Herman Krogstad Netskar

• Philippon, Camille; Tao, Sudan; Clement, Dennis; Haroun-Izquierdo, Alvaro; Kichula, Katherine M. & Netskar, Herman Krogstad [Vis alle 21 forfattere av denne artikkelen] (2023). Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires. Blood Advances. ISSN 2473-9529. 7(16), s. 4492–4504. doi: 10.1182/bloodadvances.2023009827. Fulltekst i vitenarkiv
• Haroun-Izquierdo, Alvaro; Lanuza, Pilar M.; Pfefferle, Aline; Netskar, Herman Krogstad; Ask, Eivind Heggernes & Törlén, Johan [Vis alle 9 forfattere av denne artikkelen] (2023). Effect of mTOR Inhibition with Sirolimus on Natural Killer Cell Reconstitution in Allogeneic Stem Cell Transplantation. Transplantation and Cellular Therapy (TCT). ISSN 2666-6375. 29(6), s. 376.e1–376.e11. doi: 10.1016/j.jtct.2023.03.023. Fulltekst i vitenarkiv
• Haroun-Izquierdo, Alvaro; Vincenti, Marianna; Netskar, Herman Krogstad; van Ooijen, Hanna; Zhang, Bin & Bendzick, Laura [Vis alle 30 forfattere av denne artikkelen] (2022). Adaptive single-KIR+NKG2C+ NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia. Journal for ImmunoTherapy of Cancer (JITC). 10:e005577(11), s. 1–13. doi: 10.1136/jitc-2022-005577. Fulltekst i vitenarkiv
• Hammer, Quirin; Dunst, Josefine; Christ, Wanda; Picarazzi, Francesca; Wendorff, Mareike & Momayyezi, Pouria [Vis alle 51 forfattere av denne artikkelen] (2022). SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells. Cell reports. ISSN 2211-1247. 38(10). doi: 10.1016/j.celrep.2022.110503. Fulltekst i vitenarkiv Vis sammendrag

  Natural killer (NK) cells are innate immune cells that contribute to host defense against virus infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and are activated in patients with acute coronavirus disease 2019 (COVID-19). However, by which mechanisms NK cells detect SARS-CoV-2-infected cells remains largely unknown. Here, we show that the Non-structural protein 13 of SARS-CoV-2 encodes for a peptide that is presented by human leukocyte antigen E (HLA-E). In contrast with self-peptides, the viral peptide prevents binding of HLA-E to the inhibitory receptor NKG2A, thereby rendering target cells susceptible to NK cell attack. In line with these observations, NKG2A-expressing NK cells are particularly activated in patients with COVID-19 and proficiently limit SARS-CoV-2 replication in infected lung epithelial cells in vitro. Thus, these data suggest that a viral peptide presented by HLA-E abrogates inhibition of NKG2A+ NK cells, resulting in missing self-recognition.

• Klopotowska, Marta; Bajor, Malgorzata; Graczyk-Jarzynka, Agnieszka; Kraft, Agnieszka; Pilch, Zofia & Zhylko, Andriy [Vis alle 25 forfattere av denne artikkelen] (2021). PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress. Cancer immunology research. ISSN 2326-6066. doi: 10.1158/2326-6066.CIR-20-1023.
• Sohlberg, Ebba; Pfefferle, Aline; Ask, Eivind Heggernes; Tschan-Plessl, Astrid; Jacobs, Benedikt Marcel & Netskar, Herman Krogstad [Vis alle 16 forfattere av denne artikkelen] (2021). Perturbed NK Cell Homeostasis Associated with Disease Severity in Chronic Neutropenia. Blood. ISSN 0006-4971. doi: 10.1182/blood.2021013233. Fulltekst i vitenarkiv
• Pfefferle, Aline; Jacobs, Benedikt Marcel; Netskar, Herman; Ask, Eivind Heggernes; Lorenz, Susanne & Clancy, Trevor [Vis alle 9 forfattere av denne artikkelen] (2019). Intra-lineage plasticity and functional reprogramming maintain natural killer cell repertoire diversity. Cell reports. ISSN 2211-1247. 29(8), s. 2284–2294.e4. doi: 10.1016/j.celrep.2019.10.058. Fulltekst i vitenarkiv

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