Einar Osland Vik-Mo

• Luque Fernandez, Lidia; Skogen, Karoline; MacIntosh, Bradley; Emblem, Kyrre E; Larsson, Christopher & Bouget, David Nicolas Jean-Marie [Vis alle 14 forfattere av denne artikkelen] (2024). Standardized evaluation of the extent of resection in glioblastoma with automated early post-operative segmentation. Frontiers in Radiology. ISSN 2673-8740. 4. doi: 10.3389/fradi.2024.1357341.
• Blakstad, Hanne Kristin; Mireles, Eduardo Erasmo Mendoza; Kierulf-Vieira, Kirsten Strømme; Singireddy, Divija; Mdala, Ibrahimu & Heggebø, Liv Cathrine [Vis alle 16 forfattere av denne artikkelen] (2024). The impact of cancer patient pathway on timing of radiotherapy and survival: a cohort study in glioblastoma patients. Journal of Neuro-Oncology. ISSN 0167-594X. doi: 10.1007/s11060-024-04709-z.
• Halldórsso, Skarphéðinn; Nagymihaly, Richard; Patel, Areeba; Brandal, Petter; Panagopoulos, Ioannis & Leske, Henning [Vis alle 9 forfattere av denne artikkelen] (2024). Accurate and comprehensive evaluation of O6-methylguanine-DNA methyltransferase promoter methylation by nanopore sequencing. Neuropathology and Applied Neurobiology. ISSN 0305-1846. 50(3). doi: 10.1111/nan.12984.
• Skaga, Erlend; Trewin-Nybråten, Cassia Bree; Niehusmann, Pitt; Johannessen, Tom Børge; Marienhagen, Kirsten & Oltedal, Leif [Vis alle 14 forfattere av denne artikkelen] (2024). Stable glioma incidence and increased patient survival over the past two decades in Norway: a nationwide registry-based cohort study. Acta Oncologica. ISSN 0284-186X. 63, s. 83–94. doi: 10.2340/1651-226X.2024.24970.
• Blakstad, Hanne Kristin; Mireles, Eduardo Erasmo Mendoza; Heggebø, Liv Cathrine; Magelssen, Henriette; Sprauten, Mette & Johannesen, Tom Børge [Vis alle 13 forfattere av denne artikkelen] (2023). Incidence and outcome of pseudoprogression after radiation therapy in glioblastoma patients: A cohort study. Neuro-Oncology Practice. ISSN 2054-2577. 11(1), s. 36–45. doi: 10.1093/nop/npad063.
• Brynjulvsen, Marit; Solli, Elise; Walewska, Maria; Zucknick, Manuela; Djirackor, Luna & Langmoen, Iver Arne [Vis alle 10 forfattere av denne artikkelen] (2023). Functional and Molecular Heterogeneity in Glioma Stem Cells Derived from Multiregional Sampling. Cancers. ISSN 2072-6694. 15(24). doi: 10.3390/cancers15245826. Fulltekst i vitenarkiv
• Mireles, Eduardo Erasmo Mendoza; Skaga, Erlend; Server, Andrés; Leske, Henning; Brandal, Petter & Helseth, Eirik [Vis alle 8 forfattere av denne artikkelen] (2023). The benefit of complete resection of contrast enhancing tumor in glioblastoma patients: A population-based study. Neuro-Oncology Practice. ISSN 2054-2577. 10(6), s. 555–564. doi: 10.1093/nop/npad037. Fulltekst i vitenarkiv
• Rootwelt, Rebecca; Skovlund, Eva; Andreassen, Joakim Stray; Arvidsson, Lisa; Halvardson, Jonathan & Solheim, Ole Skeidsvoll [Vis alle 10 forfattere av denne artikkelen] (2023). Preoperative Prognostic Index for Patients with Brain Metastases—A Population-Based Multi-Centre Study. Cancers. ISSN 2072-6694. 15(12). doi: 10.3390/cancers15123174. Fulltekst i vitenarkiv
• Svensson, Siri Fløgstad; Halldórsso, Skarphéðinn; Latysheva, Anna; Fuster i Garcia, Elies; Hjornevik, Trine & Fraser-Green, Jorunn [Vis alle 12 forfattere av denne artikkelen] (2023). MR elastography identifies regions of extracellular matrix reorganization associated with shorter survival in glioblastoma patients. Neuro-Oncology Advances (NOA). 5(1). doi: 10.1093/noajnl/vdad021. Fulltekst i vitenarkiv
• Berg, Henriette Engen; Halldórsso, Skarphéðinn; Bakketeig, Eris Aas; Thiede, Bernd; Sandberg, Cecilie & Lundanes, Elsa [Vis alle 8 forfattere av denne artikkelen] (2022). Micro‐pillar array columns (µPAC): An efficient tool for comparing tissue and cultured cells of glioblastoma. Journal of chromatography open. ISSN 2772-3917. 2. doi: 10.1016/j.jcoa.2022.100047.
• Skaga, Erlend; Kulesskiy, Evgeny; Potdar, Swapnil; Panagopoulos, Ioannis; Micci, Francesca & Langmoen, Iver Arne [Vis alle 8 forfattere av denne artikkelen] (2022). Functional temozolomide sensitivity testing of patient-specific glioblastoma stem cell cultures is predictive of clinical outcome. Translational Oncology. ISSN 1944-7124. 26, s. 1–9. doi: 10.1016/j.tranon.2022.101535. Fulltekst i vitenarkiv
• Rootwelt, Rebecca; Hjermstad, Marianne Jensen; Skovlund, Eva; Aass, Nina Kathrine; Helseth, Eirik & Kaasa, Stein [Vis alle 8 forfattere av denne artikkelen] (2022). Surgery for brain metastases—impact of the extent of resection. Acta Neurochirurgica. ISSN 0001-6268. 164, s. 2773–2780. doi: 10.1007/s00701-021-05104-7. Fulltekst i vitenarkiv
• Svensson, Siri Fløgstad; Fuster i Garcia, Elies; Latysheva, Anna; Fraser-Green, Jorunn; Nordhøy, Wibeke & Darwish, Omar Isam [Vis alle 11 forfattere av denne artikkelen] (2021). Decreased tissue stiffness in glioblastoma by MR elastography is associated with increased cerebral blood flow. European Journal of Radiology. ISSN 0720-048X. 147. doi: 10.1016/j.ejrad.2021.110136. Fulltekst i vitenarkiv
• Skaga, Erlend; Skretteberg, Marthe Andrea; Johannesen, Tom Børge; Brandal, Petter; Vik-Mo, Einar O. & Helseth, Eirik [Vis alle 7 forfattere av denne artikkelen] (2021). Real-world validity of randomized controlled phase III trials in newly diagnosed glioblastoma: To whom do the results of the trials apply? Neuro-Oncology Advances (NOA). 3(1). doi: 10.1093/noajnl/vdab008. Fulltekst i vitenarkiv Vis sammendrag

  Background The survival rates in population-based series of glioblastoma (GBM) differ substantially from those reported in clinical trials. This discrepancy may be attributed to that patients recruited to trials tend to be younger with better performance status. However, the proportion and characteristics of the patients in a population considered either eligible or ineligible for trials is unknown. The generalizability of trial results is therefore also uncertain. Methods Using the Cancer Registry of Norway and the Brain Tumor Database at Oslo University Hospital, we tracked all patients within a well-defined geographical area with newly diagnosed GBM during the years 2012–2017. Based on data from these registries and the medical records, the patients were evaluated for trial eligibility according to criteria employed in recent phase III trials for GBM. Results We identified 512 patients. The median survival was 11.7 months. When we selected a potential trial population at the start of concurrent chemoradiotherapy (radiotherapy [RT]/ temozolomide [TMZ]) by the parameters age (18–70 y), passed surgery for a supratentorial GBM, Eastern Cooperative Oncology Group (ECOG) ≤2, normal hematologic, hepatic and renal function, and lack of severe comorbidity, 57% of the patients were excluded. Further filtering the patients who progressed during RT/TMZ and never completed RT/TMZ resulted in exclusion of 59% and 63% of the patients, respectively. The survival of patients potentially eligible for trials was significantly higher than of the patients not fulfilling trial eligibility criteria (P < .0001). Conclusions Patients considered eligible for phase III clinical trials represent a highly selected minority of patients in a real-world GBM population.

• Djirackor, Luna; Halldórsson, Skarphéðinn; Niehusmann, Pitt; Leske, Henning; Capper, David & Kuschel, Luis P. [Vis alle 12 forfattere av denne artikkelen] (2021). Intraoperative DNA methylation classification of brain tumors impacts neurosurgical strategy. Neuro-Oncology Advances (NOA). 3(1), s. 1–10. doi: 10.1093/noajnl/vdab149. Fulltekst i vitenarkiv
• Munkvold, Bodil Karoline Ravn; Solheim, Ole; Bartek, Jiri; Corell, Alba; De Dios, Eddie & Gulati, Sasha [Vis alle 27 forfattere av denne artikkelen] (2021). Variations in the management of diffuse low-grade gliomas - A Scandinavian multicenter study. Neuro-Oncology Practice. ISSN 2054-2577. 8(6), s. 706–717. doi: 10.1093/nop/npab054. Fulltekst i vitenarkiv Vis sammendrag

  Background Early extensive surgery is a cornerstone in treatment of diffuse low-grade gliomas (DLGGs), and an additional survival benefit has been demonstrated from early radiochemotherapy in selected “high-risk” patients. Still, there are a number of controversies related to DLGG management. The objective of this multicenter population-based cohort study was to explore potential variations in diagnostic work-up and treatment between treating centers in 2 Scandinavian countries with similar public health care systems. Methods Patients screened for inclusion underwent primary surgery of a histopathologically verified diffuse WHO grade II glioma in the time period 2012 through 2017. Clinical and radiological data were collected from medical records and locally conducted research projects, whereupon differences between countries and inter-hospital variations were explored. Results A total of 642 patients were included (male:female ratio 1:4), and annual age-standardized incidence rates were 0.9 and 0.8 per 100 000 in Norway and Sweden, respectively. Considerable inter-hospital variations were observed in preoperative work-up, tumor diagnostics, surgical strategies, techniques for intraoperative guidance, as well as choice and timing of adjuvant therapy. Conclusions Despite geographical population-based case selection, similar health care organizations, and existing guidelines, there were considerable variations in DLGG management. While some can be attributed to differences in clinical implementation of current scientific knowledge, some of the observed inter-hospital variations reflect controversies related to diagnostics and treatment. Quantification of these disparities renders possible identification of treatment patterns associated with better or worse outcomes and may thus represent a step toward more uniform evidence-based care.

• Rootwelt, Rebecca; Vik-Mo, Einar Osland; Yri, Olav Erich; Aass, Nina Kathrine; Kaasa, Stein & Skovlund, Eva [Vis alle 8 forfattere av denne artikkelen] (2021). Surgery for brain metastases – real-world prognostic factors’ association with survival. Acta Oncologica. ISSN 0284-186X. 60(9), s. 1161–1168. doi: 10.1080/0284186X.2021.1930150. Fulltekst i vitenarkiv
• Svensson, Siri Fløgstad; De Arcos, José; Darwish, Omar Isam; Fraser-Green, Jorunn; Storås, Tryggve & Holm, Sverre [Vis alle 9 forfattere av denne artikkelen] (2021). Robustness of MR Elastography in the Healthy Brain: Repeatability, Reliability, and Effect of Different Reconstruction Methods. Journal of Magnetic Resonance Imaging. ISSN 1053-1807. 53(5), s. 1510–1521. doi: 10.1002/jmri.27475. Fulltekst i vitenarkiv
• Kierulf-Vieira, Kirsten Strømme; Sandberg, Cecilie; Waaler, Jo; Lund, Kaja; Skaga, Erlend & Saberniak, Birthe Mikkelsen [Vis alle 11 forfattere av denne artikkelen] (2020). A small-molecule tankyrase inhibitor reduces glioma stem cell proliferation and sphere formation. Cancers. ISSN 2072-6694. 12(6), s. 1–16. doi: 10.3390/cancers12061630. Fulltekst i vitenarkiv
• Digernes, Ingrid; Nilsen, Line; Grøvik, Endre; Bjørnerud, Atle; Løvland, Grethe & Vik-Mo, Einar O. [Vis alle 12 forfattere av denne artikkelen] (2020). Noise dependency in vascular parameters from combined gradient-echo and spin-echo DSC MRI. Physics in Medicine and Biology. ISSN 0031-9155. 65(22). doi: 10.1088/1361-6560/abb71a. Fulltekst i vitenarkiv
• Latysheva, Anna; Geier, Oliver; Hope, Tuva Roaldsdatter; Brunetti, Marta; Micci, Francesca & Vik-Mo, Einar O. [Vis alle 8 forfattere av denne artikkelen] (2020). Diagnostic utility of Restriction Spectrum Imaging in the characterization of the peritumoral brain zone in glioblastoma: Analysis of overall and progression-free survival. European Journal of Radiology. ISSN 0720-048X. 132:109289, s. 1–8. doi: 10.1016/j.ejrad.2020.109289. Fulltekst i vitenarkiv
• Hovden, Ivar Thokle; Geier, Oliver; Digernes, Ingrid; Fuster i Garcia, Elies; Løvland, Grethe & Vik-Mo, Einar O. [Vis alle 8 forfattere av denne artikkelen] (2020). The impact of EPI-based distortion correction of dynamic susceptibility contrast MRI on cerebral blood volume estimation in patients with glioblastoma. European Journal of Radiology. ISSN 0720-048X. doi: 10.1016/j.ejrad.2020.109278. Vis sammendrag

  Purpose Relative cerebral blood volume (rCBV) from dynamic susceptibility contrast (DSC)-MRI is a valuable biomarker in patients with glioblastoma for assessing treatment response and predicting overall survival. DSC-MRI based on echo planar images (EPI) may possess severe geometric distortions from magnetic field inhomogeneities up to the order of centimeters. The aim of this study is to assess how much two readily available EPI-based geometric distortion correction methods, FSL TOPUP and EPIC, affect rCBV values from DSC-MRI in patients with confirmed glioblastoma. Method We used a combined single-shot 2D gradient-echo (T2*), spin-echo (T2) EPI sequence to estimate both T2* and T2-weighted rCBV from the same contrast agent injection. Effects of distortion correction on the positive phase-encoded T2- and T2*-images were assessed in healthy anatomical brain regions in terms of Wilcoxon signed rank tests on median rCBV change and on Dice coefficients, as well as in tumor lesions in terms of Wilcoxon signed rank tests on median rCBV change. Results Our results show that following distortion correction, both gradient-echo and spin-echo rCBV increased in cortical areas of the frontal, temporal and occipital lobe, including the posterior orbital gyri in the frontal lobe and middle frontal gyri (p 

• Skaga, Erlend; Kulesskiy, Evgeny; Brynjulvsen, Marit; Sandberg, Cecilie; Potdar, Swapnil & Langmoen, Iver Arne [Vis alle 11 forfattere av denne artikkelen] (2019). Feasibility study of using high‑throughput drug sensitivity testing to target recurrent glioblastoma stem cells for individualized treatment. Clinical and Translational Medicine. ISSN 2001-1326. 8(33). doi: 10.1186/s40169-019-0253-6.
• Skaga, Erlend; Kulesskiy, Evgeny; Fayzullin, Artem; Sandberg, Cecilie; Potdar, Swapnil & Kyttälä, Aija [Vis alle 12 forfattere av denne artikkelen] (2019). Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naive glioblastoma. BMC Cancer. ISSN 1471-2407. 19:628, s. 1–14. doi: 10.1186/s12885-019-5861-4.
• Skaga, Erlend; Skaga, Ida Ø; Grieg, Zanina Zilic; Sandberg, Cecilie; Langmoen, Iver Arne & Vik-Mo, Einar O. (2019). The efficacy of a coordinated pharmacological blockade in glioblastoma stem cells with nine repurposed drugs using the CUSP9 strategy. Journal of Cancer Research and Clinical Oncology. ISSN 0171-5216. 145(6), s. 1495–1507. doi: 10.1007/s00432-019-02920-4. Fulltekst i vitenarkiv
• Latysheva, Anna; Emblem, Kyrre Eeg; Brandal, Petter; Vik-Mo, Einar O.; Pahnke, Jens & Røysland, Kjetil [Vis alle 8 forfattere av denne artikkelen] (2019). Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach. Neuroradiology. ISSN 0028-3940. 61(5), s. 545–555. doi: 10.1007/s00234-019-02173-5. Fulltekst i vitenarkiv Vis sammendrag

  Purpose According to the revised World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) of 2016, oligodendrogliomas are now defined primarily by a specific molecular signature (presence of IDH mutation and 1p19q codeletion). The purpose of our study was to assess the value of dynamic susceptibility contrast MR imaging (DSC-MRI) and diffusion-weighted imaging (DWI) to characterize oligodendrogliomas and to distinguish them from astrocytomas. Methods Seventy-one adult patients with untreated WHO grade II and grade III diffuse infiltrating gliomas and known 1p/19q codeletion status were retrospectively identified and analyzed using relative cerebral blood volume (rCBV) and apparent diffusion coefficient (ADC) maps based on whole-tumor volume histograms. The Mann-Whitney U test and logistic regression were used to assess the ability of rCBV and ADC to differentiate between oligodendrogliomas and astrocytomas both independently, but also related to the WHO grade. Prediction performance was evaluated in leave-one-out cross-validation (LOOCV). Results Oligodendrogliomas showed significantly higher microvascularity (higher rCBVMean ≥ 0.80, p = 0.013) and higher vascular heterogeneity (lower rCBVPeak ≤ 0.044, p = 0.015) than astrocytomas. Diffuse gliomas with higher cellular density (lower ADCMean ≤ 1094 × 10−6 mm2/s, p = 0.009) were more likely to be oligodendrogliomas than astrocytomas. Histogram analysis of rCBV and ADC was able to differentiate between diffuse astrocytomas (WHO grade II) and anaplastic astrocytomas (WHO grade III). Conclusion Histogram-derived rCBV and ADC parameter may be used as biomarkers for identification of oligodendrogliomas and may help characterize diffuse gliomas based upon their genetic characteristics. Keywords Diffuse glioma Perfusion MRI Diffusion MRI

• Hvinden, Ingvild Comfort; Berg, Henriette Engen; Sachse, Daniel; Skaga, Erlend; Skottvoll, Frøydis Sved & Lundanes, Elsa [Vis alle 10 forfattere av denne artikkelen] (2019). Nuclear Magnetic Resonance Spectroscopy to Identify Metabolite Biomarkers of Nonresponsiveness to Targeted Therapy in Glioblastoma Tumor Stem Cells. Journal of Proteome Research. ISSN 1535-3893. 18(5), s. 2012–2020. doi: 10.1021/acs.jproteome.8b00801.
• Fayzullin, Artem; Sandberg, Cecilie; Spreadbury, Matthew; Saberniak, Birthe Mikkelsen; Grieg, Zanina Zilic & Skaga, Erlend [Vis alle 8 forfattere av denne artikkelen] (2019). Phenotypic and Expressional Heterogeneity in the Invasive Glioma Cells. Translational Oncology. ISSN 1944-7124. 12(1), s. 122–133. doi: 10.1016/j.tranon.2018.09.014.
• Skottvoll, Frøydis Sved; Berg, Henriette Engen; Bjørseth, Kamilla; Lund, Kaja; Roos, Norbert & Bekhradnia, Sara [Vis alle 13 forfattere av denne artikkelen] (2018). Ultracentrifugation versus kit exosome isolation: nanoLC-MS and other tools reveal similar performance biomarkers, but also contaminations. Future science OA. ISSN 2056-5623. 5(1). doi: 10.4155/fsoa-2018-0088. Fulltekst i vitenarkiv
• Mughal, Awais; Zhang, Lili; Fayzullin, Artem; Server, Andrés; Li, Yuping & Wu, Yingxi [Vis alle 11 forfattere av denne artikkelen] (2018). Patterns of Invasive Growth in Malignant Gliomas - The Hippocampus Emerges as an Invasion-Spared Brain Region. Neoplasia. ISSN 1522-8002. 20(7), s. 643–656. doi: 10.1016/j.neo.2018.04.001. Fulltekst i vitenarkiv
• Digernes, Ingrid; Bjørnerud, Atle; Vatnehol, Svein Are Sirirud; Løvland, Grethe; Courivaud, Fredric A A & Vik-Mo, Einar O. [Vis alle 8 forfattere av denne artikkelen] (2017). A theoretical framework for determining cerebral vascular function and heterogeneity from dynamic susceptibility contrast MRI. Journal of Cerebral Blood Flow and Metabolism. ISSN 0271-678X. 37(6), s. 2237–2248. doi: 10.1177/0271678X17694187. Fulltekst i vitenarkiv
• Fayzullin, Artem; Tuvnes, Frode Alexander; Skjellegrind, Håvard; Behnan, Jinan; Mughal, Awais & Langmoen, Iver Arne [Vis alle 7 forfattere av denne artikkelen] (2016). Time-lapse phenotyping of invasive glioma cells ex vivo reveals subtype-specific movement patterns guided by tumor core signaling. Experimental Cell Research. ISSN 0014-4827. 349(2), s. 199–213. doi: 10.1016/j.yexcr.2016.08.001.
• Skjellegrind, Håvard Kjesbu; Fayzullin, Artem; Johnsen, Erik Otter; Eide, Lars; Langmoen, Iver Arne & Moe, Morten Carsten [Vis alle 7 forfattere av denne artikkelen] (2016). Short-Term Differentiation of Glioblastoma Stem Cells Induces Hypoxia Tolerance. Neurochemical Research. ISSN 0364-3190. 41(7), s. 1545–1558. doi: 10.1007/s11064-016-1868-2.
• Kierulf-Vieira, Kirsten Strømme; Sandberg, Cecilie; Grieg, Zanina Zilic; Günther, Clara-Cecilie; Langmoen, Iver Arne & Vik-Mo, Einar O. (2016). Wnt inhibition is dysregulated in gliomas and its re-establishment inhibits proliferation and tumor sphere formation. Experimental Cell Research. ISSN 0014-4827. 340(1), s. 53–61. doi: 10.1016/j.yexcr.2015.12.010. Vis sammendrag

  Evidence indicates that the growth of glioblastoma (GBM), the most common and malignant primary brain cancer, is driven by glioma stem cells (GSCs) resistant to current treatment. As Wnt-signaling is pivotal in stem cell maintenance, we wanted to explore its role in GSCs with the objective of finding distinct signaling mechanisms that could serve as potential therapeutic targets. We compared gene expression in GSCs (n=9) and neural stem cells from the adult human brain (ahNSC; n=3) to identify dysregulated genes in the Wnt signaling pathway. This identified a six-gene Wnt signature present in all nine primary GSC cultures, and the combined expression of three of these genes (SFRP1, SFRP4 and FZD7) reduced median survival of glioma patients from 38 to 17 months. Treatment with recombinant SFRP1 protein in primary cell cultures downregulated nuclear β-catenin and decreased in vitro proliferation and sphere formation in a dose-dependent manner. Furthermore, expressional and functional analysis of SFRP1-treated GSCs revealed that SFRP1 halts cell cycling and induces apoptosis. These observations demonstrate that Wnt signaling is dysregulated in GSC, and that inhibition of the Wnt pathway could serve as a therapeutic strategy in the treatment of GBM.

• Stangeland, Biljana; Mughal, Awais; Grieg, Zanina Zilic; Sandberg, Cecilie; Joel, Mrinal & Nygård, Ståle [Vis alle 10 forfattere av denne artikkelen] (2015). Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells. OncoTarget. ISSN 1949-2553. 6(28), s. 26192–26215. doi: 10.18632/oncotarget.4613.
• Mughal, Awais; Grieg, Zanina Zilic; Skjellegrind, Håvard Kjesbu; Fayzullin, Artem; Lamkhannat, Mustapha & Joel, Mrinal [Vis alle 11 forfattere av denne artikkelen] (2015). Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells. Molecular Cancer. ISSN 1476-4598. 14:160. doi: 10.1186/s12943-015-0432-z.
• Sandberg, Cecilie; Vik-Mo, Einar O.; Behnan, Jinan; Helseth, Eirik & Langmoen, Iver Arne (2014). Transcriptional profiling of adult neural stem-like cells from the human brain. PLOS ONE. ISSN 1932-6203. 9(12). doi: 10.1371/journal.pone.0114739.
• Behnan, Jinan; Isakson, Pauline; Joel, Mrinal; Cilio, Corrado; Langmoen, Iver Arne & Vik-Mo, Einar O. [Vis alle 7 forfattere av denne artikkelen] (2014). Recruited brain tumor-derived mesenchymal stem cells contribute to brain tumor progression. Stem Cells. ISSN 1066-5099. 32(5), s. 1110–1123. doi: 10.1002/stem.1614.
• Kommedal, Øyvind; Wilhelmsen, Marianne; Skrede, Steinar; Meisal, Roger; Jakovljev, Aleksandra & Gaustad, Peter [Vis alle 13 forfattere av denne artikkelen] (2014). Massive parallel sequencing provides new perspectives on bacterial brain abscesses. Journal of Clinical Microbiology. ISSN 0095-1137. 52(6), s. 1990–1997. doi: 10.1128/JCM.00346-14.
• Murrell, Wayne; Palmero, Emily Herrera; Bianco, John; Stangeland, Biljana; Joel, Mrinal & Paulson, Linda Marie [Vis alle 16 forfattere av denne artikkelen] (2013). Expansion of Multipotent Stem Cells from the Adult Human Brain. PLOS ONE. ISSN 1932-6203. 8(8). doi: 10.1371/journal.pone.0071334.
• Sandberg, Cecilie; Altschuler, Gabriel; Jeong, Jieun; Strømme, Kirsten Kierulf; Stangeland, Biljana & Murrell, Wayne [Vis alle 12 forfattere av denne artikkelen] (2013). Comparison of glioma stem cells to neural stem cells from the adult human brain identifies dysregulated Wnt- signaling and a fingerprint associated with clinical outcome. Experimental Cell Research. ISSN 0014-4827. 319(14), s. 2230–2243. doi: 10.1016/j.yexcr.2013.06.004.
• Vik-Mo, Einar O.; Nyakas, Marta Sølvi; Mikkelsen, Birthe Viftrup; Moe, Morten Carsten; Due-Tønnessen, Paulina & Suso, Else Marit Inderberg [Vis alle 16 forfattere av denne artikkelen] (2013). Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma. Cancer Immunology and Immunotherapy. ISSN 0340-7004. 62(9), s. 1499–1509. doi: 10.1007/s00262-013-1453-3.
• Joel, Mrinal; Sandberg, Cecilie; Boulland, Jean-Luc; Vik-Mo, Einar O.; Langmoen, Iver Arne & Glover, Joel (2013). Inhibition of tumor formation and redirected differentiation of glioblastoma cells in a xenotypic embryonic environment. Developmental Dynamics. ISSN 1058-8388. 242(9), s. 1078–1093. doi: 10.1002/dvdy.24001.
• Boulland, Jean-Luc; Leung, Doreen; Thuen, Marte; Vik-Mo, Einar O.; Joel, Mrinal & Perreault, Marie-Claude [Vis alle 9 forfattere av denne artikkelen] (2012). Evaluation of Intracellular Labeling With Micron-Sized Particles of Iron Oxide (MPIOs) as a General Tool for In Vitro and In Vivo Tracking of Human Stem and Progenitor Cells. Cell Transplantation. ISSN 0963-6897. 21(8), s. 1743–1759. doi: 10.3727/096368911X627598.
• Fossdal, Guri; Vik-Mo, Einar O.; Sandberg, Cecilie; Varghese, Mercy; Kaarbø, Mari & Telmo, Emily Herrera [Vis alle 8 forfattere av denne artikkelen] (2012). Aqp 9 and Brain Tumour Stem Cells. Scientific World Journal. ISSN 1537-744X. doi: 10.1100/2012/915176.
• Vik-Mo, Einar O.; Sandberg, Cecilie; Joel, Mrinal; Stangeland, Biljana; Watanabe, Yasuhiro & Mackay-Sim, Alan [Vis alle 9 forfattere av denne artikkelen] (2011). A comparative study of the structural organization of spheres derived from the adult human subventricular zone and glioblastoma biopsies. Experimental Cell Research. ISSN 0014-4827. 317(7), s. 1049–1059. doi: 10.1016/j.yexcr.2010.12.022.
• Vik-Mo, Einar O.; Reinlie, Sissel; Helseth, Eirik & Langmoen, Iver Arne (2010). Neurosurgery in Oslo. World Neurosurgery. ISSN 1878-8750. 74(4-5), s. 402–406. doi: 10.1016/j.wneu.2010.10.029.
• Vik-Mo, Einar O.; Sandberg, Cecilie; Ølstørn, Håvard; Varghese, Mercy; Brandal, Petter & Ramm-Pettersen, Jon-Terje [Vis alle 8 forfattere av denne artikkelen] (2010). Brain tumor stem cells maintain overall phenotype and tumorigenicity after in vitro culturing in serum-free conditions. Neuro-Oncology. ISSN 1522-8517. 12(12), s. 1220–1230. doi: 10.1093/neuonc/noq102.
• Moe, Morten Carsten; Kolberg, RS; Sandberg, Cecilie; Vik-Mo, Einar O.; Olstorn, H & Varghese, Mercy [Vis alle 8 forfattere av denne artikkelen] (2009). A comparison of epithelial and neural properties in progenitor cells derived from the adult human ciliary body and brain. Experimental Eye Research. ISSN 0014-4835. 88(1), s. 30–38. doi: 10.1016/j.exer.2008.09.020.
• Varghese, Mercy; Ølstørn, Håvard; Sandberg, Cecilie; Vik-Mo, Einar O.; Noordhuis, Paul & Nistér, Monica [Vis alle 9 forfattere av denne artikkelen] (2008). A COMPARISON BETWEEN STEM CELLS FROM THE ADULT HUMAN BRAIN AND FROM BRAIN TUMORS. Neurosurgery. ISSN 0148-396X. 63(6), s. 1022–1033. doi: 10.1227/01.NEU.0000335792.85142.B0.

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• Schipmann, Stephanie; Sivakanesan, Sarankan; Rath, Daniel Stavne; Brandal, Petter; Vik-Mo, Einar Osland & Bjørås, Magnar [Vis alle 13 forfattere av denne artikkelen] (2023). Glioblastom hos voksne. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(2), s. 151–154. doi: 10.4045/tidsskr.22.0314. Fulltekst i vitenarkiv
• Heggebø, Liv Cathrine; Borgen, Ida Maria Henriksen; Rylander, Hillevi; Kiserud, Cecilie E.; Nordenmark, Tonje Kristin Haug & Hellebust, Taran Annette Paulsen [Vis alle 44 forfattere av denne artikkelen] (2023). Investigating survival, quality of life and cognition in PROton versus photon therapy for IDH- mutated diffuse grade 2 and 3 GLIOmas (PRO-GLIO): a randomised controlled trial in Norway and Sweden. BMJ Open. ISSN 2044-6055. 13(3). doi: 10.1136/bmjopen-2022-070071. Fulltekst i vitenarkiv
• Berg, Henriette Engen; Hvinden, Ingvild Comfort; Sachse, Daniel; Skaga, Erlend; Lundanes, Elsa & Sandberg, Cecilie [Vis alle 9 forfattere av denne artikkelen] (2020). Observation of brain cancer cells’ molecular responses to chemotherapy .
• Berg, Henriette Engen; Halldórsson, Skarphéðinn; Thiede, Bernd; Vik-Mo, Einar O.; Lundanes, Elsa & Wilson, Steven Ray Haakon (2020). Micro pillar array columns for comprehensive proteomics. Vis sammendrag

  Pillar array nano liquid chromatography columns can potentially replace packed nano liquid chromatography (nLC) columns for analyses of complex samples due to high chromatographic performance and low backpressure. In our study, pillar array columns are used for the detection of potential biomarkers in Glioblastoma Multiforme (GBM), which is the most aggressive form of brain cancer in adults. Pillar array columns consist of several micropillars etched into silicon wafers using lithographic micromachining. The interest of these columns in nLC format has increased as an option to packed nLC columns as the chromatographic efficiency could outperform nLC columns packed with sub-2 µm particles while maintaining the sensitivity [1]. In contrast to packed columns, where eddy dispersion is the main source of band broadening due to irregular flow paths between the particles, the perfectly ordered pillars in pillar array columns eliminate the eddy dispersion to a minimum. The low backpressure of pillar array columns compared to that of packed columns also permits the use of exceptionally long columns, increasing the chromatographic performance further. Using pillar array columns, plate numbers over 1 million and reduced plate heights (h) even <1 µm have been achieved [2-4]. High chromatographic performance is especially important in comprehensive proteomics. Pre-fractionation (using e.g. gel electrophoresis) is often added in proteomic protocols to increase the throughput [5]. However, performing pre-fractionation can be time-consuming in addition to the highly increased instrument time required. Recently, a micro-Chip pillar array nLC column (µPACTM) compatible with standard nLC instrumentation has been commercialized (Figure 1) [6]. Our question was; could the use of µPAC nLC columns reduce the need for pre-fractionation in comprehensive proteomics of GBM biopsies?

• Vik-Mo, Einar O.; Krossnes, Bård Kronen; Stanisic, Milo; Egge, Arild; Holter, Ellen & Taubøll, Erik [Vis alle 8 forfattere av denne artikkelen] (2014). Reactivation of occult herpes simplex meningoencephalitis after temporal lobe resection for refractory epilepsy - A case report. Seizure. ISSN 1059-1311. 23(4), s. 321–323. doi: 10.1016/j.seizure.2014.01.010.
• Vik-Mo, Einar O.; Nyakas, Marta Sølvi; Lote, K.; Aamdal, Steinar; Gaudernack, Gustav & Langmoen, Iver Arne [Vis alle 7 forfattere av denne artikkelen] (2013). CLINICAL EXPERIENCES WITH THERAPEUTIC DC VACCINES TARGETING AUTOLOGOUS CANCER STEM CELLS IN GLIOBLASTOMA. Cytotherapy. ISSN 1465-3249. 15(4), s. S14–S14.
• Moe, Morten Carsten; Frøen, Rebecca C.; Sandberg, Cecilie; Vik-Mo, Einar O.; Olstorn, H & Langmoen, Iver Arne [Vis alle 7 forfattere av denne artikkelen] (2008). A comparison of the in vitro niche of retinal - and brain progenitor cells from the adult human CNS. Acta Ophthalmologica. ISSN 1755-375X. 86, s. 30–30.
• Vik-Mo, Einar O. & Langmoen, Iver Arne (2011). Propagation and characterization of stem like cells from brain tumors - establishment of a clinical protocol for immunotherapeutic targeting of tumor stem cells in glioblastomas. Unipub forlag. ISSN 978-82-8264-143-2.

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