Lene Pålhaugen

• Knudtzon, Stephanie; Nordengen, Kaja; Grøntvedt, Gøril Rolfseng; Jarholm, Jonas Alexander; Eliassen, Ingvild Vøllo & Selnes, Per [Vis alle 12 forfattere av denne artikkelen] (2024). Age-adjusted CSF t-tau and NfL do not improve diagnostic accuracy for prodromal Alzheimer's disease. Neurobiology of Aging. ISSN 0197-4580. 141, s. 74–84. doi: 10.1016/j.neurobiolaging.2024.05.016.
• Knudtzon, Stephanie; Nordengen, Kaja; Grøntvedt, Gøril Rolfseng; Jarholm, Jonas Alexander; Eliassen, Ingvild Vøllo & Selnes, Per [Vis alle 12 forfattere av denne artikkelen] (2024). Age-adjusted CSF t-tau and NfL do not improve diagnostic accuracy for prodromal Alzheimer’s Disease. Neurobiology of Aging. ISSN 0197-4580.
• Gonzalez-Ortiz, Fernando; Kirsebom, Bjørn-Eivind Seljelid; Contador, José; Tanley, Jordan E.; Selnes, Per & Gisladottir, Berglind [Vis alle 33 forfattere av denne artikkelen] (2024). Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer’s disease. Nature Communications. ISSN 2041-1723. 15(1). doi: 10.1038/s41467-024-47286-5.
• Padrela, Beatriz; Mahroo, Amnah; Tee, Mervin; Sneve, Markus Handal; Moyaert, Paulien & Geier, Oliver [Vis alle 43 forfattere av denne artikkelen] (2024). Developing blood-brain barrier arterial spin labelling as a non-invasive early biomarker of Alzheimer's disease (DEBBIE-AD): a prospective observational multicohort study protocol. BMJ Open. ISSN 2044-6055. 14(3). doi: 10.1136/bmjopen-2023-081635.
• Nordengen, Kaja; Kirsebom, Bjørn-Eivind Seljelid; Richter, Grit; Pålhaugen, Lene; Gisladottir, Berglind & Siafarikas, Nikias Ioannis [Vis alle 22 forfattere av denne artikkelen] (2023). Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer’s disease. Journal of Neuroinflammation. ISSN 1742-2094. 20(1). doi: 10.1186/s12974-023-02973-w. Fulltekst i vitenarkiv
• Røvang, Martin Soria; Selnes, Per; MacIntosh, Bradley; Groote, Inge Rasmus; Pålhaugen, Lene & Sudre, Carole H [Vis alle 8 forfattere av denne artikkelen] (2023). Segmenting white matter hyperintensities on isotropic three-dimensional Fluid Attenuated Inversion Recovery magnetic resonance images: Assessing deep learning tools on a Norwegian imaging database. PLOS ONE. ISSN 1932-6203. 18(8). doi: 10.1371/journal.pone.0285683. Vis sammendrag

  An important step in the analysis of magnetic resonance imaging (MRI) data for neuroimaging is the automated segmentation of white matter hyperintensities (WMHs). Fluid Attenuated Inversion Recovery (FLAIR-weighted) is an MRI contrast that is particularly useful to visualize and quantify WMHs, a hallmark of cerebral small vessel disease and Alzheimer’s disease (AD). In order to achieve high spatial resolution in each of the three voxel dimensions, clinical MRI protocols are evolving to a three-dimensional (3D) FLAIR-weighted acquisition. The current study details the deployment of deep learning tools to enable automated WMH segmentation and characterization from 3D FLAIR-weighted images acquired as part of a national AD imaging initiative. Based on data from the ongoing Norwegian Disease Dementia Initiation (DDI) multicenter study, two 3D models—one off-the-shelf from the NVIDIA nnU-Net framework and the other internally developed—were trained, validated, and tested. A third cutting-edge Deep Bayesian network model (HyperMapp3r) was implemented without any de-novo tuning to serve as a comparison architecture. The 2.5D in-house developed and 3D nnU-Net models were trained and validated in-house across five national collection sites among 441 participants from the DDI study, of whom 194 were men and whose average age was (64.91 +/- 9.32) years. Both an external dataset with 29 cases from a global collaborator and a held-out subset of the internal data from the 441 participants were used to test all three models. These test sets were evaluated independently. The ground truth human-in-the-loop segmentation was compared against five established WMH performance metrics. The 3D nnU-Net had the highest performance out of the three tested networks, outperforming both the internally developed 2.5D model and the SOTA Deep Bayesian network with an average dice similarity coefficient score of 0.76 +/- 0.16. Our findings demonstrate that WMH segmentation models can achieve high performance when trained exclusively on FLAIR input volumes that are 3D volumetric acquisitions. Single image input models are desirable for ease of deployment, as reflected in the current embedded clinical research project. The 3D nnU-Net had the highest performance, which suggests a way forward for our need to automate WMH segmentation while also evaluating performance metrics during on-going data collection and model retraining.

• Jarholm, Jonas Alexander; Bjørnerud, Atle; Dalaker, Turi Olene; Sadat Akhavi, Mehdi; Kirsebom, Bjørn-Eivind & Pålhaugen, Lene [Vis alle 14 forfattere av denne artikkelen] (2023). Medial Temporal Lobe Atrophy in Predementia Alzheimer's Disease: A Longitudinal Multi-Site Study Comparing Staging and A/T/N in a Clinical Research Cohort. Journal of Alzheimer's Disease. ISSN 1387-2877. 94(1), s. 259–279. doi: 10.3233/JAD-221274. Fulltekst i vitenarkiv
• Nordengen, Kaja; Pålhaugen, Lene; Bettella, Francesco; Bahrami, Shahram; Selnes, Per & Jarholm, Jonas Alexander [Vis alle 10 forfattere av denne artikkelen] (2022). Phenotype-informed polygenic risk scores are associated with worse outcome in individuals at risk of Alzheimer's disease. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. ISSN 2352-8729. 14(1), s. 1–13. doi: 10.1002/dad2.12350. Fulltekst i vitenarkiv
• Jansen, Iris E.; van der Lee, Sven J.; Gomez-Fonseca, Duber; de Rojas, Itziar; Dalmasso, Maria Carolina & Grenier-Boley, Benjamin [Vis alle 50 forfattere av denne artikkelen] (2022). Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers. Acta Neuropathologica. ISSN 0001-6322. 144(5), s. 821–842. doi: 10.1007/s00401-022-02454-z. Fulltekst i vitenarkiv Vis sammendrag

  Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total of 13,116 individuals (discovery n = 8074; replication n = 5042 individuals). Besides the APOE locus, novel associations with two other well-established AD risk loci were observed; CR1 was shown a locus for Aβ42 and BIN1 for pTau. GMNC and C16orf95 were further identified as loci for pTau, of which the latter is novel. Clustering methods exploring the influence of all known AD risk loci on the CSF protein levels, revealed 4 biological categories suggesting multiple Aβ42 and pTau related biological pathways involved in the etiology of AD. In functional follow-up analyses, GMNC and C16orf95 both associated with lateral ventricular volume, implying an overlap in genetic etiology for tau levels and brain ventricular volume.

• Pålhaugen, Lene; Sudre, Carole H; Teceläo, Sandra Raquel Ramos; Nakling, Arne; Almdahl, Ina Selseth & Kalheim, Lisa Flem [Vis alle 13 forfattere av denne artikkelen] (2020). Brain amyloid and vascular risk are related to distinct white matter hyperintensity patterns. Journal of Cerebral Blood Flow and Metabolism. ISSN 0271-678X. s. 1–13. doi: 10.1177/0271678X20957604. Fulltekst i vitenarkiv
• Rongve, Arvid; Witoelar, Aree; Ruiz, Agustín; Athanasiu, Lavinia; Abdelnour, Carla & Clarimon, Jordi [Vis alle 40 forfattere av denne artikkelen] (2019). GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study. Scientific Reports. ISSN 2045-2322. 9. doi: 10.1038/s41598-019-43458-2. Fulltekst i vitenarkiv
• Fladby, Tormod; Pålhaugen, Lene; Selnes, Per; Waterloo, Knut; Bråthen, Geir & Hessen, Erik [Vis alle 27 forfattere av denne artikkelen] (2017). Detecting at-risk Alzheimer's disease cases. Journal of Alzheimer's Disease. ISSN 1387-2877. 60(1), s. 97–105. doi: 10.3233/JAD-170231.

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• Rongve, Arvid; Witoelar, Aree Widya; Ruiz, Agustín; Athanasiu, Lavinia; Abdelnour, Carla & Clarimon, Jordi [Vis alle 40 forfattere av denne artikkelen] (2019). Author Correction: GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study (Scientific Reports, (2019), 9, 1, (7013), 10.1038/s41598-019-43458-2). Scientific Reports. ISSN 2045-2322. 9(1). doi: 10.1038/s41598-019-51827-0.

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