Knut Håkon Hole

• Switlyk, Marta Daniela; Hopland, Olav Andreas; Reitan, Edmund; Sivanesan, Shivanthe; Brennhovd, Bjørn & Axcrona, Ulrika [Vis alle 7 forfattere av denne artikkelen] (2023). Multiparametric Magnetic Resonance Imaging of Penile Cancer: A Pictorial Review. Cancers. ISSN 2072-6694. 15(22). doi: 10.3390/cancers15225324. Fulltekst i vitenarkiv
• Mo, Torgeir; Brandal, Siri Helene Bertelsen; Geier, Oliver; Engebråten, Olav; Nilsen, Line & Kristensen, Vessela N. [Vis alle 10 forfattere av denne artikkelen] (2023). MRI Assessment of Changes in Tumor Vascularization during Neoadjuvant Anti-Angiogenic Treatment in Locally Advanced Breast Cancer Patients. Cancers. ISSN 2072-6694. 15(18). doi: 10.3390/cancers15184662. Fulltekst i vitenarkiv
• Skingen, Vilde Eide; Hompland, Tord; Fjeldbo, Christina Sæten; Salberg, Unn Beate; Helgeland, Hanna & Ragnum, Harald Bull [Vis alle 11 forfattere av denne artikkelen] (2023). Prostate cancer radiogenomics reveals proliferative gene expression programs associated with distinct MRI-based hypoxia levels. Radiotherapy and Oncology. ISSN 0167-8140. 188. doi: 10.1016/j.radonc.2023.109875. Vis sammendrag

  Background and purpose: The biology behind individual hypoxia levels in patient tumors is poorly understood. Here, we used radiogenomics to identify associations between magnetic resonance imaging (MRI)-based hypoxia levels and biological processes derived from gene expression data in prostate cancer. Materials and methods: For 85 prostate cancer patients, MRI-based hypoxia images were constructed by combining diffusion-weighted images reflecting oxygen consumption and supply. The ability to differentiate hypoxia levels in these images was verified by comparison with matched biopsy sections stained for the hypoxia marker pimonidazole. For MRI-defined hypoxia levels, corresponding hypoxic fractions were calculated and correlated with biopsy gene expression profiles. Biological processes were predicted by gene set enrichment analysis (GSEA) and validated by immunohistochemistry (Ki67 proliferation marker, reactive stroma grade) and RT-PCR (MYC). Results: Genes with correlation between expression level and hypoxic fraction were identified for 56 MRI-based hypoxia levels. At all levels, GSEA identified proliferation as the predominant biological process enriched among the correlating genes. Two independent proliferative gene signatures were developed. The Peak1 signature, upregulated at moderate/severe hypoxia, reflected MYC upregulation and high Ki67-proliferation index of cancer cells in pimonidazole-positive regions. The Peak2 signature, upregulated at mild to non-hypoxic levels, was associated with fibroblast gene signature and reactive stroma grade. High scores of both Peak1 and Peak2 indicated elevated risk of biochemical recurrence in multiple cohorts. Conclusion: Radiogenomics identified two gene expression programs activated at different hypoxia levels, reflecting proliferation of cancer cells and stroma cells. Genes involved in these programs could be candidate targets for intervention.

• Reijnen, Jeroen Sebastiaan; Ryg, Una; Marthinsen, Jon Bache; Schönhardt, Irina; Seierstad, Therese & Hole, Knut Håkon (2023). Monoparametric high-resolution diffusion weighted MRI as a possible first step in an MRI-directed diagnostic pathway for men with suspicion of prostate cancer. Frontiers in Oncology. ISSN 2234-943X. 13, s. 1–11. doi: 10.3389/fonc.2023.1102860. Fulltekst i vitenarkiv
• Lilleby, Wolfgang; Seierstad, Therese; Inderberg, Else Marit & Hole, Knut Håkon (2023). Impact of human telomerase reverse transcriptase peptide vaccine combined with androgen deprivation therapy and radiotherapy in de novo metastatic prostate cancer: Long-term clinical monitoring. International Journal of Cancer. ISSN 0020-7136. 152(10), s. 2166–2173. doi: 10.1002/ijc.34448.
• Switlyk, Marta Daniela; Hopland, Ola Andreas; Sivanesan, Shivanthe; Brennhovd, Bjørn; Ottosson, Fredrik & Berner, Kjetil [Vis alle 8 forfattere av denne artikkelen] (2023). Multi-parametric MRI without artificial erection for preoperative assessment of primary penile carcinoma: A pilot study on the correlation between imaging and histopathological findings. European Journal of Radiology Open (EJR Open). ISSN 2352-0477. 10. doi: 10.1016/j.ejro.2023.100478. Fulltekst i vitenarkiv
• Ryg, Una; Seierstad, Therese; Nilsen, Line; Hellebust, Taran Annette Paulsen; Djupvik, Linda Holth & Gustafson, Hilde [Vis alle 10 forfattere av denne artikkelen] (2022). A prospective study of high dose-rate brachytherapy or stereotactic body radiotherapy of Intra-prostatic recurrence: Toxicity and long term clinical outcome. Frontiers in Oncology. ISSN 2234-943X. 12:861127, s. 1–10. doi: 10.3389/fonc.2022.861127. Fulltekst i vitenarkiv
• Salberg, Unn Beate; Skingen, Vilde Eide; Fjeldbo, Christina Sæten; Hompland, Tord; Ragnum, Harald Bull & Vlatkovic, Ljiljana [Vis alle 9 forfattere av denne artikkelen] (2022). A prognostic hypoxia gene signature with low heterogeneity within the dominant tumour lesion in prostate cancer patients. British Journal of Cancer. ISSN 0007-0920. 127, s. 321–328. doi: 10.1038/s41416-022-01782-x. Fulltekst i vitenarkiv Vis sammendrag

  Background: Gene signatures measured in a biopsy have been proposed as hypoxia biomarkers in prostate cancer. We assessed a previously developed signature, and aimed to determine its relationship to hypoxia and its heterogeneity within the dominant (index) lesion of prostate cancer. Methods: The 32-gene signature was assessed from gene expression data of 141 biopsies from the index lesion of 94 patients treated with prostatectomy. A gene score calculated from the expression levels was applied in the analyses. Hypoxic fraction from pimonidazole immunostained whole-mount and biopsy sections was used as reference standard for hypoxia. Results: The gene score was correlated with pimonidazole-defined hypoxic fraction in whole-mount sections, and the two parameters showed almost equal association with clinical markers of tumour aggressiveness. Based on the gene score, incorrect classification according to hypoxic fraction in whole-mount sections was seen in one third of the patients. The incorrect classifications were apparently not due to intra-tumour heterogeneity, since the score had low heterogeneity compared to pimonidazole-defined hypoxic fraction in biopsies. The score showed prognostic significance in uni-and multivariate analysis in independent cohorts. Conclusions: Our signature from the index lesion reflects tumour hypoxia and predicts prognosis in prostate cancer, independent of intra-tumour heterogeneity in pimonidazole-defined hypoxia.

• Hopland, Ola Andreas; Fosså, Sophie Dorothea; Ottosson, Fredrik; Brennhovd, Bjørn; Svindland, Aud & Hole, Knut Håkon [Vis alle 10 forfattere av denne artikkelen] (2021). Robotic salvage pelvic lymph node dissection for locoregional recurrence after radical prostatectomy: a single institution experience. Scandinavian Journal of Urology. ISSN 2168-1805. 55(4). doi: 10.1080/21681805.2021.1946135. Fulltekst i vitenarkiv
• Hole, Knut Håkon; Tulipan, Andreas Julius; Reijnen, Jeroen Sebastiaan; Hernes, Eivor; Vlatkovic, Ljiljana & Lie, Kathrine [Vis alle 8 forfattere av denne artikkelen] (2021). Localization of primary prostate cancer: FACBC PET/CT compared with multiparametric MRI using histopathology as reference standard. The American Journal of Nuclear Medicine and Molecular Imaging (AJNMMI). ISSN 2160-8407. 11(5), s. 387–394. Fulltekst i vitenarkiv Vis sammendrag

  FACBC (anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid) is a FDA-approved PET-tracer in patients with suspected recurrent prostate cancer. In the diagnostic work-up of primary prostate cancer, accurate localization of the index tumor is needed for image-guidance of biopsies. We therefore assessed the performance of FACBC PET/CT to detect and localize the index tumor and compared it to multiparametric MRI (mpMRI) using whole-mount histopathology as reference standard. Twenty-three patients with biopsy-proven prostate cancer had FACBC PET/CT and mpMRI within two weeks prior to prostatectomy. FACBC PET/CT was acquired as 14 minutes list-mode and re-binned into seven 2-minutes intervals. Static FACBC was the acquired data from 4-6 minutes, whereas the dynamic FACBC included all seven intervals. Two radiologists and two nuclear medicine physicians independently interpreted the images and consensus was reached in case of discrepancy. Static PET detected 15 of 23 (65%) of the index tumors, dynamic PET detected 14 of 22 (64%), and MRI detected 20 of 23 (87%). To assess the extent of the tumor, the interpreters delineated the tumor in a 12-regions sector-based template. True positive, true negative, false positive and false negative sectors were recorded based on the template drawings and whole-mount histopathology. Both static and dynamic FACBC PET had sensitivity of 40% and specificity of 99%, whereas MRI had sensitivity of 81% and specificity of 100%. Our data indicate that FACBC PET/CT may be useful but that mpMRI is better for localizing the index tumor in patients with prostate cance

• Knuth, Franziska Hanna; Adde, Ingvild Askim; Huynh, Bao Ngoc; Grøndahl, Aurora Rosvoll; Winter, René & Negård, Anne [Vis alle 15 forfattere av denne artikkelen] (2021). MRI-based automatic segmentation of rectal cancer using 2D U-Net on two independent cohorts. Acta Oncologica. ISSN 0284-186X. 61(2), s. 255–263. doi: 10.1080/0284186X.2021.2013530. Fulltekst i vitenarkiv
• Tulipan, Andreas Julius; Salberg, Unn Beate; Hole, Knut Håkon; Vlatkovic, Ljiljana; Aarnes, Eva-Katrine & Rootwelt-Revheim, Mona Elisabeth [Vis alle 8 forfattere av denne artikkelen] (2021). Amino acid transporter expression and 18F-FACBC uptake at PET in primary prostate cancer. The American Journal of Nuclear Medicine and Molecular Imaging (AJNMMI). ISSN 2160-8407. 11(4), s. 250–259. Vis sammendrag

  Abstract Little is known about the transport mechanism of anti-3-18F-fluorocyclobutane-1-carboxylic acid (FACBC) into prostate tumors. Because of the structural similarity to natural amino acids, FACBC is anticipated to cross the cell membrane via amino acid transporters, and preclinical studies have suggested that ASCT2, LAT1 and SNAT2 are involved. In 16 patients with intermediate or high-risk prostate cancer we matched the FACBC uptake from clinical PET to the location of punch biopsies from resected prostatectomy specimens and compared maximum standardized uptake value (SUVmax) with the gene expression of 40 amino acid transporters. The study also included immunohistochemistry for the three amino acid transporters ASCT2, LAT1 and SNAT2. Furthermore, we performed global gene expression analysis of the biopsies to investigate biological processes associated with FACBC uptake. Several amino acid transporters had a higher gene expression level than the others, but we found no significant correlations between SUVmax and the gene expression levels of any of 40 different amino acid transporters. In the immunohistochemical analyses, ASCT2 and SNAT2 were highly expressed, but not correlated to SUVmax. LAT1 had low gene- and protein expression. Global gene expression analyses identified 153 unique genes that were positively correlated to SUVmax. These genes were found to be associated with gene sets reflecting intracellular transport and high metabolic activity. Based on the study findings we propose that the uptake mechanism of FACBC is more complex than mediated by a few amino acid transporters.

• Rootwelt-Revheim, Mona Elisabeth; Hole, Knut Håkon; Mo, Torgeir; Bruland, Øyvind; Reitan, Edmund & Julsrud, Lars [Vis alle 7 forfattere av denne artikkelen] (2021). Multimodal functional imaging for early response assessment in patients with gastrointestinal stromal tumor treated with tyrosine kinase inhibitors. Acta Radiologica. ISSN 0284-1851. 63(8), s. 995–1004. doi: 10.1177/02841851211027389. Fulltekst i vitenarkiv Vis sammendrag

  Background: Several imaging modalities are used in the early work-up of patients with gastrointestinal stromal tumor (GIST) receiving tyrosine kinase inhibitor (TKI) treatment and there is a need to establish whether they provide similar or complimentary information. Purpose: To compare 18F-fluorodeoxyglucose positron emission tomography (FDG PET), computed tomography (CT) and magnetic resonance imaging (MRI) as early predictors of three-month outcomes for patients with GIST receiving TKI treatment. Material and methods: Thirty-five patients with advanced GIST were prospectively included between February 2011 and June 2017. FDG PET, contrast-enhanced CT (CECT), and MRI were performed before and early after onset of TKI treatment (range 8-18 days). Early response was categorized according to mRECIST (CT), the Choi criteria (CECT), and PERCIST (FDG PET/CT). For MRI, volumetry from T2-weighted images and change in apparent diffusion coefficient (ADC) from diffusion-weighted imaging was used. The reference standard for early assessment was the three-month mRECIST evaluation based on CT. At three months, both stable disease (SD) and partial response (PR) were categorized as response. Clinical usefulness was defined as agreement between early and three-month assessment. Results: At the three-month assessment, 91% (32/35) were responders, 37% (13/35) PR, 54% (19/35) SD, and 9% (3/35) had progressive disease (PD). Early assessment correctly predicted three-month response in 93% (27/29) for MRI, 80% (28/35) for PERCIST, 74% (26/35) for Choi, and 23% (8/35) for mRECIST. Six patients had non-FDG-avid tumors. For the FDG-avid tumors, PET/CT correctly predicted three-month response in 97% (28/29). Conclusion: MRI was superior to CECT for early assessment of TKI-treatment response in GIST. If the tumor was FDG-avid, PET and MRI were equally good. Changes in functional parameters were superior to changes in longest tumor diameter (mRECIST).

• Seierstad, Therese; Hole, Knut Håkon; Tulipan, Andreas Julius; Strømme, Hilde; Lilleby, Wolfgang & Rootwelt-Revheim, Mona Elisabeth [Vis alle 7 forfattere av denne artikkelen] (2021). 18F-Fluciclovine PET for Assessment of Prostate Cancer with Histopathology as Reference Standard: A Systematic Review. PET Clinics. ISSN 1556-8598. 16(2), s. 167–176. doi: 10.1016/j.cpet.2020.12.012. Fulltekst i vitenarkiv Vis sammendrag

  Abstract The PET tracer 18F-fluciclovine (Axumin) was recently approved in the United States and Europe for men with suspected prostate cancer recurrence following prior treatment. This article summarizes studies where systematic sector-based histopathology was used as reference standard to assess the diagnostic accuracy of the tracer 18F-fluciclovine PET in patients with prostate cancer.

• Hernes, Eivor; Rootwelt-Revheim, Mona Elisabeth; Hole, Knut Håkon; Tulipan, Andreas Julius; Strømme, Hilde & Lilleby, Wolfgang [Vis alle 7 forfattere av denne artikkelen] (2021). Prostate-Specific Membrane Antigen PET for Assessment of Primary and Recurrent Prostate Cancer with Histopathology as Reference Standard: A Systematic Review and Meta-Analysis. PET Clinics. ISSN 1556-8598. 16(2), s. 147–165. doi: 10.1016/j.cpet.2020.12.001. Fulltekst i vitenarkiv Vis sammendrag

  Prostate-specific membrane antigen PET is a promising diagnostic tool in prostate cancer. The gold standard for the detection of prostate tumor and lymph node metastases is histopathology. The aim of the present review was to investigate accuracy measures of 68Ga/18F-labeled prostate-specific membrane antigen PET tracers in primary and recurrent prostate cancer with systematic sector-based histopathology as the reference standard. A systematic literature search was performed and 34 studies were included. Overall, prostate-specific membrane antigen PET showed high specificity, but variable sensitivity to localize known prostate cancer and detect pelvic lymph node metastases.

• Reijnen, Jeroen S.; Marthinsen, Jon Bache; Tysland, Alf Ole; Muller, Christoph Rainer; Schönhardt, Irina & Andersen, Erlend K F [Vis alle 8 forfattere av denne artikkelen] (2021). Results from a PI-RADS-based MRI-directed diagnostic pathway for biopsy-naive patients in a non-university hospital. Abdominal Radiology. ISSN 2366-004X. 46, s. 5639–5646. doi: 10.1007/s00261-021-03249-8. Fulltekst i vitenarkiv
• Deek, Matthew; Lilleby, Wolfgang; Vaage, Victoria; Hole, Knut Håkon; DeWeese, Theodore L. & Stensvold, Andreas [Vis alle 8 forfattere av denne artikkelen] (2020). Impact of radiation dose on recurrence in high-risk prostate cancer patients. The Prostate. ISSN 0270-4137. 80(15), s. 1322–1327. doi: 10.1002/pros.24059.
• Bains, Simer Jit; Abrahamsson, Hanna Josefine; Flatmark, Kjersti; Dueland, Svein; Hole, Knut Håkon & Seierstad, Therese [Vis alle 9 forfattere av denne artikkelen] (2019). Immunogenic cell death by neoadjuvant oxaliplatin and radiation protects against metastatic failure in high-risk rectal cancer. Cancer Immunology and Immunotherapy. ISSN 0340-7004. doi: 10.1007/s00262-019-02458-x. Fulltekst i vitenarkiv
• Meltzer, Sebastian; Bakke, Kine Mari; Rød, Karina Lund; Negård, Anne; Flatmark, Kjersti & Solbakken, Arne Mide [Vis alle 19 forfattere av denne artikkelen] (2019). Sex-related differences in primary metastatic site in rectal cancer; associated with hemodynamic factors? Clinical and Translational Radiation Oncology. ISSN 2405-6308. 21, s. 5–10. doi: 10.1016/j.ctro.2019.11.006. Fulltekst i vitenarkiv
• Abrahamsson, Hanna Josefine; Porojnicu, Alina Carmen; Lindstrøm, Jonas Christoffer; Dueland, Svein; Flatmark, Kjersti & Hole, Knut Håkon [Vis alle 11 forfattere av denne artikkelen] (2019). High level of circulating vitamin D during neoadjuvant therapy may lower risk of metastatic progression in high-risk rectal cancer. BMC Cancer. ISSN 1471-2407. 19(1). doi: 10.1186/s12885-019-5724-z. Fulltekst i vitenarkiv
• Tulipan, Andreas Julius; Hole, Knut Håkon; Vlatkovic, Ljiljana; Rootwelt-Revheim, Mona-Elisabeth; Reijnen, Jeroen Sebastiaan & Willoch, Frode [Vis alle 8 forfattere av denne artikkelen] (2018). Localization of radio-recurrence within the prostate: anti-3-18F-FACBC PET/CT compared with multiparametric MRI using histopathology as reference standard . Acta Radiologica. ISSN 0284-1851. s. 1–11. doi: 10.1177/0284185118810977.
• Hayman, Jonathan; Hole, Knut Håkon; Seierstad, Therese; Perin, Jamie; DeWeese, Theodore L & Tran, Phuoc T. [Vis alle 7 forfattere av denne artikkelen] (2018). Local failure is a dominant mode of recurrence in locally advanced and clinical node positive prostate cancer patients treated with combined pelvic IMRT and androgen deprivation therapy. Urologic Oncology. ISSN 1078-1439. 10, s. 1–14. doi: 10.1016/j.urolonc.2018.09.016.
• Tulipan, Andreas Julius; Vlatkovic, Ljiljana; Malinen, Eirik; Brennhovd, Bjørn; Hole, Knut Håkon & Lie, Kathrine [Vis alle 9 forfattere av denne artikkelen] (2018). Comparison of time curves from dynamic 18F-fluciclovine positron emission tomography and dynamic contrast-enhanced magnetic resonance imaging for primary prostate carcinomas. Physics and imaging in radiation oncology (PIRO). ISSN 2405-6316. 7, s. 51–57. doi: 10.1016/j.phro.2018.09.003. Fulltekst i vitenarkiv
• Hompland, Tord; Hole, Knut Håkon; Ragnum, Harald Bull; Aarnes, Eva-Katrine; Vlatkovic, Ljiljana & Lie, Agnes Kathrine [Vis alle 10 forfattere av denne artikkelen] (2018). Combined MR imaging of oxygen consumption and supply reveals tumor hypoxia and aggressiveness in prostate cancer patients. Cancer Research. ISSN 0008-5472. 78(16), s. 4774–4785. doi: 10.1158/0008-5472.CAN-17-3806.
• Kalanxhi, Ert; Meltzer, Sebastian; Schou, Jakob Vasehus; Larsen, Finn Ole; Dueland, Svein & Flatmark, Kjersti [Vis alle 12 forfattere av denne artikkelen] (2018). Systemic immune response induced by oxaliplatin-based neoadjuvant therapy favours survival without metastatic progression in high-risk rectal cancer. British Journal of Cancer. ISSN 0007-0920. 118(10), s. 1322–1328. doi: 10.1038/s41416-018-0085-y. Fulltekst i vitenarkiv
• Lilleby, Wolfgang; Gaudernack, Gustav; Brunsvig, Paal Fr.; Vlatkovic, Ljiljana; Schulz, Melanie-Birte & Mills, Kate [Vis alle 8 forfattere av denne artikkelen] (2017). Phase I/IIa clinical trial of a novel hTERT peptide vaccine in men with metastatic hormone-naive prostate cancer. Cancer Immunology and Immunotherapy. ISSN 0340-7004. 66(7), s. 891–901. doi: 10.1007/s00262-017-1994-y.
• Torheim, Turid K Gjerstad; Malinen, Eirik; Hole, Knut Håkon; Lund, Kjersti Vassmo; Indahl, Ulf Geir & Lyng, Heidi [Vis alle 8 forfattere av denne artikkelen] (2017). Autodelineation of cervical cancers using multiparametric magnetic resonance imaging and machine learning. Acta Oncologica. ISSN 0284-186X. 56(6), s. 806–812. doi: 10.1080/0284186X.2017.1285499.
• Bakke, Kine Mari; Hole, Knut Håkon; Dueland, Svein; Kotanska-Grøholt, Krystyna; Flatmark, Kjersti & Ree, Anne Hansen [Vis alle 8 forfattere av denne artikkelen] (2017). Diffusion-weighted magnetic resonance imaging of rectal cancer: tumour volume and perfusion fraction predict chemoradiotherapy response and survival. Acta Oncologica. ISSN 0284-186X. 56(6), s. 813–818. doi: 10.1080/0284186X.2017.1287951. Fulltekst i vitenarkiv
• Goscinski, Mariusz Adam; Hole, Knut Håkon; Tønne, Elin; Ryder, Truls; Kotanska-Grøholt, Krystyna & Flatmark, Kjersti (2016). Fibromatosis in vertical rectus abdominis myocutaneous flap imitating tumor recurrence after surgery for locally advanced rectal cancer: Case report. World Journal of Surgical Oncology (WJSO). ISSN 1477-7819. 14. doi: 10.1186/s12957-016-0818-4.
• Dueland, Svein; Ree, Anne Hansen; Kotanska-Grøholt, Krystyna; Sælen, Marie Grøn; Folkvord, Sigurd & Hole, Knut Håkon [Vis alle 12 forfattere av denne artikkelen] (2016). Oxaliplatin-containing Preoperative Therapy in Locally Advanced Rectal Cancer: Local Response, Toxicity and Long-term Outcome. Clinical Oncology. ISSN 0936-6555. 28(8), s. 532–539. doi: 10.1016/j.clon.2016.01.014.
• Flatmark, Kjersti; Sælen, Marie Grøn; Hole, Knut Håkon; Abrahamsen, Torveig Weum; Fleten, Karianne Giller & Hektoen, Helga [Vis alle 10 forfattere av denne artikkelen] (2016). Individual tumor volume responses to short-course oxaliplatin containing induction chemotherapy in locally advanced rectal cancer – Targeting the tumor for radiation sensitivity? Radiotherapy and Oncology. ISSN 0167-8140. 119(3), s. 505–511. doi: 10.1016/j.radonc.2016.02.020. Vis sammendrag

  Background Neoadjuvant treatment of locally advanced rectal cancer (LARC) involves chemoradiotherapy (CRT), which may cause significant toxicity, and the potential role and sequential placement of neoadjuvant chemotherapy (NACT) relative to CRT is under debate. Patients and methods In a non-randomized study of 72 LARC patients, short-course oxaliplatin-containing NACT was administered prior to CRT. Tumor volumes were calculated from magnetic resonance images before and after NACT, and four weeks after CRT, and associations between tumor volume responses and outcome were analyzed. Additionally, the impact of oxaliplatin exposure on radiosensitivity was examined in colorectal carcinoma cell lines. Results All tumors except one responded to NACT, with better responses in T3 than T4 cases, and 69/72 patients obtained additional tumor volume reduction after subsequent CRT. However, no associations were found between tumor volume reduction and long-term outcome. Of note, oxaliplatin-resistant cells were significantly more radiosensitive than the oxaliplatin-sensitive counterparts. Conclusions Oxaliplatin-containing NACT led to substantial tumor volume reduction with particularly good responses in T3 cases. NACT did not impede subsequent CRT response, and experimental results rather suggested enhanced radiosensitivity in oxaliplatin-exposed cells, encouraging studies to explore the administration of NACT prior to CRT. Data are still lacking to support omitting radiation in LARC management.

• Redalen, Kathrine Røe; Sitter, Beathe; Bathen, Tone Frost; Kotanska-Grøholt, Krystyna; Hole, Knut Håkon & Dueland, Svein [Vis alle 9 forfattere av denne artikkelen] (2016). High tumor glycine concentration is an adverse prognostic factor in locally advanced rectal cancer. Radiotherapy and Oncology. ISSN 0167-8140. 118(2), s. 393–398. doi: 10.1016/j.radonc.2015.11.031.
• Lilleby, Wolfgang; Narrang, Amol; Tafjord, Gunnar; Vlatkovic, Ljiljana; Russnes, Kjell Magne & Stensvold, Andreas [Vis alle 9 forfattere av denne artikkelen] (2015). Favorable outcomes in locally advanced and node positive prostate cancer patients treated with combined pelvic IMRT and androgen deprivation therapy. Radiation Oncology. ISSN 1748-717X. 10(1). doi: 10.1186/s13014-015-0540-3.
• Seierstad, Therese; Hole, Knut Håkon; Kotanska-Grøholt, Krystyna; Dueland, Svein; Ree, Anne Hansen & Flatmark, Kjersti [Vis alle 7 forfattere av denne artikkelen] (2015). MRI volumetry for prediction of tumour response to neoadjuvant chemotherapy followed by chemoradiotherapy in locally advanced rectal cancer. British Journal of Radiology (BJR). ISSN 0007-1285. 88:20150097(1051). doi: 10.1259/bjr.20150097.
• Ragnum, Harald Bull; Vlatkovic, Ljiljana; Lie, Kathrine; Axcrona, Eugen Jan Karol; Halle, Cathinka Lønning & Frikstad, Kari-Anne [Vis alle 9 forfattere av denne artikkelen] (2015). The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer. British Journal of Cancer. ISSN 0007-0920. 112, s. 382–390. doi: 10.1038/bjc.2014.604.
• Switlyk, Marta Daniela; Kongsgaard, Ulf; Skjeldal, Sigmund; Hald, John K; Hole, Knut Håkon & Knutstad, Kjetil [Vis alle 7 forfattere av denne artikkelen] (2015). Prognostic factors in patients with symptomatic spinal metastases and normal neurological function. Clinical Oncology. ISSN 0936-6555. 27(4), s. 213–221. doi: 10.1016/j.clon.2015.01.002.
• Hole, Knut Håkon; Axcrona, Karol; Lie, Kathrine; Vlatkovic, Ljiljana; Geier, Oliver & Brennhovd, Bjørn [Vis alle 9 forfattere av denne artikkelen] (2013). Routine pelvic MRI using phased-array coil for detection of extraprostatic tumour extension: accuracy and clinical significance. European Radiology. ISSN 0938-7994. 23(4), s. 1158–1166. doi: 10.1007/s00330-012-2669-x.
• Hole, Knut Håkon; Larsen, Stein Gunnar; Kotanska-Grøholt, Krystyna; Giercksky, Karl-Erik & Ree, Anne Hansen (2013). Magnetic resonance-guided histopathology for improved accuracy of tumor response evaluation of neoadjuvant treatment in organ-infiltrating rectal cancer. Radiotherapy and Oncology. ISSN 0167-8140. 107(2), s. 178–183. doi: 10.1016/j.radonc.2013.03.017.
• Andersen, Erlend K F; Hole, Knut Håkon; Lund, Kjersti Vassmo; Sundfør, Kolbein; Kristensen, Gunnar S Balle & Lyng, Heidi [Vis alle 7 forfattere av denne artikkelen] (2013). Pharmacokinetic parameters derived from dynamic contrast enhanced MRI of cervical cancers predict chemoradiotherapy outcome. Radiotherapy and Oncology. ISSN 0167-8140. 107(1), s. 117–122. doi: 10.1016/j.radonc.2012.11.007.
• Andersen, Erlend K F; Hole, Knut Håkon; Lund, Kjersti Vassmo; Sundfør, Kolbein; Kristensen, Gunnar S Balle & Lyng, Heidi [Vis alle 7 forfattere av denne artikkelen] (2012). Dynamic Contrast-Enhanced MRI of Cervical Cancers: Temporal Percentile Screening of Contrast Enhancement Identifies Parameters for Prediction of Chemoradioresistance. International Journal of Radiation Oncology, Biology, Physics. ISSN 0360-3016. 82(3), s. E485–E492. doi: 10.1016/j.ijrobp.2011.05.050.
• Switlyk, Marta Daniela; Hole, Knut Håkon; Skjeldal, Sigmund; Hald, John K; Knutstad, Kjetil & Seierstad, Therese [Vis alle 7 forfattere av denne artikkelen] (2012). MRI and neurological findings in patients with spinal metastases. Acta Radiologica. ISSN 0284-1851. 53(10), s. 1164–1172. doi: 10.1258/ar.2012.120442.
• Fosså, Alexander; Fiskvik, Idun Hege; Kolstad, Arne; Lauritzsen, Grete Fossum; Aurlien, Ellen & Blystad, Anne Kirsti [Vis alle 9 forfattere av denne artikkelen] (2012). Two escalated followed by six standard BEACOPP in advanced-stage high-risk classical Hodgkin lymphoma: high cure rates but increased risk of aseptic osteonecrosis. Annals of Oncology. ISSN 0923-7534. 23(5), s. 1254–1259. doi: 10.1093/annonc/mdr385.
• Dimmen, Magne; Vlatkovic, Ljiljana; Hole, Knut Håkon; Nesland, Jahn M; Brennhovd, Bjørn & Axcrona, Karol (2012). Transperineal prostate biopsy detects significant cancer in patients with elevated prostate-specific antigen (PSA) levels and previous negative transrectal biopsies. BJU International. ISSN 1464-4096. 110(2 Pt 2), s. E69–75. doi: 10.1111/j.1464-410x.2011.10759.x.
• Hjortland, Geir Olav; Meza, Leonardo Zepeda; Beiske, Klaus; Ree, Anne Hansen; Tveito, Siri & Høifødt, Hanne Kleppe [Vis alle 12 forfattere av denne artikkelen] (2011). Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma. BMC Cancer. ISSN 1471-2407. 11. doi: 10.1186/1471-2407-11-455.
• Fangberget, Anne; Nilsen, Line; Hole, Knut Håkon; Holmen, Marit Muri; Engebråten, Olav & Naume, Bjørn [Vis alle 9 forfattere av denne artikkelen] (2011). Neoadjuvant chemotherapy in breast cancer-response evaluation and prediction of response to treatment using dynamic contrast-enhanced and diffusion-weighted MR imaging. European Radiology. ISSN 0938-7994. 21(6), s. 1188–1199. doi: 10.1007/s00330-010-2020-3.
• Folkvord, Sigurd; Flatmark, Kjersti; Dueland, Svein; de Wijn, Rik; Grøholt, Krystyna Kotanska & Hole, Knut Håkon [Vis alle 12 forfattere av denne artikkelen] (2010). Prediction of response to preoperative chemoradiotherapy in rectal cancer by multiplex kinase activity profiling. International Journal of Radiation Oncology, Biology, Physics. ISSN 0360-3016. 78(2), s. 555–562. doi: 10.1016/j.ijrobp.2010.04.036.
• Ree, Anne Hansen; Dueland, Svein; Folkvord, Sigurd; Hole, Knut Håkon; Seierstad, Therese & Johansen, Marianne [Vis alle 8 forfattere av denne artikkelen] (2010). Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study. The Lancet Oncology. ISSN 1470-2045. 11(5), s. 459–464. doi: 10.1016/S1470-2045(10)70058-9.
• Seierstad, Therese; Hole, Knut Håkon; Sælen, Erik; Ree, Anne Hansen; Flatmark, Kjersti & Malinen, Eirik (2009). MR-guided simultaneous integrated boost in preoperative radiotherapy of locally advanced rectal cancer following neoadjuvant chemotherapy. Radiotherapy and Oncology. ISSN 0167-8140. 93(2), s. 279–284.
• Seierstad, Therese; Hole, Knut Håkon; Sælen, Erik; Ree, Anne Hansen & Flatmark, Kjersti (2009). MR-guided simultaneous integrated boost in preoperative radiotherapy of locally advanced rectal cancer following neoadjuvant chemotherapy. Radiotherapy and Oncology. ISSN 0167-8140. 93(2), s. 279–284. Vis sammendrag

  Conclusions: Tumor volume reduction for rectal cancer patients following neoadjuvant chemotherapy allows for increased tumor dose using a SIB strategy without increased OAR toxicity. (C) 2009 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 93 (2009) 279-289

• Larsen, Stein Gunnar; Wiig, Johan N.; Emblemsvaag, HL; Grøholt, Krystyna Kotanska; Hole, Knut Håkon & Bentsen, Annette [Vis alle 8 forfattere av denne artikkelen] (2009). Extended total mesorectal excision in locally advanced rectal cancer (T4a) and the clinical role of MRI-evaluated neo-adjuvant downstaging. Colorectal Disease. ISSN 1462-8910. 11(7), s. 759–767. doi: 10.1111/j.1463-1318.2008.01649.x.
• Lillleby, Wolfgang; Axcrona, Karol; Alfsen, G. Cecilie; Urnes, Thomas & Hole, Knut Håkon (2007). Diagnosis and treatment of primary signet-ring cell carcinoma of the prostate. Acta Oncologica. ISSN 0284-186X. 46, s. 1195–1197.
• Hoff, Geir; Wiig, Johan N.; Reed, Wenche; Hole, Knut Håkon; Scheistrøen, Marit & Henriksen, Halvor (2005). Short stricture of the rectum regressing on discontination of hormone replacement therapy: Endoscopic appearance, multiple biopsies and clinical improvement insufficient for diagnosis. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 40(3), s. 365–367. doi: 10.1080/00365520510011614.

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• Knuth, Franziska Hanna; Adde, Ingvild Askim; Huynh, Bao Ngoc; Grøndahl, Aurora Rosvoll; Winter, René & Negård, Anne [Vis alle 15 forfattere av denne artikkelen] (2021). MRI-based automatic segmentation of rectal cancer using 2D U-Net on two independent cohorts.
• Ryg, Una; Lilleby, Wolfgang; Hole, Knut Håkon; Lund-Iversen, Marius & Switlyk, Marta Daniela (2020). Local Recurrence of Prostate Cancer to the Intersphincteric Space: A Case Report. Urology. ISSN 0090-4295. 140, s. 18–21. doi: 10.1016/j.urology.2020.03.009.
• Bakke, Kine Mari; Hole, Knut Håkon; Dueland, Svein; Grøholt, Krystyna Kotanska; Ree, Anne Hansen & Flatmark, Kjersti [Vis alle 8 forfattere av denne artikkelen] (2017). Diffusion-weighted MRI of rectal cancer: baseline tumour perfusion fraction predicts chemoradiotherapy response and survival.
• Torheim, Turid K Gjerstad; Malinen, Eirik; Hole, Knut Håkon; Lund, Kjersti Vassmo; Indahl, Ulf Geir & Kvaal, Knut [Vis alle 8 forfattere av denne artikkelen] (2017). Autodelineation of cervical cancers using multiparametric MRI and machine learning.
• Goscinski, Mariusz Adam; Hole, Knut Håkon; Tønne, Elin; Ryder, Truls; Kotanska-Grøholt, Krystyna & Flatmark, Kjersti (2016). Fibromatosis in vertical rectus abdominis myocutaneous flap imitating tumor recurrence after surgery for locally advanced rectal cancer: case report. World Journal of Surgical Oncology (WJSO). ISSN 1477-7819. 14(63). doi: 10.1186/s12957-016-0818-4.
• Bakke, Kine Mari; Seierstad, Therese; Hole, Knut Håkon; Dueland, Svein; Flatmark, Kjersti & Ree, Anne Hansen [Vis alle 7 forfattere av denne artikkelen] (2016). Histogram analysis of ADCs from DWMRI predicts tumour response and survival for rectal cancer.
• Redalen, Kathrine Røe; Sitter, Beathe; Bathen, Tone Frost; Grøholt, Krystyna Kotanska; Hole, Knut Håkon & Dueland, Svein [Vis alle 9 forfattere av denne artikkelen] (2016). High tumour glycine concentration – an adverse prognostic factor in locally advanced rectal cancer.
• Bakke, Kine Mari; Hole, Knut Håkon; Dueland, Svein; Flatmark, Kjersti; Ree, Anne Hansen & Seierstad, Therese [Vis alle 7 forfattere av denne artikkelen] (2016). Tumour perfusion estimated from diffusion-weighted MRI of rectal cancer – an indirect marker of tumour hypoxia?
• Torheim, Turid K Gjerstad; Malinen, Eirik; Hole, Knut Håkon; Lund, Kjersti Vassmo; Indahl, Ulf Geir & Kvaal, Knut [Vis alle 8 forfattere av denne artikkelen] (2015). Cervical tumour segmentation using multi-sequence MRI and linear discriminant analysis.
• Bakke, Kine Mari; Seierstad, Therese; Hole, Knut Håkon; Ree, Anne Hansen & Redalen, Kathrine Røe (2015). Histogram analysis of apparent diffusion coefficients from diffusion-weighted MRI during neoadjuvant treatment of locally advanced rectal cancer predicts histologic tumor response and survival.
• Seierstad, Therese; Hole, Knut Håkon; Grøholt, Krystyna Kotanska; Dueland, Svein; Ree, Anne Hansen & Flatmark, Kjersti [Vis alle 7 forfattere av denne artikkelen] (2015). Prediction of response to neoadjuvant chemotherapy followed by chemoradiotherapy in rectal cancer by MRI volumetry. Radiotherapy and Oncology. ISSN 0167-8140. 115.
• Raabe, Nils Kristian; Sundfør, Kolbein; Hole, Knut Håkon; Djupvik, Linda Holth; Larsen, Stein Gunnar & Dueland, Svein (2014). Høydoserate brakyterapi mot residiverende endetarmskreft etter konvensjonell residivbehandling. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 134(20), s. 1929–1920. doi: 10.4045/tidsskr.14.1162.
• Revheim, Mona Elisabeth; Hole, Knut Håkon; Bruland, Øyvind; Reitan, Edmund; Bjerkehagen, Bodil & Julsrud, Lars [Vis alle 7 forfattere av denne artikkelen] (2014). Multimodal functional imaging for early response assessment in GIST patients treated with imatinib. Acta Oncologica. ISSN 0284-186X. 53(1), s. 143–148. doi: 10.3109/0284186X.2013.798428.
• Andersen, Erlend K F; Hole, Knut Håkon; Lund, Kjersti Vassmo; Kristensen, Gunnar S Balle; Lyng, Heidi & Malinen, Eirik (2012). IMPACT OF TUMOR DELINEATION ERRORS ON OUTCOME PREDICTION BASED ON DCE-MRI OF CERVICAL CANCER PATIENTS RECEIVING RT. Radiotherapy and Oncology. ISSN 0167-8140. 103, s. 72–72.
• Revheim, Mona-Elisabeth; Hole, Knut Håkon; Bruland, Øyvind Sverre; Haugland, Hans Kristian; Hall, Kirsten Sundby & Seierstad, Therese (2011). DW MRI for evaluation of treatment response to imatinib in a rectal gastrointestinal stromal tumour. Acta Oncologica. ISSN 0284-186X. 50(1), s. 148–150. doi: 10.3109/0284186X.2010.516273.
• Larsen, Stein Gunnar; Hole, Knut Håkon; Kotanska-Grøholt, Krystyna; Dueland, Svein & Giercksky, Karl-Erik (2010). THE PRE-TREATMENT MRI PREDICTS THE NEED FOR EXTENDED TOTAL MESORECTAL EXCISION (ETME) IN T4A RECTAL CANCER. Annals of Oncology. ISSN 0923-7534. 21, s. 60–60.

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