZ, 52% (36 of 69) in BIP, and 57% (56 of 99) in MD had risk alleles associated with higher BMI (conjunctional false discovery rate <0.05), while the rest had opposite directions of associations. Functional analyses indicated that the overlapping loci are involved in several pathways including neurodevelopment, neurotransmitter signaling, and intracellular processes, and the loci with concordant and opposite association directions pointed mostly to different pathways. CONCLUSIONS AND RELEVANCE In this genome-wide association study, extensive polygenic overlap between BMI and SCZ, BIP, and MD were found, and 111 shared genetic loci were identified, implicating novel functional mechanisms. There was mixture of association directions in SCZ and BMI, albeit with a preponderance of discordant ones

• Satizabal, Claudia L.; Adams, Hieab H.H.; Hibar, Derrek; White, Charles C.; Knol, Maria J. & Stein, Jason L. [Vis alle 289 forfattere av denne artikkelen] (2019). Genetic architecture of subcortical brain structures in 38,851 individuals. Nature Genetics. ISSN 1061-4036. 51, s. 1624–1636. doi: 10.1038/s41588-019-0511-y. Fulltekst i vitenarkiv Vis sammendrag

  Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.

• Nievergelt, Caroline M.; Maihofer, Adam X.; Klengel, Torsten; Atkinson, Elizabeth G.; Chen, Chia-Yen & Choi, Karmel W. [Vis alle 179 forfattere av denne artikkelen] (2019). International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nature Communications. ISSN 2041-1723. 10:4558, s. 1–16. doi: 10.1038/s41467-019-12576-w. Fulltekst i vitenarkiv
• Kremen, William S.; Panizzon, Matthew S.; Elman, Jeremy A.; Granholm, Eric L.; Andreassen, Ole Andreas & Dale, Anders [Vis alle 14 forfattere av denne artikkelen] (2019). Pupillary dilation responses as a midlife indicator of risk for Alzheimer's disease: association with Alzheimer's disease polygenic risk. Neurobiology of Aging. ISSN 0197-4580. 83, s. 114–121. doi: 10.1016/j.neurobiolaging.2019.09.001.
• van der Meer, Dennis; Sønderby, Ida Elken; Kaufmann, Tobias; Walters, G. Bragi; Abdellaoui, Abdel & Ames, David [Vis alle 132 forfattere av denne artikkelen] (2019). Association of copy number variation of the 15q11.2 BP1-BP2 region with cortical and subcortical morphology and cognition. JAMA psychiatry. ISSN 2168-6238. doi: 10.1001/jamapsychiatry.2019.3779. Vis sammendrag

  IMPORTANCE: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities. OBJECTIVE: To determine the association of the 15q11.2 BP1-BP2 deletion and duplication CNVs with cortical and subcortical brain morphology and cognitive task performance. DESIGN, SETTING, AND PARTICIPANTS: In this genetic association study, T1-weighted brain magnetic resonance imaging were combined with genetic data from the ENIGMA-CNV consortium and the UK Biobank, with a replication cohort from Iceland. In total, 203 deletion carriers, 45 247 noncarriers, and 306 duplication carriers were included. Data were collected from August 2015 to April 2019, and data were analyzed from September 2018 to September 2019. MAIN OUTCOMES AND MEASURES: The associations of the CNV with global and regional measures of surface area and cortical thickness as well as subcortical volumes were investigated, correcting for age, age2 , sex, scanner, and intracranial volume. Additionally, measures of cognitive ability were analyzed in the full UK Biobank cohort. RESULTS: Of 45 756 included individuals, the mean (SD) age was 55.8 (18.3) years, and 23 754 (51.9%) were female. Compared with noncarriers, deletion carriers had a lower surface area (Cohen d = −0.41; SE, 0.08; P = 4.9 × 10−8), thicker cortex (Cohen d = 0.36; SE, 0.07; P = 1.3 × 10−7), and a smaller nucleus accumbens (Cohen d = −0.27; SE, 0.07; P = 7.3 × 10−5). There was also a significant negative dose response on cortical thickness (β = −0.24; SE, 0.05; P = 6.8 × 10−7). Regional cortical analyses showed a localization of the effects to the frontal, cingulate, and parietal lobes. Further, cognitive ability was lower for deletion carriers compared with noncarriers on 5 of 7 tasks. CONCLUSIONS AND RELEVANCE: These findings, from the largest CNV neuroimaging study to date, provide evidence that 15q11.2 BP1-BP2 structural variation is associated with brain morphology and cognition, with deletion carriers being particularly affected. The pattern of results fits with known molecular functions of genes in the 15q11.2 BP1-BP2 region and suggests involvement of these genes in neuronal plasticity. These neurobiological effects likely contribute to the association of this CNV with neurodevelopmental disorders

• Hoogman, Martine; Muetzel, Ryan; Guimãraes, João-Tiago; Shumskaya, Elena; Mennes, Maarten & Zwiers, Marcel P. [Vis alle 115 forfattere av denne artikkelen] (2019). Brain imaging of the cortex in ADHD: A coordinated analysis of large-scale clinical and population-based samples. American Journal of Psychiatry. ISSN 0002-953X. 176(7), s. 531–542. doi: 10.1176/appi.ajp.2019.18091033.
• Ousdal, Olga Therese; Argyelan, Miklos; Narr, Katherine L.; Abbott, Christopher; Wade, Benjamin & Vandenbulcke, Mathieu [Vis alle 34 forfattere av denne artikkelen] (2019). Brain changes induced by electroconvulsive therapy are broadly distributed. Biological Psychiatry. ISSN 0006-3223. 87(5), s. 451–461. doi: 10.1016/j.biopsych.2019.07.010. Fulltekst i vitenarkiv
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Shadrin, Alexey A.; O`Connell, Kevin; Fan, Chun Chieh & Bahrami, Shahram [Vis alle 11 forfattere av denne artikkelen] (2019). Discovery of shared genomic loci using the conditional false discovery rate approach. Human Genetics. ISSN 0340-6717. s. 1–10. doi: 10.1007/s00439-019-02060-2. Fulltekst i vitenarkiv
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Fan, Chun-Chieh; Shadrin, Alexey A.; Dale, Anders & Andreassen, Ole Andreas (2019). The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges. Psychiatric Genetics. ISSN 0955-8829. 29(5), s. 152–159. doi: 10.1097/YPG.0000000000000234. Fulltekst i vitenarkiv Vis sammendrag

  Genome-wide association studies have transformed psychiatric genetics and provided novel insights into the genetic etiology of psychiatric disorders. Two major discoveries have emerged; the disorders are polygenic, with a large number of common variants each with a small effect and many genetic variants influence more than one phenotype, suggesting shared genetic etiology. These concepts have the potential to revolutionize the current classification system with diagnostic categories and facilitate development of better treatments. However, to reach clinical impact, we need larger samples and better analytical tools, as most polygenic factors remain undetected. We here present statistical approaches designed to improve the yield of existing genome-wide association studies for polygenic phenotypes. We review how these tools have informed the current knowledge on the genetic architecture of psychiatric disorders, focusing on schizophrenia, bipolar disorder and major depression, and overlap with psychological and cognitive traits. We discuss application of statistical tools for stratification and prediction.

• Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette & Agartz, Ingrid [Vis alle 84 forfattere av denne artikkelen] (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience. ISSN 1097-6256. 22(10), s. 1617–1623. doi: 10.1038/s41593-019-0471-7. Fulltekst i vitenarkiv
• Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J.; McQuillin, Andrew; Ripke, Stephan & Trubetskoy, Vassily [Vis alle 277 forfattere av denne artikkelen] (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics. ISSN 1061-4036. 51(5), s. 793–803. doi: 10.1038/s41588-019-0397-8. Fulltekst i vitenarkiv
• Frei, Oleksandr; Holland, Dominic; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Fan, Chun Chieh & Mæland, Steffen [Vis alle 12 forfattere av denne artikkelen] (2019). Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation. Nature Communications. ISSN 2041-1723. 10(1). doi: 10.1038/s41467-019-10310-0. Fulltekst i vitenarkiv
• Tan, Chin Hong; Bonham, Luke W.; Fan, Chun Chieh; Mormino, Elizabeth C.; Sugrue, Leo P. & Broce, Iris J. [Vis alle 24 forfattere av denne artikkelen] (2019). Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration. Brain. ISSN 0006-8950. 142(2), s. 460–470. doi: 10.1093/brain/awy327.
• Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Hagen, Espen; Næss, Solveig & Ness, Torbjørn V [Vis alle 16 forfattere av denne artikkelen] (2019). Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations. Cerebral Cortex. ISSN 1047-3211. 29(2), s. 875–891. doi: 10.1093/cercor/bhy291. Fulltekst i vitenarkiv
• Karunamuni, Roshan A.; White, Nathan S.; Fromm, Annette; Moen, Gunnar; Grüner, Renate & Dale, Anders [Vis alle 7 forfattere av denne artikkelen] (2019). Improved characterization of cerebral infarction using combined tissue T2 and high b-value diffusion MRI in post-thrombectomy patients: a feasibility study. Acta Radiologica. ISSN 0284-1851. 60(10), s. 1294–1300. doi: 10.1177/0284185118820063.
• Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree & Frei, Oleksandr [Vis alle 52 forfattere av denne artikkelen] (2019). Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes. Frontiers in Neuroscience. ISSN 1662-4548. 13. doi: 10.3389/fnins.2019.00220. Fulltekst i vitenarkiv Vis sammendrag

  Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD and BIP are related. However, it is not established if this relation is of genetic origin. Here, we applied statistical methods based on the conditional false discovery rate (FDR) framework to detect genetic overlap between AD and BIP and utilized this overlap to increase the power to identify common genetic variants associated with either or both traits. Methods: We obtained genome wide association studies data from the International Genomics of Alzheimer’s Project part 1 (17,008 AD cases and 37,154 controls) and the Psychiatric Genetic Consortium Bipolar Disorder Working Group (20,352 BIP cases and 31,358 controls). We used conditional QQ-plots to assess overlap in common genetic variants between AD and BIP. We exploited the genetic overlap to re-rank test-statistics for AD and BIP and improve detection of genetic variants using the conditional FDR framework. Results: Conditional QQ-plots demonstrated a polygenic overlap between AD and BIP. Using conditional FDR, we identified one novel genomic locus associated with AD, and nine novel loci associated with BIP. Further, we identified two novel loci jointly associated with AD and BIP implicating the MARK2 gene (lead SNP rs10792421, conjunctional FDR = 0.030, same direction of effect) and the VAC14 gene (lead SNP rs11649476, conjunctional FDR = 0.022, opposite direction of effect). Conclusion: We found polygenic overlap between AD and BIP and identified novel loci for each trait and two jointly associated loci. Further studies should examine if the shared loci implicating the MARK2 and VAC14 genes could explain parts of the shared and distinct features of AD and BIP.

• Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; O`Connell, Kevin & Savage, Jeanne E. [Vis alle 15 forfattere av denne artikkelen] (2019). Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence. Molecular Psychiatry. ISSN 1359-4184. s. 1–10. doi: 10.1038/s41380-018-0332-x. Fulltekst i vitenarkiv
• Sowa, Piotr; Harbo, Hanne Flinstad; White, Nathan S.; Celius, Elisabeth Gulowsen; Bartsch, Hauke & Berg-Hansen, Pål [Vis alle 12 forfattere av denne artikkelen] (2018). Restriction spectrum imaging of white matter and its relation to neurological disability in multiple sclerosis. Multiple Sclerosis. ISSN 1352-4585. s. 1–12. doi: 10.1177/1352458518765671. Fulltekst i vitenarkiv
• Broce, Iris J.; Tan, Chin Hong; Fan, CC; Jansen, Iris E.; Savage, Jeanne E. & Witoelar, Aree [Vis alle 34 forfattere av denne artikkelen] (2018). Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathologica. ISSN 0001-6322. doi: 10.1007/s00401-018-1928-6.
• Bonham, Luke W.; Karch, Celeste M.; Fan, Chun C.; Tan, Chin; Geier, Ethan G. & Wang, Yunpeng [Vis alle 25 forfattere av denne artikkelen] (2018). CXCR4 involvement in neurodegenerative diseases. Translational Psychiatry. ISSN 2158-3188. 8:73, s. 1–10. doi: 10.1038/s41398-017-0049-7. Fulltekst i vitenarkiv
• Vojinovic, Dina; Adams, Hieab H.; Jian, Xueqiu; Yang, Qiong; Smith, Albert Vernon & Bis, Joshua C. [Vis alle 91 forfattere av denne artikkelen] (2018). Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Nature Communications. ISSN 2041-1723. 9:3945, s. 1–11. doi: 10.1038/s41467-018-06234-w. Fulltekst i vitenarkiv
• Li, Yi; Barkovich, Matthew J.; Karch, Celeste M.; Nillo, Ryan M.; Fan, Chun-Chieh & Broce, Iris J. [Vis alle 25 forfattere av denne artikkelen] (2018). Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex. Scientific Reports. ISSN 2045-2322. 8:13373, s. 1–10. doi: 10.1038/s41598-018-31075-4. Fulltekst i vitenarkiv
• Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; Yokoyama, Jennifer S.; Kouri, Naomi & Ross, Owen A. [Vis alle 21 forfattere av denne artikkelen] (2018). Selective genetic overlap between amyotrophic lateral sclerosis and diseases of the frontotemporal dementia spectrum. JAMA Neurology. ISSN 2168-6149. 75(7), s. 860–875. doi: 10.1001/jamaneurol.2018.0372.
• Srinivasan, Saurabh; Bettella, Francesco; Frei, Oleksandr; Hill, W. David; Wang, Yunpeng & Witoelar, Aree [Vis alle 17 forfattere av denne artikkelen] (2018). Enrichment of genetic markers of recent human evolution in educational and cognitive traits. Scientific Reports. ISSN 2045-2322. 8:12585, s. 1–9. doi: 10.1038/s41598-018-30387-9. Fulltekst i vitenarkiv
• Oltedal, Leif; Narr, Katherine L.; Abbott, Christopher; Anand, Amit; Argyelan, Miklos & Bartsch, Hauke [Vis alle 26 forfattere av denne artikkelen] (2018). Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy. Biological Psychiatry. ISSN 0006-3223. 84(8), s. 574–581. doi: 10.1016/j.biopsych.2018.05.017.
• Van Erp, Theo G.M.; Walton, Esther; Hibar, Derrek; Schmaal, Lianne; Jiang, Wenhao & Glahn, David C. [Vis alle 151 forfattere av denne artikkelen] (2018). Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2018.04.023. Fulltekst i vitenarkiv
• Logue, Mark W.; Panizzon, Matthew S.; Elman, Jeremy A.; Gillespie, Nathan A.; Hatton, Sean N. & Gustavson, Daniel E. [Vis alle 14 forfattere av denne artikkelen] (2018). Use of an Alzheimer's disease polygenic risk score to identify mild cognitive impairment in adults in their 50s. Molecular Psychiatry. ISSN 1359-4184. s. 1–10. doi: 10.1038/s41380-018-0030-8.
• Fan, Chun Chieh; Smeland, Olav Bjerkehagen; Schork, Andrew J.; Chen, Chi-Hua; Holland, Dominic & Lo, Min-Tzu [Vis alle 11 forfattere av denne artikkelen] (2018). Beyond heritability: Improving discoverability in imaging genetics. Human Molecular Genetics. ISSN 0964-6906. 27(1), s. R22–R28. doi: 10.1093/hmg/ddy082.
• Fan, Chun Chieh; Schork, Andrew J.; Brown, Timothy T.; Spencer, Barbara E.; Akshoomoff, Natacha & Chen, Chi-Hua [Vis alle 16 forfattere av denne artikkelen] (2018). Williams Syndrome neuroanatomical score associates with GTF2IRD1 in large-scale magnetic resonance imaging cohorts: A proof of concept for multivariate endophenotypes. Translational Psychiatry. ISSN 2158-3188. 8:114(1), s. 1–8. doi: 10.1038/s41398-018-0166-y. Fulltekst i vitenarkiv
• Thunemann, Martin; Lu, Yichen; Liu, Xin; Kılıç, Kıvılcım; Desjardins, Michèle & Vandenberghe, Matthieu [Vis alle 16 forfattere av denne artikkelen] (2018). Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays. Nature Communications. ISSN 2041-1723. 9:2015, s. 1–12. doi: 10.1038/s41467-018-04457-5. Fulltekst i vitenarkiv
• Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle & Hill, W. David [Vis alle 221 forfattere av denne artikkelen] (2018). Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications. ISSN 2041-1723. 9(2098), s. 1–16. doi: 10.1038/s41467-018-04362-x. Fulltekst i vitenarkiv
• Ringstad, Geir; Valnes, Lars Magnus; Dale, Anders; Pripp, Are Hugo; Vatnehol, Svein Are Sirirud & Emblem, Kyrre Eeg [Vis alle 8 forfattere av denne artikkelen] (2018). Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. Journal of Clinical Investigation. ISSN 0021-9738. 3(13), s. 1–16. doi: 10.1172/jci.insight.121537. Fulltekst i vitenarkiv
• Kong, Xiang-Zhen; Mathias, Samuel R.; Guadalupe, Tulio; Agartz, Ingrid; Andreassen, Ole Andreas & Bøen, Erlend [Vis alle 33 forfattere av denne artikkelen] (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 115(22), s. E5154–E5163. doi: 10.1073/pnas.1718418115.
• Broce, Iris J.; Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; Wang, Yunpeng & Hong Tan, Chin [Vis alle 29 forfattere av denne artikkelen] (2018). Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. PLoS Medicine. ISSN 1549-1277. 15:e1002487(1), s. 1–20. doi: 10.1371/journal.pmed.1002487. Fulltekst i vitenarkiv
• Zuber, Verena; Jönsson, Erik Gunnar; Frei, Oleksandr; Witoelar, Aree; Thompson, Wesley Kurt & Schork, Andrew J. [Vis alle 18 forfattere av denne artikkelen] (2018). Identification of shared genetic variants between schizophrenia and lung cancer. Scientific Reports. ISSN 2045-2322. 674(8), s. 1–8. doi: 10.1038/s41598-017-16481-4. Fulltekst i vitenarkiv
• Seibert, Tyler M.; Fan, Chun Chieh; Wang, Yunpeng; Zuber, Verena; Karunamuni, Roshan & Parsons, J. Kellogg [Vis alle 62 forfattere av denne artikkelen] (2018). Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. The BMJ. ISSN 1756-1833. 360:j5757, s. 1–7. doi: 10.1136/bmj.j5757. Fulltekst i vitenarkiv
• Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Zayats, Tetyana; Schork, Andrew J; Frei, Oleksandr & Bettella, Francesco [Vis alle 19 forfattere av denne artikkelen] (2017). Novel loci associated with attention-deficit/hyperactivity disorder are revealed by leveraging polygenic overlap with educational attainment. Journal of the American Academy of Child and Adolescent Psychiatry. ISSN 0890-8567. 57(2), s. 86–95. doi: 10.1016/j.jaac.2017.11.013. Fulltekst i vitenarkiv
• Tan, Chin Hong; Fan, Chun Chieh; Mormino, Elizabeth C.; Sugrue, Leo P.; Broce, Iris J. & Hess, Christopher P. [Vis alle 23 forfattere av denne artikkelen] (2017). Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathologica. ISSN 0001-6322. 135(1), s. 85–93. doi: 10.1007/s00401-017-1789-4.
• Chen, Chi-Hua; Wang, Yunpeng; Lo, Min-Tzu; Schork, Andrew; Fan, Chun-Chieh & Holland, Dominic [Vis alle 15 forfattere av denne artikkelen] (2017). Leveraging genome characteristics to improve gene discovery for putamen subcortical brain structure. Scientific Reports. ISSN 2045-2322. 7:15736, s. 1–9. doi: 10.1038/s41598-017-15705-x.
• Næss, Solveig; Chintaluri, Chaitanya; Ness, Torbjørn Vefferstad; Dale, Anders; Einevoll, Gaute & Wójcik, Daniel K. (2017). Corrected four-sphere head model for EEG signals. Frontiers in Human Neuroscience. ISSN 1662-5161. 11, s. 1–7. doi: 10.3389/fnhum.2017.00490. Fulltekst i vitenarkiv Vis sammendrag

  The EEG signal is generated by electrical brain cell activity, often described in terms of current dipoles. By applying EEG forward models we can compute the contribution from such dipoles to the electrical potential recorded by EEG electrodes. Forward models are key both for generating understanding and intuition about the neural origin of EEG signals as well as inverse modeling, i.e., the estimation of the underlying dipole sources from recorded EEG signals. Different models of varying complexity and biological detail are used in the field. One such analytical model is the four-sphere model which assumes a four-layered spherical head where the layers represent brain tissue, cerebrospinal fluid (CSF), skull, and scalp, respectively. While conceptually clear, the mathematical expression for the electric potentials in the four-sphere model is cumbersome, and we observed that the formulas presented in the literature contain errors. Here, we derive and present the correct analytical formulas with a detailed derivation. A useful application of the analytical four-sphere model is that it can serve as ground truth to test the accuracy of numerical schemes such as the Finite Element Method (FEM). We performed FEM simulations of the four-sphere head model and showed that they were consistent with the corrected analytical formulas. For future reference we provide scripts for computing EEG potentials with the four-sphere model, both by means of the correct analytical formulas and numerical FEM simulations.

• Tan, Chin Hong; Hyman, Bradley T.; Tan, Jacinth J.X.; Hess, Christopher P.; Dillon, William P. & Schellenberg, Gerard D. [Vis alle 14 forfattere av denne artikkelen] (2017). Polygenic hazard scores in preclinical Alzheimer disease. Annals of Neurology. ISSN 0364-5134. 82(3), s. 484–488. doi: 10.1002/ana.25029.
• Smeland, Olav Bjerkehagen; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hibar, Derrek P & Franke, Barbara [Vis alle 13 forfattere av denne artikkelen] (2017). Genetic overlap between schizophrenia and volumes of hippocampus, putamen, and intracranial volume indicates shared molecular genetic mechanisms. Schizophrenia Bulletin. ISSN 0586-7614. 44(4), s. 854–864. doi: 10.1093/schbul/sbx148.
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Kauppi, Karolina; Hill, W. David; Li, Wen & Wang, Yunpeng [Vis alle 22 forfattere av denne artikkelen] (2017). Identification of genetic loci jointly influencing schizophrenia risk and the cognitive traits of verbal-numerical reasoning, reaction time, and general cognitive function. JAMA psychiatry. ISSN 2168-6238. 74(10), s. 1065–1075. doi: 10.1001/jamapsychiatry.2017.1986. Fulltekst i vitenarkiv
• Desikan, Rahul S.; Fan, Chun Chieh; Wang, Yunpeng; Schork, Andrew J; Cabral, Howard J & Cupples, L. Adrienne [Vis alle 34 forfattere av denne artikkelen] (2017). Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. Nature Methods. ISSN 1548-7091. 14(3:e1002258), s. 1–17. doi: 10.1371/journal.pmed.1002258.
• Witoelar, Aree; Jansen, Iris E.; Wang, Yunpeng; Desikan, Rahul S.; Gibbs, J. Raphael & Thompson, Wesley Kurt [Vis alle 26 forfattere av denne artikkelen] (2017). Genome-wide pleiotropy between Parkinson disease and autoimmune diseases. JAMA Neurology. ISSN 2168-6149. 74(7), s. 780–792. doi: 10.1001/jamaneurol.2017.0469.
• Hoogman, Martine; Bralten, Janita; Hibar, Derrek; Mennes, Maarten; Zwiers, Marcel P. & Schweren, Lizanne S.J. [Vis alle 82 forfattere av denne artikkelen] (2017). Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis. The Lancet Psychiatry. ISSN 2215-0374. 4(4), s. 310–319. doi: 10.1016/S2215-0366(17)30049-4.
• Ferrari, Raffaele; Wang, Yunpeng; Vandrovcova, Jana; Guelfi, Sebastian; Witoelar, Aree & Karch, Celeste M. [Vis alle 22 forfattere av denne artikkelen] (2017). Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. Journal of Neurology, Neurosurgery and Psychiatry. ISSN 0022-3050. 88(2), s. 152–164. doi: 10.1136/jnnp-2016-314411.
• Yokoyama, Jennifer S.; Karch, Celeste M.; Fan, Chun C.; Bonham, Luke W.; Kouri, Naomi & Ross, Owen A. [Vis alle 31 forfattere av denne artikkelen] (2017). Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta Neuropathologica. ISSN 0001-6322. 133(5), s. 825–837. doi: 10.1007/s00401-017-1693-y.
• Devor, Anna; Andreassen, Ole Andreas; Wang, Yunpeng; Mäki-Marttunen, Tuomo; Smeland, Olav Bjerkehagen & Fan, Chun Chieh [Vis alle 18 forfattere av denne artikkelen] (2017). Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia. Molecular Psychiatry. ISSN 1359-4184. 22(6), s. 792–801. doi: 10.1038/mp.2017.33. Fulltekst i vitenarkiv
• Smeland, Olav Bjerkehagen; Wang, Yunpeng; Lo, Min-Tzu; Li, Wen; Frei, Oleksandr & Witoelar, Aree [Vis alle 13 forfattere av denne artikkelen] (2017). Identification of genetic loci shared between schizophrenia and the Big Five personality traits. Scientific Reports. ISSN 2045-2322. 7:2222(1), s. 1–9. doi: 10.1038/s41598-017-02346-3. Fulltekst i vitenarkiv
• Srinivasan, Saurabh; Bettella, Francesco; Hassani, Sahar; Wang, Yunpeng; Witoelar, Aree & Schork, Andrew J. [Vis alle 13 forfattere av denne artikkelen] (2017). Probing the association between early evolutionary markers and schizophrenia. PLOS ONE. ISSN 1932-6203. 12:e0169227(1), s. 1–15. doi: 10.1371/journal.pone.0169227.
• Hibar, Derrek; Adams, Hieab H.H.; Jahanshad, Neda; Chauhan, Ganesh; Stein, Jason L. & Hofer, Edith [Vis alle 332 forfattere av denne artikkelen] (2017). Novel genetic loci associated with hippocampal volume. Nature Communications. ISSN 2041-1723. 8:13624, s. 1–12. doi: 10.1038/ncomms13624. Fulltekst i vitenarkiv
• Le Hellard, Stephanie; Wang, Yunpeng; Witoelar, Aree; Zuber, Verena; Bettella, Francesco & Hugdahl, Kenneth [Vis alle 15 forfattere av denne artikkelen] (2017). Identification of gene loci that overlap between schizophrenia and educational attainment. Schizophrenia Bulletin. ISSN 0586-7614. 43(3), s. 654–664. doi: 10.1093/schbul/sbw085.
• Lo, Min-Tzu; Hinds, David A; Tung, Joyce Y.; Franz, Carol E.; Fan, Chun Chieh & Wang, Yunpeng [Vis alle 22 forfattere av denne artikkelen] (2016). Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nature Genetics. ISSN 1061-4036. 49(1), s. 152–156. doi: 10.1038/ng.3736.
• Hope, Tuva Roaldsdatter; White, Nathan S.; Kuperman, Joshua; Chao, Ying; Yamin, Ghiam & Bartch, Hauke [Vis alle 13 forfattere av denne artikkelen] (2016). Demonstration of non-gaussian restricted diffusion in tumor cells using diffusion time-dependent diffusion-weighted magnetic resonance imaging contrast. Frontiers in Oncology. ISSN 2234-943X. 6:179. doi: 10.3389/fonc.2016.00179. Fulltekst i vitenarkiv
• Uhlirova, Hana; Kılıç, Kıvılcım; Tian, Peifang; Sakadžić, Sava; Gagnon, Louis & Thunemann, Martin [Vis alle 23 forfattere av denne artikkelen] (2016). The roadmap for estimation of cell-typespecific neuronal activity from noninvasive measurements. Philosophical Transactions of the Royal Society of London. Biological Sciences. ISSN 0962-8436. 371(1705). doi: 10.1098/rstb.2015.0356.
• Walhovd, Kristine B; Krogsrud, Stine Kleppe; Amlien, Inge Kasbohm; Bartsch, Hauke; Bjørnerud, Atle & Due-Tønnessen, Paulina [Vis alle 22 forfattere av denne artikkelen] (2016). Neurodevelopmental origins of lifespan changes in brain and cognition. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 113(33), s. 9357–9362. doi: 10.1073/pnas.1524259113. Fulltekst i vitenarkiv

Se alle arbeider i Cristin

• Einevoll, Gaute Tomas; Pettersen, Klas Henning; Sæbø, Solve; Stensola, Hanne & Dale, Anders (2023). On neuro-AI. [Internett]. Podcast "Vett og vitenskap".
• Ditmars, Hillary L.; Logue, Mark W.; Toomey, Rosemary; Mckenzie, Ruth E.; Franz, Carol E. & Panizzon, Matthew S. [Vis alle 27 forfattere av denne artikkelen] (2022). Erratum: Associations Between Depression and Cardiometabolic Health: A 27-Year Longitudinal Study (Cambridge University (2021) DOI: 10.1017/S003329172000505X). Psychological Medicine. ISSN 0033-2917. 52(14). doi: 10.1017/S0033291722003105.
• Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette & Agartz, Ingrid [Vis alle 97 forfattere av denne artikkelen] (2020). Publisher Correction: Common brain disorders are associated with heritable patterns of apparent aging of the brain (Nature Neuroscience, (2019), 22, 10, (1617-1623), 10.1038/s41593-019-0471-7). Nature Neuroscience. ISSN 1097-6256. 23(2). doi: 10.1038/s41593-019-0553-6.
• Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle & Hill, W. David [Vis alle 222 forfattere av denne artikkelen] (2019). Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (Nature Communications, (2018), 9, 1, (2098), 10.1038/s41467-018-04362-x). Nature Communications. ISSN 2041-1723. 10(1). doi: 10.1038/s41467-019-10160-w.
• Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; Savage, Jeanne E. & Watanabe, Kyoko [Vis alle 14 forfattere av denne artikkelen] (2018). Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder and intelligence .
• Smeland, Olav Bjerkehagen; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hibar, Derrek & Franke, Barbara [Vis alle 13 forfattere av denne artikkelen] (2017). Conditional false discovery rate analysis of genome-wide association studies uncovers genetic loci shared between schizophrenia and volumes of hippocampus, putamen and intracranial volume.
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Fan, Chun Chieh; Shadrin, Alexey A. & Li, Wen [Vis alle 13 forfattere av denne artikkelen] (2017). C-Reactive Protein Levels and Schizophrenia Share Genetic Influences.
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Fan, Chun Chieh; Alexey, Shadrin & Li, Wen [Vis alle 13 forfattere av denne artikkelen] (2017). Increased discovery of risk loci for bipolar disorder by leveraging prior probabilities of true associations using the covariate modulated mixture model (CM3).
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Dale, Anders & Andreassen, Ole Andreas (2017). Combined Analysis of Large Genetic Samples. New Statistical Approaches Improve Gene Discovery.
• Smeland, Olav Bjerkehagen; Kauppi, Karolina; Wang, Yunpeng; Frei, Oleksandr; Li, Wen & Hill, David W [Vis alle 17 forfattere av denne artikkelen] (2016). Schizophrenia and general cognitive function share genetic influences.
• Smeland, Olav Bjerkehagen; Witoelar, Aree; Wang, Yunpeng; Chen, Chi-Hua; Djurovic, Srdjan & Dale, Anders [Vis alle 7 forfattere av denne artikkelen] (2016). Genetic overlap between schizophrenia and brain structural volumes indicates shared molecular genetic mechanisms with potential relevance for antipsychotics .

Se alle arbeider i Cristin