Eirik Hovland

• Hovland, Eirik; Beyene, Getachew Tesfaye; Frye, Stephan Alfons; Homberset, Håvard; Balasingham, Seetha & Gomez Munoz, Marta [Vis alle 9 forfattere av denne artikkelen] (2017). DprA from Neisseria meningitidis: properties and role in natural competence for transformation. Microbiology (Reading). ISSN 1350-0872. 163(7), s. 1016–1029. doi: 10.1099/mic.0.000489. Vis sammendrag

  DNA processing chain A (DprA) is a DNA-binding protein that is ubiquitous in bacteria and expressed in some archaea. DprA is active in many bacterial species that are competent for transformation of DNA, but its role in Neisseriameningitidis (Nm) is not well characterized. An Nm mutant lacking DprA was constructed, and the phenotypes of the wild-type and ΔdprA mutant were compared. The salient feature of the phenotype of dprA null cells is the total lack of competence for genetic transformation shown by all of the donor DNA substrates tested in this study. Here, Nm wild-type and dprA null cells appeared to be equally resistant to genotoxic stress. The gene encoding DprANm was cloned and overexpressed, and the biological activities of DprANm were further investigated. DprANm binds ssDNA more strongly than dsDNA, but lacks DNA uptake sequence-specific DNA binding. DprANm dimerization and interaction with the C-terminal part of the single-stranded binding protein SSBNmwere demonstrated. dprA is co-expressed with smg, a downstream gene of unknown function, and the gene encoding topoisomerase 1, topA.

• Jenssen, Gaute Reier; Vold, Line; Hovland, Eirik; Bangstad, Hans J; Nygård, Karin Maria & Bjerre, Anna Kristina (2016). Clinical features, therapeutic interventions and long-term aspects of hemolytic-uremic syndrome in Norwegian children: A nationwide retrospective study from 1999-2008. BMC Infectious Diseases. ISSN 1471-2334. 16. doi: 10.1186/s12879-016-1627-7.
• Jenssen, Gaute Reier; Hovland, Eirik; Bangstad, Hans J; Vold, Line & Bjerre, Anna Kristina (2014). The incidence and aetiology of acute kidney injury in children in Norway between 1999 and 2008. Acta Paediatrica. Supplement. ISSN 0803-5326. 103(11), s. 1192–1197. doi: 10.1111/apa.12742.
• Jenssen, Gaute Reier; Hovland, Eirik; Bjerre, Anna Kristina; Bangstad, Hans J; Nygård, Karin Maria & Vold, Line (2014). Incidence and etiology of hemolytic-uremic syndrome in children in Norway, 1999-2008 - a retrospective study of hospital records to assess the sensitivity of surveillance. BMC Infectious Diseases. ISSN 1471-2334. 14. doi: 10.1186/1471-2334-14-265. Fulltekst i vitenarkiv
• Ambur, Ole Herman; Frye, Stephan Alfons; Nilsen, Mariann; Hovland, Eirik & Tønjum, Tone (2012). Restriction and Sequence Alterations Affect DNA Uptake Sequence-Dependent Transformation in Neisseria meningitidis. PLOS ONE. ISSN 1932-6203. 7(7). doi: 10.1371/journal.pone.0039742.
• Vahdani-Benam, Afsaneh; Lång, Emma Helena; Alfsnes, Kristian; Fleckenstein, Burkhard; Rowe, Alexander D. & Hovland, Eirik [Vis alle 9 forfattere av denne artikkelen] (2011). Structure-function relationships of the competence lipoprotein ComL and SSB in meningococcal transformation. Microbiology (Reading). ISSN 1350-0872. 157(Part 5), s. 1329–1342. doi: 10.1099/mic.0.046896-0.

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• Jenssen, Gaute Reier; Hovland, Eirik; Bangstad, Hans-Jacob; Bjerre, Anna Kristina; Vold, Line & Nygard, Karin (2012). CLINICAL ASPECTS AND OUTCOME OF HEMOLYTIC-UREMIC SYNDROME IN CHILDREN IN NORWAY, 1999-2008. Pediatric nephrology (Berlin, West). ISSN 0931-041X. 27(9), s. 1769–1770.
• Jenssen, Gaute Reier; Bangstad, Hans J; Bjerre, Anna Kristina; Vold, Line; Nygård, Karin Maria & Hovland, Eirik (2011). Hemolytic-uremic syndrome in children in Norway, 1999-2008. Pediatric nephrology (Berlin, West). ISSN 0931-041X. 26(9), s. 1650–1650.
• Jenssen, Gaute Reier; Bangstad, Hans J; Bjerre, Anna Kristina; Vold, Line; Nygård, Karin Maria & Hovland, Eirik (2011). Acute renal failure in children in Norway, 1999-2008. Pediatric nephrology (Berlin, West). ISSN 0931-041X. 26(9), s. 1583–1583.

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