John-Peder Kvitting

Førsteamanuensis - Thoraxkirurgisk avdeling

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E-post j.p.kvitting@medisin.uio.no

Brukernavn

Besøksadresse Sognsvannsveien 20 Rikshospitalet 0372 Oslo

Postadresse Postboks 4950 Nydalen OUS HF Rikshospitalet 0424 Oslo

Last ned visittkort

John-Peder Escobar Kvitting received his M.D. at Linköping University, Sweden in 2002. He defended his Ph.D., in 2004 at Linköping University, with the title “Quantification of Cardiovascular Flow and Motion: Aspects of Regional Myocardial Function and Flow Patterns in the Aortic Root and the Aorta.” He trained in general and cardiothoracic surgery at Linköping University Hospital. From 2008-2010 he did a post-doctoral fellowship at the department of cardiovascular and thoracic surgery, Stanford University School of Medicine under the supervision of Professor D. Craig Miller. He currently works as a consultant cardiothoracic surgeon at Oslo University Hospital, Rikshospitalet and as an associated professor in cardiothoracic surgery at the University of Oslo. His clinical and research interest are aortic valve repair, valve-sparing aortic root replacement, aortic arch surgery and experimental mitral valve surgery.

kvitting JP - Search Results - PubMed (nih.gov)

John-Peder Escobar Kvitting (0000-0001-5648-7688) - ORCID

‪John-Peder Escobar Kvitting‬ - ‪Google Scholar‬

Zabirnyk, Arsenii; Evensen, Daria; Kvitting, John-Peder; Kaljusto, Mari-Liis; Stensløkken, Kåre-Olav & Vaage, Ingvar Jarle (2024). Hyperglycemia-simulating environment attenuated experimentally induced calcification in cultured human aortic valve interstitial cells. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 58(1). doi: 10.1080/14017431.2024.2353070.
Kvitting, John-Peder; Lindenskov, Paal Helge H. & MOENE, KALLE (2024). Supersoniske passasjerfly, Ødipusfellen og snuvegring. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 144(4), s. 1–7. doi: 10.4045/tidsskr.24.0021.
Ribic, Darijan; Remme, Espen; Smiseth, Otto Armin; Massey, Richard; Eek, Christian & Kvitting, John-Peder [Vis alle 9 forfattere av denne artikkelen] (2024). Non-invasive myocardial work in aortic stenosis: Validation and improvement in left ventricular pressure estimation. European Heart Journal-Cardiovascular Imaging. ISSN 2047-2404. 25(2), s. 201–212. doi: 10.1093/ehjci/jead227.
Ravnestad, Håvard; Andersen, Rune; Birkeland, Sigurd; Svalebjørg, Morten; Lingaas, Per Snorre & Gude, Einar [Vis alle 10 forfattere av denne artikkelen] (2023). Pulmonary endarterectomy and balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension: Comparison of changes in hemodynamics and functional capacity. Pulmonary Circulation (PC). ISSN 2045-8932. 13(1), s. 1–12. doi: 10.1002/pul2.12199. Fulltekst i vitenarkiv
Törnudd, Mattias; Ramström, Sofia; Kvitting, John-Peder; Alfredsson, Joakim; Nyberg, Linnea & Björkman, Erik [Vis alle 7 forfattere av denne artikkelen] (2023). Platelet Function is Preserved After Moderate Cardiopulmonary Bypass Times But Transiently Impaired After Protamine. Journal of Cardiothoracic and Vascular Anesthesia. ISSN 1053-0770. 37(7), s. 1110–1120. doi: 10.1053/j.jvca.2023.03.013. Fulltekst i vitenarkiv
Persson, Robert; Aguilera, Hans Martin Dahl; Kvitting, John-Peder; Grong, Ketil; Prot, Victorien Emile & Salminen, Pirjo-Riitta [Vis alle 11 forfattere av denne artikkelen] (2023). Mitral annular dynamics are influenced by left ventricular load and contractility in an acute animal model. Physiological Reports. ISSN 2051-817X. 11(7). doi: 10.14814/phy2.15665. Fulltekst i vitenarkiv
Seim, Bjørn Edvard; Holt, Margrethe Flesvig; Ratajska, Aleksandra; Michelsen, Annika Elisabet; Ringseth, Monica Myklebust & Halvorsen, Bente [Vis alle 14 forfattere av denne artikkelen] (2022). Markers of extracellular matrix remodeling and systemic inflammation in patients with heritable thoracic aortic diseases. Frontiers in Cardiovascular Medicine. ISSN 2297-055X. 9, s. 1–9. doi: 10.3389/fcvm.2022.1073069. Fulltekst i vitenarkiv
Semenova, Daria; Zabirnyk, Arsenii; Lobov, Arseniy; Boyarskaya, Nadezda; Kachanova, Olga & Uspensky, Vladimir [Vis alle 16 forfattere av denne artikkelen] (2022). Multi-omics of in vitro aortic valve calcification. Frontiers in Cardiovascular Medicine. ISSN 2297-055X. 9. doi: 10.3389/fcvm.2022.1043165. Fulltekst i vitenarkiv
Bogdanova, Mariia; Zabirnyk, Arsenii; Malashicheva, Anna; Semenova, Daria; Kvitting, John-Peder & Kaljusto, Mari-Liis [Vis alle 12 forfattere av denne artikkelen] (2022). Models and Techniques to Study Aortic Valve Calcification in Vitro, ex Vivo and in Vivo. An Overview. Frontiers in Pharmacology. ISSN 1663-9812. 13. doi: 10.3389/fphar.2022.835825. Fulltekst i vitenarkiv
Dumont, Karl-Andreas; Aguilera, Hans Martin; Persson, Robert; Prot, Victorien Emile; Kvitting, John-Peder & Urheim, Stig (2022). Mitral Annular Elasticity Determines Severity of Regurgitation in Barlow's Mitral Valve Disease. Journal of the American Society of Echocardiography. ISSN 0894-7317. 35(10), s. 1037–1046. doi: 10.1016/j.echo.2022.07.001.
Törnudd, Mattias; Rodwan Al Ghraoui, Mohamad; Wahlgren, Sofia; Björkman, Erik; Berg, Sören & Kvitting, John-Peder [Vis alle 8 forfattere av denne artikkelen] (2022). Quantification of platelet function - a comparative study of venous and arterial blood using a novel flow cytometry protocol. Platelets. ISSN 0953-7104. doi: 10.1080/09537104.2021.2019209. Vis sammendrag
Studies of platelet function in surgical patients often involve both arterial and venous sampling. Possible effects of different sampling sites could be important, but have not been thoroughly investigated. We aimed to compare platelet function in arterial and venous blood samples using a novel flow cytometry protocol and impedance aggregometry. Arterial and venous blood was collected before anesthesia in 10 patients undergoing cardiac surgery of which nine was treated with acetylsalicylic acid until the day before surgery. Flow cytometry included simultaneous analysis of phosphatidylserine exposure, active conformation of the fibrinogen receptor (PAC-1 binding), α-granule and lysosomal release (P-selectin and LAMP-1 exposure) and mitochondrial membrane integrity. Platelets were activated with ADP or peptides activating thrombin receptors (PAR1-AP/PAR4-AP) or collagen receptor GPVI (CRP-XL). Leukocyte-platelet conjugates and P-selectin exposure were evaluated immediately in fixated samples. For impedance aggregometry (Multiplate®), ADP, arachidonic acid, collagen and PAR1-AP (TRAP) were used as activators. Using impedance aggregometry and in 27 out of 37 parameters studied with flow cytometry there was no significant difference between venous and arterial blood sampling. Arterial blood showed more PAC-1 positive platelets when activated with PAR1-AP or PAR4-AP and venous blood showed more monocyte-platelet and neutrophil-platelet conjugates and higher phosphatidylserine exposure with CRP-XL alone and combined with PAR1-AP or PAR4-AP. We found no differences using impedance aggregometry. In conclusion, testing of platelet function by flow cytometry and impedance aggregometry gave comparable results for most of the studied parameters in venous and arterial samples. Flow cytometry identified differences in PAC-1 binding when activated with PAR1-AP, exposure of phosphatidyl serine and monocyte/neutrophil-platelet conjugates, which might reflect differences in blood sampling technique or in flow conditions in this patient cohort with coronary artery disease. These differences might be considered when comparing data from different sample sites, but caution should be exercised if a different protocol is used or another patient group is studied.
Kvitting, John-Peder; Beitnes, Jan Otto & Lundblad, Runar (2021). Early results after aortic annuloplasty with a complete external Dacron band. General Thoracic and Cardiovascular Surgery. ISSN 1863-6705. doi: 10.1007/s11748-021-01695-1.
Bugge, Anders; Kvitting, John-Peder; Sundset, Arve & Birkeland, Sigurd (2021). Lung autotransplantation and extra-anatomic bypass to treat an aortobronchial fistula after previous surgery for aortic coarctation. Journal of Cardiac Surgery. ISSN 0886-0440. 36(8), s. 2924–2927. doi: 10.1111/jocs.15660.
Soknes, Maria; Lingaas, Per Snorre; Lundblad, Runar & Kvitting, John-Peder (2021). Total aortic arch replacement using the thoraflex hybrid prosthesis: early- and medium-term results from a Scandinavian center. Scandinavian Cardiovascular Journal. ISSN 1401-7431. doi: 10.1080/14017431.2021.1970800.
Törnudd, Mattias; Ramström, Sofia; Kvitting, John-Peder; Alfredsson, Joakim; Pihl, Richard & Berg, Sören (2020). Protamine stimulates platelet aggregation in vitro with activation of the fibrinogen receptor and alpha-granule release, but impairs secondary activation via ADP and thrombin receptors. Platelets. ISSN 0953-7104. s. 90–96. doi: 10.1080/09537104.2020.1719992.
Holt, Margrethe Flesvig; Seim, Bjørn Edvard; Øgaard, Jonas; Olsen, Maria Belland; Woldbæk, Per R & Kvitting, John Peder Escobar [Vis alle 12 forfattere av denne artikkelen] (2019). Selective and marked decrease of complement receptor C5aR2 in human thoracic aortic aneurysms: A dysregulation with potential inflammatory effects. Open heart. ISSN 2053-3624. 6.e001098(2), s. 1–8. doi: 10.1136/openhrt-2019-001098. Fulltekst i vitenarkiv
Zabirnyk, Arsenii; Ferrer, Miguel David; Bogdanova, Mariia; Perez, MM; Salcedo, C & Kaljusto, Mari-Liis [Vis alle 10 forfattere av denne artikkelen] (2019). SNF472, a novel anti-crystallization agent, inhibits induced calcification in an in vitro model of human aortic valve calcification. Vascular pharmacology. ISSN 1537-1891. s. 1–7. doi: 10.1016/j.vph.2019.106583. Fulltekst i vitenarkiv
Bogdanova, Mariia; Zabirnyk, Arsenii; Malashicheva, Anna; Zihlavnikova, Katarina; Karlsen, Tommy Aleksander & Kaljusto, Mari-Liis [Vis alle 13 forfattere av denne artikkelen] (2019). Interstitial cells in calcified aortic valves have reduced differentiation potential and stem cell-like properties. Scientific Reports. ISSN 2045-2322. 9:12934, s. 1–13. doi: 10.1038/s41598-019-49016-0. Fulltekst i vitenarkiv Vis sammendrag
Valve interstitial cells (VICs) are crucial in the development of calcific aortic valve disease. The purpose of the present investigation was to compare the phenotype, differentiation potential and stem cell-like properties of cells from calcified and healthy aortic valves. VICs were isolated from human healthy and calcified aortic valves. Calcification was induced with osteogenic medium. Unlike VICs from healthy valves, VICs from calcified valves cultured without osteogenic medium stained positively for calcium deposits with Alizarin Red confirming their calcific phenotype. Stimulation of VICs from calcified valves with osteogenic medium increased calcification (p = 0.02), but not significantly different from healthy VICs. When stimulated with myofibroblastic medium, VICs from calcified valves had lower expression of myofibroblastic markers, measured by flow cytometry and RT-qPCR, compared to healthy VICs. Contraction of collagen gel (a measure of myofibroblastic activity) was attenuated in cells from calcified valves (p = 0.04). Moreover, VICs from calcified valves, unlike cells from healthy valves had lower potential to differentiate into adipogenic pathway and lower expression of stem cell-associated markers CD106 (p = 0.04) and aldehyde dehydrogenase (p = 0.04). In conclusion, VICs from calcified aortic have reduced multipotency compared to cells from healthy valves, which should be considered when investigating possible medical treatments of aortic valve calcification.
Bothe, Wolfgang; Kvitting, John Peder Escobar; Rausch, Manuel K; Timek, Tomasz A; Swanson, Julia C & Liang, David H [Vis alle 10 forfattere av denne artikkelen] (2019). Do annuloplasty rings designed to treat ischemic/functional mitral regurgitation alter left-ventricular dimensions in the acutely ischemic ovine heart? Journal of Thoracic and Cardiovascular Surgery. ISSN 0022-5223. s. 1–11. doi: 10.1016/j.jtcvs.2018.12.077.
Ha, Hojin; Kvitting, John Peder Escobar; Dyverfeldt, Petter & Ebbers, Tino (2019). 4D Flow MRI quantification of blood flow patterns, turbulence and pressure drop in normal and stenotic prosthetic heart valves. Magnetic Resonance Imaging. ISSN 0730-725X. 55, s. 118–127. doi: 10.1016/j.mri.2018.09.024.
Kvitting, John Peder Escobar; Hermansson, Ulf & Vanhanen, Ingemar (2018). Resection of a plasma cell granuloma combining a conventional posterolateral left-sided thoracotomy with a minimally invasive valve approach. General Thoracic and Cardiovascular Surgery. ISSN 1863-6705. s. 1–3. doi: 10.1007/s11748-018-0986-y.
Bogdanova, Mariia; Kostina, Aleksandra; Zihlavnikova, Katarina; Zabirnyk, Arsenii; Malashicheva, Anna & Stensløkken, Kåre-Olav [Vis alle 12 forfattere av denne artikkelen] (2018). Inflammation and Mechanical Stress Stimulate Osteogenic Differentiation of Human Aortic Valve Interstitial Cells. Frontiers in Physiology. ISSN 1664-042X. 9. doi: 10.3389/fphys.2018.01635. Fulltekst i vitenarkiv
Kvitting, John Peder Escobar; Nielsen, Niels-Erik; Vanhanen, Ingemar & Baranowski, Jacek (2018). Surgical management of outflow tract obstruction after transapical mitral valve implantation. Journal of Cardiac Surgery. ISSN 0886-0440. 33(9), s. 545–547. doi: 10.1111/jocs.13771.
Dumont, Karl-Andreas; Kvitting, John Peder Escobar; Karlsen, Jørn S.; Remme, Espen W.; Hausken, John & Lundblad, Runar [Vis alle 8 forfattere av denne artikkelen] (2018). Validation of a holographic display for quantification of mitral annular dynamics by three-dimensional echocardiography. Journal of the American Society of Echocardiography. ISSN 0894-7317. s. 1–18. doi: 10.1016/j.echo.2018.08.010.
Ha, Hojin; Kvitting, John Peder Escobar; Dyverfeldt, Petter & Ebbers, Tino (2017). Validation of pressure drop assessment using 4D flow MRI-based turbulence production in various shapes of aortic stenoses. Magnetic Resonance in Medicine. ISSN 0740-3194. 81(2), s. 893–906. doi: 10.1002/mrm.27437.
Johansson, Mats J; Kvitting, John Peder Escobar; Flatebø, Torun; Nicolaysen, Anne; Nicolaysen, Gunnar & Walther, Sten M (2016). Inhibition of constitutive nitric oxide synthase does not influence ventilation-perfusion matching in normal prone adult sheep with mechanical ventilation. Anesthesia and Analgesia. ISSN 0003-2999. 123(6), s. 1492–1499. doi: 10.1213/ANE.0000000000001556.
Kvitting, John Peder Escobar & Geiran, Odd (2016). Karl Viktor Hall: From In Situ Vein Bypass to the Tilting Disc Heart Valve Prosthesis. Annals of Thoracic Surgery. ISSN 0003-4975. 102(5), s. 1756–1761. doi: 10.1016/j.athoracsur.2016.03.120.

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Kvitting, John-Peder; Lindenskov, Paal Helge H. & Moene, Kalle (2022). Sorte svaner og fete haler. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 142(18), s. 1–14. doi: 10.4045/tidsskr.22.0496.
Kvitting, John-Peder; Koul, Bansi & Geiran, Odd (2022). Bjarne K. H. Semb: The contriver of the first implantation of a total artificial heart in Europe. Artificial Organs. ISSN 0160-564X. 46(7), s. 1221–1226. doi: 10.1111/aor.14252.
Kvitting, John-Peder; Eek, Christian; Andreassen, Arne K. & Lundblad, Runar (2022). Thrombus formation in the noncoronary sinus of Valsalva following primary graft dysfunction. Journal of Cardiac Surgery. ISSN 0886-0440. doi: 10.1111/jocs.16482. Fulltekst i vitenarkiv

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Publisert 11. jan. 2021 13:25 - Sist endret 17. okt. 2023 14:46