-
Aronsen, Jan Magnus; Skogestad, Jonas; Albert, Ingrid; Melleby, Arne Olav & Carlson, Cathrine Rein
(2023).
Response by Aronsen et al to Letter Regarding Article, "Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure".
Circulation.
ISSN 0009-7322.
148(10),
s. 857–858.
doi:
10.1161/CIRCULATIONAHA.123.065884.
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Pejšková, Lucie; Rønning, Sissel Beate; Kent, Matthew Peter; Wold, Jens Petter; Mosleth, Ellen Færgestad & Høst, Vibeke
[Vis alle 11 forfattere av denne artikkelen]
(2023).
Shedding of syndecans play a crucial role in the extensive remodelling of the extracellular matrix in skeletal muscle myopathy in chicken .
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Pejšková, Lucie; Rønning, Sissel Beate; Kent, Matthew Peter; Høst, Vibeke; Solberg, Nina & Kolset, Svein Olav
[Vis alle 9 forfattere av denne artikkelen]
(2023).
Syndecans as potential regulators of the severe skeletal muscle myopathy .
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Tønnessen, Theis; Christensen, Geir; Carlson, Cathrine Rein; Skrbic, Biljana & Sjaastad, Ivar
(2022).
Calcineurin-NFAT dynamics corresponds to cardiac remodeling during aortic banding and debanding, mimicking aortic valve replacement.
Frontiers in Molecular Medicine for Cardiology.
doi:
10.3389/fmmed.2022.980717.
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Rønning, Sissel Beate; Carlson, Cathrine Rein; Aronsen, Jan Magnus; Høst, Vibeke; Pisconti, Addolorate & Lunde, Marianne
[Vis alle 11 forfattere av denne artikkelen]
(2019).
Extracellular Matrix remodeling and multiple signaling pathways are regulated by syndecan-4 during myogenesis.
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Rønning, Sissel Beate; Carlson, Cathrine Rein; Aronsen, Jan Magnus; Høst, Vibeke; Liland, Kristian Hovde & Stang, Espen
[Vis alle 10 forfattere av denne artikkelen]
(2017).
Syndecan-4 is a skeletal muscle regenerator and is important for normal skeletal muscle fibre development.
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Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Laver, Derek R; Myhre, Peder Langeland; Dalhus, Bjørn & Lunde, Per Kristian
[Vis alle 14 forfattere av denne artikkelen]
(2017).
Secretoneurin is an Endogenous CaMKII Inhibitor That Attenuates Ca2+-Dependent Arrhythmogenesis.
Circulation.
ISSN 0009-7322.
136.
-
Mathiesen, Sabrina Bech; Lunde, Marianne; Christensen, Geir Arve & Carlson, Cathrine Rein
(2016).
Mass spectrometry analysis of cytoplasmic binding partners of cardiac syndecan - 2.
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Hafver, Tandekile Lubelwana; De Souza, Gustavo Antonio; Wanichawan, Pimthanya; Lunde, Marianne; Martinsen, Marita & Sejersted, Ole M
[Vis alle 7 forfattere av denne artikkelen]
(2016).
In vivo protein-protein interaction map of cardiac NCX1.
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Aronsen, Jan Magnus; Skogestad, Jonas; Hougen, Karina; Lunde, Marianne; Lothe, Gustav B & Albert, Ingrid
[Vis alle 13 forfattere av denne artikkelen]
(2016).
Physical coupling of PDE3A regulates SERCA2 activity in cardiomyocytes.
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Albert, Ingrid; Skogestad, Jonas; Carlson, Cathrine Rein; Lunde, Marianne; Marshall, Serena & Lunde, Per Kristian
[Vis alle 8 forfattere av denne artikkelen]
(2016).
Development of PDE3A-SERCA2 disruptor agents for SERCA2 activation.
-
Manotheepan, Ravinea; Danielsen, Tore Kristian; Saberniak, Jorg; Sadredini, Mani; Anderson, Mark e. & Carlson, Cathrine Rein
[Vis alle 11 forfattere av denne artikkelen]
(2016).
Exercise training as anti-arrhythmic therapy in cathecholaminergic polymorphic ventricular tachycardia type 1.
-
Mathiesen, Sabrina Bech; Lunde, Marianne; Christensen, Geir Arve & Carlson, Cathrine Rein
(2016).
Mass spectrometry analysis of cytoplasmic binding partners of cardiac syndecan-2.
-
Wanichawan, Pimthanya; Hafver, Tandekile Lubelwana; Lunde, Marianne; Martinsen, Marita; Louch, William Edward & Sejersted, Ole M
[Vis alle 7 forfattere av denne artikkelen]
(2016).
The N-terminal membrane occupation and recognition nexus (MORN) domains of junctophilin-2 bind to Na+/Ca2+ exchanger.
-
Rønning, Sissel Beate; Pedersen, Mona Elisabeth & Carlson, Cathrine Rein
(2016).
Syndecan-4 in skeletal muscle development and regeneration.
-
Rønning, Sissel Beate; Carlson, Cathrine Rein; Høst, Vibeke; Aronsen, Jan Magnus; Liland, Kristian Hovde & Stang, Espen
[Vis alle 9 forfattere av denne artikkelen]
(2016).
Syndecan-4 is important for normal skeletal muscle fibre development
.
-
Rønning, Sissel Beate; Carlson, Cathrine Rein; Hollung, Kristin; Pedersen, Mona Elisabeth; Stang, Espen & Kolset, Svein Olav
[Vis alle 7 forfattere av denne artikkelen]
(2015).
Syndecan-4 in skeletal muscle development and regeneration.
-
Hafver, Tandekile Lubelwana; De Souza, Gustavo Antonio; Lunde, Marianne; Martinsen, Marita; Sejersted, Ole M & Carlson, Cathrine Rein
(2015).
The in vitro NCX1 interactome.
-
Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Louch, William Edward; Johansen, Rune F.; Stridsberg, Mats & Jarstadmarken, Hilde
[Vis alle 12 forfattere av denne artikkelen]
(2015).
Chromogranin A is a potent prognostic biomarker in acute heart failure, and its fragment catestatin regulates cardiomyocyte calcium homeostasis by CaMKII inhibition.
-
Aronsen, Jan Magnus; Skogestad, Jonas; Hougen, Karina; Lunde, Marianne; Lothe, Gustav B & Albert, Ingrid
[Vis alle 12 forfattere av denne artikkelen]
(2015).
Physical coupling between SERCA2 and PDE3A regulates SERCA2 activity in cardiomyocytes.
-
Hafver, Tandekile Lubelwana; De Souza, Gustavo Antonio; Lunde, Marianne; Martinsen, Marita; Sejersted, Ole M & Carlson, Cathrine Rein
(2015).
Identification of the in vitro NCX1 interactome.
-
Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Louch, William Edward; Dahl, Mai Britt; Sandbu, Ragnhild Askeland & Johansen, Rune F.
[Vis alle 15 forfattere av denne artikkelen]
(2015).
Enhanced myocardial chromogranin A glycosylation in acute heart failure: reduced processing and potential impact on cardiomyocyte calcium homeostasis.
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Hafver, Tandekile Lubelwana; De Souza, Gustavo Antonio; Lunde, Marianne; Martinsen, Marita; Sejersted, Ole M & Carlson, Cathrine Rein
(2015).
Mapping the in vitro interactome of NCX1.
-
Hafver, Tandekile Lubelwana; Hodne, Kjetil; Wanichawan, Pimthanya; Aronsen, Jan Magnus; Dalhus, Bjørn & Lunde, Per Kristian
[Vis alle 12 forfattere av denne artikkelen]
(2015).
PP1 associated with cardiac NCX1 regulates exchange activity by dephosphorylating pSer-68-PLM.
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Wanichawan, Pimthanya; Hodne, Kjetil; Hafver, Tandekile Lubelwana; Lunde, Marianne; Martinsen, Marita & Louch, William Edward
[Vis alle 8 forfattere av denne artikkelen]
(2015).
Development of a high affinity phospholemman binding peptide that reverses phosphorylated serine 68 phospholemman inhibition of the cardiac sodium-calcium exchanger 1.
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Børstad, Mira Halvorsen; Albert, Ingrid; Lunde, Marianne; Carlson, Cathrine Rein; Sjaastad, Ivar & Aronsen, Jan Magnus
(2015).
Molecular mechanisms for PDE3A mediated inhibition of SERCA2 activity.
-
Rønning, Sissel Beate; Carlson, Cathrine Rein; Stang, Espen; Kolset, Svein Olav; Christensen, Geir Arve & Hollung, Kristin
[Vis alle 7 forfattere av denne artikkelen]
(2015).
Syndecan-4 is important for skeletal muscle development.
-
Marshall, Serena; Aronsen, Jan Magnus; Skogestad, Jonas; Albert, Ingrid; Lothe, Gustav B & Lunde, Per Kristian
[Vis alle 13 forfattere av denne artikkelen]
(2015).
Dual PDE3A coupling to AKAP18 and SERCA2 Controls SERCA2 Activity in adult cardiomyocytes.
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Manotheepan, Ravinea; Danielsen, Tore Kristian; Sadredini, Mani Nikoo; Anderson, Mark e.; Carlson, Cathrine Rein & Lehnart, Stefan
[Vis alle 8 forfattere av denne artikkelen]
(2015).
Exercise training reduced CaMKII-dependent arrhythmogenic Ca2+ release and prevents ventricular tachycardia in CPVT 1.
-
Carlson, Cathrine Rein; Nygård, Ståle; Sirnes, Solveig; Jarstadmarken, Hilde; Martinsen, Marita & Lunde, Marianne
[Vis alle 9 forfattere av denne artikkelen]
(2015).
A protein-protein interaction (PPI) map of cardiac syndecan-4.
-
-
Rønning, Sissel Beate; Carlson, Cathrine Rein; Pedersen, Mona Elisabeth; Hollung, Kristin; Kolset, Svein Olav & Stang, Espen
(2015).
Syndecan-4 in skeletal muscle development and regeneration.
-
Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Edwards, Andrew; Landsverk, Ole J. B.; Johansen, Rune Forstrøm & Moe, Morten Kaare
[Vis alle 12 forfattere av denne artikkelen]
(2015).
Secretoneurin,a novel endogenous CaMKII inhibitor, augments cardiomyocyte Calcium handling and inhibits arrhythmogenic Calcium release.
Biophysical Journal.
ISSN 0006-3495.
108,
s. 340a–340a.
-
Hodne, Kjetil; Wanichawan, Pimthanya; Lubelwana, Tandekile; Louch, William Edward; Lunde, Marianne & Mathisen, Marita
[Vis alle 8 forfattere av denne artikkelen]
(2015).
Liberation of Pser68-Plm inhibition of NCX1 by an optimized anchoring disruptor peptide.
Biophysical Journal.
ISSN 0006-3495.
108,
s. 434a–434a.
-
Hafver, Tandekile Lubelwana; Wanichawan, Pimthanya; Hodne, Kjetil; Aronsen, Jan Magnus; Dalhus, Bjørn & Lunde, Marianne
[Vis alle 12 forfattere av denne artikkelen]
(2015).
Anchoring onto NCX1 facilitates dephosphorylation of P-SER68-PLM.
Biophysical Journal.
ISSN 0006-3495.
108,
s. 584a–584a.
-
Pedersen, Mona Elisabeth; Rønning, Sissel Beate; Carlson, Cathrine Rein; Stang, Espen; Kolset, Svein Olav & Hollung, Kristin
(2015).
Syndecan-4 is important for skeletal muscle development.
-
Hafver, Tandekile Lubelwana; Wanichawan, Pimthanya; Hodne, Kjetil; Aronsen, Jan Magnus; Dalhus, Bjørn & Lunde, Marianne
[Vis alle 10 forfattere av denne artikkelen]
(2014).
Molecular analysis of PP1 anchoring to NCX1 macromolecular complex.
Vis sammendrag
Introduction: The cardiac Na+/Ca2+ exchanger 1 (NCX1) modulates excitation-contraction coupling and contributes to Ca2+ removal in cardiomyocytes. Altered expression and activity of NCX1 is linked to dysfunctional Ca2+ handling in chronic heart disease. Consequently, modulation of NCX1 activity has been proposed as a therapeutic target, but detailed understanding of NCX1 regulation is warranted. It has been shown that NCX1 exists in a macromolecular complex which would allow for regulation of its activity. NCX1 is also regulated by its accessory protein phospholemman (PLM) which inhibits NCX1 activity when phosphorylated at serine 68 (pSer68-PLM). Protein phosphatase 1 (PP1) dephosphorylates pSer68-PLM, and thus indirectly regulates NCX1 activity. Although no anchoring site is known, PP1 co-precipitates NCX1. We hypothesised that PP1 regulates NCX1 activity and that a direct and functional NCX1-PP1 interaction is a prerequisite for pSer68-PLM dephosphorylation. We set out to identify PP1 binding sites to the pPLM-NCX1 complex and assess the biological function of the interaction.
Methods and results: NCX1 co-precipitated PP1 and PLM in wild-type rat left ventricular lysates and PLM-NCX1 co transfected HEK 293 cells. NCX1 protein levels were upregulated, PP1/NCX1 protein levels were downregulated while pSer68-PLM/total PLM protein levels were upregulated in our pressure overload model. The proximity ligation assay showed that cardiac NCX1 and PP1 colocalize within <40nm in isolated cardiomyocytes. Bioinformatic analysis revealed three putative PP1 binding sites on NCX1. Overlay assays of NCX1 and PP1α showed that PP1α bound directly to the consensus sequence R/KVxF in CBD1 (calcium binding domain 1) in NCX1, which is preserved across isoforms. The reciprocal NCX1 binding site was identified within residues 235-260 in PP1α, a region which harbours the aspartic acid, leucine and arginine docking motif. Binding data were confirmed by immunoprecipitations, mutation analysis of NCX1-GFP and FLAG-HIS-PP1α deletion mutants expressed in HEK 293 cells and in pulldown assays using NCX1 biotinylated peptides. We have generated a peptide docking model of the R/KVxF motif bound close to the PP1α active site. Single and double mutations of residues in the docking motif confirmed the interaction. Biacore analysis indicated that the NCX1-PPIα binding is strong. In competition assay using NCX1, PP1 and PLM co transfected HEK cells a NCX1 peptide disruptor was able to displace the interaction, p<0.05, indicating that PP1 dephosphorylates pSer68-PLM when anchored to NCX1.
Conclusion: The R/KVxF motif in CBD1 of NCX1 facilitates PP1 anchoring to NCX1 and is directly and functionally required for pSer68-PLM dephosphorylation.
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Hafver, Tandekile Lubelwana; Wanichawan, Pimthanya; Hodne, Kjetil; Aronsen, Jan Magnus; Dalhus, Bjørn & Lunde, Marianne
[Vis alle 10 forfattere av denne artikkelen]
(2014).
Molecular analysis of the pPLM-NCX1-PP1 complex.
Vis sammendrag
Introduction: The cardiac Na+/Ca2+ exchanger (NCX1) is an ion transporting membrane protein which modulates excitation-contraction coupling and contributes to Ca2+ removal in cardiomyocytes. Altered expression and activity of NCX1 has been linked to dysfunctional Ca2+ handling in chronic heart disease. Consequently, modulation of NCX1 activity has been proposed as a therapeutic target, but detailed understanding of NCX1 regulation is warranted. In the rat heart, NCX1 exists in a macromolecular complex comprising of kinases, phosphatases, anchoring and adaptor proteins, which enables fine tuning of signals which converge on NCX1. NCX1 is also regulated by its accessory protein phospholemman (PLM). When phosphorylated at Serine 68 by PKA and PKC, PLM binds to and inhibits NCX1 activity. It has been shown that phospho Serine 68-PLM (pSer68-PLM) is dephosphorylated by protein phosphatase 1 (PP1) and furthermore PP1 co-precipitate with NCX1, however, no anchoring site is known. We hypothesised that PP1 regulates NCX1 activity and that a direct and functional NCX1-PP1 interaction is a prerequisite for pSer68-PLM dephosphorylation. We set out to identify PP1 binding sites to the pPLM-NCX1 complex and assess the biological function of the interaction.
Methods and results: We have shown that NCX1 exists in a macromolecular complex with PP1 and PLM in wild-type rat left ventricular lysates and in transfected HEK cells. The proximity ligation assay was used to show that cardiac NCX1 and PP1 colocalize within <40nm in isolated cardiomyocytes. Bioinformatic analysis revealed three putative PP1 binding sites on NCX1. Overlay assays of NCX1 and PP1α showed that PP1α bound directly to the consensus sequence R/KVxF in CBD1 (calcium binding region 1) in NCX1, which is preserved across isoforms. The reciprocal NCX1 binding site was identified within residues 235-260 in PP1, a region which harbours the aspartic acid (Asp), leucine (Leu) and arginine (Arg) docking motif. Immunoprecipitations and mutation analysis of NCX1-GFP and FLAG-HIS-PP1α deletion mutants expressed in HEK 293 cells confirmed this interaction. A peptide docking model of the R/KVxF motif bound to the PP1α active site showed that the Asp 242 and Leu 243, identified from the PP1α overlay, make contact with the Valine (Val) and Phenylalanine (Phe) in the R/KVxF motif. Single and double mutations of Asp 242, Leu 243 and Arg 257 confirmed the interaction. Biacore analysis also showed that recombinant NCX1 cytoplasmic part bound to GST-PP1α recombinant protein.
Conclusion: PP1 anchored directly to NCX1 through an R/KVxF motif in CBD1, whereas NCX1 bound to a DL motif within residues 235-260 in PP1. The biological role of the R/KVxF motif in PLM and NCX1 regulation is currently being assessed.
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Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Louch, William Edward; Stridsberg, Mats; Høiseth, Arne Didrik & Brynildsen, Jon
[Vis alle 10 forfattere av denne artikkelen]
(2014).
Chromogranin A is a potent risk marker in acute heart failure and directly associated with cardiomyocyTe Ca2+ handling.
European Heart Journal.
ISSN 0195-668X.
35,
s. 328–328.
-
-
Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Kurola, Jouni & Johansen, Rune Forstrøm
[Vis alle 18 forfattere av denne artikkelen]
(2014).
Secretoneurin provides independent prognostic information in patients with heart failure and cardiac arrest, and has a direct inhibitory effect on diastolic Ca2+ leak and arrhythmogenic Ca2+ waves via CaMKII inhibition.
Circulation Research.
ISSN 0009-7330.
115.
-
Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Louch, William Edward; Høiseth, Arne Didrick; Brynildsen, Jon & Stridsberg, Mats
[Vis alle 9 forfattere av denne artikkelen]
(2014).
Chromogranin A directly modifies cardiomyocyte Ca2+ homeostasis via CaMKII inhibition and is a strong prognostic biomarker in acute heart failure.
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Aronsen, Jan Magnus; Skogestad, Jonas; Hougen, Karina; Lunde, Marianne; Lothe, Gustav B & Lunde, Per Kristian
[Vis alle 10 forfattere av denne artikkelen]
(2014).
Hypokalemia induce CA2+ waves by lowering NKA alpha 2 activity in rat ventricular cardiomyocytes.
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Aronsen, Jan Magnus; Skogestad, Jonas; Hougen, Karina; Lunde, Marianne; Lothe, Gustav B & Lunde, Per Kristian
[Vis alle 10 forfattere av denne artikkelen]
(2014).
Physical coupling of PDE3A to SERCA2 regulates SERCA2 activity in cardiomyoyctes.
-
Hodne, Kjetil; Wanichawan, Pimthanya; Hafver, Tandekile Lubelwana; Aronsen, Jan Magnus; Lunde, Ida Gjervold & Lunde, Marianne
[Vis alle 12 forfattere av denne artikkelen]
(2014).
Identification and functional role of calpain cleavage site in Na+-Ca2+ exchanger 1 (NCX1).
Biophysical Journal.
ISSN 0006-3495.
106.
-
Rønning, Sissel Beate; Carlson, Cathrine Rein; Kolset, Svein Olav; Stang, Espen; Hollung, Kristin & Pedersen, Mona Elisabeth
(2014).
Syndecan-4 is involved in regulation of muscle differentiation at multiple stages and by different mechanisms.
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Rønning, Sissel Beate; Carlson, Cathrine Rein; Kolset, Svein Olav; Stang, Espen; Hollung, Kristin & Pedersen, Mona Elisabeth
(2014).
Syndecan-4 in muscel development.
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Rønning, Sissel Beate; Carlson, Cathrine Rein; Kolset, Svein Olav; Stang, Espen; Hollung, Kristin & Pedersen, Mona Elisabeth
(2014).
The cell surface proteoglycan syndecan 4 is important for in vitro muscle cell differentiation.
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Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Johansen, Rune Forstrøm & Moe, Morten Kaare
[Vis alle 10 forfattere av denne artikkelen]
(2013).
Secretoneurin regulates cardiomyocyte calcium homeostasis via CaMKII inhibition and is a potent marker of mortality in patients with acute heart failure.
European Heart Journal.
ISSN 0195-668X.
34,
s. 6–7.
-
Skrbic, Biljana; Engebretsen, Kristin V Thunheim; Strand, Mari Elen; Marstein, Henriette; Sjaastad, Ivar & Lunde, Ida Gjervold
[Vis alle 10 forfattere av denne artikkelen]
(2013).
Lack of collagen type 8 in pressure overload causes left ventricular dilatation and overt heart failure in mice, suggesting a role in transition to heart failure in patients with aortic stenosis.
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Skrbic, Biljana; Engebretsen, Kristin V Thunheim; Strand, Mari Elen; Marstein, Henriette; Sjaastad, Ivar & Lunde, Ida Gjervold
[Vis alle 10 forfattere av denne artikkelen]
(2013).
Lack of collagen type 8 in pressure overload causes left ventricular dilatation and overt heart failure in mice, suggesting a role in transition to heart failure in patients with aortic stenosis.
Circulation.
ISSN 0009-7322.
128.
-
Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Johansen, Rune forstrom & Moe, Morten Carsten
[Vis alle 14 forfattere av denne artikkelen]
(2013).
Secretoneurin regulates cardiomyocyte calcium homeostasis via CaMKIIinhibition and is a potent marker of mortality in patients with acute heart failure.
-
Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Johansen, Rune forstrom & Moe, Morten
[Vis alle 10 forfattere av denne artikkelen]
(2013).
Secretoneurin regulates cardiomyocyte calcium homeostasis CaMKIIinhibition and is a potent marker of mortality in patients with acute heart failure.
-
Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Johansen, Rune forstrom & Moe, Morten
[Vis alle 14 forfattere av denne artikkelen]
(2013).
Secretoneurin is a novel endogenous CaMKII inhibitor that regulates cardiomyocyte calcium handling and is closely associated with mortality in patients with acute heart failure.
Circulation.
ISSN 0009-7322.
128.
-
Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Johansen, Rune Forstrom & Moe, Morten
[Vis alle 14 forfattere av denne artikkelen]
(2013).
32. Secretoneurin is a novel endogenous CaMKII inhibitor that regulates cardiomyocyte calcium handling and is closely associated with mortality in patients with acute heart failure.
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Wanichawan, Pimthanya; Lunde, Ida Gjervold; Aronsen, Jan Magnus; Austbø, Bjørg; Lunde, Marianne & Tønnessen, Theis
[Vis alle 9 forfattere av denne artikkelen]
(2013).
Calpain mediates proteolysis of the cardiac Na+- Ca2+ exchanger 1(NCX1) in failing hearts through its catalytic site (IIb) and domain III.
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Lunde, Ida Gjervold; Skrbic, Biljana; Tønnessen, Theis; Kvaløy, Heidi; Enger, Ulla Helene & Dahl, Christen Peder
[Vis alle 9 forfattere av denne artikkelen]
(2013).
Clinical and Experimental Aortic Stenosis; Attenuation of Activated Pro-Hypertrophic NFAT Transcription Factor Isoforms by Relief of Pressure Overload.
Circulation.
ISSN 0009-7322.
128.
-
Aspelin, Trude; Eriksen, Morten; Carlson, Cathrine Rein; Ilebekk, Arnfinn & Lyberg, Torstein
(2013).
Bradykinin enhances nerve-induced cardiac tPA release possibly by transactivation of the β2-adrenergic receptor.
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Aspelin, Trude; Eriksen, Morten; Ilebekk, Arnfinn; Carlson, Cathrine Rein & Lyberg, Torstein
(2013).
Heterodimerization of bradykinin receptor-2 (BK2R) and B-adrenergic receptor-2 (B2AR) with physiological consequences on cardiact tPA release in vivo.
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Wanichawan, Pimthanya; Hafver, Tandekile; Aronsen, Jan Magnus; Lunde, Ida Gjervold; Lunde, Marianne & Kvaløy, Heidi
[Vis alle 10 forfattere av denne artikkelen]
(2013).
Modulation of the Sodium-calcium Exchanger 1 (NCX1) by Calpain; Molecular Interactions and Identification of a Calpain Cleavage Site.
Circulation.
ISSN 0009-7322.
128.
-
Grønland, Mari Therese; Eijsink, Vincent; Dalhus, Bjørn; Bjørås, Magnar & Carlson, Cathrine Rein
(2015).
Human CaMKIId mutanter – proteinekspresjon, rensing, krystallisering og analyse av SN-peptid binding.
NMBU,IKBM.