Asle Wilhelm Medhus

• Wiken, Thea H.; Høivik, Marte Lie; Anisdahl, Karoline; Buer, Lydia Celine Tansem; Warren, David & Bolstad, Nils [Vis alle 9 forfattere av denne artikkelen] (2024). Subcutaneous Vedolizumab Treatment in a Real-World Inflammatory Bowel Disease Cohort Switched From Intravenous Vedolizumab: Eighteen-Month Prospective Follow-up Study. Crohn's & Colitis 360. ISSN 2631-827X. 6(1). doi: 10.1093/crocol/otae013.
• Anisdahl, Karoline; Lirhus, Sandre Svatun; Medhus, Asle Wilhelm; Moum, Bjørn Allan; Melberg, Hans Olav & Høivik, Marte Lie (2024). Frailty risk and treatment strategy in elderly-onset inflammatory bowel disease. A Norwegian nationwide population-based registry study. Digestive and Liver Disease. ISSN 1590-8658. doi: 10.1016/j.dld.2024.02.002.
• Zerouga, Insaf; Valeur, Jørgen; Sommer, Christine; Småstuen, Milada Cvancarova; Medhus, Asle Wilhelm & Lund, Charlotte [Vis alle 22 forfattere av denne artikkelen] (2024). Dietary intake and nutritional status in patients with newly diagnosed inflammatory bowel disease: insights from the IBSEN III study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. s. 1–9. doi: 10.1080/00365521.2024.2313056. Vis sammendrag

  Background: Dietary recommendations in inflammatory bowel disease (IBD) are inconclusive, and patients may follow restrictive diets with increased risk of malnutrition. The aim of this study was to compare dietary intakes and nutritional status in men and women with newly diagnosed IBD with a general population sample, and to investigate whether intakes were in line with the Nordic Nutrition Recommendations. Methods: This was a cross-sectional study including adults≥ 40 years with IBD from the Inflammatory Bowel Disease in South-Eastern Norway (IBSEN) III cohort study. A validated food frequency questionnaire (FFQ) was used in dietary data collection, and a sample from the seventh survey of the Tromsø Study was included as a comparison group. Results: A total of 227 men and women with IBD were included. IBD patients had higher intake of grain products, sweetened beverages, energy, fat and polyunsaturated fat (PUFA), but lower intake of dairy products, alcohol and iodine compared to adults from the comparison sample (p < 0.01). Intakes of saturated fat and carbohydrates in both genders, and vitamin D in women were not within recommended levels. Anemia and hypoalbuminemia were more prevalent in IBD patients than in the comparison sample. Conclusions: Dietary intakes in newly diagnosed IBD patients were mostly in line with Nordic Nutrition Recommendations. Higher proportion of IBD patients exceeded recommended allowances of fat and added sugar than the comparison sample. Insufficient micronutrient intake, anemia and hypoalbuminemia are present challenges in IBD patients that require monitoring.

• Mikalsen, Ina; Breder, Sigurd; Medhus, Asle Wilhelm; Folseraas, Trine; Aabakken, Lars & Ånonsen, Kim Vidar (2023). ERCP for the initial management of malignant biliary obstruction–real world data on 596 procedures. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. doi: 10.1080/00365521.2023.2282375. Fulltekst i vitenarkiv
• Evensen, Helge; Sandstad, Olav; Larssen, Lene; Hagen, Milada ; Kristensen, Vendel Ailin & Søvik, Torgeir Thorson [Vis alle 9 forfattere av denne artikkelen] (2023). Intraoperative distensibility measurement in POEM for achalasia: impact on patient outcome and associations with other outcome variables at 1-year follow-up. Surgical Endoscopy. ISSN 0930-2794. 37, s. 9283–9290. doi: 10.1007/s00464-023-10494-z. Fulltekst i vitenarkiv
• Svanevik, Marius; Lorentzen, Jolanta Halabowska; Borgeraas, Heidi; Sandbu, Rune; Seip, Birgitte Karen Berggreen & Medhus, Asle Wilhelm [Vis alle 11 forfattere av denne artikkelen] (2023). Patient-reported outcomes, weight loss, and remission of type 2 diabetes 3 years after gastric bypass and sleeve gastrectomy (Oseberg); a single-centre, randomised controlled trial. The Lancet Diabetes and Endocrinology. ISSN 2213-8587. 11(8), s. 555–566. doi: 10.1016/S2213-8587(23)00127-4. Vis sammendrag

  Little is known about the comparative effects of various bariatric procedures on patient-reported outcomes. We aimed to compare 3-year effects of gastric bypass and sleeve gastrectomy on patient-reported outcome measures in patients with obesity and type 2 diabetes. Methods The Oseberg trial was a single-centre, parallel-group, randomised trial at Vestfold Hospital Trust, a public tertiary obesity centre in Tønsberg, Norway. Eligible patients were aged 18 years or older with previously verified BMI 35·0 kg/m 2 or greater. Diabetes was diagnosed if glycated haemoglobin was at least 6·5% (48 mmol/mol) or by their use of anti-diabetic medications with glycated haemoglobin at least 6·1% (43 mmol/mol). Eligible patients were randomly assigned (1:1) to gastric bypass or sleeve gastrectomy. All patients received identical preoperative and postoperative treatment. Randomisation was done with a computerised random number generator and a block size of ten. Study personnel, patients, and the primary outcome assessor were blinded to allocations for 1 year. The prespecified secondary outcomes reported here were 3-year changes in several clinically important patient-reported outcomes, weight loss, and diabetes remission. Analyses were done in the intention to treat population. This trial is ongoing, closed to recruitment and is registered with ClinicalTrials.gov , NCT01778738 . Findings Between Oct 15, 2012 and Sept 1, 2017, 319 consecutive patients with type 2 diabetes scheduled for bariatric surgery were assessed for eligibility. 101 patients were not eligible (29 did not have type 2 diabetes according to inclusion criteria and 72 other exclusion criteria) and 93 declined to participate. 109 patients were enrolled and randomly assigned to sleeve gastrectomy (n=55) or gastric bypass (n=54). 72 (66%) of 109 patients were female and 37 (34%) were male. 104 (95%) of patients were White. 16 patients were lost to follow up and 93 (85%) patients completed the 3-year follow-up. Three additional patients were contacted by phone for registration of comorbidities Compared with sleeve gastrectomy, gastric bypass was associated with a greater improvement in weight-related quality of life (between group difference 9·4, 95% CI 3·3 to 15·5), less reflux symptoms (0·54, 0·17 to –0·90), greater total bodyweight loss (8% difference, 25% vs 17%), and a higher probability of diabetes remission (67% vs 33%, risk ratio 2·00; 95% CI 1·27 to 3·14). Five patients reported postprandial hypoglycaemia in the third year after gastric bypass versus none after sleeve-gastrectomy (p=0·059). Symptoms of abdominal pain, indigestion, diarrhoea, dumping syndrome, depression, binge eating, and appetitive drive did not differ between groups. Interpretation At 3 years, gastric bypass was superior to sleeve gastrectomy in patients with type 2 diabetes and obesity regarding weight related quality of life, reflux symptoms, weight loss, and remission of diabetes, while symptoms of abdominal pain, indigestion, diarrhoea, dumping, depression and binge eating did not differ between groups. This new patient-reported knowledge can be used in the shared decision-making process to inform patients about similarities and differences between expected outcomes after the two surgical procedures.

• Holten, Kristina Ingeborg; Bernklev, Tomm; Opheim, Randi; Johansen, Ingunn; Olsen, Bjørn Christian Elias Grova & Lund, Charlotte [Vis alle 22 forfattere av denne artikkelen] (2023). Fatigue in Patients with Newly Diagnosed Inflammatory Bowel Disease: Results from a Prospective Inception Cohort, the IBSEN III Study. Journal of Crohn's and Colitis. ISSN 1873-9946. 17(11), s. 1781–1790. doi: 10.1093/ecco-jcc/jjad094. Fulltekst i vitenarkiv
• Helm, Thea Elisabeth; Høivik, Marte Lie; Buer, Lydia Celine Tansem; Warren, David; Bolstad, Nils & Moum, Bjørn Allan [Vis alle 9 forfattere av denne artikkelen] (2023). Switching from intravenous to subcutaneous vedolizumab maintenance treatment in patients with inflammatory bowel disease followed by therapeutic drug monitoring. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 58(8), s. 863–873. doi: 10.1080/00365521.2023.2176252. Fulltekst i vitenarkiv
• Jørgensen, Kristin Kaasen; Høivik, Marte Lie; Chopra, Adity; Saltyte Benth, Jurate; Ricanek, Petr & Moum, Bjørn Allan [Vis alle 18 forfattere av denne artikkelen] (2023). Humoral immune response to SARS-CoV-2 vaccination in patients with inflammatory bowel disease on immunosuppressive medication: association to serum drug levels and disease type. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 58(8), s. 874–882. doi: 10.1080/00365521.2023.2177884. Fulltekst i vitenarkiv
• Evensen, Helge; Hjermstad, Marianne Jensen; Småstuen, Milada Cvancarova; Kristensen, Vendel Ailin; Larssen, Lene & Skattum, Jorunn Pettersen [Vis alle 9 forfattere av denne artikkelen] (2022). Quality of life in patients with achalasia: Associations with Eckardt score and objective treatment outcomes after peroral endoscopic myotomy. Endoscopy International Open. ISSN 2196-9736. 10(12). doi: 10.1055/a-1968-7682. Fulltekst i vitenarkiv Vis sammendrag

  Background and study aims Knowledge on self-reported quality of life (QoL) in achalasia and QoL improvements after peroral endoscopic myotomy (POEM) is limited. Furthermore, the clinical role of QoL in achalasia follow-up has not been evaluated. The present study aimed to examine QoL in achalasia patients before and after POEM and assess associations between QoL, Eckardt score (ES) and objective results. Patients and methods This was a single-center prospective study of treatment-naïve achalasia patients with 12-month follow-up after POEM including manometry, upper endoscopy, 24-hour pH registration, and timed barium esophagogram. QoL data were registered using European Organisation for Research and Treatment of Cancer core questionnaire (QLQ-C30) and esophageal module (QLQ-OES18). Comparison with a reference population was performed to assess impact of achalasia on QoL and effect of therapy. Mixed models for repeated measures were applied. Results Fifty patients (26 females) with a median age of 47 years (18-76) were included. Before treatment, all QoL domains were significantly impaired compared with an age- and gender-adjusted reference population ( P < 0.05). No significant QoL-differences were found after POEM, except for fatigue and nausea/vomiting. Clinically relevant QoL improvement was observed in ≥ 50 % of the patients in all QoL domains, except for physical and role functioning. QoL was significantly associated with ES ( P < 0.05) but not with objective results. Conclusions Achalasia is associated with severe QoL impairment. Following POEM, a significant and clinically relevant QoL improvement is observed. QoL is associated with ES, but not with objective results after POEM. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

• Tran, Trung; Vaage, Eline Benno; Mehta, Adi; Chopra, Adity; Tietze, Lisa & Kolderup, Heidi Anette [Vis alle 40 forfattere av denne artikkelen] (2022). Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants. npj Vaccines. ISSN 2059-0105. 7(1). doi: 10.1038/s41541-022-00586-7. Fulltekst i vitenarkiv
• Hole, Mikal Jacob; Jørgensen, Kristin Kaasen; Holm, Kristian; Braadland, Peder Rustøen; Meyer-Myklestad, Malin Holm & Medhus, Asle Wilhelm [Vis alle 13 forfattere av denne artikkelen] (2022). A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation. Hepatology. ISSN 0270-9139. doi: 10.1002/hep.32773. Fulltekst i vitenarkiv
• Kazmi, Syed Sajid Hussain; Safi, Natkai; Berge, Simen Tveten; Kazmi, Marryam; Sundhagen, Jon Otto & Julien, Kari [Vis alle 10 forfattere av denne artikkelen] (2022). Plasma α-Glutathione S-Transferase in Patients with Chronic Mesenteric Ischemia and Median Arcuate Ligament Syndrome. Vascular Health and Risk Management. ISSN 1176-6344. 18, s. 567–574. doi: 10.2147/VHRM.S365625. Fulltekst i vitenarkiv Vis sammendrag

  Background: Chronic mesenteric ischemia (CMI) due to either atherosclerosis of the mesenteric arteries or median arcuate ligament syndrome (MALS) is an underdiagnosed entity. The etiology of MALS and its existence have been debated and questioned. We aimed to identify plasma biomarkers indicating mesenteric ischemia in patients with CMI and MALS. Methods: Plasma α-glutathione S-transferase (α-GST), intestinal fatty acid-binding protein (I-FABP), citrulline, and ischemia modified albumin (IMA) were analyzed in fifty-eight patients with CMI (Group A, n=44) and MALS (Group B, n=14) before and after revascularization. The plasma levels of these potential biomarkers were compared with those of healthy individuals (Group C, n=16). Group comparison was performed with the Mann–Whitney U-test. Cross-tabulation and its derivatives were obtained. Receiver operating characteristic (ROC) curves and area under the curve (AUC) were calculated. Results: Plasma levels of α-GST were significantly raised in the patients with CMI (7.8 ng/mL, p< 0.001) and MALS (8.4 ng/mL, p< 0.001), as compared with the control Group C (3.3 ng/mL). The threshold for normal median plasma α-GST levels of 4 ng/mL yielded a sensitivity of 93% and 86%, specificity of 86% and 88%, respectively, for the diagnosis of CMI due to atherosclerosis and MALS. AUC of ROC curves was 0.96 (p< 0.0001) for CMI and 0.85 (p< 0.002) for MALS. The patient groups did not differ from the healthy controls in any other biomarkers. Conclusion: Plasma α-GST levels are elevated in CMI and MALS patients. Elevated plasma levels of α-GST suggest ischemia as the etiology of MALS.

• Safi, Natkai; Ånonsen, Kim Vidar; Berge, Simen Tveten; Medhus, Asle Wilhelm; Sundhagen, Jon Otto & Hisdal, Jonny [Vis alle 7 forfattere av denne artikkelen] (2022). Early Identification of Chronic Mesenteric Ischemia with Endoscopic Duplex Ultrasound. Vascular Health and Risk Management. ISSN 1176-6344. s. 233–243. doi: 10.2147/VHRM.S358570. Fulltekst i vitenarkiv
• Meyer-Myklestad, Malin Holm; Medhus, Asle Wilhelm; Stiksrud, Birgitte; Lorvik, Kristina Berg; Seljeflot, Ingebjørg & Hansen, Simen Hyll [Vis alle 13 forfattere av denne artikkelen] (2022). Probiotics to HIV-infected immunological nonresponders: Altered mucosal immunity and microbial diversity restricted to ileum. Journal of Acquired Immune Deficiency Syndromes. ISSN 1525-4135. 89(1), s. 77–86. doi: 10.1097/QAI.0000000000002817.
• Pedersen, Ina Borgenheim; Rawa-Goleblewska, Anna; Calderwood, Audrey H.; Brix, Lone D.; Grode, Louise B. & Botteri, Edoardo [Vis alle 17 forfattere av denne artikkelen] (2022). Complete Polyp Resection with Cold versus Hot snare Polypectomy for Polyps sized 4-9 mm: A randomized controlled trial. Endoscopy. ISSN 0013-726X. 54(10), s. 961–969. doi: 10.1055/a-1734-7952. Vis sammendrag

  Background: Endoscopic screening with polypectomy reduces the incidence of colorectal cancer (CRC). Incomplete polyp removal may attenuate the effect of screening. This randomized trial compared cold snare polypectomy (CSP) with hot snare polypectomy (HSP) in terms of complete polyp resection. Methods: We included patients ≥ 40 years of age at eight hospitals in four countries who had at least one non-pedunculated polyp of 4-9 mm detected at colonoscopy. Patients were randomized 1:1 to CSP or HSP. Biopsies from the resection margins were obtained systematically after polypectomy in both groups. We hypothesized that CSP would be non-inferior to HSP, with a non-inferiority margin of 5 %. Logistic regression models were fitted to identify the factors explaining incomplete resection. Results: 425 patients, with 601 polyps, randomized to either CSP or HSP were included in the analysis. Of 318 polyps removed by CSP and 283 polyps removed by HSP, 34 (10.7 %) and 21 (7.4 %) were incompletely resected, respectively, with an adjusted risk difference of 3.2 % (95 %CI -1.4 % to 7.8 %). There was no difference between the groups in terms of post-polypectomy bleeding, perforation, or abdominal pain. Independent risk factors for incomplete removal were serrated histology (odds ratio [OR] 3.96; 95 %CI 1.63 to 9.66) and hyperplastic histology (OR 2.52; 95 %CI 1.30 to 4.86) in adjusted analyses. Conclusion: In this randomized trial, non-inferiority for CSP could not be demonstrated. Polyps with serrated histology are more prone to incomplete resection compared with adenomas. CSP can be used safely for small polyps in routine colonoscopy practice.

• Evensen, Helge; Småstuen, Milada Cvancarova; Schulz, Anselm; Kristensen, Vendel Ailin; Larssen, Lene & Skattum, Jorunn Pettersen [Vis alle 9 forfattere av denne artikkelen] (2021). One year comprehensive prospective follow-up of achalasia patients after peroral endoscopic myotomy. Annals of Medicine. ISSN 0785-3890. 53(1), s. 2227–2235. doi: 10.1080/07853890.2021.2005253. Fulltekst i vitenarkiv
• Tønnesen, Christer Julseth; Hjelmesæth, Jøran; Hofsø, Dag; Tonstad, Serena; Hertel, Jens Kristoffer & Heggen, Eli [Vis alle 14 forfattere av denne artikkelen] (2021). A novel intragastric balloon for treatment of obesity and type 2 diabetes. A two-center pilot trial. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 57(2), s. 232–238. doi: 10.1080/00365521.2021.1994641. Fulltekst i vitenarkiv
• Lorvik, Kristina Berg; Meyer-Myklestad, Malin Holm; Kushekhar, Kushi; Handeland, Charlotte Andrea; Medhus, Asle Wilhelm & Lund-Iversen, Marius [Vis alle 11 forfattere av denne artikkelen] (2021). Enhanced Gut-Homing Dynamics and Pronounced Exhaustion of Mucosal and Blood CD4⁺ T Cells in HIV-Infected Immunological Non-Responders. Frontiers in Immunology. ISSN 1664-3224. 12, s. 1–12. doi: 10.3389/fimmu.2021.744155. Fulltekst i vitenarkiv
• Lorentzen, Jolanta Halabowska; Medhus, Asle Wilhelm; Hofsø, Dag; Svanevik, Marius; Seip, Birgitte Karen Berggreen & Hjelmesæth, Jøran (2021). Sleeve gastrectomy confers higher risk of gastroesophageal reflux disease than gastric bypass. A Randomized Controlled Trial From the Oseberg Reflux Working Group. Gastroenterology. ISSN 0016-5085. 161(6), s. 2044–2046. doi: 10.1053/j.gastro.2021.08.021. Fulltekst i vitenarkiv
• Anisdahl, Karoline; Lirhus, Sandre Svatun; Medhus, Asle Wilhelm; Moum, Bjørn; Melberg, Hans Olav & Høivik, Marte Lie (2021). First-line biologic treatment of inflammatory bowel disease during the first 12 months after diagnosis from 2010 to 2016: a Norwegian nationwide registry study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. s. 1–7. doi: 10.1080/00365521.2021.1955147. Fulltekst i vitenarkiv
• Kristensen, Vendel Ailin; Opheim, Randi; Perminow, Gøri Margrete; Huppertz-Hauss, Gert; Detlie, Trond Espen & Lund, Charlotte [Vis alle 39 forfattere av denne artikkelen] (2021). Inflammatory bowel disease in South-Eastern Norway III (IBSEN III): a new population-based inception cohort study from South-Eastern Norway. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 56(8), s. 899–905. doi: 10.1080/00365521.2021.1922746. Fulltekst i vitenarkiv Vis sammendrag

  Background and aim: Modern treatment strategies for inflammatory bowel disease (IBD) are postulated to change the natural disease course. Inception cohort studies are the gold standard for investigating such changes. We have initiated a new population-based inception cohort study; Inflammatory bowel disease in South Eastern Norway III (IBSEN III). In this article, we describe the study protocol and baseline characteristics of the cohort. Methods: IBSEN III is an ongoing, population-based observational inception cohort study with prospective follow-up. Adult and pediatric patients with suspected IBD in the South-Eastern Health Region of Norway (catchment area of 2.95 million inhabitants in 2017), during the 3-year period from 2017 to 2019, were eligible for inclusion. Comprehensive clinical, biochemical, endoscopic, demographic, and patient-reported data were collected at the time of diagnosis and throughout standardized follow-up. For a portion of the patients, extensive biological material was biobanked. Results: The study included 2168 patients, of whom 1779 were diagnosed with IBD (Crohn's disease: 626, ulcerative colitis: 1082, IBD unclassified: 71). In 124 patients, there were subtle findings indicative of, but not diagnostic for, IBD. The remaining 265 patients were classified as symptomatic non-IBD controls. Conclusion: We have included patients in a comprehensive population-based IBD cohort from a catchment population of 2.95 million, and a unique biobank with materials from newly diagnosed and treatment-naïve IBD patients and symptomatic non-IBD controls. We believe this cohort will add important knowledge about IBD in the years to come.

• Hoff, Geir; Botteri, Edoardo; Huppertz-Hauss, Gert; Kvamme, Jan-Magnus; Holme, Øyvind & Aabakken, Lars [Vis alle 13 forfattere av denne artikkelen] (2021). The effect of train-the-colonoscopy-trainer course on colonoscopy quality indicators. Endoscopy. ISSN 0013-726X. 53(12), s. 1229–1234. doi: 10.1055/a-1352-4583. Fulltekst i vitenarkiv Vis sammendrag

  Background: Systematic training in colonoscopy is highly recommended; however, we have limited knowledge of the effects of "training-the-colonoscopy-trainer" (TCT) courses. Using a national quality register on colonoscopy performance, we aimed to evaluate the effects of TCT participation on defined quality indicators. Methods: This observational study compared quality indicators (pain, cecal intubation, and polyp detection) between centers participating versus not participating in a TCT course. Nonparticipating centers were assigned a pseudoparticipating year to match their participating counterparts. Results were compared between first year after and the year before TCT (pseudo)participation. Time trends up to 5 years after TCT (pseudo)participation were also compared. Generalized estimating equation models, adjusted for age, sex, and bowel cleansing, were used. Results: 11 participating and 11 nonparticipating centers contributed 18 555 and 10 730 colonoscopies, respectively. In participating centers, there was a significant increase in detection of polyps ≥ 5 mm, from 26.4 % to 29.2 % (P = 0.035), and reduction in moderate/severe pain experienced by women, from 38.2 % to 33.6 % (P = 0.043); no significant changes were found in nonparticipating centers. Over 5 years, 20 participating and 18 nonparticipating centers contributed 85 691 and 41 569 colonoscopies, respectively. In participating centers, polyp detection rate increased linearly (P = 0.003), and pain decreased linearly in women (P = 0.004). Nonparticipating centers did not show any significant time trend during the study period. Conclusions: Participation in a TCT course improved polyp detection rates and reduced pain experienced by women. These effects were maintained during a 5-year follow-up.

• Meyer-Myklestad, Malin Holm; Medhus, Asle Wilhelm; Lorvik, Kristina Berg; Seljeflot, Ingebjørg; Hansen, Simen Hyll & Holm, Kristian [Vis alle 13 forfattere av denne artikkelen] (2020). HIV-infected immunological non-responders have colon-restricted gut mucosal immune dysfunction. Journal of Infectious Diseases. ISSN 0022-1899. doi: 10.1093/infdis/jiaa714. Fulltekst i vitenarkiv
• Safi, Nathkai; Johannessen, Hans Olaf; Medhus, Asle Wilhelm; Mala, Tom & Kazmi, Syed Sajid Hussain (2020). Laser doppler flowmetry and visible light spectroscopy of the gastric tube during minimally invasive esophagectomy. Vascular Health and Risk Management. ISSN 1176-6344. 16, s. 497–505. doi: 10.2147/VHRM.S269138. Fulltekst i vitenarkiv
• Berge, Simen Tveten; Safi, Nathkai; Medhus, Asle Wilhelm; Sundhagen, Jon Otto; Hisdal, Jonny & Kazmi, Syed Sajid Hussain (2020). Perioperative microcirculatory changes detected with gastroscopy assisted laser doppler flowmetry and visible light spectroscopy in patients with median arcuate ligament syndrome. Vascular Health and Risk Management. ISSN 1176-6344. 16, s. 331–341. doi: 10.2147/VHRM.S252192. Fulltekst i vitenarkiv
• Kazmi, Syed Sajid Hussain; Berge, Simen Tveten; Sahba, Mehdi; Medhus, Asle Wilhelm & Sundhagen, Jon Otto (2020). A Short Series of Laparoscopic Mesenteric Bypasses for Chronic Mesenteric Ischemia. Vascular Health and Risk Management. ISSN 1176-6344. 16, s. 87–97. doi: 10.2147/VHRM.S243264. Fulltekst i vitenarkiv
• Lorentzen, Jolanta Halabowska; Medhus, Asle Wilhelm; Hertel, Jens Kristoffer; Borgeraas, Heidi; Karlsen, Tor-Ivar & Kolotkin, Ronette Loganzo [Vis alle 12 forfattere av denne artikkelen] (2020). Erosive Esophagitis and Symptoms of Gastroesophageal Reflux Disease in Patients with Morbid Obesity with and without Type 2 Diabetes: a Cross-sectional Study. Obesity Surgery. ISSN 0960-8923. 30, s. 2667–2675. doi: 10.1007/s11695-020-04545-w. Fulltekst i vitenarkiv Vis sammendrag

  Background Type 2 diabetes (T2DM) is associated with gastroesophageal reflux disease (GERD) in the general population, but the relationship between these conditions in candidates for bariatric surgery is uncertain. We compared the prevalence of GERD and the association between GERD symptoms and esophagitis among bariatric candidates with and without T2DM. Methods Cross-sectional study of baseline data from the Oseberg study in Norway. Both groups underwent gastroduodenoscopy and completed validated questionnaires: Gastrointestinal Symptom Rating Scale and Gastroesophageal Reflux Disease Questionnaire. Participants with T2DM underwent 24-h pH-metry. Results A total of 124 patients with T2DM, 81 women, mean (SD) age 48.6 (9.4) years and BMI 42.3 (5.5) kg/m2, and 64 patients without T2DM, 46 women, age 43.0 (11.0) years and BMI 43.0 (5.0) kg/m2, were included. The proportions of patients reporting GERD-symptoms were low (< 29%) and did not differ significantly between groups, while the proportions of patients with esophagitis were high both in the T2DM and non-T2DM group, 58% versus 47%, p = 0.16. The majority of patients with esophagitis did not have GERD-symptoms (68–80%). Further, 55% of the patients with T2DM had pathologic acid reflux. Among these, 71% also had erosive esophagitis, whereof 67% were asymptomatic. Conclusions The prevalence of GERD was similar in bariatric patients with or without T2DM, and the proportion of patients with asymptomatic GERD was high independent of the presence or absence of T2DM. Accordingly, GERD may be underdiagnosed in patients not undergoing a preoperative endoscopy or acid reflux assessment

• Berge, Simen Tveten; Safi, Nathkai; Medhus, Asle Wilhelm; Ånonsen, Kim Vidar; Sundhagen, Jon Otto & Hisdal, Jonny [Vis alle 7 forfattere av denne artikkelen] (2019). Gastroscopy assisted laser Doppler flowmetry and visible light spectroscopy in patients with chronic mesenteric ischemia. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 79(7), s. 541–549. doi: 10.1080/00365513.2019.1672084. Fulltekst i vitenarkiv
• Bjørkhaug, Steinar Traae; Neupane, Sudan Prasad; Bramness, Jørgen Gustav; Aanes, Håvard; Skar, Viggo Øystein & Medhus, Asle Wilhelm [Vis alle 7 forfattere av denne artikkelen] (2019). Plasma cytokine levels in patients with chronic alcohol overconsumption: relations to gut microbiota markers and clinical correlates. Alcohol. ISSN 0741-8329. 85, s. 35–40. doi: 10.1016/j.alcohol.2019.10.002. Vis sammendrag

  BACKGROUND: Alcohol-related morbidity may involve changes in the gut microbiota and immune dysregulation. We have previously demonstrated alterations in gut microbiota composition and functions in patients with alcohol overconsumption, and now aimed to investigate possible associations between cytokine levels, gut microbiota and clinical symptoms. METHODS: We included hospital inpatients with a history of chronic alcohol overconsumption. For comparison, we included control patients with a low alcohol intake. Cytokine levels (TGF-β1, TNF-α, IL-10, IL-8, IL-6, IFN-γ, MCP-1, IL-1RA, IL-1β and IL-17) were determined using a customized V-plex assay. We then examined associations of cytokine levels with the abundance of Proteobacteria and Faecalibacterium, percentage of the short-chain fatty acid butyrate, psychiatric symptoms (Hospital Anxiety and Depression Scale) and biochemical liver variables. RESULTS: We included 28 patients with alcohol overconsumption (79% men), and 25 control patients (72% men). Patients with alcohol overconsumption had higher levels of IL-6 (p = 0.002), IFN-γ (p = 0.018) and MCP-1 (p = 0.006), and lower levels of TGF-β1 (p = 0.017) compared with control patients. Inverse correlations were found between Proteobacteria abundance and TNF-α (Rs = -0.55, p = 0.02) and IL-8 (Rs = -0.58, p = 0.014), and between Faecalibacterium and MCP-1 levels (Rs = -0.56, p = 0.02) in the control patients, but not in patients with alcohol overconsumption. Patients with alcohol overconsumption reported more psychiatric symptoms, and these symptoms were inversely correlated with IL-10 levels. There were positive correlations between several of the assessed cytokines and biochemical liver variables, and negative correlations between cytokine levels and albumin. CONCLUSION: Patients with alcohol overconsumption had a cytokine profile suggestive of increased systemic inflammatory activity, with higher levels of pro-inflammatory cytokines (IL-6, IFN-γ and MCP-1) and lower levels of anti-inflammatory cytokines (TGF-β1). The findings may represent a link between alcohol use and alcohol-related morbidity. Copyright © 2019 Elsevier Inc. All rights reserved. KEYWORDS: HADS; alcoholism; immune system; inflammation

• Bjørkhaug, Steinar Traae; Aanes, Håvard; Neupane, Sudan Prasad; Bramness, Jørgen Gustav; Malvik, Stine & Henriksen, Christine [Vis alle 9 forfattere av denne artikkelen] (2019). Characterization of gut microbiota composition and functions in patients with chronic alcohol overconsumption. Gut microbes. ISSN 1949-0976. 10(6), s. 663–675. doi: 10.1080/19490976.2019.1580097. Fulltekst i vitenarkiv
• Evensen, Helge; Kristensen, Vendel Ailin; Larssen, Lene; Sandstad, Olav; Hauge, Truls & Medhus, Asle Wilhelm (2019). Outcome of peroral endoscopic myotomy (POEM) in treatment-naive patients. A systematic review. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 54(1), s. 1–7. doi: 10.1080/00365521.2018.1549271. Fulltekst i vitenarkiv
• Buer, Lydia Celine Tansem; Moum, Bjørn; Småstuen, Milada Cvancarova; Warren, David; Bolstad, Nils & Medhus, Asle Wilhelm [Vis alle 7 forfattere av denne artikkelen] (2018). Real world data on effectiveness, safety and therapeutic drug monitoring of vedolizumab in patients with inflammatory bowel disease. A single center cohort. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. s. 1–9. doi: 10.1080/00365521.2018.1548646.
• Høivik, Marte Lie; Buer, Lydia Celine Tansem; Småstuen, Milada Cvancarova; Warren, David; Bolstad, Nils & Moum, Bjørn [Vis alle 7 forfattere av denne artikkelen] (2018). Switching from originator to biosimilar infliximab?real world data of a prospective 18 months follow-up of a single-centre IBD population. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 53(6), s. 692–699. doi: 10.1080/00365521.2018.1463391.
• Buer, Lydia Celine Tansem; Høivik, Marte Lie; Warren, David; Medhus, Asle Wilhelm & Moum, Bjørn (2018). Combining Anti-TNF-? and Vedolizumab in the Treatment of Inflammatory Bowel Disease: A Case Series. Inflammatory Bowel Diseases. ISSN 1078-0998. 24(5), s. 997–1004. doi: 10.1093/ibd/izx110. Vis sammendrag

  Background Anti-tumor necrosis factor α (anti-TNF-α) is important in the treatment of inflammatory bowel disease, but some patients experience only a partial response. In these patients, a combination of anti-TNF-α and vedolizumab (VDZ) may act as a bridge until the full VDZ effect occurs. At present, clinical data on combination treatment with anti-TNF-α and VDZ are not available. The aim of this case series was to evaluate the safety and clinical response of combination therapy with anti-TNF-α and VDZ in clinical practice. Methods All patients started on combination treatment with anti-TNF-α and VDZ from November 2015 to July 2016 were prospectively followed for at least 12 months. Results Six patients with ulcerative colitis and four patients with Crohn’s disease received combination treatment. These patients were followed for a median of 1712–20 months. No more adverse events than expected with anti-TNF-α alone were observed during combination treatment. At the end of follow-up, all patients were in clinical remission, and 8 patients could discontinue anti-TNF-α treatment and receive VDZ monotherapy. Two of the patients with Crohn’s disease required combination treatment throughout follow-up to obtain sustained remission. Conclusion Our findings suggest that combination treatment with anti TNF-α and VDZ is safe and might represent a long-term treatment option in selected patients.

• Holme, Øyvind; Pedersen, Ina Borgenheim; Medhus, Asle Wilhelm; Aabakken, Lars; Glomsaker, Tom Birger & Kvamme, Jan-Magnus [Vis alle 14 forfattere av denne artikkelen] (2018). Endoscopy assistants influence the quality of colonoscopy. Endoscopy. ISSN 0013-726X. 50(9), s. 871–877. doi: 10.1055/s-0044-101706. Fulltekst i vitenarkiv
• Buer, Lydia Celine Tansem; Høivik, Marte Lie; Medhus, Asle Wilhelm & Moum, Bjørn (2017). Does the Introduction of Biosimilars Change Our Understanding about Treatment Modalities for Inflammatory Bowel Disease? Digestive Diseases. ISSN 0257-2753. 35(1-2), s. 74–82. doi: 10.1159/000449087.
• Bjørkhaug, Steinar Traae; Skar, Viggo Øystein; Medhus, Asle Wilhelm; Tollisen, Anita; Bramness, Jørgen Gustav & Valeur, Jørgen (2017). Chronic alcohol overconsumption may alter gut microbial metabolism: a retrospective study of 719 13C-D-xylose breath test results. Microbial Ecology in Health and Disease. ISSN 0891-060X. 28(1). doi: 10.1080/16512235.2017.1301725. Vis sammendrag

  Objective: Alterations of gut microbiota composition or function may participate in the pathophysiology of several diseases. We aimed to explore the effect of chronic alcohol overconsumption on gut microbial metabolism, as assessed by evaluating 13C-D-xylose breath test results. Materials and methods: We investigated all 13C-D-xylose breath tests performed at Lovisenberg Diaconal Hospital during the years 2005 to 2011, using patient files for diagnosing the patients into one of three patient categories: alcohol overconsumption, coeliac disease and functional bowel disorder. In addition, a group of healthy controls was included. The time curves of 13CO2 excretion in breath samples were divided into two phases, evaluating small intestinal absorption (0–60 min) and colonic microbial metabolism (90–240 min), respectively. Results: A total of 719 patients underwent 13C-D-xylose breath testing during the inclusion period. Thirty-five had a history of alcohol overconsumption, 66 had coeliac disease, and 216 had a functional bowel disorder, while 44 healthy controls were included for comparison. The alcohol overconsumption group had similar small intestinal phase results as the group of patients with untreated coeliac disease. During the colonic phase, the group of patients with alcohol overconsumption differed from all the other groups in terms of 13C-xylose recovery, with significantly less 13CO2 excretion compared to the other groups. Conclusion: The results suggest that patients with a history of alcohol overconsumption suffer from both small intestinal malabsorption and impaired colonic microbial metabolism. The role of gut microbiota in chronic alcohol overconsumption should be investigated further.

• Knatten, Charlotte Kristensen; Fjeld, Jan Gunnar; Medhus, Asle Wilhelm; Pripp, Are Hugo; Fyhn, Thomas Johan & Aabakken, Lars [Vis alle 10 forfattere av denne artikkelen] (2017). Preoperative liquid gastric emptying rate does not predict outcome after fundoplication. Journal of Pediatric Surgery. ISSN 0022-3468. 52(4), s. 540–543. doi: 10.1016/j.jpedsurg.2016.09.068.
• Buer, Lydia Celine Tansem; Moum, Bjørn; Småstuen, Milada Cvancarova; Warren, David; Medhus, Asle Wilhelm & Høivik, Marte Lie (2016). Switching from Remicade® to Remsima® is well tolerated and feasible: a prospective, open-label study. Journal - Crohn's and Colitis Foundation of Canada. ISSN 1197-4982. doi: 10.1093/ecco-jcc/jjw166.
• Brun, Anne Charlotte; Olafsdottir, Edda Jonina; Bentsen, Beint Sigmund; Størdal, Ketil; Johannesdottir, Groa B & Medhus, Asle Wilhelm (2014). Electrogastrography in children with cerebral palsy: Abnormal postprandial response to both fast- and slow-emptying meals. e - SPEN: the European e-journal of clinical nutrition and metabolism. ISSN 1751-4991. 9(6), s. e215–e219. doi: 10.1016/j.clnme.2014.09.003.
• Brun, Anne Charlotte; Størdal, Ketil; JOHANNESDOTTIR, GROA; Fossum, Vibeke; Bentsen, Beint Sigmund & Medhus, Asle Wilhelm (2013). Nissen fundoplication in children with cerebral palsy: Influence on rate of gastric emptying and postprandial symptoms in relation to protein source in caloric liquid meals. Clinical Nutrition. ISSN 0261-5614. 32(4), s. 619–623. doi: 10.1016/j.clnu.2012.11.010.
• Knatten, Charlotte Kristensen; Åvitsland, Tone Lise; Medhus, Asle Wilhelm; Fjeld, Jan Gunnar; Pripp, Are Hugo & Emblem, Ragnhild [Vis alle 7 forfattere av denne artikkelen] (2013). Gastric emptying in children with gastroesophageal reflux and in healthy children. Journal of Pediatric Surgery. ISSN 0022-3468. 48(9), s. 1856–1861. doi: 10.1016/j.jpedsurg.2013.03.076.
• Finnes, Trine Elisabeth; Meyer, Haakon E; Falch, Jan Arvid; Medhus, Asle Wilhelm; Wentzel-Larsen, Tore & Lofthus, Cathrine Marie (2013). Secular reduction of excess mortality in hip fracture patients > 85 years. BMC Geriatrics. ISSN 1471-2318. 13. doi: 10.1186/1471-2318-13-25. Fulltekst i vitenarkiv
• Larssen, Lene; Medhus, Asle Wilhelm; Kørner, Hartwig; Glomsaker, Tom Birger; Søberg, Taran & Gleditsch, Dagfinn [Vis alle 11 forfattere av denne artikkelen] (2012). Long-term outcome of palliative treatment with self-expanding metal stents for malignant obstructions of the GI tract. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 47(12), s. 1505–1514. doi: 10.3109/00365521.2012.711854.
• Larssen, Lene; Hauge, Truls & Medhus, Asle Wilhelm (2012). Stent treatment of malignant gastric outlet obstruction: the effect on rate of gastric emptying, symptoms, and survival. Surgical Endoscopy. ISSN 0930-2794. 26(10), s. 2955–2960. doi: 10.1007/s00464-012-2291-7.
• Hope, Håvar Blich; Skar, Viggo Øystein ; Sandstad, Olav; Husebye, Einar & Medhus, Asle Wilhelm (2012). Small intestinal malabsorption in chronic alcoholism: a retrospective study of alcoholic patients by the C-14-D-xylose breath test. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 47(4), s. 428–434. doi: 10.3109/00365521.2011.648951.
• Brun, Anne Charlotte; Størdal, Ketil; Johannesdottir, Groa B; Bentsen, Beint Sigmund & Medhus, Asle Wilhelm (2012). The effect of protein composition in liquid meals on gastric emptying rate in children with cerebral palsy. Clinical Nutrition. ISSN 0261-5614. 31(1), s. 108–112. doi: 10.1016/j.clnu.2011.07.009.
• Larssen, Lene; Medhus, Asle Wilhelm; Hjermstad, Marianne Jensen; Kørner, Hartwig; Glomsaker, Tom & Søberg, Taran [Vis alle 12 forfattere av denne artikkelen] (2011). Patient-reported outcomes in palliative gastrointestinal stenting: a Norwegian multicenter study. Surgical Endoscopy. ISSN 0930-2794. 25(10), s. 3162–3169. doi: 10.1007/s00464-011-1680-7.
• Hope, Håvar Blich; Medhus, Asle Wilhelm; Sandstad, Olav; Borge, Christine Råheim & Skar, Viggo Øystein (2011). Reduced C-13-D-xylose absorption in alcoholics is more likely caused by alterations in small intestinal mucosa than delayed gastric emptying. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 46(4), s. 414–419. doi: 10.3109/00365521.2010.536252.
• Medhus, Asle Wilhelm; Bjørnland, Kristin; Emblem, Ragnhild & Husebye, Einar (2010). Motility of the oesophagus and small bowel in adults treated for Hirschsprung's disease during early childhood. Neurogastroenterology and Motility. ISSN 1350-1925. 22(2). doi: 10.1111/j.1365-2982.2009.01397.x.
• Larssen, Lene; Medhus, Asle Wilhelm & Hauge, Truls (2009). Treatment of malignant gastric outlet obstruction with stents: An evaluation of the reported variables for clinical outcome. BMC Gastroenterology. ISSN 1471-230X. 9. doi: 10.1186/1471-230X-9-45.
• Lofthus, Cathrine Marie; Cappelen, Inger; Osnes, Eivind Kaare; Falch, Jan Arvid; Kristiansen, Ivar Sønbø & Medhus, Asle Wilhelm [Vis alle 8 forfattere av denne artikkelen] (2005). Local and national electronic databases in Norway demonstrate a varying degree of validity. Journal of Clinical Epidemiology. ISSN 0895-4356. 58, s. 280–285.

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• Bazov, I.; Kruse, R.; Bergemalm, D.; Eriksson, C.; Hedin, C.R. & van Nieuwenhoven, M. [Vis alle 28 forfattere av denne artikkelen] (2023). A novel serum protein signature as biomarker for Inflammatory Bowel Disease: A diagnostic performance and prediction modelling study using data from two independent inception cohorts. Journal of Crohn's and Colitis. ISSN 1873-9946. 17, s. i314–i315. doi: 10.1093/ecco-jcc/jjac190.0284.
• Hole, Mikal Jacob; Jørgensen, Kristin Kaasen; Holm, Kristian; Braadland, Peder Rustøen; Meyer-Myklestad, Malin Holm & Medhus, Asle Wilhelm [Vis alle 13 forfattere av denne artikkelen] (2023). Reply: The mucosal gut signature in primary sclerosing cholangitis before and after liver transplantation. Is the dysbiosis index really predictive for the recurrence of PSC? Hepatology. ISSN 0270-9139. 77(6), s. E188–E189. doi: 10.1097/HEP.0000000000000340.
• Tran, Trung; Vaage, Eline Benno; Mehta, Adi; Chopra, Adity; Tietze, Lisa & Kolderup, Heidi Anette [Vis alle 40 forfattere av denne artikkelen] (2023). Author Correction: Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants (npj Vaccines, (2022), 7, 1, (174), 10.1038/s41541-022-00586-7). npj Vaccines. ISSN 2059-0105. 8(1). doi: 10.1038/s41541-023-00600-6.
• Hansen, Simen Hyll; Gjerstad Maseng, M; Bjørkqvist, O; Halfvarsson, J; Bang, C & Detlie, Trond Espen [Vis alle 23 forfattere av denne artikkelen] (2023). Gut microbiota at diagnosis is associated with clinical features and future disease course in Inflammatory Bowel Disease: Data from IBSEN III, a new large Norwegian population-based inception cohort. Journal of Crohn's and Colitis. ISSN 1873-9946. 17, s. i1028–I2029. doi: 10.1093/ecco-jcc/jjac190.1050.
• Lorentzen, Jolanta Halabowska; Medhus, Asle Wilhelm; Hofsø, Dag; Svanevik, Marius; Seip, Birgitte Karen Berggreen & Hjelmesæth, Jøran Sture (2022). Letter to the Editor regarding the article «Gerd symptoms after laparoscopic Roux-en-Y gastric bypass: an emerging scenario» by Antonella Santonicola, Luigi Ruggiero, Rossella Palma, Luigi Angrisani and Paola Iovino. International Journal of Obesity (2022) 46:1076–1078. International Journal of Obesity. ISSN 0307-0565. 46(10), s. 1936–1937. doi: 10.1038/s41366-022-01200-5.
• Evensen, Helge & Medhus, Asle Wilhelm (2019). Response to letter to the editor: ‘Outcome of peroral endoscopic myotomy (POEM) in treatment-naive patients. A systematic review’. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 54(4). doi: 10.1080/00365521.2019.1599416.
• Lorentzen, Jolanta Halabowska; Medhus, Asle Wilhelm; Hertel, Jens Kristoffer; Karlsen, Tor-Ivar; Borgeraas, Heidi & Sandbu, Rune [Vis alle 10 forfattere av denne artikkelen] (2019). Gastroesophageal reflux disease in patients With severe obesity and type 2 diabetes one year after sleeve gastrectomy or roux-en-y gastric bypass. A Randomized controlled trial. Surgery for Obesity and Related Diseases. ISSN 1550-7289. 15, s. S3–S3. doi: 10.1016/j.soard.2019.08.052.
• Lorvik, Kristina Berg; Meyer-Myklestad, Malin Holm; Medhus, Asle Wilhelm; Kvale, Dag; Dyrhol-Riise, Anne Ma & Reikvam, Dag Henrik [Vis alle 7 forfattere av denne artikkelen] (2019). Increased expression of gut and blood CD4+ T cells in people living with HIV and insufficient response to antiviral therapy.
• Meyer-Myklestad, Malin Holm; Kummen, Martin; Stiksrud, Birgitte; Holm, Kristian; Dyrhol-Riise, Anne Ma & Kvale, Dag [Vis alle 11 forfattere av denne artikkelen] (2019). ALTERED GUT IMMUNITY IN IMMUNOLOGICAL NONRESPONDERS PARTLY RESTORED BY PROBIOTICS.
• Bjørkhaug, Steinar Traae; Aanes, Håvard; Medhus, Asle Wilhelm; Skar, Viggo Øystein; Malvik, Stine & Henriksen, Christine [Vis alle 9 forfattere av denne artikkelen] (2018). Tarmfloraendringer hos pasienter med forhøyet alkoholkonsum.
• Bjørkhaug, Steinar Traae; Aanes, Håvard; Skar, Viggo Øystein; Medhus, Asle Wilhelm; Bramness, Jørgen Gustav & Valeur, Jørgen (2017). Chronic alcohol overconsumption may alter composition of gut microbiota.
• Bjørkhaug, Steinar Traae; Aanes, Håvard; Skar, Viggo Øystein; Medhus, Asle Wilhelm; Bramness, Jørgen Gustav & Valeur, Jørgen (2017). Alterations of gut microbiota composition in patients with chronic alcohol overconsumption.
• Bjørkhaug, Steinar Traae; Aanes, Håvard; Skar, Viggo Øystein; Medhus, Asle Wilhelm; Bramness, Jørgen Gustav & Valeur, Jørgen (2017). Alterations of gut microbiota composition in patients with chronic alcohol overconsumption. Neurogastroenterology and Motility. ISSN 1350-1925. 29, s. 84–85.
• Lorentzen, Jolanta Halabowska; Medhus, Asle Wilhelm; Hjelmesæth, Jøran; Hofsø, Dag; Karlsen, Tor-Ivar & Sandbu, Rune [Vis alle 8 forfattere av denne artikkelen] (2016). GERDQ- og GSRS-skjemaer kan være utilstrekkelig til å diagnostisere gastroøsofageal reflukssykdom (GØRS). Oseberg Refluksstudie, Tønsberg.
• Bjørkhaug, Steinar Traae; Skar, Viggo Øystein; Bramness, Jørgen Gustav; Medhus, Asle Wilhelm; Tollisen, Anita & Valeur, Jørgen (2016). Påvirker alkohol tarmens mikroflora? En retrospektiv studie av 719 13C-D-Xylose pusteprøver.
• Sandbu, Rune; Seip, Birgitte Karen Berggreen; Medhus, Asle Wilhelm; Lorentzen, Jolanta Halabowska; Hjelmesæth, Jøran & Hofsø, Dag [Vis alle 7 forfattere av denne artikkelen] (2015). Esophageal motility in morbidly obese patients with type 2 diabetes. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406.
• Lorentzen, Jolanta Halabowska; Hjelmesæth, Jøran; Medhus, Asle Wilhelm; Hofsø, Dag; Karlsen, Tor-Ivar & Sandbu, Rune [Vis alle 7 forfattere av denne artikkelen] (2015). Questionnaires may be insufficient to diagnose gastroesophageal reflux disease (GERD) in morbidly obese patients with type 2 diabetes. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406.
• Lorentzen, Jolanta; Medhus, Asle Wilhelm; Hjelmesæth, Jøran; Hofsø, Dag; Karlsen, Tor-Ivar & Sandbu, Rune [Vis alle 7 forfattere av denne artikkelen] (2015). Esophageal motility in morbidly obese patients with type 2 diabetes.
• Lorentzen, Jolanta; Hjelmesæth, Jøran; Medhus, Asle Wilhelm; Hofsø, Dag; Karlsen, Tor-Ivar & Sandbu, Rune [Vis alle 7 forfattere av denne artikkelen] (2015). Questionnaires may be insufficient to diagnose gastroesophageal reflux disease (GERD) in morbidly obese patients with type 2 diabetes.
• Finnes, Trine Elisabeth; Meyer, Haakon E; Falch, Jan Arvid; Medhus, Asle Wilhelm; Wentzel-Larsen, Tore & Lofthus, Cathrine Marie (2012). DURATION OF EXCESS MORTALITY AFTER HIP FRACTURES IN OSLO, NORWAY: A LONG TERM FOLLOW UP. Osteoporosis International. ISSN 0937-941X. 23, s. S123–S124.
• Larssen, Lene; Medhus, Asle Wilhelm; Wayessa, Seoum; Tholfsen, Jan K.; Nesbakken, Arild & Hauge, Truls (2007). Register over stentbehandling ved GI-cancer.
• Medhus, Asle Wilhelm & Meling, Torstein Ragnar (1993). Sammensatte ord og apostrof som genitivsmerke på norsk og engelsk. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 25.
• Meling, Torstein Ragnar & Medhus, Asle Wilhelm (1993). Nobelprisvinnerdagene 1993. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 23, s. 2944–2947.

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