Knut Jørgen Labori

• Labori, Knut Jørgen; Bratlie, Svein Olav; Andersson, Bodil; Angelsen, Jon-Helge; Biörserud, Christina & Björnsson, Bergthor [Vis alle 36 forfattere av denne artikkelen] (2024). Neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer (NORPACT-1): a multicentre, randomised, phase 2 trial. The Lancet Gastroenterology and Hepatology. ISSN 2468-1253. 9(3), s. 205–217. doi: 10.1016/S2468-1253(23)00405-3.
• Farnes, Ingvild; Kleive, Dyre; Verbeke, Caroline Sophie; Aabakken, Lars; Issa-Epe, Aart Imran & Småstuen, Milada Cvancarova [Vis alle 10 forfattere av denne artikkelen] (2023). Resection rates and intention-to-treat outcomes in borderline and locally advanced pancreatic cancer: real-world data from a population-based, prospective cohort study (NORPACT-2). BJS Open. ISSN 2474-9842. 7:zrad137(6), s. 1–10. doi: 10.1093/bjsopen/zrad137. Fulltekst i vitenarkiv
• Farnes, Ingvild; Paulsen, Vemund; Verbeke, Caroline Sophie; Tønnesen, Christer Julseth; Aabakken, Lars & Labori, Knut Jørgen (2023). Performance and safety of diagnostic EUS FNA/FNB and therapeutic ERCP in patients with borderline resectable and locally advanced pancreatic cancer - results from a population-based, prospective cohort study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 0, s. 1–7. doi: 10.1080/00365521.2023.2290456. Fulltekst i vitenarkiv
• Khan, Ammar; Fosby, Bjarte; Labori, Knut Jørgen; Lanari, Jacopo; Dorenberg, Eric & Line, Pål Dag (2023). Management of Coeliac and Hepatic Artery Aneurysms: A Single Institution Experience of 84 Cases. European Journal of Vascular and Endovascular Surgery. ISSN 1078-5884. 66(6), s. 814–820. doi: 10.1016/j.ejvs.2023.09.032. Fulltekst i vitenarkiv
• Yakub, Sheraz; Tholfsen, Tore; Waage, Anne; Kleive, Dyre & Labori, Knut Jørgen (2023). Pancreatoduodenectomy after Roux-en-Y gastric bypass surgery: Single-center experience and literature review. Scandinavian Journal of Surgery. ISSN 1457-4969. 112, s. 98–104. doi: 10.1177/14574969231156350. Fulltekst i vitenarkiv Vis sammendrag

  Background and objective: Bariatric surgery with Roux-en-Y gastric bypass (RYGB) is widely used to treat morbid obesity and present diagnostic and therapeutic challenges in patients with pancreatic and periampullary tumors. The aim of this study was to describe diagnostic tools and challenges in performing pancreatoduodenectomy (PD) on patients with altered anatomy after RYGB. Methods: Patients undergoing PD after RYGB from April 2015 to June 2022 at a tertiary referral center were identified. Preoperative workup, operative techniques, and outcomes were reviewed. A literature search was performed to identify articles reporting PD in post-RYGB patients. Results: Of a total of 788 PDs, six patients had previous RYGB. The majority were women (n = 5), and median age was 59 years. The patients most commonly presented with pain (50%) and jaundice (50%) with a median of 5.5 years after RYGB. The gastric remnant was resected in all cases, and reconstruction of the pancreatobiliary drainage was achieved using the distal part of the pre-existing pancreatobiliary limb in all patients. Median follow-up was 60 months. The Clavien–Dindo grade ⩾3 complications occurred in two patients (33.3%), and 90 days mortality occurred in one patient (16.6%). The literature search revealed 9 articles reporting a total of 122 cases, specifically addressing PD after RYGB. Conclusions: Reconstruction after PD in post-RYGB patients may be challenging. Resection of the gastric remnant and use of the pre-existing biliopancreatic limb may be a safe strategy, but surgeons should be prepared for other reconstruction options for creation of a new pancreatobiliary limb.

• Ghotbi, Jacob; Sahakyan, Mushegh; Søreide, Kjetil; Fretland, Åsmund Avdem; Røsok, Bård Ingvald & Tholfsen, Tore [Vis alle 11 forfattere av denne artikkelen] (2022). Minimally Invasive Pancreatoduodenectomy: Contemporary Practice, Evidence, and Knowledge Gaps. Oncology and Therapy. ISSN 2366-1070. 10(2). doi: 10.1007/s40487-022-00203-6. Fulltekst i vitenarkiv
• van Veldhuisen, Eran; Klompmaker, Sjors; Janssen, Quisette P.; Hilal, Mohammed Abu; Alseidi, Adnan & Balduzzi, Alberto [Vis alle 42 forfattere av denne artikkelen] (2022). Surgical and Oncological Outcomes After Preoperative FOLFIRINOX Chemotherapy in Resected Pancreatic Cancer: An International Multicenter Cohort Study. Annals of Surgical Oncology. ISSN 1068-9265. doi: 10.1245/s10434-022-12387-2.
• Amrutkar, Manoj; Verbeke, Caroline Sophie; Vefferstad, Anette; Dorg, Linda Trobe; Labori, Knut Jørgen & Gladhaug, Ivar Prydz (2022). Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma. Molecular Oncology. ISSN 1574-7891. 17(1), s. 59–81. doi: 10.1002/1878-0261.13344. Fulltekst i vitenarkiv Vis sammendrag

  he modest clinical benefits of neoadjuvant chemotherapy (NAT) in pancreatic ductal adenocarcinoma (PDAC) are associated with a lack of robust data on treatment-induced changes in the tumor. To this end, comparative proteomic profiling of tumor tissue samples from treatment-naïve (TN, n = 20) and NAT-treated (n = 22) PDACs was performed. Differentially expressed proteins were identified and correlation with overall survival (OS) was performed. Tumors were also examined for histopathological changes and expression of cancer stem cell (CSC) markers. Serum from 33 matched patients was analyzed for metabolic markers. Cytotoxicity, proliferation, and expression of CSC markers were assessed in chemoresistant Panc-1 and Mia PaCa-2 cells. Of the 2265 proteins identified, 227 and 144 proteins showed significantly altered expression and differential phosphorylation, respectively, in NAT compared with TN samples. The majority of these were metabolism-related proteins, and 14 of these correlated moderately with OS. NAT-treated tumors and chemoresistant cancer cells showed increased expression of CSC markers. Serum ALDH1A1 was higher in NAT compared with TN. Differentially phosphorylated proteins were mainly involved in cytoskeleton organization, cell locomotion, motility, and migration, and 17 of these showed a strong positive correlation with OS. This study provides evidence of the effects of NAT on PDAC metabolism at both the tumor and the systemic levels. NAT-treated tumors showed significantly lower expression of metabolic proteins, and patients who underwent NAT showed reduced serum lactate and high-density lipoprotein-cholesterol. Lastly, cancer cells that survived cytotoxic treatment expressed higher CSC markers, both in vivo and in vitro.

• Waage, Anne; Holmquist, Olof Dan Sebastian; Labori, Knut Jørgen; Paulsen, Vemund; Lenz, Harald & Aabakken, Lars [Vis alle 9 forfattere av denne artikkelen] (2022). Tailored surgery in chronic pancreatitis after implementation of a multidisciplinary team assessment; a prospective observational study. HPB. ISSN 1365-182X. doi: 10.1016/j.hpb.2022.09.007. Fulltekst i vitenarkiv
• Latenstein, Anouk E.J.; Scholten, Lianne; Al-Saffar, Hasan Ahmad; Björnsson, Bergthor; Butturini, Giovanni & Capretti, Giovanni [Vis alle 36 forfattere av denne artikkelen] (2022). Clinical Outcomes After Total Pancreatectomy: A Prospective Multicenter Pan-European Snapshot Study. Annals of Surgery. ISSN 0003-4932. 276(5), s. E536–E543. doi: 10.1097/SLA.0000000000004551.
• Silwal-Pandit, Laxmi; Stålberg, Stina Margrethe; Johansson, Henrik J.; Mermelekas, Georgios; Lothe, Inger Marie Bowitz & Skrede, Martina Landschoof [Vis alle 14 forfattere av denne artikkelen] (2022). Proteome Analysis of Pancreatic Tumors Implicates Extracellular Matrix in Patient Outcome. Cancer Research Communications. ISSN 2767-9764. 2(6), s. 434–446. doi: 10.1158/2767-9764.CRC-21-0100. Fulltekst i vitenarkiv Vis sammendrag

  Pancreatic cancer remains a disease with unmet clinical needs and inadequate diagnostic, prognostic, and predictive biomarkers. In-depth characterization of the disease proteome is limited. This study thus aims to define and describe protein networks underlying pancreatic cancer and identify protein centric subtypes with clinical relevance. Mass spectrometry–based proteomics was used to identify and quantify the proteome in tumor tissue, tumor-adjacent tissue, and patient-derived xenografts (PDX)-derived cell lines from patients with pancreatic cancer, and tissues from patients with chronic pancreatitis. We identified, quantified, and characterized 11,634 proteins from 72 pancreatic tissue samples. Network focused analysis of the proteomics data led to identification of a tumor epithelium–specific module and an extracellular matrix (ECM)-associated module that discriminated pancreatic tumor tissue from both tumor adjacent tissue and pancreatitis tissue. On the basis of the ECM module, we defined an ECM-high and an ECM-low subgroup, where the ECM-high subgroup was associated with poor prognosis (median survival months: 15.3 vs. 22.9 months; log-rank test, P = 0.02). The ECM-high tumors were characterized by elevated epithelial–mesenchymal transition and glycolytic activities, and low oxidative phosphorylation, E2F, and DNA repair pathway activities. This study offers novel insights into the protein network underlying pancreatic cancer opening up for proteome precision medicine development. Significance: Pancreatic cancer lacks reliable biomarkers for prognostication and treatment of patients. We analyzed the proteome of pancreatic tumors, nonmalignant tissues of the pancreas and PDX-derived cell lines, and identified proteins that discriminate between patients with good and poor survival. The proteomics data also unraveled potential novel drug targets.

• Yaqub, Sheraz; Jensenius, Mogens; Heieren, Ole E. B.; Drolsum, Anders; Pettersen, Frank O. & Labori, Knut Jørgen (2022). Echinococcosis in a non-endemic country–20-years’ surgical experience from a Norwegian tertiary referral Centre. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 57(8), s. 953–957. doi: 10.1080/00365521.2022.2046846. Fulltekst i vitenarkiv
• Yaqub, Sheraz; Bjørnbeth, Bjørn Atle; Angelsen, Jon-Helge; Fristrup, Claus W.; Grønbech, Jon Erik & Hemmingsson, Oskar [Vis alle 29 forfattere av denne artikkelen] (2021). Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial. Trials. ISSN 1745-6215. 22(1). doi: 10.1186/s13063-021-05587-w. Fulltekst i vitenarkiv Vis sammendrag

  Background: Colorectal cancer is one the most common cancers in the western world with increasing incidence. Approximately 50% of the patients develop liver metastases. Resection of liver metastases is the treatment of choice although almost half of the resected patients get recurrence in the liver. Methods: The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled study to determine whether adjuvant treatment with low-dose aspirin (acetylsalicylic acid (ASA)) can improve disease-free survival in patients treated for colorectal cancer liver metastases (CRCLM). Up to 800 patients operated for CRCLM will be randomized to Arm#1 ASA 160 mg once daily or Arm#2 Placebo, for a period of 3 years or until disease recurrence. The patients will be recruited at all major hepatobiliary surgical units in Norway, Sweden and Denmark and have follow-up according to standard of care and the National Guidelines. Discussion: The ASAC trial will be the first clinical interventional trial to assess the potential beneficial role of ASA in recurrence of CRCLM and survival. ASA is an inexpensive, well-tolerated and easily accessible drug that will be highly potential as adjuvant drug in secondary prevention of CRCLM if the study shows a beneficial effect. We will also determine the effect of ASA as adjuvant treatment on Health-Related Quality of Life and the cost-effectiveness. Trial registration: ClinicalTrials.gov NCT03326791. Registered on 31 October 2017.

• Grut, Harald; Line, Pål Dag; Labori, Knut Jørgen; Schulz, Anselm & Dueland, Svein (2021). Survival after liver resection and liver transplantation for colorectal liver metastases: a comparative analysis stratified by metabolic tumor volume assessed by 18F-FDG PET/CT. HPB. ISSN 1365-182X. doi: 10.1016/j.hpb.2021.11.015.
• Lindholm, Espen; Bergmann, Gisli Björn; Haugaa, Håkon; Labori, Knut Jørgen; Yaqub, Sheraz & Bjørnbeth, Bjørn Atle [Vis alle 11 forfattere av denne artikkelen] (2021). Early detection of anastomotic leakage after pancreatoduodenectomy with microdialysis catheters: an observational Study. HPB. ISSN 1365-182X. 24(6), s. 901–909. doi: 10.1016/j.hpb.2021.10.020. Fulltekst i vitenarkiv Vis sammendrag

  Background Microdialysis catheters can detect focal inflammation and ischemia, and thereby have a potential for early detection of anastomotic leakages after pancreatoduodenectomy. The aim was to investigate whether microdialysis catheters placed near the pancreaticojejunostomy can detect leakage earlier than the current standard of care. Methods Thirty-five patients with a median age 69 years were included. Two microdialysis catheters were placed at the end of surgery; one at the pancreaticojejunostomy, and one at the hepaticojejunostomy. Concentrations of glucose, lactate, pyruvate, and glycerol were analyzed hourly in the microdialysate during the first 24 h, and every 2–4 h thereafter. Results Seven patients with postoperative pancreatic fistulae (POPF) had significantly higher glycerol levels (P < 0.01) in the microdialysate already in the first postoperative samples. Glycerol concentrations >400 μmol/L during the first 12 postoperative hours detected patients with POPF with a sensitivity of 100% and a specificity of 93% (P < 0.001). After 24 h, lactate and lactate-to-pyruvate ratio were significantly higher (P < 0.05) and glucose was significantly lower (P < 0.05) in patients with POPF. Conclusion High levels of glycerol in microdialysate was an early detector of POPF. The subsequent inflammation was detected as increase in lactate and lactate-to-pyruvate ratio and a decrease in glucose (NCT03627559).

• Sahakyan, Mushegh A.; Verbeke, Caroline S.; Tholfsen, Tore; Ignjatovic, Dejan; Kleive, Dyre & Buanes, Trond [Vis alle 10 forfattere av denne artikkelen] (2021). Prognostic Impact of Resection Margin Status in Distal Pancreatectomy for Ductal Adenocarcinoma. Annals of Surgical Oncology. ISSN 1068-9265. 29, s. 366–375. doi: 10.1245/s10434-021-10464-6. Fulltekst i vitenarkiv
• Labori, Knut Jørgen; Tholfsen, Tore; Yaqub, Sheraz; Lassen, Kristoffer; Kleive, Dyre & Waage, Anne (2021). Gastro- or Duodenojejunostomy Leaks After Pancreatoduodenectomy: Single Center Experience and Narrative Literature Review. Journal of Gastrointestinal Surgery. ISSN 1091-255X. s. 1–7. doi: 10.1007/s11605-021-05058-2. Fulltekst i vitenarkiv
• Sahakyan, Mushegh; Røsok, Bård Ingvald; Tholfsen, Tore; Kleive, Dyre; Waage, Anne & Ignjatovic, Dejan [Vis alle 9 forfattere av denne artikkelen] (2021). Implementation and training with laparoscopic distal pancreatectomy: 23-year experience from a high-volume center. Surgical Endoscopy. ISSN 0930-2794. s. 1–12. doi: 10.1007/s00464-021-08306-3. Fulltekst i vitenarkiv
• Hugenschmidt, Harald; Labori, Knut Jørgen; Borgen, Elin; Brunborg, Cathrine; Schirmer, Cecilie & Seeberg, Lars Thomas [Vis alle 8 forfattere av denne artikkelen] (2021). Preoperative CTC-Detection by CellSearch ® Is Associated with Early Distant Metastasis and Impaired Survival in Resected Pancreatic Cancer . Cancers. ISSN 2072-6694. 13(3). doi: 10.3390/cancers13030485. Fulltekst i vitenarkiv Vis sammendrag

  n patients with presumed pancreatic ductal adenocarcinoma (PDAC), biomarkers that may open for personalised, risk-adapted treatment are lacking. The study analysed the impact of CTCs-presence on the patterns of recurrence and survival in 98 patients resected for PDAC with 5–10 years of follow-up. Preoperative samples were analysed by the CellSearch® system for EpCAM+/DAPI+/CK+/CD45-CTCs. CTCs were detected in 7 of the 98 patients. CTCs predicted a significantly shorter median disease-free survival (DFS) of 3.3 vs. 9.2 months and a median cancer specific survival (CSS)of 6.3 vs. 18.5 months. Relapse status was confirmed by imaging for 87 patients. Of these, 58 patients developed distant metastases (DM) and 29 developed isolated local recurrence (ILR) as the first sign of cancer relapse. All patients with CTCs experienced DM. pN-status and histological grade >2 were other independent risk factors for DM, but only CTCs predicted significantly shorter cancer-specific, disease-free and post-recurrence survival. Preoperative parameters did not affect clinical outcome. We conclude that CTC presence in resected PDAC patients predicted early distant metastasis and impaired survival. Preoperative CTCs alone or in combination with histopathological factors may guide initial treatment decisions in patients with resectable PDAC in the future

• Roessel, Stijn; Veldhuisen, Eran; Klompmaker, Sjors; Janssen, Quisette; Hilal, Mohammed Abu & Alseidi, Adnan [Vis alle 44 forfattere av denne artikkelen] (2020). Evaluation of adjuvant chenotherapy in patients with resected pancreatic cancer after neoadjuvant FOLFIRINOX treatment. JAMA Oncology. ISSN 2374-2437. 6(11), s. 1733–1740. doi: 10.1001/jamaoncol.2020.3537.
• Labori, Knut Jørgen; Kleive, Dyre; Khan, Ammar; Farnes, Ingvild; Fosby, Bjarte & Line, Pål Dag (2020). Graft type for superior mesenteric and portal vein reconstruction in pancreatic surgery – A systematic review. HPB. ISSN 1365-182X. s. 1–12. doi: 10.1016/j.hpb.2020.11.008. Fulltekst i vitenarkiv
• Khan, Ammar; Kleive, Dyre; Aandahl, Einar Martin; Fosby, Bjarte; Line, Pål Dag & Dorenberg, Eric Jürgen [Vis alle 8 forfattere av denne artikkelen] (2020). Portal vein stent placement after hepatobiliary and pancreatic surgery. Langenbeck's Archives of Surgery. ISSN 1435-2443. 405, s. 657–664. doi: 10.1007/s00423-020-01917-9. Fulltekst i vitenarkiv
• Grut, Harald; Stern, Nadide; Dueland, Svein; Labori, Knut Jørgen; Dormagen, Johann Baptist & Schulz, Anselm (2020). Preoperative Preoperative 18F-FDG PET/computed tomography predicts survival following resection for colorectal liver metastases. Nuclear medicine communications. ISSN 0143-3636. 41(9), s. 916–923. doi: 10.1097/MNM.0000000000001235.
• Nymo, Linn Såve; Kleive, Dyre; Waardal, Kim; Bringeland, Erling Audun; Søreide, Jon Arne & Labori, Knut Jørgen [Vis alle 9 forfattere av denne artikkelen] (2020). Centralizing a national pancreatoduodenectomy service: striking the right balance. BJS Open. ISSN 2474-9842. 4(5), s. 904–913. doi: 10.1002/bjs5.50342. Fulltekst i vitenarkiv
• Hugenschmidt, Harald; Labori, Knut Jørgen; Brunborg, Cathrine; Verbeke, Caroline Sophie; Seeberg, Lars Thomas & Schirmer, Cecilie [Vis alle 10 forfattere av denne artikkelen] (2020). Cytokeratin-positive cells in the bone marrow from patients with pancreatic, periampullary malignancy and benign pancreatic disease show no prognostic information . BMC Cancer. ISSN 1471-2407. 20:1107, s. 1–13. doi: 10.1186/s12885-020-07510-z. Fulltekst i vitenarkiv Vis sammendrag

  Background: Pancreatic and periampullary carcinoma are aggressive tumours where preoperative assessment is challenging. Disseminated tumour cells (DTC) in the bone marrow (BM) are associated with impaired prognosis in a variety of epithelial cancers. In a cohort of patients with presumed resectable pancreatic and periampullary carcinoma, we evaluated the frequency and the potential prognostic impact of the preoperative presence of DTC, defined as cytokeratin-positive cells detected by immunocytochemistry (ICC). Methods: Preoperative BM samples from 242 patients selected for surgical resection of presumed resectable pancreatic and periampullary carcinoma from 09/2009 to 12/2014, were analysed for presence of CK-positive cells by ICC. The median observation time was 21.5 months. Overall survival (OS) and disease-free survival (DFS) were calculated by Kaplan-Meier and Cox regression analysis. Results: Successful resections of malignant tumours were performed in 179 of the cases, 30 patients resected had benign pancreatic disease based on postoperative histology, and 33 were deemed inoperable intraoperatively due to advanced disease. Overall survival for patients with resected carcinoma was 21.1 months (95% CI: 18.0-24.1), for those with benign disease OS was 101 months (95% CI: 69.4-132) and for those with advanced disease OS was 8.8 months (95% CI: 4.3-13.3). The proportion of patients with detected CK-positive cells was 6/168 (3.6%) in resected malignant cases, 2/31 (6.5%) in advanced disease and 4/29 (13.8%) in benign disease. The presence of CK-positive cells was not correlated to OS or DFS, neither in the entire cohort nor in the subgroup negative for circulating tumour cells (CTC). Conclusions: The results indicate that CK-positive cells may be present in both patients with malignant and benign diseases of the pancreas. Detection of CK-positive cells was not associated with differences in prognosis for the entire cohort or any of the subgroups analysed.

• Sahakyan, Mushegh; Tholfsen, Tore; Kleive, Dyre; Yaqub, Sheraz; Kazaryan, Airazat M. & Buanes, Trond [Vis alle 9 forfattere av denne artikkelen] (2020). Laparoscopic distal pancreatectomy following prior upper abdominal surgery (pancreatectomy and prior surgery). Journal of Gastrointestinal Surgery. ISSN 1091-255X. s. 1–8. doi: 10.1007/s11605-020-04858-2. Fulltekst i vitenarkiv
• Sahakyan, Mushegh; Tholfsen, Tore; Kleive, Dyre; Waage, Anne; Buanes, Trond & Labori, Knut Jørgen [Vis alle 8 forfattere av denne artikkelen] (2020). Laparoscopic distal pancreatectomy in patients with poor physical status. HPB. ISSN 1365-182X. s. 1–5. doi: 10.1016/j.hpb.2020.10.004.
• Klompmaker, Sjors; Peters, Niek A; van Hilst, Jony; Bassi, Claudio; Boggi, Ugo & Busch, Olivier R. [Vis alle 28 forfattere av denne artikkelen] (2019). Outcomes and Risk Score for Distal Pancreatectomy with Celiac Axis Resection (DP-CAR): An International Multicenter Analysis. Annals of Surgical Oncology. ISSN 1068-9265. 26(3), s. 772–781. doi: 10.1245/s10434-018-07101-0.
• Sandhu, Vandana; Labori, Knut Jørgen; Borgida, Ayelet; Lungu, Ilinca; Bartlett, John & Hafezi-Bakhtiari, Sara [Vis alle 15 forfattere av denne artikkelen] (2019). Meta-analysis of 1,200 transcriptomic profiles identifies a prognostic model for pancreatic ductal adenocarcinoma. JCO Clinical Cancer Informatics. ISSN 2473-4276. 3, s. 1–16. doi: 10.1200/CCI.18.00102. Fulltekst i vitenarkiv Vis sammendrag

  PURPOSE With a dismal 8% median 5-year overall survival, pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy. Only 10% to 20% of patients are eligible for surgery, and more than 50% of these patients will die within 1 year of surgery. Building a molecular predictor of early death would enable the selection of patients with PDAC who are at high risk. MATERIALS AND METHODS We developed the Pancreatic Cancer Overall Survival Predictor (PCOSP), a prognostic model built from a unique set of 89 PDAC tumors in which gene expression was profiled using both microarray and sequencing platforms. We used a meta-analysis framework that was based on the binary gene pair method to create gene expression barcodes that were robust to biases arising from heterogeneous profiling platforms and batch effects. Leveraging the largest compendium of PDAC transcriptomic data sets to date, we show that PCOSP is a robust single-sample predictor of early death—1 year or less—after surgery in a subset of 823 samples with available transcriptomics and survival data. RESULTS The PCOSP model was strongly and significantly prognostic, with a meta-estimate of the area under the receiver operating curve of 0.70 (P = 2.6E−22) and d-index (robust hazard ratio) of 1.9 (range, 1.6 to 2.3; ( = 1.4E−04) for binary and survival predictions, respectively. The prognostic value of PCOSP was independent of clinicopathologic parameters and molecular subtypes. Over-representation analysis of the PCOSP 2,619 gene pairs—1,070 unique genes—unveiled pathways associated with Hedgehog signaling, epithelial–mesenchymal transition, and extracellular matrix signaling. CONCLUSION PCOSP could improve treatment decisions by identifying patients who will not benefit from standard surgery/chemotherapy but who may benefit from a more aggressive treatment approach or enrollment in a clinical trial.

• Ånonsen, Kim Vidar; Sahakyan, Mushegh; Kleive, Dyre; Waage, Anne; Verbeke, Caroline Sophie & Hauge, Truls [Vis alle 9 forfattere av denne artikkelen] (2019). Trends in management and outcome of cystic pancreatic lesions - analysis of 322 cases undergoing surgical resection. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 54(8), s. 1051–1057. doi: 10.1080/00365521.2019.1642379. Fulltekst i vitenarkiv
• Thorsen, Trygve; Solheim, Jon Magnus Aarstrand; Labori, Knut Jørgen; Line, Pål Dag & Aandahl, Einar Martin (2019). Liver transplantation as a lifesaving procedure for posthepatectomy liver failure and iatrogenic liver injuries. Langenbeck's Archives of Surgery. ISSN 1435-2443. doi: 10.1007/s00423-019-01780-3. Fulltekst i vitenarkiv
• Kleive, Dyre; Sahakyan, Mushegh; Labori, Knut Jørgen & Lassen, Kristoffer (2019). Nasogastric Tube on Demand is Rarely Necessary After Pancreatoduodenectomy Within an Enhanced Recovery Pathway. World Journal of Surgery. ISSN 0364-2313. s. 1–7. doi: 10.1007/s00268-019-05045-4. Fulltekst i vitenarkiv
• Kleive, Dyre; Labori, Knut Jørgen; Line, Pål Dag; Gladhaug, Ivar Prydz & Verbeke, Caroline Sophie (2019). Pancreatoduodenectomy with venous resection for ductal adenocarcinoma rarely achieves complete (R0) resection. HPB. ISSN 1365-182X. 22(1), s. 50–57. doi: 10.1016/j.hpb.2019.05.005. Fulltekst i vitenarkiv
• Søreide, Kjetil; Primavesi, Florian; Labori, Knut Jørgen; Watson, Martin & Stättner, Stefan (2019). Molecular biology in pancreatic ductal adenocarcinoma: implications for future diagnostics and therapy. European Surgery. ISSN 1682-8631. 51(3), s. 126–134. doi: 10.1007/s10353-019-0575-z. Fulltekst i vitenarkiv
• Sahakyan, Mushegh; Labori, Knut Jørgen; Primavesi, Florian; Søreide, Kjetil; Stättner, Stefan & Edwin, Bjørn (2019). Minimally invasive pancreatic surgery-where are we going? European Surgery. ISSN 1682-8631. 51(3), s. 98–104. doi: 10.1007/s10353-019-0576-y. Fulltekst i vitenarkiv
• Lothe, Inger Marie Bowitz; Kleive, Dyre; Pomianowska, Ewa; Småstuen, Milada Cvancarova; Kure, Elin Wenche Hegland & Dueland, Svein [Vis alle 8 forfattere av denne artikkelen] (2019). Clinical relevance of pancreatobiliary and intestinal subtypes of ampullary and duodenal adenocarcinoma: Pattern of recurrence, chemotherapy, and survival after pancreatoduodenectomy. Pancreatology (Print). ISSN 1424-3903. 19(2), s. 316–324. doi: 10.1016/j.pan.2019.01.019. Fulltekst i vitenarkiv
• Brudvik, Kristoffer Watten; Røsok, Bård Ingvald; naresh, usha; Yaqub, Sheraz; Fretland, Åsmund Avdem & Labori, Knut Jørgen [Vis alle 8 forfattere av denne artikkelen] (2018). Survival after resection of colorectal liver metastases in octogenarians and sexagenarians compared to their respective age-matched national population. Hepatobiliary surgery and nutrition. ISSN 2304-3881. 7(4), s. 234–241. doi: 10.21037/hbsn.2017.09.03..
• Klompmaker, Sjors; van Hilst, Jony; Gerritsen, Sarah L.; Adham, Mustapha; Albiol Quer, M. Teresa & Bassi, Claudio [Vis alle 37 forfattere av denne artikkelen] (2018). Outcomes after distal pancreatectomy with celiac axis resection for pancreatic cancer: A pan-European retrospective cohort study. Annals of Surgical Oncology. ISSN 1068-9265. 25(5), s. 1440–1447. doi: 10.1245/s10434-018-6391-z.
• Kleive, Dyre; Sahakyan, Mushegh; Søreide, Kjetil; Brudvik, Kristoffer Watten; Line, Pål Dag & Gladhaug, Ivar Prydz [Vis alle 7 forfattere av denne artikkelen] (2018). Risk for hemorrhage after pancreatoduodenectomy with venous resection. Langenbeck's Archives of Surgery. ISSN 1435-2443. s. 1–9. doi: 10.1007/s00423-018-1721-y.
• Sahakyan, Mushegh; Kleive, Dyre; Kazaryan, Airazat M.; Aghayan, Davit; Ignjatovic, Dejan & Labori, Knut Jørgen [Vis alle 8 forfattere av denne artikkelen] (2018). Extended laparoscopic distal pancreatectomy for adenocarcinoma in the body and tail of the pancreas: a single-center experience. Langenbeck's Archives of Surgery. ISSN 1435-2443. s. 1–8. doi: 10.1007/s00423-018-1730-x.
• Hugenschmidt, Harald; Labori, Knut Jørgen; Brunborg, Cathrine; Verbeke, Caroline Sophie; Seeberg, Lars Thomas & Schirmer, Cecilie [Vis alle 10 forfattere av denne artikkelen] (2018). Circulating Tumor Cells are an Independent Predictor of Shorter Survival in Patients Undergoing Resection for Pancreatic and Periampullary Adenocarcinoma. Annals of Surgery. ISSN 0003-4932. 271(3), s. 549–558. doi: 10.1097/SLA.0000000000003035.
• Baekelandt, Bart Maria Gilbert; Fagerland, Morten; Hjermstad, Marianne Jensen; Heiberg, Turid; Labori, Knut Jørgen & Buanes, Trond (2018). Survival, Complications and Patient Reported Outcomes after Pancreatic Surgery. HPB. ISSN 1365-182X. doi: 10.1016/j.hpb.2018.07.023. Fulltekst i vitenarkiv
• Kleive, Dyre; Sahakyan, Mushegh; Khan, Ammar; Fosby, Bjarte; Line, Pål Dag & Labori, Knut Jørgen (2018). Incidence and management of arterial injuries during pancreatectomy. Langenbeck's Archives of Surgery. ISSN 1435-2443. 403(3), s. 341–348. doi: 10.1007/s00423-018-1666-1.
• Sahakyan, Mushegh; Haugvik, Sven-Petter; Røsok, Bård Ingvald; Kazaryan, Airazat M.; Ignjatovic, Dejan & Buanes, Trond [Vis alle 9 forfattere av denne artikkelen] (2018). Can standardized pathology examination increase the lymph node yield following laparoscopic distal pancreatectomy for ductal adenocarcinoma? HPB. ISSN 1365-182X. 20(2), s. 175–181. doi: 10.1016/j.hpb.2017.08.038.
• Chellappa, Stalin ; Hugenschmidt, Harald; Hagness, Morten; Subramani, Saranya; Melum, Espen & Line, Pål Dag [Vis alle 10 forfattere av denne artikkelen] (2017). CD8+ T Cells That Coexpress RORγt and T-bet Are Functionally Impaired and Expand in Patients with Distal Bile Duct Cancer. Journal of Immunology. ISSN 0022-1767. 198(4), s. 1729–1739. doi: 10.4049/jimmunol.1600061.
• Kleive, Dyre; Berstad, Audun Elnæs; Sahakyan, Mushegh; Verbeke, Caroline Sophie; Naper, Christian & Haugvik, Sven-Petter [Vis alle 9 forfattere av denne artikkelen] (2017). Portal vein reconstruction using primary anastomosis or venous interposition allograft in pancreatic surgery. Journal of Vascular Surgery: Venous and Lymphatic Disorders (JVS-VL). ISSN 2213-333X. 6(1), s. 66–74. doi: 10.1016/j.jvsv.2017.09.003.
• Sahakyan, Mushegh; Kim, Song Cheol; Kleive, Dyre; Kazaryan, Airazat M.; Song, Ki Byung & Ignjatovic, Dejan [Vis alle 10 forfattere av denne artikkelen] (2017). Laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: Long-term oncologic outcomes after standard resection. Surgery. ISSN 0039-6060. 162(4), s. 802–811. doi: 10.1016/j.surg.2017.06.009.
• Labori, Knut Jørgen; Guren, Marianne; Brudvik, Kristoffer Watten; Røsok, Bård Ingvald; Waage, Anne & Nesbakken, Arild [Vis alle 10 forfattere av denne artikkelen] (2017). Resection of synchronous liver metastases between radiotherapy and definitive surgery for locally advanced rectal cancer: short-term surgical outcomes, overall survival and recurrence-free survival. Colorectal Disease. ISSN 1462-8910. 19(8), s. 731–738. doi: 10.1111/codi.13622.
• Kleive, Dyre; Sahakyan, Mushegh; Berstad, Audun Elnæs; Verbeke, Caroline Sophie; Gladhaug, Ivar Prydz & Edwin, Bjørn [Vis alle 9 forfattere av denne artikkelen] (2017). Trends in indications, complications and outcomes for venous resection during pancreatoduodenectomy. British Journal of Surgery. ISSN 0007-1323. 104(11), s. 1558–1567. doi: 10.1002/bjs.10603.
• Labori, Knut Jørgen; Lassen, Kristoffer; Hoem, Dag; Grønbech, Jon Erik; Søreide, Jon Arne & Mortensen, Kim Erlend [Vis alle 10 forfattere av denne artikkelen] (2017). Neoadjuvant chemotherapy versus surgery first for resectable pancreatic cancer (Norwegian Pancreatic Cancer Trial - 1 (NorPACT-1)) – study protocol for a national multicentre randomized controlled trial. BMC Surgery. ISSN 1471-2482. 17(1). doi: 10.1186/s12893-017-0291-1. Fulltekst i vitenarkiv
• Ånonsen, Kim Vidar; Fagerland, Morten; Edwin, Bjørn; Labori, Knut Jørgen; Kure, E.H. & Hauge, Truls [Vis alle 7 forfattere av denne artikkelen] (2017). Cyst fluid CEA concentration discriminates between benign and premalignant/malignant pancreatic cystic lesions. A prospective cohort study. Short title: Diagnostic yield of pancreatic cyst fluid CEA analysis . EC Gastroenterology and Digestive System. ISSN 2276-1209. 02, s. 426–436. Fulltekst i vitenarkiv
• Sahakyan, Mushegh; Edwin, Bjørn; Kazaryan, Airazat M.; Barkhatov, Leonid; Buanes, Trond & Ignjatovic, Dejan [Vis alle 8 forfattere av denne artikkelen] (2017). Perioperative outcomes and survival in elderly patients undergoing laparoscopic distal pancreatectomy. Journal of Hepato-Biliary-Pancreatic Sciences. ISSN 1868-6974. 24(1), s. 42–48. doi: 10.1002/jhbp.409.
• Gunasekaran, Stalin Chellappa; Hugenschmidt, Harald; Hagness, Morten; Subramani, Saranya; Melum, Espen & Line, Pål Dag [Vis alle 10 forfattere av denne artikkelen] (2017). CD8+ T cells that coexpress ROR?t and T-bet are functionally impaired and expand in patients with distal bile duct cancer. Journal of Immunology. ISSN 0022-1767. 198(4), s. 1729–1739. doi: 10.4049/jimmunol.1600061.
• Schulz, Anselm; Viktil, Ellen; Godt, Johannes Jakob C; Johansen, Cathrine Kiperberg; Dormagen, Johann Baptist & Holtedahl, Jon Erik [Vis alle 9 forfattere av denne artikkelen] (2016). Diagnostic performance of CT, MRI and PET/CT in patients with suspected colorectal liver metastases: The superiority of MRI. Acta Radiologica. ISSN 0284-1851. 57(9), s. 1040–1048. doi: 10.1177/0284185115617349.
• Sahakyan, Mushegh; Yaqub, Sheraz; Kazaryan, Airazat M.; Villanger, Olaug; Berstad, Audun Elnæs & Labori, Knut Jørgen [Vis alle 8 forfattere av denne artikkelen] (2016). Laparoscopic Completion Pancreatectomy for Local Recurrence in the Pancreatic Remnant after Pancreaticoduodenectomy: Case Reports and Review of the Literature. Journal of Gastrointestinal Cancer. ISSN 1941-6628. 47(4), s. 509–513. doi: 10.1007/s12029-015-9796-y.
• Kleive, Dyre; Berstad, Audun Elnæs; Verbeke, Caroline Sophie; Haugvik, Sven-Petter; Gladhaug, Ivar Prydz & Line, Pål Dag [Vis alle 7 forfattere av denne artikkelen] (2016). Cold-stored cadaveric venous allograft for superior mesenteric/portal vein reconstruction during pancreatic surgery. HPB. ISSN 1365-182X. 18(7), s. 615–622. doi: 10.1016/j.hpb.2016.05.010. Vis sammendrag

  Background SMV/PV resection has become common practice in pancreatic surgery. The aim of this study was to evaluate the technical feasibility and surgical outcome of using cold-stored cadaveric venous allografts (AG) for superior mesenteric vein (SMV) and portal vein (PV) reconstruction during pancreatectomy. Methods Patients who underwent pancreatic resection with concomitant vascular resection and reconstruction with AG between January 2006 and December 2014 were identified from our institutional prospective database. Medical records and pre- and postoperative CT-images were reviewed. Results Forty-five patients underwent SMV/PV reconstruction with AG interposition (n = 37) or AG patch (n = 8). The median operative time and blood loss were 488 min (IQR: 450–551) and 900 ml (IQR: 600-2000), respectively. Major morbidity (Clavien ≥ III) occurred in 16 patients. Four patients were reoperated (thrombosis n = 2, graft kinking/low flow n = 2) and in-hospital mortality occurred in two patients. On last available CT scan, 3 patients had thrombosis, all of whom also had local recurrence. Estimated cumulative patency rate (reduction in SMV/PV luminal diameter <70% and no thrombosis) at 12 months was 52%. Conclusion Cold-stored cadaveric venous AG for SMV/PV reconstruction during pancreatic surgery is safe and associated with acceptable long-term patency.

• Sahakyan, Mushegh; Røsok, Bård Ingvald; Kazaryan, Airazat M.; Barkhatov, Leonid; Lai, Xiaoran & Kleive, Dyre [Vis alle 9 forfattere av denne artikkelen] (2016). Impact of obesity on surgical outcomes of laparoscopic distal pancreatectomy: A Norwegian single-center study. Surgery. ISSN 0039-6060. 160(5), s. 1271–1278. doi: 10.1016/j.surg.2016.05.046. Vis sammendrag

  Background Obesity is known as a risk factor for intra- and postoperative complications in pancreatic operation. However, the operative outcomes in obese patients undergoing laparoscopic distal pancreatectomy remain unclear. Methods A total number of 423 patients underwent laparoscopic distal pancreatectomy at Oslo University Hospital-Rikshospitalet from April 1997 to December 2015. Patients were categorized into 3 groups based on the body mass index: normal weight (18.5–24.9 kg/m2), overweight (25–29.9 kg/m2), and obese (≥30 kg/m2). After excluding underweight patients, 402 patients were enrolled in this study. Results Obese patients had significantly longer operative time and increased blood loss compared with overweight and normal weight patients (190 [61–480] minutes vs 158 [56–520] minutes vs 153 [29–374] minutes, P = .009 and 200 [0–2,800] mL vs 50 [0–6250] mL vs 90 [0–2,000] mL, P = .01, respectively). A multiple linear regression analysis identified obesity as predictive of prolonged operative time and increased blood loss during laparoscopic distal pancreatectomy. The rates of clinically relevant pancreatic fistula and severe complications (≥grade III by Accordion classification) were comparable in the 3 groups (P = .23 and P = .37, respectively). A multivariate logistic regression model did not demonstrate an association between obesity and postoperative morbidity (P = .09). The duration of hospital stay was comparable in the 3 groups (P = .13). Conclusion In spite of longer operative time and greater blood loss, laparoscopic distal pancreatectomy in obese patients is associated with satisfactory postoperative outcomes, similar to those in normal weight and overweight patients. Hence, laparoscopic distal pancreatectomy should be equally considered both in obese and nonobese patients.

• Sahakyan, Mushegh; Røsok, Bård Ingvald; Kazaryan, Airazat M.; Barkhatov, Leonid; Haugvik, Sven-Petter & Fretland, Åsmund Avdem [Vis alle 9 forfattere av denne artikkelen] (2016). Role of laparoscopic enucleation in the treatment of pancreatic lesions: case series and case-matched analysis. Surgical Endoscopy. ISSN 0930-2794. Published ahead of print, s. 1–7. doi: 10.1007/s00464-016-5233-y.
• Søreide, Kjetil & Labori, Knut Jørgen (2016). Risk factors and preventive strategies for post-operative pancreatic fistula after pancreatic surgery: a comprehensive review. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 51(10), s. 1147–1154. doi: 10.3109/00365521.2016.1169317.
• Pozzi-Mucelli, Raffaella Maria; Rinta-Kiikka, Irina; Wünsche, Katharina; Laukkarinen, Johanna; Labori, Knut Jørgen & Ånonsen, Kim Vidar [Vis alle 9 forfattere av denne artikkelen] (2016). Pancreatic MRI for the surveillance of cystic neoplasms: comparison of a short with a comprehensive imaging protocol. European Radiology. ISSN 0938-7994. 27(1), s. 41–50. doi: 10.1007/s00330-016-4377-4.
• Haugvik, Sven-Petter; Kaemmerer, Daniel; Gaujoux, Sebastien; Labori, Knut Jørgen; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2016). Pathology and Surgical Treatment of High-Grade Pancreatic Neuroendocrine Carcinoma: an Evolving Landscape. Current Oncology Reports. ISSN 1523-3790. 18(5). doi: 10.1007/s11912-016-0518-9.
• Gunasekaran, Stalin Chellappa; Hugenschmidt, Harald; Hagness, Morten; Line, Pål Dag; Labori, Knut Jørgen & Wiedswang, Gro [Vis alle 8 forfattere av denne artikkelen] (2016). Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer. Oncoimmunology. ISSN 2162-4011. 5(4). doi: 10.1080/2162402X.2015.1102828.
• Sandhu, Vandana; Wedge, David C.; Lothe, Inger Marie Bowitz; Labori, Knut Jørgen; Dentro, Stefan C. & Buanes, Trond [Vis alle 16 forfattere av denne artikkelen] (2016). The genomic landscape of pancreatic and periampullary adenocarcinoma. Cancer Research. ISSN 0008-5472. 76(17), s. 5092–5102. doi: 10.1158/0008-5472.CAN-16-0658.
• Baekelandt, Bart Maria Gilbert; Hjermstad, Marianne Jensen; Nordby, Tom; Fagerland, Morten; Kure, Elin H. & Heiberg, Turid [Vis alle 8 forfattere av denne artikkelen] (2016). Preoperative cognitive function predicts survival in patients with resectable pancreatic ductal adenocarcinoma. HPB. ISSN 1365-182X. 18(3), s. 247–254. doi: 10.1016/j.hpb.2015.09.004.
• Labori, Knut Jørgen; Matthew H, Katz; Tzeng, Ching; Bjørnbeth, Bjørn Atle; Småstuen, Milada Cvancarova & Edwin, Bjørn [Vis alle 11 forfattere av denne artikkelen] (2016). Impact of early disease progression and surgical complications on adjuvant chemotherapy completion rates and survival in patients undergoing the surgery first approach for resectable pancreatic ductal adenocarcinoma - A population-based cohort study. Acta Oncologica. ISSN 0284-186X. 55(3), s. 265–277. doi: 10.3109/0284186X.2015.1068445.
• Haugvik, Sven-Petter; Janson, Eva Tiensuu; Osterlund, Pia; Langer, Seppo W; Falk, Ragnhild Sørum & Labori, Knut Jørgen [Vis alle 10 forfattere av denne artikkelen] (2016). Surgical Treatment as a Principle for Patients with High-Grade Pancreatic Neuroendocrine Carcinoma: A Nordic Multicenter Comparative Study. Annals of Surgical Oncology. ISSN 1068-9265. 23(5), s. 1721–1728. doi: 10.1245/s10434-015-5013-2.
• Sandhu, Vandana; Lothe, Inger Marie Bowitz; Labori, Knut Jørgen; Skrede, Martina; Hamfjord, Julian & Larsen, Astrid Marie [Vis alle 14 forfattere av denne artikkelen] (2016). Differential expression of miRNAs in pancreatobiliary type of periampullary adenocarcinoma and its associated stroma. Molecular Oncology. ISSN 1574-7891. 10(2), s. 303–316. doi: 10.1016/j.molonc.2015.10.011.
• Labori, Knut Jørgen; Schulz, Anselm; Drolsum, Anders; Guren, Marianne; Kløw, Nils-Einar & Bjørnbeth, Bjørn Atle (2015). Radiofrequency ablation of unresectable colorectal liver metastases: trends in management and outcome during a decade at a single center. Acta Radiologica Open. ISSN 2058-4601. 4(7), s. 1–9. doi: 10.1177/2058460115580877.
• Hoshino, Ayuko; Costa-Silva, Bruno; Shen, Tang-Long; Rodrigues, Goncalo; Hashimoto, Ayako & Tesic Mark, Milica [Vis alle 54 forfattere av denne artikkelen] (2015). Tumour exosome integrins determine organotropic metastasis. Nature. ISSN 0028-0836. 527(7578), s. 329–335. doi: 10.1038/nature15756.
• Sahakyan, Mushegh; Kazaryan, Airazat M.; Rawashdeh, Majd; Fuks, David; Shmavonyan, Mark & Haugvik, Sven-Petter [Vis alle 14 forfattere av denne artikkelen] (2015). Laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: results of a multicenter cohort study on 196 patients. Surgical Endoscopy. ISSN 0930-2794. s. 1–10. doi: 10.1007/s00464-015-4623-x.
• Schulz, Anselm; Godt, Johannes Jakob C; Dormagen, Johann Baptist; Holtedahl, Jon Erik; Bogsrud, Trond & Labori, Knut Jørgen [Vis alle 8 forfattere av denne artikkelen] (2015). Respiratory gated PET/CT of the liver: A novel method and its impact on the detection of colorectal liver metastases. European Journal of Radiology. ISSN 0720-048X. 84(8), s. 1424–1431. doi: 10.1016/j.ejrad.2015.05.011.
• Hamfjord, Julian; Saldova, Radka; Stockmann, Henning; Sandhu, Vandana; Lothe, Inger Marie Bowitz & Buanes, Trond [Vis alle 10 forfattere av denne artikkelen] (2015). Serum N-glycome characterization in patients with resectable periampullary adenocarcinoma. Journal of Proteome Research. ISSN 1535-3893. 14(12), s. 5144–5156. doi: 10.1021/acs.jproteome.5b00395.
• Costa-Silva, Bruno; Aiello, Nicole M.; Ocean, Allyson J.; Singh, Swarnima; Zhang, Haiying & Thakur, Basant Kumar [Vis alle 37 forfattere av denne artikkelen] (2015). Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nature Cell Biology. ISSN 1465-7392. 17(6), s. 816–826. doi: 10.1038/ncb3169.
• Sandhu, Vandana; Lothe, Inger Marie Bowitz; Labori, Knut Jørgen; Lingjærde, Ole Christian; Buanes, Trond & Dalsgaard, Astrid Marie [Vis alle 13 forfattere av denne artikkelen] (2015). Molecular signatures of mRNAs and miRNAs as prognostic biomarkers in pancreatobiliary and intestinal types of periampullary adenocarcinomas. Molecular Oncology. ISSN 1574-7891. 9(4), s. 758–771. doi: 10.1016/j.molonc.2014.12.002.
• Brudvik, Kristoffer Watten; Bains, Simer Jit; Seeberg, Lars Thomas; Labori, Knut Jørgen; Waage, Anne & Tasken, Kjetil [Vis alle 8 forfattere av denne artikkelen] (2013). Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival: A Scandinavian Single-Center Experience. HPB Surgery. ISSN 0894-8569. doi: 10.1155/2013/727095.
• Nordby, Tom; Hugenschmidt, Harald; Fagerland, Morten; Ikdahl, Tone ; Buanes, Trond & Labori, Knut Jørgen (2013). Follow-up after curative surgery for pancreatic ductal adenocarcinoma: Asymptomatic recurrence is associated with improved survival. European Journal of Surgical Oncology. ISSN 0748-7983. 39(6), s. 559–566. doi: 10.1016/j.ejso.2013.02.020.
• Haugvik, Sven-Petter; Labori, Knut Jørgen; Waage, Anne; Line, Pål Dag; Mathisen, Øystein & Gladhaug, Ivar Prydz (2013). Pancreatic Surgery with Vascular Reconstruction in Patients with Locally Advanced Pancreatic Neuroendocrine Tumors. Journal of Gastrointestinal Surgery. ISSN 1091-255X. 17(7), s. 1224–1232. doi: 10.1007/s11605-013-2221-6.
• Nordby, Tom; Andersen, Tone Ikdahl; Lothe, Inger Marie Bowitz; Ånonsen, Kim Vidar; Hauge, Truls & Edwin, Bjørn [Vis alle 9 forfattere av denne artikkelen] (2013). Opportunities of improvement in the management of pancreatic and periampullary tumors: Prospective evaluation of outcome from a multidisciplinary research program. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 48(5), s. 617–625. doi: 10.3109/00365521.2013.781218.
• Nordby, Tom; Ikdahl, Tone; Lothe, Inger Marie Bowitz; Fagerland, Morten; Heiberg, Turid & Hauge, Truls [Vis alle 8 forfattere av denne artikkelen] (2013). Improved survival and quality of life in patients undergoing R1 pancreatic resection compared to patients with locally advanced unresectable pancreatic adenocarcinoma. Pancreatology (Print). ISSN 1424-3903. 13(2), s. 180–185. doi: 10.1016/j.pan.2013.01.003.
• Schulz, Anselm; Dormagen, Johann Baptist; Drolsum, Anders; Bjørnbeth, Bjørn Atle; Labori, Knut Jørgen & Klow, Nils-Einar (2012). Impact of contrast-enhanced intraoperative ultrasound on operation strategy in case of colorectal liver metastasis. Acta Radiologica. ISSN 0284-1851. 53(10), s. 1081–1087. doi: 10.1258/ar.2012.120049.
• Haugvik, Sven-Petter; Labori, Knut Jørgen; Edwin, Bjørn; Mathisen, Øystein & Gladhaug, Ivar Prydz (2012). Surgical Treatment of Sporadic Pancreatic Neuroendocrine Tumors: A State of the Art Review. Scientific World Journal. ISSN 1537-744X. Article ID 357475, s. 9–sider. doi: 10.1100/2012/357475.
• Haugen, Fred; Labori, Knut Jørgen; Noreng, Hans Jørgen; Buanes, Trond; Iversen, Per Ole & Drevon, Christian A (2011). Altered expression of genes in adipose tissues associated with reduced fat mass in patients with pancreatic cancer. Archives of Physiology and Biochemistry. ISSN 1381-3455. 117(2), s. 78–87. doi: 10.3109/13813455.2011.560609.
• Nakken, Karl Esten; Labori, Knut Jørgen; Rødningen, Olaug Kristin; Nakken, Sigve; Berge, Knut Erik & Eiklid, Kristin Louise [Vis alle 7 forfattere av denne artikkelen] (2009). ABCB4 sequence variations in young adults with cholesterol gallstone disease. Liver international (Print). ISSN 1478-3223. 29(5), s. 743–747. doi: 10.1111/j.1478-3231.2008.01914.x.
• Labori, Knut Jørgen; TRONDSEN, ERIK; Buanes, Trond & Hauge, Truls (2009). Endoscopic sealing of pancreatic fistulas: Four case reports and review of the literature. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 44(12), s. 1491–1496. doi: 10.3109/00365520903362610.
• Nakken, Ester; Nygård, Ståle; Haaland, Therese Kristina; Berge, K.E.; Ødegaard, Annlaug & Labori, Knut Jørgen [Vis alle 7 forfattere av denne artikkelen] (2009). Gene expression profiles reflect sclerosing cholangitis activity in abcb4 (-/ -) mice. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 44(2), s. 211–218. doi: 10.1080/00365520802400867.
• Labori, Knut Jørgen; Lyberg, Torstein & Ræder, Morten (2009). Effects of bilirubin ditaurate overload on canalicular membrane function and ultrastructure of the pig liver. Injury. ISSN 0020-1383. 40(8), s. 868–872. doi: 10.1016/j.injury.2008.11.017.
• Nakken, Karl Esten; Labori, Knut Jørgen; Rødningen, Olaug Kristin; Nakken, Sigve; Berge, Knut & Eiklid, Kristin Louise [Vis alle 7 forfattere av denne artikkelen] (2008). ABCB4 sequence variations in young adults with cholesterol gallstone disease. Liver international (Print). ISSN 1478-3223.
• Nakken, Karl Esten; Nygård, Ståle; Haaland, Therese Kristina; Berge, Knut Erik; Arnkværn, Kristin & Ødegaard, Annlaug [Vis alle 8 forfattere av denne artikkelen] (2007). Multiple inflammatory-, tissue remodelling- and fibrosis genes are differentially transcribed in the livers of Abcb4 (-/-) mice harbouring chronic cholangitis. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 42, s. 1245–1255. doi: 10.1080/00365520701320521.

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• Labori, Knut Jørgen; Bratlie, Svein Olav; Dueland, Svein & Lassen, Kristoffer (2024). NORPACT-1: implications for future trials – Authors' reply. The Lancet Gastroenterology and Hepatology. ISSN 2468-1253. 9(5), s. 408–409. doi: 10.1016/S2468-1253(24)00079-7.
• van Dam, Dam; Verkolf, E.M.M.; Dekker, E.N.; Bonsing, B.A.; Bratlie, S.O. & Brosens, L.A.A. [Vis alle 31 forfattere av denne artikkelen] (2023). Perioperative or adjuvant mFOLFIRINOX for resectable pancreatic cancer (PREOPANC-3): study protocol for a multicenter randomized controlled trial. BMC Cancer. ISSN 1471-2407. 23. doi: 10.1186/s12885-023-11141-5. Fulltekst i vitenarkiv
• Labori, Knut Jørgen (2022). Short-Course or Total Neoadjuvant Chemotherapy in Resectable and Borderline Resectable Pancreatic Cancer - Current Status and Future Perspectives. Frontiers in surgery. ISSN 2296-875X. 9. doi: 10.3389/fsurg.2022.839339. Fulltekst i vitenarkiv
• Fosheim, Ingrid Knutsdotter; Hårvig, Karina Roheim; Heldal, Kristian; Mariathasan, Anthony Burton; Lundesgaard, Kristoffer & BENTERUD, BJØRN PETTER [Vis alle 9 forfattere av denne artikkelen] (2021). En ung kvinne som ikke våknet etter omfattende operasjon. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(15), s. 1–8. doi: 10.4045/tidsskr.21.0184.
• Silwal-Pandit, Laxmi; Stålberg, Stina Margrethe; Mermelekas, G; Lothe, Inger Marie Bowitz; Skrede, Martina Landschoof & Dalsgaard, Astrid M. [Vis alle 11 forfattere av denne artikkelen] (2019). Proteomic Landscape of Pancreatic Ductal Adenocarcinoma.
• Klompmaker, Sjors; van Hilst, Jony; Gerritsen, Sarah L.; Adham, Mustapha; Teresa Albiol Quer, Albiol & Bassi, Claudio [Vis alle 37 forfattere av denne artikkelen] (2018). Correction to: Outcomes After Distal Pancreatectomy with Celiac Axis Resection for Pancreatic Cancer: A Pan-European Retrospective Cohort Study. Annals of Surgical Oncology. ISSN 1068-9265. 25. doi: 10.1245/s10434-018-6442-5.
• Labori, Knut Jørgen & Brudvik, Kristoffer Watten (2017). Follow-up after surgery for pancreatic ductal adenocarcinoma. Pancreas. ISSN 0885-3177. 46(1), s. e2–e3. doi: 10.1097/MPA.0000000000000689.
• Labori, Knut Jørgen; Haugvik, Sven-Petter & Line, Pål Dag (2016). Letter to the editor: Multidisciplinary management of pancreatic neuroendocrine tumors - The importance of an aggressive surgical approach. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 51(3), s. 383–384. doi: 10.3109/00365521.2015.1094125.
• Kartalis, Nikolaos; Rinta-Kiikka, Irina; Wünsche, Katharina; Laukkarinen, Johanna; Labori, Knut Jørgen & Ånonsen, Kim Vidar [Vis alle 9 forfattere av denne artikkelen] (2015). Pancreatic MRI for the follow-up of cystic neoplasms: Comparison of a short with a comprehensive imaging protocol.
• Labori, Knut Jørgen; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2015). Information needs among patients and a surveillance strategy after surgery for pancreatic and periampullary cancer. HPB Surgery. ISSN 0894-8569. 17(7). doi: 10.1111/hpb.12411.
• Labori, Knut Jørgen (2010). Spontan hemoperitoneum. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 130(21).
• Nakken, Karl Esten; Nygård, Ståle; Haaland, T.; Berge, KE; Arnkværn, Kristin & Ødegaard, Annlaug [Vis alle 8 forfattere av denne artikkelen] (2007). Multiple inflammatoriske-, remodellering- og fibrose gener er differensielt uttrykt i ABCB4(-/-) mus med skleroserende kolangitt.

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