Jeannette Nilsen

• Grevys, Algirdas; Frick, Rahel; Mester, Simone; Flem-Karlsen, Karine; Nilsen, Jeannette & Foss, Stian [Vis alle 13 forfattere av denne artikkelen] (2022). Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life. iScience. ISSN 2589-0042. 25:103746(2), s. 1–22. doi: 10.1016/j.isci.2022.103746. Fulltekst i vitenarkiv
• Azevedo, Cláudia; Pinto, Soraia; Benjakul, Sopisa; Nilsen, Jeannette; Santos, Helder A. & Traverso, Giovanni [Vis alle 8 forfattere av denne artikkelen] (2021). Prevention of diabetes-associated fibrosis: Strategies in FcRn-targeted nanosystems for oral drug delivery. Advanced Drug Delivery Reviews. ISSN 0169-409X. 175. doi: 10.1016/j.addr.2021.04.016. Fulltekst i vitenarkiv
• Merten, Hannes; Brandl, Fabian; Zimmermann, Martina; Schaefer, Jonas V.; Irpinio, Linda & Sand, Kine M.K. [Vis alle 10 forfattere av denne artikkelen] (2021). Half-life extension of efficiently produced DARPin serum albumin fusions as a function of FcRn affinity and recycling. European journal of pharmaceutics and biopharmaceutics. ISSN 0939-6411. 167, s. 104–113. doi: 10.1016/j.ejpb.2021.07.011. Fulltekst i vitenarkiv
• Mester, Simone; Evers, Mitchell; Meyer, Saskia; Nilsen, Jeannette; Greiff, Victor & Sandlie, Inger [Vis alle 8 forfattere av denne artikkelen] (2021). Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo. mAbs. ISSN 1942-0862. 13:1893888(1), s. 1–14. doi: 10.1080/19420862.2021.1893888. Fulltekst i vitenarkiv
• Lombardi, Silvia; Hovden Aaen, Kristin; Nilsen, Jeannette; Ferrarese, Mattia; Tollefsrud Gjølberg, Torleif & Bernardi, Francesco [Vis alle 9 forfattere av denne artikkelen] (2021). Fusion of engineered albumin with factor IX Padua extends half-life and improves coagulant activity. British Journal of Haematology. ISSN 0007-1048. 194(2), s. 453–462. doi: 10.1111/bjh.17559. Fulltekst i vitenarkiv
• Hovden Aaen, Kristin; Anthi, Aina Karen; Sandlie, Inger; Nilsen, Jeannette; Mester, Simone & Andersen, Jan Terje (2020). The neonatal Fc receptor in mucosal immune regulation. Scandinavian Journal of Immunology. ISSN 0300-9475. doi: 10.1111/sji.13017.
• Nilsen, Jeannette; Trabjerg, Esben; Grevys, Algirdas; Azevedo, Claudia; Brennan, Stephen O. & Stensland, Maria [Vis alle 14 forfattere av denne artikkelen] (2020). An intact C-terminal end of albumin is required for its long half-life in humans. Communications Biology. ISSN 2399-3642. 3(1). doi: 10.1038/s42003-020-0903-7. Fulltekst i vitenarkiv
• Bern, Malin C.; Nilsen, Jeannette; Ferrarese, Mattia; Sand, Kine Marita Knudsen; Tollefsrud Gjølberg, Torleif & Lode, Heidrun Elisabeth [Vis alle 24 forfattere av denne artikkelen] (2020). An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics. Science Translational Medicine. ISSN 1946-6234. 12(565), s. 1–13. doi: 10.1126/scitranslmed.abb0580. Fulltekst i vitenarkiv
• Nilsen, Jeannette; Bern, Malin C.; Sand, Kine Marita Knudsen; Grevys, Algirdas; Dalhus, Bjørn & Sandlie, Inger [Vis alle 7 forfattere av denne artikkelen] (2018). Human and mouse albumin bind their respective neonatal Fc receptors differently. Scientific Reports. ISSN 2045-2322. 8:14648, s. 1–12. doi: 10.1038/s41598-018-32817-0. Fulltekst i vitenarkiv
• Grevys, Algirdas; Nilsen, Jeannette; Sand, Kine Marita Knudsen; Daba, Muluneh Bekele; Øynebråten, Inger & Bern, Malin C. [Vis alle 15 forfattere av denne artikkelen] (2018). A human endothelial cell-based recycling assay for screening of FcRn targeted molecules. Nature Communications. ISSN 2041-1723. 9. doi: 10.1038/s41467-018-03061-x. Fulltekst i vitenarkiv
• Nilsen, Jeannette; Sandlie, Inger; Roopenian, Derry C. & Andersen, Jan Terje (2018). Animal models for evaluation of albumin-based therapeutics. Current Opinion in Chemical Engineering. ISSN 2211-3398. 19, s. 68–76. doi: 10.1016/j.coche.2017.11.007. Fulltekst i vitenarkiv Vis sammendrag

  Albumin has a long serum half-life due to its unique ability to bind the cellular neonatal Fc receptor (FcRn), which provides protection from intracellular degradation. The interaction can be capitalized to improve the efficacy of drugs by extending their serum persistence. However, species-specific binding of albumin to FcRn Challenges preclinical development. The goal of this brief review is to provide Insights into how FcRn and cross-species binding differences affect the pharmacokinetics of human serum albumin (HSA) in different animal models, and gives an overview of genetically modified mice that may serve as improved models for testing of albumin-based drugs.

• Bern, Malin C.; Sand, Kine Marita Knudsen; Nilsen, Jeannette; Sandlie, Inger & Andersen, Jan Terje (2015). The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery. Journal of Controlled Release. ISSN 0168-3659. 211, s. 144–162. doi: 10.1016/j.jconrel.2015.06.006.
• Sand, Kine Marita Knudsen; Bern, Malin C.; Nilsen, Jeannette; Noordzij, Hanna Theodora; Sandlie, Inger & Andersen, Jan Terje (2015). Unraveling the interaction between FcRn and albumin: Opportunities for design of albumin-based therapeutics. Frontiers in Immunology. ISSN 1664-3224. 5:682. doi: 10.3389/fimmu.2014.00682. Fulltekst i vitenarkiv
• Sand, Kine Marita Knudsen; Bern, Malin C.; Nilsen, Jeannette; Dalhus, Bjørn; Gunnarsen, Kristin Støen & Cameron, Jason [Vis alle 10 forfattere av denne artikkelen] (2014). Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc Receptor (FcRn). Journal of Biological Chemistry. ISSN 0021-9258. 289(50), s. 34583–34594. doi: 10.1074/jbc.M114.587675.

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