Kathrine Sivertsen Nordhus

• Oldereid, Tine Simensen; Jiang, Xiaojun; Nordhus, Kathrine Sivertsen; Ponzetta, Andrea; Bjørnholt, Jørgen & Björkström, Niklas K. [Vis alle 8 forfattere av denne artikkelen] (2023). Role of bacteria and microbial metabolites in immune modulation during early life. Scandinavian Journal of Immunology. ISSN 0300-9475. doi: 10.1111/sji.13336. Fulltekst i vitenarkiv
• Harrison, Sean Philip; Siller, Richard; Tanaka, Yoshiaki; Chollet Dugarte, Maria Eugenia; de la Morena-Barrio, María Eugenia & Xiang, Yangfei [Vis alle 36 forfattere av denne artikkelen] (2023). Scalable production of tissue-like vascularized liver organoids from human PSCs. Experimental and Molecular Medicine. ISSN 1226-3613. 55, s. 2005–2024. doi: 10.1038/s12276-023-01074-1. Fulltekst i vitenarkiv
• Harrison, Sean; Siller, Richard; Tanaka, Yoshiaki; Xiang, Yangfei; Patterson, Benjamin & Kempf, Henning [Vis alle 29 forfattere av denne artikkelen] (2020). Scalable production of tissue-like vascularised liver organoids from human PSCs. bioRxiv. ISSN 2692-8205. doi: 10.1101/2020.12.02.406835.
• Åsrud, Kathrine Sivertsen; Bjørnstad, Ronja; Kopperud, Reidun Kristin; Pedersen, Line; van der Hoeven, Barbara & Karlsen, Tine Veronica [Vis alle 12 forfattere av denne artikkelen] (2020). Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions. Acta Physiologica. ISSN 1748-1708. 229(1). doi: 10.1111/apha.13442. Fulltekst i vitenarkiv
• Åsrud, Kathrine Sivertsen; Pedersen, Line; Aesoy, Reidun; Muwonge, Haruna; Aasebø, Elise & Pettersen, Ina Katrine Nitschke [Vis alle 14 forfattere av denne artikkelen] (2019). Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy. Scientific Reports. ISSN 2045-2322. 9:13789, s. 1–17. doi: 10.1038/s41598-019-50219-8. Fulltekst i vitenarkiv
• Aesoy, Reidun; Muwonge, Haruna; Sivertsen Åsrud, Kathrine; Sabir, Misbah; Witsø, Solveig Lund & Bjørnstad, Ronja [Vis alle 10 forfattere av denne artikkelen] (2018). Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice. PLOS ONE. ISSN 1932-6203. 13(7). doi: 10.1371/journal.pone.0200935.
• Nygaard, Gyrid; Herfindal, Lars; Sivertsen Åsrud, Kathrine; Bjørnstad, Ronja; Kopperud, Reidun Kristin & Oveland, Eystein [Vis alle 13 forfattere av denne artikkelen] (2017). Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. Scientific Reports. ISSN 2045-2322. 7:8725, s. 1–15. doi: 10.1038/s41598-017-08975-y. Fulltekst i vitenarkiv
• Edland, Ravn Fritdtjov; Wergeland, Anita; Kopperud, Reidun Kristin; Sivertsen åsrud, Kathrine; Høivik, Erling Andre & Witsø, Solveig Lund [Vis alle 12 forfattere av denne artikkelen] (2016). Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling. Nutrition & Metabolism. ISSN 1743-7075. 13(1), s. 1–11. doi: 10.1186/s12986-016-0147-1. Fulltekst i vitenarkiv
• Æsøy, Reidun; Gradin, Katarina; Åsrud, Kathrine Sivertsen; Høivik, Erling Andre; Ruas, Jorge Lira & Poellinger, Lorenz [Vis alle 7 forfattere av denne artikkelen] (2014). Regulation of CDKN2B expression by interaction of Arnt with Miz-1 - a basis for functional integration between the HIF and Myc gene regulatory pathways. Molecular Cancer. ISSN 1476-4598. 13(1:54). doi: 10.1186/1476-4598-13-54. Fulltekst i vitenarkiv

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• Åsrud, Kathrine Sivertsen & Bakke, Marit (2017). Physiological Roles of Exchange Factors Directly Activated by cAMP (Epac); Characterization of gene knockout models. Universitetet i Bergen. ISSN 978-82-308-3038-3.
• Pedersen, Line; Bakke, Marit & Åsrud, Kathrine Sivertsen (2014). Characterization of liver functions in Epac knockout models. Universitetet i Bergen. Vis sammendrag

  The discovery of the exchange proteins directly activated by cAMP 1 and 2 (Epac1 and Epac2) opened up new avenues in cAMP-related research. Since their discovery in the late 1990’s, physiological roles have been described for Epac1/2 in the brain, heart, kidneys and lungs. However, despite the fact that the liver expresses a unique Epac2 isoform, the functions of the Epac proteins in this organ remains virtually unknown, and have not been investigated in in vivo models. In this master project I used genetic mouse models deleted for both Epac1 and Epac2 (Epac1/2-/- mice) to study whether loss of Epac proteins affects crucial liver functions. The present study is the first to suggest roles of Epac1/2 in liver regeneration after partial hepatectomy. I demonstrate that deletion of Epac1/2 leads to a remarkably increase in proliferating hepatocytes in the regenerating liver, as assessed by BrdU-incorporation. Of great interest is also the finding that fat vacuoles, which normally accumulate in rodent livers after partial hepatectomy, are nearly absent in regenerated livers of Epac1/2-/- mice. Moreover, determination of oxygen consumption in liver extracts revealed increased rates of mitochondrial respiration and fatty acid driven respiration in Epac1/2-/- mice, which might be associated with the loss of fat vacuoles. The amount of bile acids in feces was not altered as a consequence of deleting Epac1/2 when the mice were housed under standard conditions. However, at the mRNA level, the expression of specific enzymes and transcription factors involved in bile acid biosynthesis were differently expressed in mice deleted for Epac1/2. This effect was especially pronounced in response to food deprivation. Taken together the results presented in this thesis show that although deletion of Epac1/2 does not cause gross morphological changes and liver dysfunction in mice kept at standard protected conditions in the animal facility, various stressful conditions do lead to penetration of liver specific phenotypes in Epac1/2-/- mice. The obtained data provide novel insights into liver physiology, and moreover, will serve as a basis for future studies to more precisely describe the role of the Epac proteins in the liver. A detailed understanding of the molecular mechanisms that underlie liver function and hepatocyte proliferation is important and clinically relevant as hepatectomy is a therapeutic option for patients with severe liver diseases.

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