Guy Frederick Lanyon Hindley

• Frei, Oleksandr; Hindley, Guy; Shadrin, Alexey; van der Meer, Dennis; Akdeniz, Bayram Cevdet & Hagen, Espen [Vis alle 16 forfattere av denne artikkelen] (2024). Improved functional mapping of complex trait heritability with GSA-MiXeR implicates biologically specific gene sets. Nature Genetics. ISSN 1061-4036. 56(6), s. 1310–1318. doi: 10.1038/s41588-024-01771-1.
• Beck, Dani; de Lange, Ann-Marie Glasø; Gurholt, Tiril Pedersen; Voldsbekk, Irene; Maximov, Ivan & Subramaniapillai, Sivaniya [Vis alle 19 forfattere av denne artikkelen] (2024). Dissecting unique and common variance across body and brain health indicators using age prediction. Human Brain Mapping. ISSN 1065-9471. 45(6). doi: 10.1002/hbm.26685.
• Tissink, E.P.; Shadrin, Alexey; van der Meer, Dennis; Parker, Nadine; Hindley, Guy & Roelfs, Daniel [Vis alle 18 forfattere av denne artikkelen] (2024). Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study. Nature Communications. ISSN 2041-1723. 15(1). doi: 10.1038/s41467-024-46817-4.
• Holen, Børge; Kutrolli, Gleda; Shadrin, Alexey; Icick, Romain; Hindley, Guy & Rødevand, Linn [Vis alle 16 forfattere av denne artikkelen] (2023). Genome-wide analyses reveal shared genetic architecture and novel risk loci between opioid use disorder and general cognitive ability. Drug and Alcohol Dependence. ISSN 0376-8716. 256. doi: 10.1016/j.drugalcdep.2023.111058. Fulltekst i vitenarkiv
• Bakken, Nora R.; Parker, Nadine; Hannigan, Laurie J.; Hagen, Espen; Parekh, Pravesh & Shadrin, Alexey [Vis alle 15 forfattere av denne artikkelen] (2023). Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders. medRxiv. doi: 10.1101/2023.11.21.23298804.
• Jaholkowski, Piotr Pawel; Hindley, Guy; Shadrin, Alexey; Tesfaye, Markos ; Bahrami, Shahram & Nerhus, Mari [Vis alle 19 forfattere av denne artikkelen] (2023). Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci. Schizophrenia Bulletin. ISSN 0586-7614. 49(6), s. 1654–1664. doi: 10.1093/schbul/sbad063. Fulltekst i vitenarkiv
• Rødevand, Linn Nilsen; Rahman, Zillur; Hindley, Guy Frederick Lanyon; Smeland, Olav Bjerkehagen; Frei, Oleksandr & Filiz, Tahir Tekin [Vis alle 15 forfattere av denne artikkelen] (2023). Characterizing the Shared Genetic Underpinnings of Schizophrenia and Cardiovascular Disease Risk Factors. American Journal of Psychiatry. ISSN 0002-953X. 180(11), s. 815–826. doi: 10.1176/APPI.AJP.20220660.
• Steen, Nils Eiel; Rahman, Zillur; Szabo, Attila; Hindley, Guy; Parker, Nadine & Cheng, Weiqiu [Vis alle 20 forfattere av denne artikkelen] (2023). Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities. Schizophrenia Bulletin. ISSN 0586-7614. 49(5), s. 1345–1354. doi: 10.1093/schbul/sbad082. Fulltekst i vitenarkiv
• Parker, Nadine; Cheng, Weiqiu; Hindley, Guy; Parekh, Pravesh; Shadrin, Alexey & Maximov, Ivan [Vis alle 12 forfattere av denne artikkelen] (2023). Psychiatric disorders and brain white matter exhibit genetic overlap implicating developmental and neural cell biology. Molecular Psychiatry. ISSN 1359-4184. doi: 10.1038/s41380-023-02264-z.
• Hindley, Guy; Drange, Ole Kristian; Lin, Aihua; Kutrolli, Gleda; Shadrin, Alexey & Parker, Nadine [Vis alle 20 forfattere av denne artikkelen] (2023). Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders. Psychoneuroendocrinology. ISSN 0306-4530. 157. doi: 10.1016/j.psyneuen.2023.106368. Fulltekst i vitenarkiv
• Woldeyohannes, Markos Tesfaye; Jaholkowski, Piotr Pawel; Hindley, Guy; Shadrin, Alexey; Rahman, Zillur & Bahrami, Shahram [Vis alle 17 forfattere av denne artikkelen] (2023). Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis. Genome Medicine. ISSN 1756-994X. 15(1). doi: 10.1186/s13073-023-01212-4. Fulltekst i vitenarkiv
• Hope, Sigrun; Shadrin, Alexey; Lin, Aihua; Bahrami, Shahram; Rødevand, Linn & Frei, Oleksandr [Vis alle 17 forfattere av denne artikkelen] (2023). Bidirectional genetic overlap between autism spectrum disorder and cognitive traits. Translational Psychiatry. ISSN 2158-3188. 13(1), s. 1–9. doi: 10.1038/s41398-023-02563-7. Fulltekst i vitenarkiv
• Bang, Lasse; Bahrami, Shahram; Hindley, Guy; Smeland, Olav Bjerkehagen; Rødevand, Linn & Jaholkowski, Piotr Pawel [Vis alle 18 forfattere av denne artikkelen] (2023). Genome-wide analysis of anorexia nervosa and major psychiatric disorders and related traits reveals genetic overlap and identifies novel risk loci for anorexia nervosa. Translational Psychiatry. ISSN 2158-3188. 13. doi: 10.1038/s41398-023-02585-1. Fulltekst i vitenarkiv
• Parker, Nadine; Cheng, Weiqiu; Hindley, Guy; O'Connell, Kevin Sean; Karthikeyan, Sandeep & Holen, Børge [Vis alle 19 forfattere av denne artikkelen] (2023). Genetic Overlap Between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts. Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2023.06.008. Fulltekst i vitenarkiv
• Jaholkowski, Piotr; Shadrin, Alexey A.; Jangmo, Andreas; Frei, Evgeniia; Woldeyohannes, Markos Tesfaye & Hindley, Guy F. L. [Vis alle 23 forfattere av denne artikkelen] (2023). Associations Between Symptoms of Premenstrual Disorders and Polygenic Liability for Major Psychiatric Disorders. JAMA psychiatry. ISSN 2168-6238. 80(7), s. 738–742. doi: 10.1001/jamapsychiatry.2023.1137.
• Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Winsvold, Bendik Slagvold; O`Connell, Kevin S.; Frei, Oleksandr & Shadrin, Alexey [Vis alle 16 forfattere av denne artikkelen] (2022). Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools. Brain. ISSN 0006-8950. doi: 10.1093/brain/awab267.
• Hindley, Guy; Frei, Oleksandr; Shadrin, Alexey; Cheng, Weiqiu; O'Connell, Kevin Sean & Icick, Romain [Vis alle 17 forfattere av denne artikkelen] (2022). Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation. American Journal of Psychiatry. ISSN 0002-953X. 179(11), s. 833–843. doi: 10.1176/appi.ajp.21101051.
• Icick, Romain; Shadrin, Alexey; Holen, Børge; Karadag, Naz; Lin, Aihua & Hindley, Guy [Vis alle 17 forfattere av denne artikkelen] (2022). Genetic overlap between mood instability and alcohol-related phenotypes suggests shared biological underpinnings. Neuropsychopharmacology. ISSN 0893-133X. 47, s. 1883–1891. doi: 10.1038/s41386-022-01401-6.
• Motazedi, Ehsan; Cheng, Weiqiu; Thomassen, Jesper Qvist; Frei, Oleksandr; Rongve, Arvid & Athanasiu, Lavinia [Vis alle 30 forfattere av denne artikkelen] (2022). Using Polygenic Hazard Scores to Predict Age at Onset of Alzheimer's Disease in Nordic Populations. Journal of Alzheimer's Disease. ISSN 1387-2877. 88(4), s. 1533–1544. doi: 10.3233/JAD-220174. Vis sammendrag

  Background: Polygenic hazard scores (PHS) estimate age-dependent genetic risk of late-onset Alzheimer’s disease (AD), but there is limited information about the performance of PHS on real-world data where the population of interest differs from the model development population and part of the model genotypes are missing or need to be imputed. Objective: The aim of this study was to estimate age-dependent risk of late-onset AD using polygenic predictors in Nordic populations. Methods: We used Desikan PHS model, based on Cox proportional hazards assumption, to obtain age-dependent hazard scores for AD from individual genotypes in the Norwegian DemGene cohort (n = 2,772). We assessed the risk discrimination and calibration of Desikan model and extended it by adding new genotype markers (the Desikan Nordic model). Finally, we evaluated both Desikan and Desikan Nordic models in two independent Danish cohorts: The Copenhagen City Heart Study (CCHS) cohort (n = 7,643) and The Copenhagen General Population Study (CGPS) cohort (n = 10,886). Results: We showed a robust prediction efficiency of Desikan model in stratifying AD risk groups in Nordic populations, even when some of the model SNPs were missing or imputed. We attempted to improve Desikan PHS model by adding new SNPs to it, but we still achieved similar risk discrimination and calibration with the extended model. Conclusion: PHS modeling has the potential to guide the timing of treatment initiation based on individual risk profiles and can help enrich clinical trials with people at high risk to AD in Nordic populations.

• Hindley, Guy Frederick Lanyon; Bahrami, Shahram; Steen, Nils Eiel; O’Connell, Kevin S.; Frei, Oleksandr & Shadrin, Alexey [Vis alle 13 forfattere av denne artikkelen] (2021). Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking. Translational Psychiatry. ISSN 2158-3188. doi: 10.1038/s41398-021-01576-4.
• Gergel, Tania; Das, Preety; Owen, Gareth; Stephenson, Lucy; Rifkin, Larry & Hindley, Guy Frederick Lanyon [Vis alle 8 forfattere av denne artikkelen] (2021). Reasons for endorsing or rejecting self-binding directives in bipolar disorder: a qualitative study of survey responses from UK service users. The Lancet Psychiatry. ISSN 2215-0374. 8(7), s. 599–609. doi: 10.1016/S2215-0366(21)00115-2. Fulltekst i vitenarkiv
• O'Connell, Kevin Sean; Frei, Oleksandr; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco & Cheng, Weiqiu [Vis alle 16 forfattere av denne artikkelen] (2021). Characterizing the Genetic Overlap Between Psychiatric Disorders and Sleep-Related Phenotypes. Biological Psychiatry. ISSN 0006-3223. s. 1–11. doi: 10.1016/j.biopsych.2021.07.007. Fulltekst i vitenarkiv
• Cheng, Weiqiu; Frei, Oleksandr; van der Meer, Dennis; Wang, Yunpeng; O`Connell, Kevin & Chu, Yunhan [Vis alle 20 forfattere av denne artikkelen] (2021). Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness. JAMA psychiatry. ISSN 2168-6238. 78(9), s. 1020–1030. doi: 10.1001/jamapsychiatry.2021.1435. Fulltekst i vitenarkiv
• Bahrami, Shahram; Shadrin, Alexey A.; Frei, Oleksandr; O`Connell, Kevin; Bettella, Francesco & Krull, Florian [Vis alle 15 forfattere av denne artikkelen] (2021). Genetic loci shared between major depression and intelligence with mixed directions of effect. Nature Human Behaviour. ISSN 2397-3374. s. 1–9. doi: 10.1038/s41562-020-01031-2.

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• Hindley, Guy; Drange, Ole Kristian; Lin, Aihua; Kutrolli, Gleda; Shadrin, Alexey & Parker, Nadine [Vis alle 20 forfattere av denne artikkelen] (2024). Corrigendum to “Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders” [Psychoneuroendocrinology 157 (2023) 106368] (Psychoneuroendocrinology (2023) 157, (S0306453023003463), (10.1016/j.psyneuen.2023.106368)). Psychoneuroendocrinology. ISSN 0306-4530. doi: 10.1016/j.psyneuen.2024.106980.
• Gergel, Tania; Das, Preety; Owen, Gareth; Stephenson, Lucy; Rifkin, Larry & Hindley, Guy (2021). Advance directives reduce friction over involuntary treatment – Authors' reply. The Lancet Psychiatry. ISSN 2215-0374. 8(9), s. 750–751. doi: 10.1016/S2215-0366(21)00290-X.

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