Elisabeth Qvigstad

• Kvist , Ahalya Anita Suntharalingam ; Sharma, Archana; Sommer, Christine; Qvigstad, Elisabeth; Gulseth, Hanne Løvdal & Sollid, Stina Therese [Vis alle 12 forfattere av denne artikkelen] (2024). Adipose Tissue Insulin Resistance in South Asian and Nordic Women after Gestational Diabetes Mellitus. Metabolites. ISSN 2218-1989. 14(5). doi: 10.3390/metabo14050288.
• Lopez-Doriga Ruiz, Paz; Karlstad, Øystein; Nøkleby, Kjersti; Slåtsve, Kristina Barbara; Gulseth, Hanne Løvdal & Meyer, Haakon E. [Vis alle 9 forfattere av denne artikkelen] (2024). Pharmacological treatment of obesity in adults in Norway 2004–2022. Diabetes, obesity and metabolism. ISSN 1462-8902. 26, s. 2102–2110. doi: 10.1111/dom.15515. Fulltekst i vitenarkiv
• Linares-Pineda, Teresa M.; Fragoso Bargas, Nicolas; Picón, María José; Molina-Vega, Maria; Jenum, Anne Karen & Sletner, Line [Vis alle 14 forfattere av denne artikkelen] (2024). DNA methylation risk score for type 2 diabetes is associated with gestational diabetes. Cardiovascular Diabetology. ISSN 1475-2840. 23(1). doi: 10.1186/s12933-024-02151-z.
• Opsahl, J. O.; Fragoso-Bargas, N.; Lee, Y.; Carlsen, E. Ø.; Lekanova, N. & Qvigstad, E. [Vis alle 13 forfattere av denne artikkelen] (2024). Epigenome-wide association study of DNA methylation in maternal blood leukocytes with BMI in pregnancy and gestational weight gain. International Journal of Obesity. ISSN 0307-0565. s. 1–10. doi: 10.1038/s41366-024-01458-x. Fulltekst i vitenarkiv
• Rai, Anam Shakil; Sletner, Line; Jenum, Anne Karen; Øverby, Nina Cecilie; Stafne, Signe Nilssen & Qvigstad, Elisabeth [Vis alle 8 forfattere av denne artikkelen] (2023). Employing fasting plasma glucose to safely limit the use of oral glucose tolerance tests in pregnancy: a pooled analysis of four Norwegian studies. Frontiers in Endocrinology. ISSN 1664-2392. 14. doi: 10.3389/fendo.2023.1278523. Fulltekst i vitenarkiv
• Rai, Anam Shakil; Sletner, Line; Jenum, Anne Karen; Øverby, Nina Cecilie; Stafne, Signe Nilssen & Qvigstad, Elisabeth [Vis alle 8 forfattere av denne artikkelen] (2023). Adverse pregnancy outcomes among women in Norway with gestational diabetes using three diagnostic criteria. PLOS ONE. ISSN 1932-6203. 18(7). doi: 10.1371/journal.pone.0280750. Fulltekst i vitenarkiv Vis sammendrag

  Introduction The aim of this study was to examine the risk of adverse perinatal outcomes in women diagnosed with GDM by the World Health Organization (WHO) 1999 criteria, and in those retrospectively identified by the Norwegian-2017 and WHO-2013 criteria but not by WHO-1999 criteria. We also examine the effect of maternal overweight/obesity and ethnicity. Material and methods We used pooled data from four Norwegian cohorts (2002–2013), encompassing 2970 mother-child pairs. Results from universally offered 75-g oral glucose tolerance tests measuring fasting plasma glucose (FPG) and 2-hour glucose (2HG) were used to assign women into three diagnostic groups: Diagnosed and treated by WHO-1999 (FPG≥7.0 or (2HG ≥7.8 mmol/L), identified by WHO-2013 (FPG ≥5.1 or 2HG ≥8.5 mmol/L), and identified by Norwegian-2017 criteria (FPG ≥5.3 or 2HG ≥9.0 mmol/L). Perinatal outcomes included large-for-gestational-age (LGA) infants, cesarean section, operative vaginal delivery, preterm birth and preeclampsia. Results Compared to the non-GDM group, women diagnosed with GDM by either of the three criteria had an increased risk of large-for-gestational-age infants (adjusted odds ratios (OR) 1.7–2.2). Those identified by the WHO-2013 and Norwegian-2017 criteria but not diagnosed and treated by WHO-1999 criteria had an additional increased risk of cesarean section (OR 1.36, 95% CI 1.02,1.83 and 1.44, 95% CI 1.03,2.02, respectively) and operative vaginal delivery (OR 1.35, 95% CI 1.1,1.7 and 1.5, 95% CI 1.1,2.0, respectively). The proportions of LGA neonates and cesarean section were higher for women with GDM in both normal-weight and overweight/obese women. Asians had a lower risk of delivering large-for-gestational-age infants than Europeans applying national birthweight references, but maternal glucose values were similarly positively associated with birthweight in all ethnic groups. Conclusions Women who met the WHO-2013 and Norwegian-2017 criteria, but were not diagnosed by the WHO-1999 criteria and therefore not treated, had an increased risk of LGA, cesarean section and operative vaginal delivery compared to women without GDM.

• Solé-Navais, Pol; Flatley, Christopher; Steinthorsdottir, Valgerdur; Vaudel, Marc; Juodakis, Julius & Chen, Jing [Vis alle 85 forfattere av denne artikkelen] (2023). Genetic effects on the timing of parturition and links to fetal birth weight. Nature Genetics. ISSN 1061-4036. 55, s. 559–567. doi: 10.1038/s41588-023-01343-9. Fulltekst i vitenarkiv
• Fragoso-Bargas, Nicolas; Page, Christian Magnus; Joubert, Bonnie R.; London, Stephanie J.; Lee-Ødegård, Sindre & Opsahl, Julia Onsrud [Vis alle 13 forfattere av denne artikkelen] (2023). Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes. Epigenomics. ISSN 1750-1911. 15(1), s. 39–52. doi: 10.2217/epi-2022-0427. Fulltekst i vitenarkiv
• Stalheim, Astrid Melteig; Iversen, Marjolein M.; Jenum, Anne Karen; Sletner, Line; Stafne, Signe Nilssen & Qvigstad, Elisabeth [Vis alle 10 forfattere av denne artikkelen] (2023). Seasonal variation in gestational diabetes mellitus among women in Norway: a national population-based study. BMJ Open. ISSN 2044-6055. 13(3), s. 1–8. doi: 10.1136/bmjopen-2022-063725. Fulltekst i vitenarkiv Vis sammendrag

  Objectives Previous research on seasonal variation in the incidence of gestational diabetes mellitus (GDM) has shown inconclusive results. Furthermore, little is known about whether a seasonal variation in GDM might be associated with the maternal country of birth. We examined whether there was seasonal variation in GDM incidence by the maternal country background. Design National population-based registry study. Setting and participants We used national population-based data from the Medical Birth Registry of Norway (MBRN), n=1 443 857 (1990–2016) and data from four merged community-based studies (4GDM) with universal screening for GDM, n=2 978 (2002–2013). Outcome measures The association between season of pregnancy onset with incidence of GDM was examined separately in both datasets using logistic regression analyses, stratified by the mother’s country background using two broad geographical categories (MBRN: Norwegian and immigrant; 4GDM: European and African/Asian ethnicity). Winter season was used as reference category. Results The incidence of GDM in MBRN was highest when the pregnancy started during the winter (Norwegian-born: 1.21%; immigrants: 3.32%) and lowest when pregnancy started during the summer for both Norwegian and immigrant women (Norwegian-born: 1.03% (OR 0.85, 95% CI 0.81 to 0.98); immigrants: 2.99% (OR 0.90, 95% CI 0.84 to 0.96)). The 4GDM data showed that women with European ancestry had the highest incidence of GDM when pregnancy started during autumn (10.7%, OR 1.01, 95% CI 0.69 to 1.46) and winter (10.6%), while ethnic African and Asian women had the highest incidence when pregnancy onset was during the summer (15.3%, OR 1.17, 95% CI 0.54 to 2.53). Conclusions Based on national population-based data, this study suggests that GDM incidence varies by season in both Norwegian-born and immigrant women. The 4GDM dataset did not show a clear seasonal variation in GDM incidence, possibly due to the relatively small sample. Causes for the seasonal variation in GDM should be explored further.

• Tronstad, Christian; Amini, Maryam; Olesen, Eline; Qvigstad, Elisabeth; Pabst, Oliver & Martinsen, Tormod [Vis alle 11 forfattere av denne artikkelen] (2022). Diabetic foot assessment using skin impedance in a custom made sensor-sock. Journal of Electrical Bioimpedance. ISSN 1891-5469. 13(1), s. 136–142. doi: 10.2478/joeb-2022-0019. Fulltekst i vitenarkiv
• Fragoso-Bargas, Nicolas; Elliott, Hannah R.; Lee-Ødegård, Sindre; Opsahl, Julia Onsrud; Sletner, Line & Jenum, Anne Karen [Vis alle 12 forfattere av denne artikkelen] (2022). Cross-Ancestry DNA Methylation Marks of Insulin Resistance in Pregnancy: An Integrative Epigenome-Wide Association Study. Diabetes. ISSN 0012-1797. 72(3), s. 415–426. doi: 10.2337/db22-0504.
• Tronstad, Christian; Pabst, Oliver; Amini, Maryam; Kleggetveit, Inge Petter; Elvebakk, Ole & Martinsen, Ørjan Grøttem [Vis alle 10 forfattere av denne artikkelen] (2022). Development of a prototype toe sensor for detection of diabetic peripheral small fiber neuropathy. Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). ISSN 2694-0604. doi: 10.1109/EMBC48229.2022.9871101.
• Sharma, Archana; Lee-Ødegård, Sindre; Qvigstad, Elisabeth; Sommer, Christine; Sattar, Naveed & Gill, Jason M.R. [Vis alle 10 forfattere av denne artikkelen] (2022). β-Cell Function, Hepatic Insulin Clearance, and Insulin Sensitivity in South Asian and Nordic Women After Gestational Diabetes Mellitus. Diabetes. ISSN 0012-1797. 71(12), s. 2530–2538. doi: 10.2337/db22-0622. Fulltekst i vitenarkiv
• Pervjakova, Natalia; Moen, Gunn-Helen Øiseth; Borges, Maria-Carolina; Ferreira, Teresa; Cook, James P. & Allard, Catherine [Vis alle 73 forfattere av denne artikkelen] (2022). Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes. Human Molecular Genetics. ISSN 0964-6906. 31(19), s. 3377–3391. doi: 10.1093/hmg/ddac050. Fulltekst i vitenarkiv
• Sharma, Archana; Nermoen, Ingrid; Qvigstad, Elisabeth; Tran, Anh Thi; Sommer, Christine & Sattar, Naveed [Vis alle 10 forfattere av denne artikkelen] (2022). High prevalence and significant ethnic differences in actionable HbA1C after gestational diabetes mellitus in women living in Norway. BMC Medicine. ISSN 1741-7015. 20(1), s. 1–10. doi: 10.1186/s12916-022-02515-w. Fulltekst i vitenarkiv
• Fragoso-Bargas, Nicolas; Opsahl, Julia Onsrud; Kiryushchenko, Nadezhda; Böttcher, Yvonne; Lee-Ødegård, Sindre & Qvigstad, Elisabeth [Vis alle 15 forfattere av denne artikkelen] (2021). Cohort profile: Epigenetics in Pregnancy (EPIPREG) – Population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes. PLOS ONE. ISSN 1932-6203. 16(8), s. 1–15. doi: 10.1371/journal.pone.0256158. Fulltekst i vitenarkiv
• Lund, Agnethe; Ebbing, Cathrine; Rasmussen, Svein; Qvigstad, Elisabeth; Kiserud, Torvid & Kessler, Jørg (2021). Pre-gestational diabetes: Maternal body mass index and gestational weight gain are associated with augmented umbilical venous flow, fetal liver perfusion, and thus birthweight. PLOS ONE. ISSN 1932-6203. 16(8), s. 1–17. doi: 10.1371/journal.pone.0256171. Fulltekst i vitenarkiv
• Sharma, Archana; Birkeland, Kåre I.; Nermoen, Ingrid; Qvigstad, Elisabeth; Tran, Anh T. & Gulseth, Hanne L. [Vis alle 9 forfattere av denne artikkelen] (2021). Understanding mechanisms behind unwanted health behaviours in Nordic and South Asian women and how they affect their gestational diabetes follow-ups: A qualitative study. Diabetic Medicine. ISSN 0742-3071. 38(10), s. 1–12. doi: 10.1111/dme.14651. Fulltekst i vitenarkiv Vis sammendrag

  Aims: The type 2 diabetes risk following gestational diabetes mellitus (GDM) is high, particularly among South Asian women in Western countries. Our study aimed to advance the knowledge regarding the mechanisms behind suboptimal follow-up in the Nordic and South Asian women with previous GDM by comparing (1) their experiences, (2) health and disease perceptions and (3) barriers to and facilitators of health-promoting behaviours. Methods: This qualitative study was conducted in three hospital outpatient clinics in Norway, comprising six focus group interviews with 28 women 1–3 years after a pregnancy with GDM. The participants were purposively sampled and grouped according to their ethnicity. The data were analysed using thematic analysis, and a theoretical approach was applied to support the analysis and discuss the study's findings. Results: Five main themes were identified: lack of resilience, emotional distress, ‘caught between a rock and a hard place’, postpartum abandonment and insufficient guidance. The key determinants of the maintenance of unwanted health behaviours after GDM were consistent across the ethnic groups. Although the importance of a culturally sensitive approach was emphasised, it appeared secondary to the need for a more organised public healthcare during and after GDM. Conclusions: Women's real-life constraints, combined with the inadequate healthcare-service implementation, could explain the non-adherence to the lifestyle-changes guidelines essential for preventing diabetes post-GDM. We suggest promoting specific coping strategies and changing the healthcare service approach rather than relying on women's capacity to initiate the necessary changes.

• Sletner, Line; Jenum, Anne Karen; Qvigstad, Elisabeth & Hammerstad, Sara Salehi (2021). Thyroid Function during Pregnancy in A Multiethnic Population in Norway. Journal of the Endocrine Society (JES). ISSN 2472-1972. 5(7), s. 1–12. doi: 10.1210/jendso/bvab078. Fulltekst i vitenarkiv
• Opsahl, Julia; Moen, Gunn-Helen Øiseth; Qvigstad, Elisabeth; Böttcher, Yvonne; Birkeland, Kåre Inge & Sommer, Christine (2020). Epigenetic signatures associated with maternal body mass index or gestational weight gain: a systematic review. Journal of Developmental Origins of Health and Disease. ISSN 2040-1744. doi: 10.1017/S2040174420000811.
• Opsahl, Julia Onsrud; Moen, Gunn-Helen; Qvigstad, Elisabeth; Böttcher, Yvonne; Birkeland, Kåre I. & Sommer, Christine (2020). Epigenetic signatures associated with maternal body mass index or gestational weight gain: A systematic review. Journal of Developmental Origins of Health and Disease. ISSN 2040-1744. s. 1–11. doi: 10.1017/S2040174420000811. Fulltekst i vitenarkiv
• Arora, G. P.; Åkerlund, M.; Bruns, C; Moen, Gunn-Helen; Wasenius, N. S. & Sommer, Christine [Vis alle 17 forfattere av denne artikkelen] (2019). Phenotypic and genotypic differences between Indian and Scandinavian women with gestational diabetes mellitus. Journal of Internal Medicine. ISSN 0954-6820. doi: 10.1111/joim.12903.
• Moen, Gunn-Helen Øiseth; LeBlanc, Marissa; Sommer, Christine; Prasad, Rashmi B.; Lekva, Tove & Normann, Kjersti Ringvoll [Vis alle 11 forfattere av denne artikkelen] (2018). Genetic determinants of glucose levels in pregnancy: Genetic risk scores analysis and GWAS in the Norwegian STORK cohort. European Journal of Endocrinology (EJE). ISSN 0804-4643. 179(6), s. 363–372. doi: 10.1530/EJE-18-0478.
• Moen, Gunn-Helen Øiseth; Qvigstad, Elisabeth; Birkeland, Kåre I.; Evans, David & Sommer, Christine (2018). Are serum concentrations of vitamin B-12 causally related to cardiometabolic risk factors and disease? A Mendelian randomization study . American Journal of Clinical Nutrition. ISSN 0002-9165. 108(2), s. 398–404. doi: 10.1093/ajcn/nqy101.
• Lekva, Tove; Godang, Kristin; Michelsen, Annika; Qvigstad, Elisabeth; Normann, Kjersti Ringvoll & Norwitz, Errol R. [Vis alle 11 forfattere av denne artikkelen] (2018). Prediction of gestational diabetes mellitus and pre-diabetes 5 years postpartum using 75 g oral glucose tolerance test at 14-16 Weeks' gestation. Scientific Reports. ISSN 2045-2322. 8:13392, s. 1–9. doi: 10.1038/s41598-018-31614-z. Fulltekst i vitenarkiv
• Moen, Gunn-Helen Øiseth; Sommer, Christine; Prasad, Rashmi B.; Sletner, Line; Groop, Leif & Qvigstad, Elisabeth [Vis alle 7 forfattere av denne artikkelen] (2017). Epigenetic modifications and gestational diabetes: A Systematic review of published literature. European Journal of Endocrinology (EJE). ISSN 0804-4643. 176(5), s. R247–R267. doi: 10.1530/EJE-16-1017.
• Christensen, Jacob J.; Retterstøl, Kjetil; Godang, Kristin; Roland Paasche, Marie Cecilie; Qvigstad, Elisabeth & Bollerslev, Jens [Vis alle 9 forfattere av denne artikkelen] (2016). LDL cholesterol in early pregnancy and offspring cardiovascular disease risk factors. Journal of Clinical Lipidology. ISSN 1933-2874. 10(6), s. 1369–1378. doi: 10.1016/j.jacl.2016.08.016. Vis sammendrag

  Background Vast amounts of data show associations between maternal obesity, dysglycemia, diabetes, and undernutrition during pregnancy and increased cardiovascular disease risk in offspring. However, elevated maternal LDL cholesterol (LDL-C) in pregnancy and offspring cardiovascular disease (CVD) risk has scarcely been studied. Objective Our objective was to investigate the associations between elevated maternal LDL-C in pregnancy and CVD risk factors in 6-to-13-year-old offspring. Methods We recruited 6-to-13-year-old children whose mothers attended a pregnancy cohort and who had high or low cholesterol in pregnancy, defined as LDL-C over the 90th percentile or below the 10th percentile within the pregnancy cohort, respectively. We measured CVD risk factors in the children in the 2 groups. Results Maternal plasma LDL-C at gestational week 14 to 16 was 4.0 and 1.4 mmol/L in the hypercholesterolemic (n = 27) and hypocholesterolemic (n = 34) groups, respectively (P < .001). Interestingly, offspring plasma LDL-C was 0.4 mmol/L higher in children whose mothers had hypercholesterolemia during pregnancy (P < .01). We found no difference in birthweight or any other clinical or biochemical CVD risk factors or dietary intake between the children at 6–13 years. Conclusions Women with elevated LDL-C during early pregnancy have offspring with higher LDL-C already at the age of 6–13 years. Unless cholesterol-reducing measures are successfully implemented, the affected children may be at increased cardiovascular risk.

• Frøslie, Kathrine Frey; Røislien, Jo; Qvigstad, Elisabeth; Godang, Kristin; Bollerslev, Jens & Henriksen, Tore [Vis alle 7 forfattere av denne artikkelen] (2014). Shape information in repeated glucose curves during pregnancy provided significant physiological information for neonatal outcomes. PLOS ONE. ISSN 1932-6203. 9(3). doi: 10.1371/journal.pone.0090798.
• Godang, Kristin; Frøslie, Kathrine Frey; Henriksen, Tore; Qvigstad, Elisabeth & Bollerslev, Jens (2014). Seasonal variation in maternal and umbilical cord 25(OH) vitamin D and their associations with neonatal adiposity. European Journal of Endocrinology (EJE). ISSN 0804-4643. 170(4), s. 609–617. doi: 10.1530/EJE-13-0842.
• Friis, Camilla Margrethe; Qvigstad, Elisabeth; Paasche, Marie Cecilie; Godang, Kristin; Voldner, Nanna & Bollerslev, Jens [Vis alle 7 forfattere av denne artikkelen] (2013). Newborn Body Fat: Associations with Maternal Metabolic State and Placental Size. PLOS ONE. ISSN 1932-6203. 8(2). doi: 10.1371/journal.pone.0057467.
• Frøslie, Kathrine Frey; Røislien, Jo; Qvigstad, Elisabeth; Godang, Kristin; Bollerslev, Jens & Voldner, Nanna [Vis alle 8 forfattere av denne artikkelen] (2013). Shape information from glucose curves: Functional data analysis compared with traditional summary measures. BMC Medical Research Methodology. ISSN 1471-2288. 13. doi: 10.1186/1471-2288-13-6.
• Frøslie, Kathrine Frey; Godang, Kristin; Bollerslev, Jens; Henriksen, Tore; Røislien, Jo & Veierød, Marit Bragelien [Vis alle 7 forfattere av denne artikkelen] (2011). Time-dependent trends in glucose values during long-term use of a glucose measurement system. Clinical Biochemistry. ISSN 0009-9120. 44(17-18), s. 1483–1486. doi: 10.1016/j.clinbiochem.2011.08.1150.
• Frøslie, Kathrine Frey; Røislien, Jo; Laake, Petter; Henriksen, Tore; Qvigstad, Elisabeth & Veierød, Marit Bragelien (2010). Categorisation of continuous exposure variables revisited. A response to the Hyperglycaemia and Adverse Pregnancy Outcome (HAPO) Study. BMC Medical Research Methodology. ISSN 1471-2288. 10. doi: 10.1186/1471-2288-10-103.
• Voldner, Nanna; Qvigstad, Elisabeth; Frøslie, Kathrine Frey; Godang, Kristin; Henriksen, Tore & Bollerslev, Jens (2010). Increased risk of macrosomia among overweight women with high gestational rise in fasting glucose. Journal of Maternal-Fetal & Neonatal Medicine. ISSN 1476-7058. 23(1), s. 74–81. doi: 10.3109/14767050903121472.
• Godang, Kristin; Qvigstad, Elisabeth; Voldner, Nanna; Isaksen, Gunhild Aker; Frøslie, Kathrine Frey & Nøtthellen, Jacob A [Vis alle 8 forfattere av denne artikkelen] (2010). Assessing Body Composition in Healthy Newborn Infants: Reliability of Dual-Energy X-Ray Absorptiometry. Journal of clinical densitometry. ISSN 1094-6950. 13(2), s. 151–160. doi: 10.1016/j.jocd.2010.01.121.
• Grill, Valdemar; Radtke, Maria; Qvigstad, Elisabeth; Kollind, Magnus & Bjorklund, A (2009). Beneficial effects of K-ATP channel openers in diabetes: an update on mechanisms and clinical experiences. Diabetes, obesity and metabolism. ISSN 1462-8902. 11, s. 143–148. doi: 10.1111/j.1463-1326.2009.01119.x.
• Radtke, Maria; Kollind, Magnus; Qvigstad, Elisabeth & Grill, Valdemar (2007). Twelve weeks' treatment with diazoxide without insulin supplementation in Type 2 diabetes is feasible but does not improve insulin secretion. Diabetic Medicine. ISSN 0742-3071. 24(2), s. 172–177. doi: 10.1111/j.1464-5491.2006.02056.x.
• Mostad, Ingrid Løvold; Qvigstad, Elisabeth; Bjerve, Kristian S & Grill, Valdemar (2004). Effects of a 3-day low-fat diet on metabolic control, insulin sensitivity, lipids and adipocyte hormones in Norwegian subjects with hypertriacylglycerolaemia and type 2 diabetes. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 64(6), s. 565–74.
• Qvigstad, Elisabeth; Kollind, M & Grill, Valdemar (2004). Nine weeks of bedtime diazoxide is well tolerated and improves beta-cell function in subjects with Type 2 diabetes. Diabetic Medicine. ISSN 0742-3071. 21(1), s. 73–76.
• Qvigstad, Elisabeth; Kollind, Magnus & Grill, Valdemar (2004). Nine weeks of bedtime diazoxide is well tolerated and improves beta-cell function in subjects with Type 2 diabetes. Diabetic Medicine. ISSN 0742-3071. 21, s. 73–76.
• Qvigstad, Elisabeth; Grill, Valdemar; Bjerve, Kristian S & Mostad, Ingrid Løvold (2003). Acute lowering of fatty acids improves insulin secretion in a subset of type II diabetes subjects. American Journal of Physiology. Endocrinology and Metabolism. ISSN 0193-1849. 284, s. E129–E137. Vis sammendrag

  We tested the effects of acute perturbations of elevated fatty acids (FA) on insulin secretion in type II diabetes. Twenty-one type II diabetes subjects with hypertriglyceridemia (triacylglycerol > 2.2mmol/l) and ten age-matched non-diabetic subjects participated. Glucose-stimulated insulin secretion was monitored during hyperglycemic clamps for 120 min. An infusion of Intralipid and heparin was added during min 60-120. In one of two tests, the subjects ingested 250mg of Acipimox 60 min before the hyperglycemic clamp. A third test (also with Acipimox) was performed in seventeen of the diabetic subjects after three days of a low-fat diet. Acipimox lowered FA levels and enhanced insulin sensitivity in non-diabetic diabetic and diabetic subjects alike. Acipimox administration failed to affect insulin secretion rates in non-diabetic subjects and in the group of diabetic subjects as a whole. However, in the diabetic subjects Acipimox increased integrated insulin secretion rates during min 60-120 min in the 50% having the lowest levels of hemoglobin A1c (379 ± 34 with vs. 326 ± 30 pmol·kg-1·min-1 without Acipimox, P<0.05). A three day dietary intervention diminished energy from fat from 39 to 23% without affecting FA levels and without improving the insulin response during clamps. Elevated FA levels may tonically inhibit stimulated insulin secretion in a subset of type II diabetic subjects.

• Qvigstad, Elisabeth; Grill, Valdemar & Bjerve, Kristian S (2002). Effects of long-term fasting on insulin responses to fatty acids in man. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 62, s. 271–278. Vis sammendrag

  Objective: To investigate whether the prolonged physiological elevation of non-esterified fatty acids (NEFA) seen in man during fasting associates with an altered acute insulin response to NEFA. Subjects and methods: Fourteen non-diabetic subjects, age18-25 years, BMI 23,2 ± 0,8 kg/m2 underwent hyperglycemic clamps (blood glucose 11 mM) for 120 min. during which either saline or Intralipid was administered during the last 60 min. Subjects were tested after an overnight as well as after a 58h fast. Results: After the overnight fast insulin levels increased during Intralipid infusion, reaching at min 120 an increment of 33,0 ± 8,5 mU/ml vs. 9,5 ± 4,4 mU/ml during saline, p<0,05 for difference. Conversely, after the 58 h fast, Intralipid failed to promote a successive increase of insulin levels (increment during Intralipid at min 120: 0,5 ± 5,8 mU/ml versus -4,3 ± 2,5 mU/ml during saline, NS). Insulin sensitivity as assessed by the amount of infused glucose and its ratio to insulin was enhanced by Intralipid after an overnight fast but was decreased after a 58 h fast. Conclusion: Long term elevated NEFA during fasting associates with diminished beta cell responsiveness to an acute elevation of fatty acids in conjunction with negative effects on insulin sensitivity.

• Qvigstad, Elisabeth; Mostad, Ingrid Løvold; Bjerve, Kristian S & Grill, Valdemar (2002). Acute lowering of circulating fatty acids improves insulin secretion in a subset of type 2 diabetes subjects. American Journal of Physiology. Endocrinology and Metabolism. ISSN 0193-1849. 284, s. 129–137.

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• Fragoso Bargas, Nicolas; Linares-Pineda, Teresa; Molina-Vega, María; Picón, María José; Jenum, Anne Karen & Sletner, Line [Vis alle 14 forfattere av denne artikkelen] (2023). Methylation risk score for gestational diabetes on DNA methylation patterns associated with type 2 diabetes.
• Lopez-Doriga Ruiz, Paz; Cohen, Jacqueline Mallory; Kjerpeseth, Lars Jøran; Furu, Kari & Qvigstad, Elisabeth (2023). Paternal use of Metformin and Risk of Major Congenital Malformations.
• Solé-Navais, Pol; Flatley, Christopher; Steinthorsdottir, Valgerdur; Vaudel, Marc; Juodakis, Julius & Chen, Jing [Vis alle 85 forfattere av denne artikkelen] (2023). Author Correction: Genetic effects on the timing of parturition and links to fetal birth weight (Nature Genetics, (2023), 55, 4, (559-567), 10.1038/s41588-023-01343-9). Nature Genetics. ISSN 1061-4036. doi: 10.1038/s41588-023-01412-z.
• Fragoso-Bargas, Nicolas; Lee-Ødegård, Sindre; Moen, Gunn-Helen Øiseth; Oppsahl, JO; Sletner, Line & Jenum, Anne Karen [Vis alle 12 forfattere av denne artikkelen] (2022). Epigenome-Wide Association Study of objectively measured physical activity in pregnancy.
• Fragoso-Bargas, Nicolas; Lee-Ødegård, Sindre; Moen, Gunn-Helen Øiseth; oppsahl, JO; Sletner, Line & Jenum, Anne Karen [Vis alle 13 forfattere av denne artikkelen] (2022). Epigenome-Wide Association Study of objectively measured moderate physical activity in pregnan. Vis sammendrag

  Epigenome-Wide Association Study of objectively measured moderate physical activity in pregnancy Nicolas Fragoso-Bargas1,2, Sindre Lee-Ødegård2, Gunn-Helen Moen2,3,4,5, Julia O. Opsahl2, Line Sletner2,6, Anne Karen Jenum2, Paul Franks7, Rashmi B. Prasad8, Leif C. Groop8, Elisabeth Qvigstad1,2, Kåre I. Birkeland2, Kåre R. Richardsen9, Christine Sommer1 1Oslo University Hospital, Oslo, Norway, 2University of Oslo, Oslo, Norway, 3The University of Queensland Diamantina Institute, Brisbane, Australia, 4Norwegian University of Science and Technology, Trondheim, Norway, 5University of Bristol, UK, 6Akershus University Hospital, Oslo, Norway, 7Lund University Genetic and Molecular Epidemiology, Malmö, Sweden, 8Lund University Diabetes Centre, Malmö, Sweden,9Oslo Metropolitan University, Oslo, Norway. Physical activity (PA) is recommended during pregnancy to reduce the risk of excessive weight gain and gestational diabetes mellitus, and to improve general health. DNA methylation (DNAm) has been proposed as a potential molecular mechanism through which physical activity (PA) mediates the effects on the transcriptome. Here we performed an epigenome-wide association study (EWAS) of objectively measured moderate physical activity in pregnancy, which has not been performed previously. In EPIPREG (a sub-sample of the population-based STORK Groruddalen study) we quantified DNAm at gestational week 28 (±2 SD) with Illumina’s Infinium Methylation EPIC BeadChip. With SenseWear™ Pro3 Armband, we measured hours per day of moderate PA (3.0 to 6.0 metabolic equivalent for task (MET)) and steps/day. DNAm outliers that were 4 times the interquartile range below or above the 25TH and 75TH percentiles respectively were removed, before the beta values were transformed to M-values. Of the 472 that passed the EWAS quality control, 239 European (EUR) and 109 South Asian women (SA) had two valid days of recorded PA (19.2h per day), and were non-outliers (±4 SD) in their respective ethnic group. We used two approaches to test the association between M-values and moderate PA (hours/day): 1) A trans-ethnic approach using mixed linear models adjusted for blood cell proportions, age, smoking, number of steps, number of valid days (between 2 to 8), and ethnicity as a random intercept, and 2) through separate analyses in EUR and SA using linear modelling adjusted with the before mentioned covariates. We accepted a false discovery rate of 10%. In the trans-ethnic analysis, only cg08148261 located in the promoter area of LDHB was significantly associated with moderate PA. In Europeans, eight sites were significant: cg19031974 (BSN-AS2), cg19053287 (MCF2L) cg14930390 (MUTED), cg18517050 (CIAPIN1) and cg26191378 (TMUB1), located near promoter areas, cg27160968 (ESRRA) and cg15879426 (c17orf101) located in exon boundaries, and cg10421808 which is unannotated. In South Asians, only cg05999993 in the promoter area of AOAH was associated with moderate PA. Most of the sites showed decreased DNAm at increased moderate PA (hours/day), while in cg10421808, cg14930390 and cg15879426 the opposite was observed. In conclusion, we found several significant associations between DNAm and moderate PA. Several CpGs were located near gene promoter areas, which could imply altered transcription of the respective genes. These findings suggest that PA may exert changes in DNAm with important transcriptional implications during pregnancy.

• Stalheim, Astrid M.; Iversen, Marjolein M.; Jenum, Anne Karen; Sletner, Line; Stafne, Signe Nilssen & Qvigstad, Elisabeth [Vis alle 10 forfattere av denne artikkelen] (2022). Seasonal variation in gestational diabetes mellitus.
• Qvigstad, Elisabeth (2018). The diversity of gestational diabetes: A therapeutic challenge. European Journal of Endocrinology (EJE). ISSN 0804-4643. 178(3), s. C1–C5. doi: 10.1530/EJE-18-0012.
• Christensen, Jacob J.; Retterstøl, Kjetil; Godang, Kristin; Roland, Marie Cecilie; Qvigstad, Elisabeth & Bollerslev, Jens [Vis alle 9 forfattere av denne artikkelen] (2017). LDL cholesterol in early pregnancy and offspring cardiovascular disease risk factors.
• Christensen, Jacob J.; Retterstøl, Kjetil; Godang, Kristin; Roland, Marie Cecilie Paasche; Qvigstad, Elisabeth & Bollerslev, Jens [Vis alle 9 forfattere av denne artikkelen] (2016). Women with elevated LDL-C in early pregnancy have offspring with elevated LDL-C at 6-13 years of age.
• Christensen, Jacob J.; Retterstøl, Kjetil; Godang, Kristin; Roland, Marie Cecilie Paasche; Qvigstad, Elisabeth & Bollerslev, Jens [Vis alle 9 forfattere av denne artikkelen] (2016). LDL cholesterol in early pregnancy and offspring cardiovascular disease risk factors.
• Christensen, Jacob J.; Retterstøl, Kjetil; Godang, Kristin; Roland, Marie Cecilie Paasche; Qvigstad, Elisabeth & Bollerslev, Jens [Vis alle 9 forfattere av denne artikkelen] (2016). Women with elevated LDL-C in early pregnancy have offspring with elevated LDL-C at 6-13 years of age.
• Christensen, Jacob J.; Retterstøl, Kjetil; Godang, Kristin; Roland, Marie Cecilie Paasche; Qvigstad, Elisabeth & Bollerslev, Jens [Vis alle 9 forfattere av denne artikkelen] (2016). Women with elevated LDL-C in early pregnancy have offspring with elevated LDL-C at 6-13 years of age.
• Christensen, Jacob J.; Retterstøl, Kjetil; Godang, Kristin; Roland, Marie Cecilie Paasche; Qvigstad, Elisabeth & Bollerslev, Jens [Vis alle 9 forfattere av denne artikkelen] (2016). Women with elevated LDL-C in early pregnancy have offspring with elevated LDL-C at 6-13 years of age.
• Christensen, Jacob J.; Retterstøl, Kjetil; Godang, Kristin; Roland, Marie Cecilie Paasche; Qvigstad, Elisabeth & Bollerslev, Jens [Vis alle 9 forfattere av denne artikkelen] (2016). LDL cholesterol in early pregnancy and offspring cardiovascular disease risk factors.
• Qvigstad, Elisabeth; Gulseth, Hanne Løvdal; Risstad, Hilde; le Roux, Carel W.; Berg, Tore Julsrud & Mala, Tom [Vis alle 7 forfattere av denne artikkelen] (2016). A novel technique of Roux-en-Y gastric bypass reversal for postprandial hyperinsulinemic hypoglycaemia: A case report. International Journal of Surgery Case Reports (IJSCR). ISSN 2210-2612. 21, s. 91–94. doi: 10.1016/j.ijscr.2016.02.033.
• Qvigstad, Elisabeth; Voldner, Nanna; Bollerslev, Jens & Henriksen, Tore (2009). Diabetes i svangerskapet - forebygging over generasjoner. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 129(23), s. 2494–2496.
• Qvigstad, Elisabeth; Grill, Valdemar & Kollind, Magnus (2002). Nine weeks of bedtime diazoxide is well tolerated and beta cell beneficial in subjects with type 2 diabetes. Vis sammendrag

  Twenty-seven type 2 diabetic subjects (17M, 10F) using BTI and metformin participated. Half of the subjects received added treatment with Diazoxide, 100mg at bedtime, and half with placebo for 9 weeks. We registered no side effects of Diazoxide. Treatment with Diazoxide did not incur any increase in BTI. Plasma C-peptide responses to glucagon increased (0,15 ± 0,06nmol/l vs. -0,01 ± 0,04nmol/l for placebo, p<0,06 for difference). Plasma insulin levels were 66,2 ± 41,7pmol/l for Diazoxide vs. -84,2 ± 51,5, for placebo p<0,03. Bedtime Diazoxide decreased fasting glucagon levels by 41% vs. placebo, p<0,03. HbA1c levels did not change, whereas levels of blood glucose post breakfast were higher during Diazoxide (1,34 ± 0,43mmol/l, p<0,01 vs. placebo), but not at other time points. A breakfast test in the presence of repaglinide elicited a robust insulin response in Diazoxide treated subjects. Diazoxide taken at bedtime with BTI was well tolerated and produced beneficial effects on insulin and glucagon secretion, but failed to improve metabolic control.

• Grill, Valdemar; Kollind, Magnus & Qvigstad, Elisabeth (2002). Nine weeks of bedtime diazoxide is well tolerated and beta cell beneficial in subjects with type 2 diabetes. Vis sammendrag

  Twenty-seven type 2 diabetic subjects (17M, 10F) using BTI and metformin participated. Half of the subjects received added treatment with Diazoxide, 100mg at bedtime, and half with placebo for 9 weeks. We registered no side effects of Diazoxide. Treatment with Diazoxide did not incur any increase in BTI. Plasma C-peptide responses to glucagon increased (0,15 ± 0,06nmol/l vs. -0,01 ± 0,04nmol/l for placebo, p<0,06 for difference). Plasma insulin levels were 66,2 ± 41,7pmol/l for Diazoxide vs. -84,2 ± 51,5, for placebo p<0,03. Bedtime Diazoxide decreased fasting glucagon levels by 41% vs. placebo, p<0,03. HbA1c levels did not change, whereas levels of blood glucose post breakfast were higher during Diazoxide (1,34 ± 0,43mmol/l, p<0,01 vs. placebo), but not at other time points. A breakfast test in the presence of repaglinide elicited a robust insulin response in Diazoxide treated subjects. Diazoxide taken at bedtime with BTI was well tolerated and produced beneficial effects on insulin and glucagon secretion, but failed to improve metabolic control.

• Grill, Valdemar; Qvigstad, Elisabeth & Kollind, Magnus (2002). Nine weeks of bedtime diazoxide is well tolerated and beta cell beneficial in subjects with type 2 diabetes. Vis sammendrag

  Twenty-seven type 2 diabetic subjects (17M, 10F) using BTI and metformin participated. Half of the subjects received added treatment with Diazoxide, 100mg at bedtime, and half with placebo for 9 weeks. We registered no side effects of Diazoxide. Treatment with Diazoxide did not incur any increase in BTI. Plasma C-peptide responses to glucagon increased (0,15 ± 0,06nmol/l vs. -0,01 ± 0,04nmol/l for placebo, p<0,06 for difference). Plasma insulin levels were 66,2 ± 41,7pmol/l for Diazoxide vs. -84,2 ± 51,5, for placebo p<0,03. Bedtime Diazoxide decreased fasting glucagon levels by 41% vs. placebo, p<0,03. HbA1c levels did not change, whereas levels of blood glucose post breakfast were higher during Diazoxide (1,34 ± 0,43mmol/l, p<0,01 vs. placebo), but not at other time points. A breakfast test in the presence of repaglinide elicited a robust insulin response in Diazoxide treated subjects. Diazoxide taken at bedtime with BTI was well tolerated and produced beneficial effects on insulin and glucagon secretion, but failed to improve metabolic control.

• Qvigstad, Elisabeth (2001). Effekter av frie fettsyrer på insulinfrigjøringen. Vis sammendrag

  En omdiskutert faktor for beta-cellesvikten ved type-2 diabetes er effekten av høye nivåer av sirkulerende frie fettsyrer, som er forhøyet under faste og ved type-2 diabetes. En langvarig forhøyelse av fettsyrer hemmer insulinfrigjøring o g insulinbio s yntese. Med denne bakgrunn, startet vi en studie med 21 type-2 diabetes pasienter med hypertriglyceridemi (>2.2 mmol/l) for å se om en akutt reduksjon av fettsyrer med acipimox vil bedre insulinfrigjøringen. Den akutte reduksjonen av fr ie fettsy rer på grunn av acipimox var assosiert med en noe bedret insulinfrigjøring og glukoseforbruk. Effekten var tydeligst hos de individene som hadde relativt god blodsukkerkontroll. 17 av forsøkspersonene deltok deretter i en kostholdsintervensj o n. Kos t ble registrert i 3 dager, deretter var det et intervall på 2-4 uker, deltakerne fikk så kostråd for å oppnå en redusert fettmengde, som de gjennomførte i 3 dager. Den kortvarige intervensjonen med fettredusert kost gav ingen økning i insul infrig jøri ng, men hadde en overraskende negativ effekt på insulinfølsomheten. Fettsyrene øker også betydelig ved faste. Vi undersøkte derfor om et økt fettsyrenivå forårsaket av langvarig faste ville virke negativt på insulinfrigjøringen. 14 fr iske personer gjennomførte både en 10t og en 58t faste, med etterfølgende tester. Langvarig faste hos ikke-diabetiske individer i hovedsak er assosiert med en negativ påvirkning av fettsyrer på glukose-stimulert insulinfrigjøring og også en parallell negativ virkning på insulinfølsomheten. Begge effektene kan være tilpasninger til redusert tilgang av føde og behov for å unngå hypoglykemi. Man kan tenke seg at disse effektene er utviklet som en fysiologisk respons og at de samme fettsyre-ef fekte ne trer i funksjon også ved type-2 diabetes - men da med et uhensiktsmessig resultat. Forandringer i fettsyrenivåene har betydning for insulinfrigjøringen hos mennesker. Dog er det foreløpig for tidlig å trekke linjen til klinisk anvendelse ved ty pe-2 diabetes.

• Mostad, Ingrid Løvold; Qvigstad, Elisabeth; Bjerve, Kristian S & Grill, Valdemar (2000). A low-fat diet for three days decreases insulin sensitivity in type-2 diabetes patients with hypertriglyceridemia.
• Qvigstad, Elisabeth & Grill, Valdemar (2000). Modulation by fatty acids of glucose-induced insulin secretion: diminished stimulatory effects after prolonged fasting.
• Qvigstad, Elisabeth & Grill, Valdemar (2000). Modulation by fatty acids of glucose-induced insulin secretion: diminished stimulatory effects after prolonged fasting.
• Qvigstad, Elisabeth; Mostad, Ingrid Løvold; Bjerve, Kristian & Grill, Valdemar (1999). Akutt senking av fettsyrer øker insulinfrigjøringen ved type 2-diabetes.
• Qvigstad, Elisabeth; Mostad, Ingrid Løvold; Bjerve, Kristian S & Grill, Valdemar (1999). Lowering of fatty acids by acipimox improves insulin secretion in type-2 diabetes.
• Qvigstad, Elisabeth; Mostad, Ingrid Løvold; Bjerve, Kristian S & Grill, Valdemar (1999). Acute reduction of fatty acids increases insulin secretion in type-2 diabetes.

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