Øystein Fodstad

• Nunes-Xavier, Caroline Elisabeth; Emaldi, Maite; Mingo, Janire; Øyjord, Tove Ragnhild; Mælandsmo, Gunhild Mari & Fodstad, Øystein [Vis alle 11 forfattere av denne artikkelen] (2023). The expression pattern of pyruvate dehydrogenase kinases predicts prognosis and correlates with immune exhaustion in clear cell renal cell carcinoma. Scientific Reports. ISSN 2045-2322. 13(1). doi: 10.1038/s41598-023-34087-x. Fulltekst i vitenarkiv
• Getu, Ayechew Adera; Tigabu, Abiye; Zhou, Ming; Lu, Jianrong; Fodstad, Øystein & Tan, Ming (2023). New frontiers in immune checkpoint B7-H3 (CD276) research and drug development. Molecular Cancer. ISSN 1476-4598. 22(1). doi: 10.1186/s12943-023-01751-9.
• Nunes-Xavier, Caroline Elisabeth; Emaldi, Maite; Guldvik, Ingrid Jenny; Ramberg, Håkon; Tasken, Kristin Austlid & Mælandsmo, Gunhild Mari [Vis alle 10 forfattere av denne artikkelen] (2022). Correlation of expression of Major Vault Protein with androgen receptor and immune checkpoint protein B7-H3, and with poor prognosis in prostate cancer. Pathology, Research and Practice. ISSN 0344-0338. 241. doi: 10.1016/j.prp.2022.154243. Fulltekst i vitenarkiv
• Nunes-Xavier, Caroline Elisabeth; Mingo, Janire; Emaldi, Maite; Flem-Karlsen, Karine; Mælandsmo, Gunhild Mari & Fodstad, Øystein [Vis alle 9 forfattere av denne artikkelen] (2022). Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer. Frontiers in Oncology. ISSN 2234-943X. 12. doi: 10.3389/fonc.2022.873516.
• Nunes-Xavier, Caroline Elisabeth; Kildal, Wanja; Kleppe, Andreas; Danielsen, Håvard Emil Greger; Wæhre, Håkon & Llarena, Roberto [Vis alle 10 forfattere av denne artikkelen] (2021). Immune checkpoint B7-H3 protein expression is associated with poor outcome and androgen receptor status in prostate cancer. The Prostate. ISSN 0270-4137. doi: 10.1002/pros.24180. Fulltekst i vitenarkiv
• Svendsen, Henrik Aasrum; Meling, Torstein Ragnar; Nygaard, Vigdis; Waagene, Stein; Russnes, Hege Elisabeth Giercksky & Juell, Siri [Vis alle 11 forfattere av denne artikkelen] (2021). Novel human melanoma brain metastasis models in athymic nude fox1^nu mice: Site-specific metastasis patterns reflecting their clinical origin. Cancer Medicine. ISSN 2045-7634. 10(23), s. 8604–8613. doi: 10.1002/cam4.4334. Fulltekst i vitenarkiv
• Thorgersen, Ebbe Billmann; Asvall, Jørund; Frøysnes, Ida Storhaug; Schjalm, Camilla; Larsen, Stein Gunnar & Dueland, Svein [Vis alle 10 forfattere av denne artikkelen] (2021). Increased Local Inflammatory Response to MOC31PE Immunotoxin After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Annals of Surgical Oncology. ISSN 1068-9265. doi: 10.1245/s10434-021-10022-0. Fulltekst i vitenarkiv
• Flem-Karlsen, Karine; Fodstad, Øystein & Nunes-Xavier, Caroline Elisabeth (2020). B7-H3 immune checkpoint protein in human cancer. Current Medicinal Chemistry. ISSN 0929-8673. 27(24), s. 4062–4086. doi: 10.2174/0929867326666190517115515.
• Saeednejad Zanjani, Leili; Madjd, Zahra; Axcrona, Ulrika; Abolhasani, Maryam; Rasti, Arezoo & Asgari, Mojgan [Vis alle 8 forfattere av denne artikkelen] (2020). Cytoplasmic expression of B7-H3 and membranous EpCAM expression are associated with higher grade and survival outcomes in patients with clear cell renal cell carcinoma. Annals of Diagnostic Pathology. ISSN 1092-9134. 46:151483, s. 1–13. doi: 10.1016/j.anndiagpath.2020.151483.
• Andersson, Yvonne; Inderberg, Else Marit ; Kvalheim, Gunnar; Herud, Morten Theodor Malmer; Engebråten, Olav & Flatmark, Kjersti [Vis alle 8 forfattere av denne artikkelen] (2019). Immune stimulatory effect of anti-EpCAM immunotoxin - improved overall survival of metastatic colorectal cancer patients. Acta Oncologica. ISSN 0284-186X. s. 1–7. doi: 10.1080/0284186X.2019.1704864.
• Saeednejad Zanjani, Leili; Madjd, Zahra; Rasti, Arezoo; Asgari, Mojgan; Abolhasani, Maryam & Tam, Kevin J [Vis alle 10 forfattere av denne artikkelen] (2019). Spheroid-Derived Cells From Renal Adenocarcinoma Have Low Telomerase Activity and High Stem-Like and Invasive Characteristics. Frontiers in Oncology. ISSN 2234-943X. 9. doi: 10.3389/fonc.2019.01302.
• Frøysnes, Ida Storhaug; Andersson, Yvonne; Larsen, Stein Gunnar; Davidson, Ben; Øien, Janne-Merete & Julsrud, Lars [Vis alle 9 forfattere av denne artikkelen] (2019). ImmunoPeCa trial: Long-term outcome following intraperitoneal MOC31PE immunotoxin treatment in colorectal peritoneal metastasis. European Journal of Surgical Oncology. ISSN 0748-7983. s. 1–5. doi: 10.1016/j.ejso.2019.04.014. Fulltekst i vitenarkiv
• Saeednejad Zanjani, Leili; Madjd, Zahra; Abolhasani, Maryam; Rasti, Arezoo; Shariftabrizi, Ahmad & Mehrazma, Mitra [Vis alle 8 forfattere av denne artikkelen] (2019). Human telomerase reverse transcriptase protein expression predicts tumour aggressiveness and survival in patients with clear cell renal cell carcinoma. Pathology (Sydney). ISSN 0031-3025. 51(1), s. 21–31. doi: 10.1016/j.pathol.2018.08.019. Fulltekst i vitenarkiv
• Flem-Karlsen, Karine; Tekle, Christina; Øyjord, Tove Ragnhild; Flørenes, Vivi Ann; Mælandsmo, Gunhild Mari & Fodstad, Øystein [Vis alle 7 forfattere av denne artikkelen] (2019). p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance. Scientific Reports. ISSN 2045-2322. 9(1). doi: 10.1038/s41598-019-42303-w. Fulltekst i vitenarkiv
• Karlsen, Karine Flem; Fodstad, Øystein; Tan, Ming & Nunes-Xavier, Caroline Elisabeth (2018). B7-H3 in Cancer ? Beyond Immune Regulation. Trends in Cancer. ISSN 2405-8033. doi: 10.1016/j.trecan.2018.03.010. Fulltekst i vitenarkiv
• Zanjani, Leili Saeednejad; Madjd, Zahra; Abolhasani, Maryam; Rasti, Arezoo; Fodstad, Øystein & Andersson, Yvonne [Vis alle 7 forfattere av denne artikkelen] (2017). Increased expression of CD44 is associated with more aggressive behavior in clear cell renal cell carcinoma. Biomarkers in Medicine. ISSN 1752-0363. 12(1), s. 45–61. doi: 10.2217/bmm-2017-0142. Vis sammendrag

  Although CD44 has been suggested as a prognostic marker in renal cell carcinoma (RCC), the prognostic significance of this marker in three main subtypes of RCC is still unclear. Thus, the present study was conducted to evaluate the expression and prognostic significance of CD44 as a cancer stem cell marker in different histological subtypes of RCC. Methodology & results: CD44 expression was evaluated in 206 well-defined renal tumor samples using immunohistochemistry on tissue microarrays. Higher CD44 expression was associated with more aggressive behavior, tumor progression and worse prognosis in clear cell RCC (ccRCC) but not in papillary and chromophobe RCC subtypes.

• Eide, Nils; Faye, Ragnar Solberg; Høifødt, Hanne Kleppe; Sandvik, Leiv; Qvale, Geir Aksel & Faber, Rowan Thomas [Vis alle 9 forfattere av denne artikkelen] (2017). The Results of Stricter Inclusion Criteria in an Immunomagnetic Detection Study of Micrometastatic Cells in Bone Marrow of Uveal Melanoma Patients - Relevance for Dormancy. Pathology and Oncology Research. ISSN 1219-4956. s. 1–8. doi: 10.1007/s12253-017-0355-7.
• Andersson, Yvonne; Ihler, Synne; Davidson, Ben; Dørum, Anne; Fleten, Karianne Giller & Fodstad, Øystein [Vis alle 7 forfattere av denne artikkelen] (2017). MOC31PE immunotoxin - targeting peritoneal metastasis from epithelial ovarian cancer. OncoTarget. ISSN 1949-2553. 8(37), s. 61800–61809. doi: 10.18632/oncotarget.18694.
• Karlsen, Karine Flem; Tekle, Christina; Andersson, Yvonne; Flatmark, Kjersti; Fodstad, Øystein & Nunes-Xavier, Caroline Elisabeth (2017). Immunoregulatory protein B7-H3 promotes growth and decreases sensitivity to therapy in metastatic melanoma cells. Pigment Cell & Melanoma Research. ISSN 1755-1471. 30(5), s. 467–476. doi: 10.1111/pcmr.12599. Fulltekst i vitenarkiv
• Lim, Sangbin; Phillips, Joshua B.; da Silva, Luciana Madeira; Zhou, Ming; Fodstad, Øystein & Owen, Laurie B. [Vis alle 7 forfattere av denne artikkelen] (2017). Interplay between immune checkpoint proteins and cellular metabolism. Cancer Research. ISSN 0008-5472. 77(6), s. 1245–1249. doi: 10.1158/0008-5472.CAN-16-1647.
• Frøysnes, Ida Storhaug; Andersson, Yvonne; Larsen, Stein Gunnar; Davidson, Ben; Øien, Janne-Merete & Olsen, Kari Hauge [Vis alle 11 forfattere av denne artikkelen] (2017). Novel treatment with intraperitoneal MOC31PE immunotoxin in colorectal peritoneal metastasis: results from the ImmunoPeCa Phase 1 Trial. Annals of Surgical Oncology. ISSN 1068-9265. 24(7), s. 1916–1922. doi: 10.1245/s10434-017-5814-6.
• Wang, Mengyu; Nestvold, Janne M.; Rekdal, Øystein; Kvalheim, Gunnar & Fodstad, Øystein (2017). A novel rat fibrosarcoma cell line from transformed bone marrow-derived mesenchymal stem cells with maintained in vitro and in vivo stemness properties. Experimental Cell Research. ISSN 0014-4827. 352(2), s. 218–224. doi: 10.1016/j.yexcr.2017.02.005.
• Sas-Chen, Aldema; Aure, Miriam Ragle; Leibovich, Limor; Carvalho, Silvia; Enuka, Yehoshua & Körner, Cindy [Vis alle 38 forfattere av denne artikkelen] (2016). LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer. EMBO Molecular Medicine. ISSN 1757-4676. 8(9), s. 1052–1064. doi: 10.15252/emmm.201606198. Fulltekst i vitenarkiv
• Rud, Ane Kristine Kongsgaard; Pedersen, Kjetil Boye; Fodstad, Øystein; Juell, Siri; Jørgensen, Lars Hilmar & Solberg, Steinar [Vis alle 9 forfattere av denne artikkelen] (2016). Detection of disseminated tumor cells in lymph nodes from patients with early stage non-small cell lung cancer. Diagnostic Pathology. ISSN 1746-1596. 11(50). doi: 10.1186/s13000-016-0504-4. Fulltekst i vitenarkiv
• Lim, Sangbin; Liu, Hao; da Silva, Luciana Madeira; Arora, Ritu; Liu, Zixing & Phillips, Joshua B. [Vis alle 14 forfattere av denne artikkelen] (2016). Immunoregulatory protein B7-H3 reprograms glucose metabolism in cancer cells by ROS-mediated stabilization of HIF1a. Cancer Research. ISSN 0008-5472. 76(8), s. 2231–2242. doi: 10.1158/0008-5472.CAN-15-1538.
• Nunes-Xavier, Caroline Elisabeth; Flem Karlsen, Karine; Tekle, Christina; Pedersen, Cathrine; Øyjord, Tove Ragnhild & Hongisto, Vesa [Vis alle 10 forfattere av denne artikkelen] (2016). Decreased expression of B7-H3 reduces the glycolytic capacity and sensitizes breast cancer cells to AKT/mTOR inhibitors. OncoTarget. ISSN 1949-2553. 7(6), s. 6891–6901. doi: 10.18632/oncotarget.6902. Fulltekst i vitenarkiv
• Eide, Nils; Garred, Øystein; Beiske, Klaus & Fodstad, Øystein (2016). Bilateral uveal melanomas with different gene expression detected with 7 years interval. Acta Ophthalmologica. ISSN 1755-375X. 94(1), s. 99–102. doi: 10.1111/aos.12857.
• Hoshino, Ayuko; Costa-Silva, Bruno; Shen, Tang-Long; Rodrigues, Goncalo; Hashimoto, Ayako & Tesic Mark, Milica [Vis alle 54 forfattere av denne artikkelen] (2015). Tumour exosome integrins determine organotropic metastasis. Nature. ISSN 0028-0836. 527(7578), s. 329–335. doi: 10.1038/nature15756.
• Andersson, Yvonne; Engebråten, Olav; Juell, Siri; Aamdal, Steinar; Brunsvig, Paal Fr. & Fodstad, Øystein [Vis alle 7 forfattere av denne artikkelen] (2015). Phase I trial of EpCAM-targeting immunotoxin MOC31PE, alone and in combination with cyclosporin. British Journal of Cancer. ISSN 0007-0920. 113(11), s. 1548–1555. doi: 10.1038/bjc.2015.380.
• Srivastava, Sanjeev K.; Bhardwaj, Ashwani; Arora, Sumit; Tyagi, Nikhil; Singh, Ajay P. & Carter, James E. [Vis alle 9 forfattere av denne artikkelen] (2015). Interleukin-8 is a key mediator of FKBP51-induced melanoma growth, angiogenesis and metastasis. British Journal of Cancer. ISSN 0007-0920. 112, s. 1772–1781. doi: 10.1038/bjc.2015.154.
• Eide, Nils; Faye, Ragnar Solberg; Høifødt, Hanne Kleppe; Sandstad, Berit; Qvale, Geir Aksel & Faber, Rowan Thomas [Vis alle 9 forfattere av denne artikkelen] (2015). Immunomagnetic detection of micrometastatic cells in bone marrow of uveal melanoma patients: A paradox. Acta Ophthalmologica. ISSN 1755-375X. 93(1), s. 59–66. doi: 10.1111/aos.12462.
• Nygren, Marit; Tekle, Christina; Ingebrigtsen, Vibeke Anett; Mäkelä, Rami; Krohn, Marit & Aure, Miriam Ragle [Vis alle 17 forfattere av denne artikkelen] (2014). Identifyinig microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c. British Journal of Cancer. ISSN 0007-0920. 15. doi: 10.1038/bjc.2014.113.
• Wiiger, Merete Thune; Bideli, Hemaseh; Fodstad, Øystein; Flatmark, Kjersti & Andersson, Yvonne (2014). The MOC31PE immunotoxin reduces cell migration and induces gene expression and cell death in ovarian cancer cells. Journal of Ovarian Research. ISSN 1757-2215. 7(1). doi: 10.1186/1757-2215-7-23.
• Ingebrigtsen, Vibeke Anett; Boye, Kjetil; Nesland, Jahn M; Nesbakken, Arild; Flatmark, Kjersti & Fodstad, Øystein (2014). B7-H3 expression in colorectal cancer: associations with clinicopathological parameters and patient outcome. BMC Cancer. ISSN 1471-2407. 20(14). doi: 10.1186/1471-2407-14-602.
• Eide, Nils; Høifødt, Hanne Kleppe; Nesland, Jahn M; Faye, Ragnar Solberg; Qvale, Geir Aksel & Faber, Rowan Thomas [Vis alle 9 forfattere av denne artikkelen] (2013). Disseminated tumour cells in bone marrow of patients with uveal melanoma. Acta Ophthalmologica. ISSN 1755-375X. 91(4), s. 343–348. doi: 10.1111/j.1755-3768.2012.02449.x.
• Wang, Ping; Suo, Zhenhe; Wang, Mengyu; Høifødt, Hanne Kleppe; Fodstad, Øystein & Gaudernack, Gustav [Vis alle 7 forfattere av denne artikkelen] (2013). In vitro and in vivo properties of CD133 expressing cells from human lung cancer cell lines. Experimental hematology and oncology. ISSN 2162-3619. 2(16). doi: 10.1186/2162-3619-2-16.
• Flatmark, Kjersti; Guldvik, Ingrid Jenny; Svensson, Hege Christin; Fleten, Karianne Giller; Flørenes, Vivi Ann & Reed, Wenche [Vis alle 9 forfattere av denne artikkelen] (2013). Immunotoxin targeting EpCAM effectively inhibits peritoneal tumor growth in experimental models of mucinous peritoneal surface malignancies. International Journal of Cancer. ISSN 0020-7136. 133(6), s. 1497–1506. doi: 10.1002/ijc.28158.
• Zhai, Haiyan; Fesler, Andrew; Schee, Kristina; Fodstad, Øystein; Flatmark, Kjersti & Ju, Jingfang (2013). Clinical significance of long intergenic noncoding RNA-p21 in colorectal cancer. Clinical colorectal cancer. ISSN 1533-0028. 12(4), s. 261–266. doi: 10.1016/j.clcc.2013.06.003.
• Bruheim, Skjalg; Sandvold, Marit Liland; Mælandsmo, Gunhild & Fodstad, Øystein (2013). Antitumor Activity of Elacytarabine Combined with Bevacizumab, Cetuximab and Trastuzumab in Human NSCLC Xenografts. Anticancer Research. ISSN 0250-7005. 33(9), s. 3615–3621.
• Schee, Kristina; Lorenz, Susanne; Worren, Merete Molton; Günther, Clara-Cecilie; Holden, Marit & Hovig, Johannes Eivind [Vis alle 9 forfattere av denne artikkelen] (2013). Deep Sequencing the MicroRNA Transcriptome in Colorectal Cancer. PLOS ONE. ISSN 1932-6203. 8(6). doi: 10.1371/journal.pone.0066165. Vis sammendrag

  Colorectal cancer (CRC) is one of the leading causes of cancer related deaths and the search for prognostic biomarkers that might improve treatment decisions is warranted. MicroRNAs (miRNAs) are short non-coding RNA molecules involved in regulating gene expression and have been proposed as possible biomarkers in CRC. In order to characterize the miRNA transcriptome, a large cohort including 88 CRC tumors with long-term follow-up was deep sequenced. 523 mature miRNAs were expressed in our cohort, and they exhibited largely uniform expression patterns across tumor samples. Few associations were found between clinical parameters and miRNA expression, among them, low expression of miR-592 and high expression of miR-10b-5p and miR-615-3p were associated with tumors located in the right colon relative to the left colon and rectum. High expression of miR-615-3p was also associated with poorly differentiated tumors. No prognostic biomarker candidates for overall and metastasis-free survival were identified by applying the LASSO method in a Cox proportional hazards model or univariate Cox. Examination of the five most abundantly expressed miRNAs in the cohort (miR-10a-5p, miR-21-5p, miR-22-3p, miR-143-3p and miR-192-5p) revealed that their collective expression represented 54% of the detected miRNA sequences. Pathway analysis of the target genes regulated by the five most highly expressed miRNAs uncovered a significant number of genes involved in the CRC pathway, including APC, TGFβ and PI3K, thus suggesting that these miRNAs are relevant in CRC.

• Rud, Ane Kristine Kongsgaard; Borgen, Elin; Mælandsmo, Gunhild; Flatmark, Kjersti; Le, Hang Ngoc Thi & Josefsen, Dag [Vis alle 13 forfattere av denne artikkelen] (2013). Clinical significance of disseminated tumour cells in non-small cell lung cancer. British Journal of Cancer. ISSN 0007-0920. 109(5), s. 1264–1270. doi: 10.1038/bjc.2013.450. Fulltekst i vitenarkiv
• Desai, Shruti; Liu, Zixing; Yao, Jun; Patel, Nishant; Chen, Jieqing & Wu, Yun [Vis alle 9 forfattere av denne artikkelen] (2013). Heat Shock Factor 1 (HSF1) Controls Chemoresistance and Autophagy through Transcriptional Regulation of Autophagy-related Protein 7 (ATG7). Journal of Biological Chemistry. ISSN 0021-9258. 288(13), s. 9165–9176. doi: 10.1074/jbc.M112.422071.
• Liu, Zixing; Liu, Hao; Desai, Shruti; Schmitt, David; Zhou, Ming & Khong, Hung T. [Vis alle 10 forfattere av denne artikkelen] (2013). miR-125b Functions as a Key Mediator for Snail-induced Stem Cell Propagation and Chemoresistance. Journal of Biological Chemistry. ISSN 0021-9258. 288(6), s. 4334–4345. doi: 10.1074/jbc.M112.419168.
• Vincent, Andrew J.; Ren, Suping; Harris, Lillianne G.; Devine, Daniel J.; Samant, Rajeev S. & Fodstad, Øystein [Vis alle 7 forfattere av denne artikkelen] (2012). Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance NUPR1 and p21 in chemoresistance. FEBS Letters. ISSN 0014-5793. 586(19), s. 3429–3434. doi: 10.1016/j.febslet.2012.07.063.
• Ingebrigtsen, Vibeke Anett; Boye, Kjetil ; Tekle, Christina; Nesland, Jahn M; Flatmark, Kjersti & Fodstad, Øystein (2012). B7-H3 expression in colorectal cancer: Nuclear localization strongly predicts poor outcome in colon cancer. International Journal of Cancer. ISSN 0020-7136. 131(11), s. 2528–2536. doi: 10.1002/ijc.27566.
• Tekle, Christina; Nygren, Marit Kveine; Chen, Yih-Wen; Dybsjord, Indrejit; Nesland, Jahn M & Mælandsmo, Gunhild [Vis alle 7 forfattere av denne artikkelen] (2012). B7-H3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis-associated genes. International Journal of Cancer. ISSN 0020-7136. 130(10), s. 2282–2290. doi: 10.1002/ijc.26238.
• Ding, Yan; Liu, Zixing; Desai, Shruti; Zhao, Yuhua; Liu, Hao & Pannell, Lewis K [Vis alle 15 forfattere av denne artikkelen] (2012). Receptor tyrosine kinase ErbB2 translocates into mitochondria and regulates cellular metabolism. Nature Communications. ISSN 2041-1723. 3. doi: 10.1038/ncomms2236.
• Schee, Kristina; Boye, Kjetil; Abrahamsen, Torveig Weum; Fodstad, Øystein & Flatmark, Kjersti (2012). Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer. BMC Cancer. ISSN 1471-2407. 12(505). doi: 10.1186/1471-2407-12-505.
• Wang, Bin; Howel, Paul; Bruheim, Skjalg; Ju, Jingfang; Owen, Laurie B. & Fodstad, Øystein [Vis alle 7 forfattere av denne artikkelen] (2011). Systematic evaluation of three microRNA profiling platforms: microarray, beads array, and quantitative real-time PCR array. PLOS ONE. ISSN 1932-6203. 6(2). doi: 10.1371/journal.pone.0017167.
• Tveito, Siri; Andersen, Kristin; Kåresen, Rolf & Fodstad, Øystein (2011). Analysis of EpCAM positive cells isolated from sentinel lymph nodes of breast cancer patients identifies subpopulations of cells with distinct transcription profiles. Breast Cancer Research. ISSN 1465-5411. 13(4). doi: 10.1186/bcr2922.
• Sælen, Marie Grøn; Flatmark, Kjersti; Folkvord, Sigurd; de Wijn, Rik; Rasmussen, Heidi & Fodstad, Øystein [Vis alle 7 forfattere av denne artikkelen] (2011). Tumor kinase activity in locally advanced rectal cancer: angiogenic signaling and early systemic dissemination. Angiogenesis. ISSN 0969-6970. 14(4), s. 481–489. doi: 10.1007/s10456-011-9231-3.
• Hjortland, Geir Olav; Meza, Leonardo Zepeda; Beiske, Klaus; Ree, Anne Hansen; Tveito, Siri & Høifødt, Hanne Kleppe [Vis alle 12 forfattere av denne artikkelen] (2011). Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma. BMC Cancer. ISSN 1471-2407. 11. doi: 10.1186/1471-2407-11-455.
• Zhao, Yuhua; Liu, Hao; Riker, Adam I; Fodstad, Øystein; Ledoux, Susan P. & Wilson, Glenn L. [Vis alle 7 forfattere av denne artikkelen] (2011). Emerging Metabolic Targets in Cancer Therapy. Frontiers in Bioscience. ISSN 1093-9946. 16, s. 1844–1860. doi: 10.2741/3826.
• Risberg, Karianne; Guldvik, Ingrid Jenny; Palchaudhuri, Rahul; Xi, Yaguang; Ju, Jingfang & Fodstad, Øystein [Vis alle 8 forfattere av denne artikkelen] (2011). Triphenylmethyl Derivatives Enhances the Anticancer Effect of Immunotoxins. Journal of immunotherapy. ISSN 1524-9557. 34(5), s. 438–447. doi: 10.1097/CJI.0b013e31821e00ae.
• Zhao, Yuhua; Liu, Hao; Liu, Zixing; Ding, Yan; Ledoux, Susan P. & Wilson, Glenn L. [Vis alle 16 forfattere av denne artikkelen] (2011). Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism. Cancer Research. ISSN 0008-5472. 71(13), s. 4585–4597. doi: 10.1158/0008-5472.CAN-11-0127.
• Bergman, A.M; Adema, A.D.; Balzarini, J.; Bruheim, Skjalg; Fichtner, I. & Noordhuis, P. [Vis alle 11 forfattere av denne artikkelen] (2011). Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models. Investigational new drugs. ISSN 0167-6997. 29(3), s. 456–466. doi: 10.1007/s10637-009-9377-7.
• Risberg, Karianne; Fodstad, Øystein & Andersson, Yvonne (2011). Synergistic Anticancer Effects of the 9.2.27PE Immunotoxin and ABT-737 in Melanoma. PLOS ONE. ISSN 1932-6203. 6(9). doi: 10.1371/journal.pone.0024012.
• Liu, Hao; Tekle, Christina; Chen, Yih Wen; Kristian, Alexandr; Zhao, Yuhua & Zhou, Ming [Vis alle 13 forfattere av denne artikkelen] (2011). B7-H3 Silencing Increases Paclitaxel Sensitivity by Abrogating Jak2/Stat3 Phosphorylation. Molecular Cancer Therapeutics. ISSN 1535-7163. 10(6), s. 960–971. doi: 10.1158/1535-7163.MCT-11-0072.
• Flatmark, Kjersti; Borgen, Elin; Nesland, Jahn M; Rasmussen, Heidi; Johannessen, Hans Olaf & Bukholm, Ida Rashida Khan [Vis alle 12 forfattere av denne artikkelen] (2011). Disseminated tumour cells as a prognostic biomarker in colorectal cancer. British Journal of Cancer. ISSN 0007-0920. 104(9), s. 1434–1439. doi: 10.1038/bjc.2011.97.
• Bruheim, Skjalg; Kristian, Alexandr; Uenaka, Toshimitsu; Suo, Zhenhe; Tsuruoka, Akihiko & Nesland, Jahn M [Vis alle 7 forfattere av denne artikkelen] (2011). Antitumour activity of oral E7080, a novel inhibitor of multiple tyrosine kinases, in human sarcoma xenografts. International Journal of Cancer. ISSN 0020-7136. 129(3), s. 742–750. doi: 10.1002/ijc.25922.
• Mercapide, Javier; Rappa, Germana; Anzanello, Fabio; King, Judy A; Fodstad, Øystein & Lorico, Aurelio (2010). Primary gene-engineered neural stem/progenitor cells demonstrate tumor-selective migration and antitumor effects in glioma. International Journal of Cancer. ISSN 0020-7136. 126(5), s. 1206–1215. doi: 10.1002/ijc.24809.
• Ren, Suping; Liu, Suhu; Howell, Paul; Zhang, Guangyu; Pannell, Lewis & Samant, Rajeev S. [Vis alle 10 forfattere av denne artikkelen] (2010). Functional characterization of the progestagen-associated endometrial protein gene in human melanoma. Journal of Cellular and Molecular Medicine. ISSN 1582-1838. 14(6B), s. 1432–1442. doi: 10.1111/j.1582-4934.2009.00922.x.
• Schee, Kristina; Fodstad, Øystein & Flatmark, Kjersti (2010). MicroRNAs as Biomarkers in Colorectal Cancer. American Journal of Pathology. ISSN 0002-9440. 177(4), s. 1592–1599. doi: 10.2353/ajpath.2010.100024.
• Zhou, Ming; Liu, Zixing; Zhao, Yuhua; Ding, Yan; Liu, Hao & Xi, Yaguang [Vis alle 12 forfattere av denne artikkelen] (2010). MicroRNA-125b Confers the Resistance of Breast Cancer Cells to Paclitaxel through Suppression of Pro-apoptotic Bcl-2 Antagonist Killer 1 (Bak1) Expression. Journal of Biological Chemistry. ISSN 0021-9258. 285(28), s. 21496–21507. doi: 10.1074/jbc.M109.083337.
• Wiiger, Merete Thune; Gehrken, Hege Brandt; Fodstad, Øystein; Mælandsmo, Gunhild M & Andersson, Yvonne (2010). A novel human recombinant single-chain antibody targeting CD166/ALCAM inhibits cancer cell invasion in vitro and in vivo tumour growth. Cancer Immunology and Immunotherapy. ISSN 0340-7004. 59(11), s. 1665–1674. doi: 10.1007/s00262-010-0892-3.
• Briggs, Jon; Haugen, Mads Haugland; Johansen, Harald Thidemann; Riker, Adam I; Abrahamson, Magnus & Fodstad, Øystein [Vis alle 8 forfattere av denne artikkelen] (2010). Cystatin E/M suppresses legumain activity and invasion of human melanoma. BMC Cancer. ISSN 1471-2407. 10(1). doi: 10.1186/1471-2407-10-17.
• Risberg, Karianne; Fodstad, Øystein & Andersson, Yvonne (2010). Anti-Melanoma Activity of the 9.2.27PE Immunotoxin in Dacarbazine Resistant Cells. Journal of immunotherapy. ISSN 1524-9557. 33(3), s. 272–278. doi: 10.1097/CJI.0b013e3181c54991.
• Metge, Brandon J.; Liu, Suhu; Riker, Adam I; Fodstad, Øystein; Samant, Rajeev S. & Shevde, Lalita A. (2010). Elevated Osteopontin Levels in Metastatic Melanoma Correlate with Epigenetic Silencing of Breast Cancer Metastasis Suppressor 1. Oncology. ISSN 0030-2414. 78(1), s. 75–86. doi: 10.1159/000292363.
• Zhou, Ming; Zhao, Yuhua; Ding, Yan; Liu, Hao; Liu, Zixing & Fodstad, Øystein [Vis alle 12 forfattere av denne artikkelen] (2010). Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol. Molecular Cancer. ISSN 1476-4598. 9. doi: 10.1186/1476-4598-9-33.
• Eide, Nils; Faye, Ragnar Solberg; Høifødt, Hanne Kleppe; Øvergaard, Ralf Gunnar; Jebsen, Peter Wilhelm & Kvalheim, Gunnar [Vis alle 7 forfattere av denne artikkelen] (2009). Immunomagnetic detection of micrometastatic cells in bone marrow in uveal melanoma patients. Acta Ophthalmologica. ISSN 1755-375X. 87(8), s. 830–836. doi: 10.1111/j.1755-3768.2008.01378.x.
• Engebråten, Olav; Trikha, M; Juell, S; Garman-Vik, S & Fodstad, Øystein (2009). Inhibition of In Vivo Tumour Growth by the Blocking of Host alpha(v)beta(3) and alpha IIb beta(3) Integrins. Anticancer Research. ISSN 0250-7005. 29(1), s. 131–137.
• Risberg, Karianne; Fodstad, Øystein & Andersson, Yvonne (2009). The melanoma specific 9.2.27PE immunotoxin efficiently kills melanoma cells in vitro. International Journal of Cancer. ISSN 0020-7136. 125(1), s. 23–33. doi: 10.1002/ijc.24317.
• Zhao, YH; Zhou, M; Liu, H; Ding, Y; Khong, HT & Yu, D. [Vis alle 8 forfattere av denne artikkelen] (2009). Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth. Oncogene. ISSN 0950-9232. 28(42), s. 3689–3701. doi: 10.1038/onc.2009.229. Vis sammendrag

  ErbB2 has been shown to activate signaling molecules that may regulate glucose metabolism. However, there is no evidence reported to directly link ErbB2 to glycolysis, and the mechanism underlying ErbB2-enhanced glycolysis is poorly understood. In this study, we investigated the role and mechanism of ErbB2 in regulating glycolysis. We found that ErbB2-overexpressing cells possessed a significantly higher level of glycolysis when compared to the ErbB2-low-expressing cells, and the downregulation of ErbB2 markedly decreased glycolysis. Overexpression of ErbB2 increased the expression of glycolysis-regulating molecules lactate dehydrogenase A (LDH-A) and heat shock factor 1 (HSF1). ErbB2 activated HSF1, indicated by the increased HSF1 trimer formation, and promoted HSF1 protein synthesis. HSF1 bound to LDH-A promoter and the downregulation of HSF1 reduced the expression of LDH-A and subsequently decreased cancer cell glycolysis and growth. Moreover, the glycolysis inhibitors, 2-deoxyglucose and oxamate, selectively inhibited the growth of ErbB2-overexpressing cells. Taken together, this study shows that in human breast cancer cells, ErbB2 promotes glycolysis at least partially through the HSF1-mediated upregulation of LDH-A. This pathway may have a major role in regulating glucose metabolism in breast cancer cells. These novel findings have important implications for the design of new approaches to target ErbB2-overexpressing breast cancers.

• Liu, Suhu; Howell, Paul; Ren, Suping; Fodstad, Øystein; Zhang, GY & Samant, R [Vis alle 10 forfattere av denne artikkelen] (2009). Expression and functional analysis of the WAP four disulfide core domain 1 gene in human melanoma. Clinical and Experimental Metastasis. ISSN 0262-0898. 26(7), s. 739–749. doi: 10.1007/s10585-009-9273-8.
• Bruheim, Skjalg; Xi, YG; Ju, JF & Fodstad, Øystein (2009). Gene Expression Profiles Classify Human Osteosarcoma Xenografts According to Sensitivity to Doxorubicin, Cisplatin, and Ifosfamide. Clinical Cancer Research. ISSN 1078-0432. 15(23), s. 7161–7169. doi: 10.1158/1078-0432.CCR-08-2816.
• Song, B; Wang, Y; Xi, Y; Kudo, K; Bruheim, Skjalg & Botchkina, GI [Vis alle 12 forfattere av denne artikkelen] (2009). Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells. Oncogene. ISSN 0950-9232. 28(46), s. 4065–4074. doi: 10.1038/onc.2009.274.
• Andersson, Y; Engebråten, Olav & Fodstad, Øystein (2009). Synergistic anti-cancer effects of immunotoxin and cyclosporin in vitro and in vivo. British Journal of Cancer. ISSN 0007-0920. 101(8), s. 1307–1315. doi: 10.1038/sj.bjc.6605312.
• Bratland, Åse; Boender, PJ; Høifødt, Hanne Kleppe; Østensen, Ingrid H.G; Ruijtenbeek, R & Wang, MY [Vis alle 10 forfattere av denne artikkelen] (2009). Osteoblast-induced EGFR/ERBB2 signaling in androgen-sensitive prostate carcinoma cells characterized by multiplex kinase activity profiling. Clinical and Experimental Metastasis. ISSN 0262-0898. 26(5), s. 485–496. doi: 10.1007/s10585-009-9248-9.
• Bergamaschi, Anna; Hjortland, Geir Olav; Triulzi, T; Sørlie, Therese; Johnsen, Hilde & Ree, Anne Hansen [Vis alle 12 forfattere av denne artikkelen] (2009). Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft models. Molecular Oncology. ISSN 1574-7891. 3(5-6), s. 469–482. doi: 10.1016/j.molonc.2009.07.003.
• Liu, Suhu; Howell, Paul; Ren, Suping; Fodstad, Øystein & Riker, Adam I (2009). The 14-3-3 sigma gene promoter is methylated in both human melanocytes and melanoma. BMC Cancer. ISSN 1471-2407. 9. doi: 10.1186/1471-2407-9-162.
• Chowdhury, Uttio Roy; Samant, Rajeev S.; Fodstad, Øystein & Shevde, Lalita A. (2009). Emerging role of nuclear protein 1 (NUPR1) in cancer biology. Cancer Metastasis Review. ISSN 0167-7659. 28(1-2), s. 225–232. doi: 10.1007/s10555-009-9183-x.
• Chen, YW; Tekle, Christina & Fodstad, Øystein (2008). The immunoregulatory protein human B7H3 is a tumor-associated antigen that regulates tumor cell migration and invasion. Current Cancer Drug Targets. ISSN 1568-0096. 8, s. 404–413.
• Clark, DW; Mitra, A; Fillmore, RA; Jiang, WG; Samant, RS & Fodstad, Øystein [Vis alle 7 forfattere av denne artikkelen] (2008). NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress. Current Cancer Drug Targets. ISSN 1568-0096. 8, s. 421–430.
• Brunsvig, Paal Fredrik; Flatmark, Kjersti; Aamdal, Steinar; Høifødt, Hanne Kleppe; Le, H & Jakobsen, E [Vis alle 8 forfattere av denne artikkelen] (2008). Bone marrow micrometastases in advanced stage non-small cell lung carcinoma patients. Lung Cancer. ISSN 0169-5002. 61(2), s. 170–176. doi: 10.1016/j.lungcan.2007.12.018.
• Lillehammer, T; Engesaeter, BO; Prasmickaite, L; Maelandsmo, GM; Fodstad, Øystein & Engebråten, Olav (2007). Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell lines. Journal of Gene Medicine. ISSN 1099-498X. 9, s. 440–451. doi: 10.1002/jgm.1036.
• Tveito, S; Maelandsmo, GM; Hoifodt, HK; Rasmussen, H & Fodstad, Øystein (2007). Specific isolation of disseminated cancer cells: a new method permitting sensitive detection of target molecules of diagnostic and therapeutic value. Clinical and Experimental Metastasis. ISSN 0262-0898. 24, s. 317–327. doi: 10.1007/s10585-006-9052-8.
• Flatmark, Kjersti; Reed, W; Halvorsen, T; Sorensen, O; Wiig, JN & Larsen, SG [Vis alle 8 forfattere av denne artikkelen] (2007). Pseudomyxoma peritonei - two novel orthotopic mouse models portray the PMCA-I histopathologic subtype. BMC Cancer. ISSN 1471-2407. 7. doi: 10.1186/1471-2407-7-116.
• Bauer, NN; Chen, YW; Samant, RS; Shevde, LA & Fodstad, Øystein (2007). Rac1 activity regulates proliferation of aggressive metastatic melanoma. Experimental Cell Research. ISSN 0014-4827. 313, s. 3832–3839.

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• Nunes-Xavier, Caroline Elisabeth; Emaldi, Maite; Mingo, Janire; Øyjord, Tove Ragnhild; Mælandsmo, Gunhild Mari & Fodstad, Øystein [Vis alle 11 forfattere av denne artikkelen] (2023). Author Correction: The expression pattern of pyruvate dehydrogenase kinases predicts prognosis and correlates with immune exhaustion in clear cell renal cell carcinoma (Scientific Reports, (2023), 13, 1, (7339), 10.1038/s41598-023-34087-x). Scientific Reports. ISSN 2045-2322. 13(1). doi: 10.1038/s41598-023-36328-5.
• Prasmickaite, Lina; Skrbo, Nirma; Høifødt, Hanne Kleppe; Suo, Zhenhe; Engebråten, Olav & Gullestad, Hans petter [Vis alle 9 forfattere av denne artikkelen] (2010). Human malignant melanoma harbours a large fraction of highly clonogenic cells that do not express markers associated with cancer stem cells. Pigment Cell & Melanoma Research. ISSN 1755-1471. 23(3), s. 449–451. doi: 10.1111/j.1755-148X.2010.00690.x.
• Fodstad, Øystein; Tveito, Siri; Kåresen, Rolf & Sauer, Torill (2010). Metastasis - gene expression differences associated with site and treatment sensitivity. European Journal of Cancer. ISSN 0959-8049. 8(5), s. 156–156.
• Wiiger, Merete Thune; Fodstad, Øystein & Andersson, Yvonne (2010). Characterization of novel recombinant human single chain cancer-specific antibodies. European Journal of Cancer. ISSN 0959-8049. 8(5), s. 56–56.
• Briggs, Jon; Haugen, Mads Haugland; Johansen, Harald Thidemann; Riker, Adam I; Abrahamson, Magnus & Fodstad, Øystein [Vis alle 8 forfattere av denne artikkelen] (2009). Cystatin E/M suppresses legumain activity and invasion of human melanoma.
• Fodstad, Øystein; Tveito, Siri; Høifødt, Hanne Kleppe; Park, Daehoon; Sauer, Torill & Kåresen, Rolf (2009). Detection and characterization of tumour cells in sentinel lymph nodes and bone marrow of patients with breast cancer. European Journal of Cancer. ISSN 0959-8049. 7(2), s. 70–71.
• Eide, Nils; Overgaard, R; Jebsen, P; Qvale, Geir Aksel; Faye, Ragnar Solberg & Hoifodt, HK [Vis alle 8 forfattere av denne artikkelen] (2008). Micrometastases in uveal melanoma, a comparison of the test results in bone marrow and clinical outcome. Acta Ophthalmologica. ISSN 1755-375X. 86, s. 40–40.
• Bruheim, Skjalg & Fodstad, Øystein (2010). Preclinical studies of human osteosarcoma -Therapy response and search for biomarkers. Unipub forlag. ISSN 978-82-8072-606-3.
• Risberg, Karianne; Andersson, Yvonne & Fodstad, Øystein (2010). Immunotoxins in targeted therapy of cancer – a study in malignant melanoma cells. Unipub forlag. ISSN 978-82-8072-602-5.
• Bratland, Åse; Ree, Anne Hansen & Fodstad, Øystein (2009). Therapeutic targeting of molecular mechanisms involved in tumor progression and metastasis. Unipub forlag. ISSN 978-82-8072-446-5.
• Bøe, Sigurd; Hovig, Eivind & Fodstad, Øystein (2009). Modulation of gene expression using natural and artificial nucleic acids combined with photochemical internalization technology. Unipub forlag. ISSN 978-82-8072-311-6.
• Liu, Fang; Hovig, Eivind; Jenssen, Tor-Kristian & Fodstad, Øystein (2007). Large-scale bioinfomatics studies of DNA denaturation and transcriptome profiling technologies. Unipub forlag. ISSN 978-82-8072-433-5.

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