Marte Lie Høivik

• Fejrskov, Anja; Füchtbauer, Johannes David; Davíðsdóttir, Lóa G; Halfvarson, Jonas; Høivik, Marte Lie & Jensen, Michael Dam [Vis alle 15 forfattere av denne artikkelen] (2024). Novel biomarker profiles to improve individual diagnosis and prognosis in patients with suspected inflammatory bowel disease: protocol for the Nordic inception cohort study (NORDTREAT). BMJ Open. ISSN 2044-6055. 14(5). doi: 10.1136/bmjopen-2023-083144.
• Salihovic, Samira; Nyström, Niklas; Mathisen, Charlotte Bache-Wiig; Kruse, Robert; Olbjørn, Christine & Andersen, Svend [Vis alle 30 forfattere av denne artikkelen] (2024). Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease. Nature Communications. ISSN 2041-1723. doi: 10.1038/s41467-024-48763-7. Vis sammendrag

  Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naïve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making.

• Strande, Vibeke; Lund, Charlotte; Hagen, Milada; Bengtson, May-Bente; Boyar Cetinkaya, Raziye & Detlie, Trond Espen [Vis alle 23 forfattere av denne artikkelen] (2024). Clinical course of ulcerative colitis: Frequent use of biologics and low colectomy rate first year after diagnosis—results from the IBSEN III inception cohort. Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. doi: 10.1111/apt.18097. Vis sammendrag

  Background: The introduction of biologic therapies and the 'treat-to-target' treatment strategy may have changed the disease course of ulcerative colitis (UC). Aims: To describe the early disease course and disease outcome at 1-year follow-up in a population-based inception cohort of adult patients with newly diagnosed UC. Methods: The Inflammatory Bowel Disease in South-Eastern Norway (IBSEN) III study is a population-based inception cohort study with prospective follow-up. Patients newly diagnosed with inflammatory bowel disease during 2017-2019 were included. Patients ≥18 years at diagnosis of UC who attended the 1-year follow-up were investigated. We registered clinical, endoscopic and demographic data at diagnosis and 1-year follow-up. Results: We included 877 patients with UC (median age 36 years (range: 18-84), 45.8% female). At diagnosis, 39.2% presented with proctitis, 24.7% left-sided colitis and 36.0% extensive colitis. At the 1-year follow-up, 13.9% experienced disease progression, and 14.5% had received one or more biologic therapies. The colectomy rate was 0.9%. Steroid-free clinical remission was observed in 76.6%, and steroid-free endoscopic remission in 68.7%. Anaemia and initiation of systemic steroid treatment at diagnosis were associated with biologic therapy within the first year after diagnosis. Conclusion: In this population-based inception cohort, colectomy rate in the first year after diagnosis was low, and a high proportion of patients were in remission at 1-year follow-up. The use of biologic therapy increases, consistent with findings from previous studies.

• Wiken, Thea H.; Høivik, Marte Lie; Anisdahl, Karoline; Buer, Lydia Celine Tansem; Warren, David & Bolstad, Nils [Vis alle 9 forfattere av denne artikkelen] (2024). Subcutaneous Vedolizumab Treatment in a Real-World Inflammatory Bowel Disease Cohort Switched From Intravenous Vedolizumab: Eighteen-Month Prospective Follow-up Study. Crohn's & Colitis 360. ISSN 2631-827X. 6(1). doi: 10.1093/crocol/otae013.
• Anisdahl, Karoline; Lirhus, Sandre Svatun; Medhus, Asle Wilhelm; Moum, Bjørn Allan; Melberg, Hans Olav & Høivik, Marte Lie (2024). Frailty risk and treatment strategy in elderly-onset inflammatory bowel disease. A Norwegian nationwide population-based registry study. Digestive and Liver Disease. ISSN 1590-8658. doi: 10.1016/j.dld.2024.02.002.
• Zerouga, Insaf; Valeur, Jørgen; Sommer, Christine; Småstuen, Milada Cvancarova; Medhus, Asle Wilhelm & Lund, Charlotte [Vis alle 22 forfattere av denne artikkelen] (2024). Dietary intake and nutritional status in patients with newly diagnosed inflammatory bowel disease: insights from the IBSEN III study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. s. 1–9. doi: 10.1080/00365521.2024.2313056. Vis sammendrag

  Background: Dietary recommendations in inflammatory bowel disease (IBD) are inconclusive, and patients may follow restrictive diets with increased risk of malnutrition. The aim of this study was to compare dietary intakes and nutritional status in men and women with newly diagnosed IBD with a general population sample, and to investigate whether intakes were in line with the Nordic Nutrition Recommendations. Methods: This was a cross-sectional study including adults≥ 40 years with IBD from the Inflammatory Bowel Disease in South-Eastern Norway (IBSEN) III cohort study. A validated food frequency questionnaire (FFQ) was used in dietary data collection, and a sample from the seventh survey of the Tromsø Study was included as a comparison group. Results: A total of 227 men and women with IBD were included. IBD patients had higher intake of grain products, sweetened beverages, energy, fat and polyunsaturated fat (PUFA), but lower intake of dairy products, alcohol and iodine compared to adults from the comparison sample (p < 0.01). Intakes of saturated fat and carbohydrates in both genders, and vitamin D in women were not within recommended levels. Anemia and hypoalbuminemia were more prevalent in IBD patients than in the comparison sample. Conclusions: Dietary intakes in newly diagnosed IBD patients were mostly in line with Nordic Nutrition Recommendations. Higher proportion of IBD patients exceeded recommended allowances of fat and added sugar than the comparison sample. Insufficient micronutrient intake, anemia and hypoalbuminemia are present challenges in IBD patients that require monitoring.

• Fossmark, Reidar; Lirhus, Sandre Svatun & Høivik, Marte Lie (2023). The impact of proton pump inhibitors on the course of ulcerative colitis: a cohort study of over 10,000 newly diagnosed patients in Norway. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. doi: 10.1080/00365521.2023.2255710. Fulltekst i vitenarkiv
• Braadland, Peder Rustøen; Bergquist, Annika; Kummen, Martin; Bossen, Lars; Engesæter, Lise Katrine & Reims, Henrik Mikael [Vis alle 21 forfattere av denne artikkelen] (2023). Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation. Journal of Hepatology. ISSN 0168-8278. 79(4), s. 955–966. doi: 10.1016/j.jhep.2023.05.038. Fulltekst i vitenarkiv
• Johansen, Ingunn; Småstuen, Milada Cvancarova; Løkkeberg, Stine Eileen Torp; Kristensen, Vendel Ailin; Høivik, Marte Lie & Lund, Charlotte [Vis alle 16 forfattere av denne artikkelen] (2023). Symptoms and symptom clusters in patients newly diagnosed with inflammatory bowel disease: results from the IBSEN III Study. BMC Gastroenterology. ISSN 1471-230X. 23(1). doi: 10.1186/s12876-023-02889-y. Fulltekst i vitenarkiv Vis sammendrag

  Patients with inflammatory bowel disease report multiple symptoms, but the relationships among co-occurring symptoms are poorly understood. This study aimed to examine the prevalence of symptoms and explore symptom clusters and possible associations between symptom clusters and socio-demographic and clinical variables in patients newly diagnosed with inflammatory bowel disease. Methods The IBSEN III study is a prospective population-based inception cohort of patients with inflammatory bowel disease. This study used patient data from the three largest hospitals in the study catchment area. The Memorial Symptom Assessment Scale was used to assess the prevalence of symptoms. Symptom clusters were identified using principal component analysis. Possible associations between socio-demographic and clinical variables and symptom cluster membership were estimated using regression analysis. Results Of the 573 patients (age, ≥18 years) diagnosed with inflammatory bowel disease, 350 (61.1%) completed the questionnaire (responders). Eleven symptoms were reported by >50% of the responders. The three most prevalent symptoms were bloating (84%), drowsiness (81%), and lack of energy (81%). Three symptom clusters were identified: psychological (56% of the patients), impaired energy (28%), and physical (16%) clusters. Multinomial regression analysis revealed that vitamin D deficiency was significantly associated with the impaired energy cluster (odds ratio=2.49, 95% confidence interval [1.00-6.2], p=0.05). Conclusions We found high symptom prevalence in patients newly diagnosed with inflammatory bowel disease. Three distinct symptom clusters were identified, and the psychological cluster includes >50% of the patients. Vitamin D deficiency is the only factor associated with cluster membership, namely the impaired energy cluster.

• Burisch, Johan; Zhao, Mirabella; Odes, Selwyn; De Cruz, Peter; Vermeire, Severine & Bernstein, Charles N [Vis alle 33 forfattere av denne artikkelen] (2023). The cost of inflammatory bowel disease in high-income settings: a Lancet Gastroenterology & Hepatology Commission. The Lancet Gastroenterology and Hepatology. ISSN 2468-1253. 8(5), s. 458–492. doi: 10.1016/S2468-1253(23)00003-1. Fulltekst i vitenarkiv
• Holten, Kristina Ingeborg; Bernklev, Tomm; Opheim, Randi; Johansen, Ingunn; Olsen, Bjørn Christian Elias Grova & Lund, Charlotte [Vis alle 22 forfattere av denne artikkelen] (2023). Fatigue in Patients with Newly Diagnosed Inflammatory Bowel Disease: Results from a Prospective Inception Cohort, the IBSEN III Study. Journal of Crohn's and Colitis. ISSN 1873-9946. 17(11), s. 1781–1790. doi: 10.1093/ecco-jcc/jjad094. Fulltekst i vitenarkiv
• Helm, Thea Elisabeth; Høivik, Marte Lie; Buer, Lydia Celine Tansem; Warren, David; Bolstad, Nils & Moum, Bjørn Allan [Vis alle 9 forfattere av denne artikkelen] (2023). Switching from intravenous to subcutaneous vedolizumab maintenance treatment in patients with inflammatory bowel disease followed by therapeutic drug monitoring. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 58(8), s. 863–873. doi: 10.1080/00365521.2023.2176252. Fulltekst i vitenarkiv
• Olsen, Bjørn Christian Elias Grova; Opheim, Randi; Høivik, Marte Lie; Lund, Charlotte; Aabrekk, Tone Bergene & Johansen, Ingunn [Vis alle 15 forfattere av denne artikkelen] (2023). Health-related quality of life in patients with newly diagnosed inflammatory bowel disease: an observational prospective cohort study (IBSEN III). Quality of Life Research. ISSN 0962-9343. 32(10), s. 2951–2964. doi: 10.1007/s11136-023-03435-9. Fulltekst i vitenarkiv
• Jørgensen, Kristin Kaasen; Høivik, Marte Lie; Chopra, Adity; Saltyte Benth, Jurate; Ricanek, Petr & Moum, Bjørn Allan [Vis alle 18 forfattere av denne artikkelen] (2023). Humoral immune response to SARS-CoV-2 vaccination in patients with inflammatory bowel disease on immunosuppressive medication: association to serum drug levels and disease type. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 58(8), s. 874–882. doi: 10.1080/00365521.2023.2177884. Fulltekst i vitenarkiv
• Tran, Trung; Vaage, Eline Benno; Mehta, Adi; Chopra, Adity; Tietze, Lisa & Kolderup, Heidi Anette [Vis alle 40 forfattere av denne artikkelen] (2022). Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants. npj Vaccines. ISSN 2059-0105. 7(1). doi: 10.1038/s41541-022-00586-7. Fulltekst i vitenarkiv
• Zhao, Mirabella; Lirhus, Sandre Svatun; Lördal, Mikael; Langholz, Ebbe; Knudsen, Torben & Voutilainen, Markku [Vis alle 15 forfattere av denne artikkelen] (2022). Therapeutic management and outcomes in inflammatory bowel diseases, 2010 to 2017 in cohorts from Denmark, Sweden and Norway. Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. 56(6), s. 989–1006. doi: 10.1111/apt.17145.
• Sousa, Paula; Ministro, Paula; Armuzzi, Alessandro; Dignass, Axel; Høivik, Marte Lie & Barreiro-de Acosta, Manuel [Vis alle 11 forfattere av denne artikkelen] (2021). Thiopurines: Use them or lose them? International survey on current and future use of thiopurines in inflammatory bowel disease. Digestive and Liver Disease. ISSN 1590-8658. 53(12), s. 1571–1579. doi: 10.1016/j.dld.2021.05.038.
• Anisdahl, Karoline; Lirhus, Sandre Svatun; Medhus, Asle Wilhelm; Moum, Bjørn; Melberg, Hans Olav & Høivik, Marte Lie (2021). First-line biologic treatment of inflammatory bowel disease during the first 12 months after diagnosis from 2010 to 2016: a Norwegian nationwide registry study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. s. 1–7. doi: 10.1080/00365521.2021.1955147. Fulltekst i vitenarkiv
• Kristensen, Vendel Ailin; Opheim, Randi; Perminow, Gøri Margrete; Huppertz-Hauss, Gert; Detlie, Trond Espen & Lund, Charlotte [Vis alle 39 forfattere av denne artikkelen] (2021). Inflammatory bowel disease in South-Eastern Norway III (IBSEN III): a new population-based inception cohort study from South-Eastern Norway. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 56(8), s. 899–905. doi: 10.1080/00365521.2021.1922746. Fulltekst i vitenarkiv Vis sammendrag

  Background and aim: Modern treatment strategies for inflammatory bowel disease (IBD) are postulated to change the natural disease course. Inception cohort studies are the gold standard for investigating such changes. We have initiated a new population-based inception cohort study; Inflammatory bowel disease in South Eastern Norway III (IBSEN III). In this article, we describe the study protocol and baseline characteristics of the cohort. Methods: IBSEN III is an ongoing, population-based observational inception cohort study with prospective follow-up. Adult and pediatric patients with suspected IBD in the South-Eastern Health Region of Norway (catchment area of 2.95 million inhabitants in 2017), during the 3-year period from 2017 to 2019, were eligible for inclusion. Comprehensive clinical, biochemical, endoscopic, demographic, and patient-reported data were collected at the time of diagnosis and throughout standardized follow-up. For a portion of the patients, extensive biological material was biobanked. Results: The study included 2168 patients, of whom 1779 were diagnosed with IBD (Crohn's disease: 626, ulcerative colitis: 1082, IBD unclassified: 71). In 124 patients, there were subtle findings indicative of, but not diagnostic for, IBD. The remaining 265 patients were classified as symptomatic non-IBD controls. Conclusion: We have included patients in a comprehensive population-based IBD cohort from a catchment population of 2.95 million, and a unique biobank with materials from newly diagnosed and treatment-naïve IBD patients and symptomatic non-IBD controls. We believe this cohort will add important knowledge about IBD in the years to come.

• Lirhus, Sandre Svatun; Høivik, Marte Lie; Moum, Bjørn; Anisdahl, Karoline & Melberg, Hans Olav (2021). Incidence and prevalence of inflammatory bowel disease in norway and the impact of different case definitions: A nationwide registry study. Clinical Epidemiology. ISSN 1179-1349. 13, s. 287–294. doi: 10.2147/CLEP.S303797. Fulltekst i vitenarkiv
• Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll & Moitinho-Silva, Lucas [Vis alle 22 forfattere av denne artikkelen] (2020). Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis. Gastroenterology. ISSN 0016-5085. doi: 10.1053/j.gastro.2020.12.058. Fulltekst i vitenarkiv
• Kravdal, Øystein; Magnus, Per; Moum, Bjørn & Høivik, Marte Lie (2020). Association of Childbearing with a Short-Term Reduced Risk of Crohn Disease in Mothers. American Journal of Epidemiology. ISSN 0002-9262. 189(4), s. 294–304. doi: 10.1093/aje/kwz285. Fulltekst i vitenarkiv
• Kristensen, Vendel Ailin; Småstuen, Milada Cvancarova; Høivik, Marte Lie; Moum, Bjørn & Vatn, Morten H (2020). Serological antibodies and surgery in a population-based inception cohort of Crohn's disease patients - the IBSEN study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. doi: 10.1080/00365521.2020.1745879.
• Klepp, Pasquale Catherine; Brackmann, Stephan; Småstuen, Milada Cvancarova; Høivik, Marte Lie; Hovde, Øistein & Henriksen, Magne [Vis alle 15 forfattere av denne artikkelen] (2020). Risk of colorectal cancer in a population-based study 20 years after diagnosis of ulcerative colitis: results from the IBSEN study. BMJ open gastroenterology. ISSN 2054-4774. 7. doi: 10.1136/bmjgast-2019-000361. Fulltekst i vitenarkiv Vis sammendrag

  Objective The association between ulcerative colitis (UC) and colorectal cancer (CRC) is widely accepted, although attenuated risk has been reported in recent years. Colonoscopic surveillance is recommended with intervals based on established clinical risk factors. Nevertheless, a significant number of patients develop interval cancers, indicating the need of improved individualised assessment. In the present study, we evaluated clinical risk factors associated with CRC during a prescheduled follow-up 20 years after diagnosis, the IBSEN study. Design A population-based inception cohort of patients diagnosed with inflammatory bowel disease from 1 January 1990 until 31 December 1993, prospectively followed at 1, 5, 10 and 20 years after diagnosis. A total of 517 patients with UC were included; 264 (51 %) men; median age at inclusion 37.4 years (4–88). Results The overall incidence of CRC was 1.6% (8/517) at a 20-year follow-up. The total lifetime risk of CRC prior to or after UC diagnosis was 2.3%. (12/517). Patients older than 70 years at diagnosis had a 15-fold higher risk of CRC compared with those diagnosed when younger than 40 years, with HR 15.68 (95% CI: 1.31 to 187.92). Neither sex, first-degree relative with CRC, extent of colitis nor primary sclerosing cholangitis affected the risk of CRC. Conclusion The risk of CRC in UC was low and comparable with the risk of CRC in the background population of Norway.

• Kravdal, Øystein; Magnus, Per; Moum, Bjørn & Høivik, Marte Lie (2020). Childbearing is Associated with a Short-term Reduced Risk of Crohn’s Disease in Mothers . American Journal of Epidemiology. ISSN 0002-9262. 189(4), s. 294–304. doi: 10.1093/aje/kwz285. Fulltekst i vitenarkiv
• Frigstad, Svein Oskar; Høivik, Marte Lie; Jahnsen, Jørgen; Småstuen, Milada C; Grimstad, Tore & Berset, Ingrid Prytz [Vis alle 11 forfattere av denne artikkelen] (2020). Pain Severity and Vitamin D Deficiency in IBD Patients. Nutrients. ISSN 2072-6643. 12(1), s. 1–12. doi: 10.3390/nu12010026. Fulltekst i vitenarkiv Vis sammendrag

  Background: Pain and vitamin D deficiency are common in inflammatory bowel disease (IBD). Disease activity, fatigue, frequent relapses, prior surgery and psychological factors all seem to influence the experience of pain in IBD. Vitamin D deficiency has been associated with muscle and skeletal pain. This study aimed to determine whether there is an association between vitamin D deficiency and severity of pain in patients with IBD, and to investigate the influence of other socio-demographic and psychological variables on the experience of pain. Methods: Patients with IBD were recruited from nine hospitals in Norway in a multicenter cross-sectional study. The Brief Pain Inventory (BPI) questionnaire was used to measure pain. Disease activity was assessed using clinical disease activity indices, C-reactive protein (CRP) and fecal calprotectin. Regression models were fitted to explore a possible association between 25-hydroxyvitamin D and pain severity. Results: Of 407 patients included in the analyses, 229 (56%) had Crohn's disease (CD) and 178 (44%) had ulcerative colitis (UC). Vitamin D deficiency was present in half (203/407) of patients. Presence of pain was reported by 76% (309/407). More severe pain was associated with female gender and increased disease activity scores, but not with increased CRP or fecal calprotectin. In CD, patients without prior intra-abdominal surgery reported more severe pain. In multivariate analyses, there was no association between 25-hydroxyvitamin D and pain severity. Conclusions: In this study, no significant association between pain severity and vitamin D deficiency was revealed in patients with IBD. Keywords: pain severity; patient reported outcomes; vitamin D deficiency.

• Ossum, Alvilde Maria; Palm, Øyvind; Småstuen, Milada C; Bernklev, Tomm; Jahnsen, Jørgen & Moum, Bjørn [Vis alle 7 forfattere av denne artikkelen] (2020). The Impact of Spondyloarthritis and Joint Symptoms on Health-Related Quality of Life and Fatigue in IBD Patients. Results from a Population-Based Inception Cohort (20-Year Follow-up in the Ibsen Study). Inflammatory Bowel Diseases. ISSN 1078-0998. doi: 10.1093/ibd/izz105. Fulltekst i vitenarkiv
• Buer, Lydia Celine Tansem; Moum, Bjørn; Småstuen, Milada Cvancarova; Warren, David; Bolstad, Nils & Medhus, Asle Wilhelm [Vis alle 7 forfattere av denne artikkelen] (2018). Real world data on effectiveness, safety and therapeutic drug monitoring of vedolizumab in patients with inflammatory bowel disease. A single center cohort. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. s. 1–9. doi: 10.1080/00365521.2018.1548646.
• Ossum, Alvilde Maria; Palm, Øyvind; Småstuen, Milada Cvancarova; Solberg, Inger Camilla; Vatn, Morten H & Moum, Bjørn [Vis alle 7 forfattere av denne artikkelen] (2018). Peripheral arthritis in patients with long-term inflammatory bowel disease. Results from 20 years of follow-up in the IBSEN study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. s. 1–8. doi: 10.1080/00365521.2018.1518482. Vis sammendrag

  Objectives: Peripheral arthritis and related musculoskeletal manifestations, often classified as peripheral spondyloarthritis, are frequently seen in patients with inflammatory bowel disease (IBD). Few long-term studies have reported on the prevalence of these conditions. The aim of this study was to determine the prevalence of IBD-related peripheral arthritis and peripheral spondyloarthritis in IBD patients during 20 years of disease course, and to assess whether these conditions were associated with the intestinal IBD severity and activity. Materials and methods: In an inception cohort (the IBSEN study), IBD patients were followed prospectively for 20 years. At the 5 year follow-up the patients underwent a rheumatological examination and at the 20 year follow-up they completed a questionnaire with identical questions. When peripheral arthritis was characteristic and not explained by other specific diagnoses, it was defined as IBDrelated peripheral arthritis. The Assessment of Spondyloarthritis International Society criteria were used to define peripheral spondyloarthritis, including patients with peripheral arthritis, enthesitis and/ or dactylitis. Results: After 20 years of follow-up, 441 patients were included (296 ulcerative colitis and 145 Crohn’s disease). The prevalence of IBD-related peripheral arthritis was 17.2% and peripheral spondyloarthritis 27.9% during the disease course. IBD severity and activity were not different between those with a history of IBD-related peripheral arthritis or peripheral spondyloarthritis and those without. A higher proportion of women had IBD-related peripheral arthritis and peripheral spondyloarthritis. Conclusion: During 20 years of disease course, more than every sixth patient had suffered from IBDrelated peripheral arthritis and every fourth from peripheral spondyloarthritis.

• Lirhus, Sandre Svatun; Høivik, Marte Lie; Moum, Bjørn & Melberg, Hans Olav (2018). Regional differences in anti-TNF-a therapy and surgery in the treatment of inflammatory bowel disease patients: a Norwegian nationwide cohort study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 53(8), s. 952–957. doi: 10.1080/00365521.2018.1495258. Fulltekst i vitenarkiv
• Høivik, Marte Lie; Buer, Lydia Celine Tansem; Småstuen, Milada Cvancarova; Warren, David; Bolstad, Nils & Moum, Bjørn [Vis alle 7 forfattere av denne artikkelen] (2018). Switching from originator to biosimilar infliximab?real world data of a prospective 18 months follow-up of a single-centre IBD population. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 53(6), s. 692–699. doi: 10.1080/00365521.2018.1463391.
• Frigstad, Svein Oskar; Høivik, Marte Lie; Jahnsen, Jørgen; Småstuen, Milada Cvancarova; Grimstad, Tore & Berset, Ingrid Prytz [Vis alle 11 forfattere av denne artikkelen] (2018). Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients . World Journal of Gastroenterology (WJG). ISSN 1007-9327. 24(29), s. 3293–3301. doi: 10.3748/wjg.v24.i29.3293.
• Buer, Lydia Celine Tansem; Høivik, Marte Lie; Warren, David; Medhus, Asle Wilhelm & Moum, Bjørn (2018). Combining Anti-TNF-? and Vedolizumab in the Treatment of Inflammatory Bowel Disease: A Case Series. Inflammatory Bowel Diseases. ISSN 1078-0998. 24(5), s. 997–1004. doi: 10.1093/ibd/izx110. Vis sammendrag

  Background Anti-tumor necrosis factor α (anti-TNF-α) is important in the treatment of inflammatory bowel disease, but some patients experience only a partial response. In these patients, a combination of anti-TNF-α and vedolizumab (VDZ) may act as a bridge until the full VDZ effect occurs. At present, clinical data on combination treatment with anti-TNF-α and VDZ are not available. The aim of this case series was to evaluate the safety and clinical response of combination therapy with anti-TNF-α and VDZ in clinical practice. Methods All patients started on combination treatment with anti-TNF-α and VDZ from November 2015 to July 2016 were prospectively followed for at least 12 months. Results Six patients with ulcerative colitis and four patients with Crohn’s disease received combination treatment. These patients were followed for a median of 1712–20 months. No more adverse events than expected with anti-TNF-α alone were observed during combination treatment. At the end of follow-up, all patients were in clinical remission, and 8 patients could discontinue anti-TNF-α treatment and receive VDZ monotherapy. Two of the patients with Crohn’s disease required combination treatment throughout follow-up to obtain sustained remission. Conclusion Our findings suggest that combination treatment with anti TNF-α and VDZ is safe and might represent a long-term treatment option in selected patients.

• Henriksen, Magne; Høivik, Marte Lie; Jelsness-Jørgensen, Lars-Petter & Moum, Bjørn (2018). Irritable bowel-like symptoms in ulcerative colitis are as common in patients in deep remission as with inflammation; results from a population-based study (the IBSEN study). Journal of Crohn's and Colitis. ISSN 1873-9946. 12(4), s. 389–393. doi: 10.1093/ECCO-JCC/JJX152.
• Ossum, Alvilde Maria; Palm, Øyvind; Kapica, Aida; Småstuen, Milada C; BANITALEBI, HASAN & Negård, Anne [Vis alle 10 forfattere av denne artikkelen] (2018). Ankylosing Spondylitis and Axial Spondyloarthritis in Patients With Long-term Inflammatory Bowel Disease: Results From 20 Years of Follow-up in the IBSEN Study. Journal of Crohn's and Colitis. ISSN 1873-9946. 12(1), s. 96–104. doi: 10.1093/ecco-jcc/jjx126.
• Tronstad, Rune Rose; Kummen, Martin; Holm, Kristian; Volkmann, Hilde Løland Von; Anmarkrud, Jarl Andreas & Høivik, Marte Lie [Vis alle 13 forfattere av denne artikkelen] (2017). Guanylate cyclase C activation shapes the intestinal microbiota in patients with familial diarrhea and increased susceptibility for Crohn's disease. Inflammatory Bowel Diseases. ISSN 1078-0998. 23(10), s. 1752–1761. doi: 10.1097/MIB.0000000000001264.
• Buer, Lydia Celine Tansem; Høivik, Marte Lie; Medhus, Asle Wilhelm & Moum, Bjørn (2017). Does the Introduction of Biosimilars Change Our Understanding about Treatment Modalities for Inflammatory Bowel Disease? Digestive Diseases. ISSN 0257-2753. 35(1-2), s. 74–82. doi: 10.1159/000449087.
• Huppertz-Hauss, Gert; Høivik, Marte; Jelsness-Jørgensen, Lars-Petter; Opheim, Randi; Henriksen, Magne & Høie, Ole Ingebreth [Vis alle 13 forfattere av denne artikkelen] (2017). Fatigue in a population-based cohort of patients with inflammatory bowel disease 20 years after diagnosis: The IBSEN study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 52(3), s. 351–358. doi: 10.1080/00365521.2016.1256425.
• Frigstad, Svein Oskar; Høivik, Marte; Jahnsen, Jørgen; Dahl, Sandra Rinne; Småstuen, Milada C & Grimstad, Tore [Vis alle 13 forfattere av denne artikkelen] (2017). Vitamin D deficiency in inflammatory bowel disease: Prevalence and predictors in a Norwegian outpatient population. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 52(1), s. 100–106. doi: 10.1080/00365521.2016.1233577. Vis sammendrag

  Background and aim: Vitamin D deficiency is common in inflammatory bowel disease (IBD). The aims of the present study were to determine the prevalence of vitamin D deficiency and to identify clinical and epidemiological variables associated with vitamin D deficiency in an outpatient population with IBD. Methods: Participants were recruited from nine hospitals in the southeastern and western regions of Norway as part of an observational, multicentre study from March 2013 to April 2014. Clinical and epidemiological data were collected by interview and from medical records. All analyses of serum 25-hydroxyvitamin D (25-OH-D) were performed in the same laboratory. Results: In total, 49% (200/408) of the patients had a 25-OH-D concentration <50 nmol/L, including 53% (122/230) of the Crohn’s disease (CD) patients and 44% (78/178) of the ulcerative colitis (UC) patients. In CD patients, disease activity, measured as the HBI, was inversely associated with vitamin D deficiency. No such association was observed with the Simple Clinical Colitis Activity Index (SCCAI) scores in UC, but in UC patients, vitamin D deficiency was associated with elevated faecal calprotectin >100 mg/kg. In patients with CD, there were significantly more relapses during the previous year in patients with vitamin D deficiency. Conclusions: Vitamin D deficiency was common, especially in CD, and was associated with increased disease activity, a relapsing disease course and higher inflammatory activity.

• Buer, Lydia Celine Tansem; Moum, Bjørn; Småstuen, Milada Cvancarova; Warren, David; Medhus, Asle Wilhelm & Høivik, Marte Lie (2016). Switching from Remicade® to Remsima® is well tolerated and feasible: a prospective, open-label study. Journal - Crohn's and Colitis Foundation of Canada. ISSN 1197-4982. doi: 10.1093/ecco-jcc/jjw166.
• Hovde, Øistein; Høivik, Marte Lie; Henriksen, Magne; Solberg, Inger Camilla; Småstuen, Milada Cvancarova & Moum, Bjørn A (2016). Malignancies in Patients with Inflammatory Bowel Disease: Results from 20 Years of Follow-up in the IBSEN Study. Journal of Crohn's and Colitis. ISSN 1873-9946. doi: 10.1093/ecco-jcc/jjw193.
• Wanderås, Magnus; Moum, Bjørn; Høivik, Marte Lie & Hovde, Øistein (2016). Predictive factors for a severe clinical course in ulcerative colitis: Results from population-based studies. World Journal of Gastrointestinal Pharmacology and Therapeutics (WJGPT). ISSN 2150-5349. 7(2), s. 235–241. doi: 10.4292/WJGPT.v7.i2.235.
• Opheim, Randi; Høivik, Marte; Bernklev, Tomm; Jelsness-Jørgensen, Lars-Petter & Moum, Bjørn (2016). The use of complementary and alternative medicine (CAM) among patients with inflammatory bowel disease (IBD) is associated with reduced health-related quality of life (HRQoL). Gastroenterology Research and Practice. ISSN 1687-6121. 2016. doi: 10.1155/2016/6453657.
• Huppertz-Hauss, Gert; Aas, Eline; Høivik, Marte; Langholz, Ebbe; Odes, Selwyn & Småstuen, Milada C [Vis alle 10 forfattere av denne artikkelen] (2016). Comparison of the Multiattribute Utility Instruments EQ-5D and SF-6D in a Europe-Wide Population-Based Cohort of Patients with Inflammatory Bowel Disease 10 Years after Diagnosis. Gastroenterology Research and Practice. ISSN 1687-6121. 2016:5023973, s. 1–9. doi: 10.1155/2016/5023973.
• Kapica, Aida; Hov, Johannes Espolin Roksund; Borthne, Arne Sigmund; Gleditsch, Jostein; Johannesen, Glenn & Tveit, Knut [Vis alle 19 forfattere av denne artikkelen] (2016). Prevalence of Sclerosing Cholangitis Detected by Magnetic Resonance Cholangiography in Patients With Long-term Inflammatory Bowel Disease. Gastroenterology. ISSN 0016-5085. 151(4), s. 660–669. doi: 10.1053/j.gastro.2016.06.021.
• Jørgensen, Silje Fjellgård; Trøseid, Marius; Kummen, Martin; Anmarkrud, Jarl Andreas; Michelsen, Annika & Osnes, Liv T. N. [Vis alle 21 forfattere av denne artikkelen] (2016). Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation. Mucosal Immunology. ISSN 1933-0219. doi: 10.1038/mi.2016.18.
• Huppertz-Hauss, Gert; Høivik, Marte; Jelsness-Jørgensen, Lars-Petter; Henriksen, Magne; Høie, Ole Ingebreth & Jahnsen, Jørgen [Vis alle 9 forfattere av denne artikkelen] (2016). Health-related quality of life in patients with inflammatory bowel disease 20 years after diagnosis: results from the IBSEN study. Inflammatory Bowel Diseases. ISSN 1078-0998. 22(7), s. 1679–1687. doi: 10.1097/MIB.0000000000000806.
• Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas; Nygård, Ståle; Vesterhus, Mette & Høivik, Marte [Vis alle 14 forfattere av denne artikkelen] (2016). The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls. Gut. ISSN 0017-5749. 66(4), s. 611–619. doi: 10.1136/gutjnl-2015-310500. Vis sammendrag

  Objective: Gut microbiota could influence gut, as well as hepatic and biliary immune responses. We therefore thoroughly characterised the gut microbiota in primary sclerosing cholangitis (PSC) compared with healthy controls (HC) and patients with ulcerative colitis without liver disease. Design: We prospectively collected 543 stool samples. After a stringent exclusion process, bacterial DNA was submitted for 16S rRNA gene sequencing. PSC and HC were randomised to an exploration panel or a validation panel, and only significant results (p<0.05, QFDR<0.20) in both panels were reported, followed by a combined comparison of all samples against UC. Results: Patients with PSC (N=85) had markedly reduced bacterial diversity compared with HC (N=263, p<0.0001), and a different global microbial composition compared with both HC (p<0.001) and UC (N=36, p<0.01). The microbiota of patients with PSC with and without IBD was similar. Twelve genera separated PSC and HC, out of which 11 were reduced in PSC. However, the Veillonella genus showed a marked increase in PSC compared with both HC (p<0.0001) and UC (p<0.02). Using receiver operating characteristic analysis, Veillonella abundance yielded an area under the curve (AUC) of 0.64 to discriminate PSC from HC, while a combination of PSC- associated genera yielded an AUC of 0.78. Conclusions: Patients with PSC exhibited a gut microbial signature distinct from both HC and UC without liver disease, but similar in PSC with and without IBD. The Veillonella genus, which is also associated with other chronic inflammatory and fibrotic conditions, was enriched in PSC.

• Hovde, Øistein; Småstuen, Milada C; Høivik, Marte; Bernklev, Tomm; Huppertz-Hauss, Gert & Høie, Ole Ingebreth [Vis alle 11 forfattere av denne artikkelen] (2016). Mortality and Causes of Death in Ulcerative Colitis: Results from 20 Years of Follow-up in the IBSEN Study. Inflammatory Bowel Diseases. ISSN 1078-0998. 22(1), s. 141–145. doi: 10.1097/MIB.0000000000000582.
• Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm; Hovde, Øistein; Berset, Ingrid Prytz; Huppertz-Hauss, Gert & Moum, Bjørn [Vis alle 7 forfattere av denne artikkelen] (2016). Patients’ perceptions of quality of care and follow-up in inflammatory bowel disease. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 51(4), s. 434–441. doi: 10.3109/00365521.2015.1102319.
• Solberg, Inger Camilla; Høivik, Marte; Småstuen, Milada C & Moum, Bjørn (2015). Risk matrix model for prediction of colectomy in a population-based study of ulcerative colitis patients (the IBSEN study). Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 50(12), s. 1456–1462. doi: 10.3109/00365521.2015.1064991.
• Huppertz-Hauss, Gert; Høivik, Marte; Langholz, E; Odes, Selwyn; Småstuen, Milada Cvancarova & Stockbrügger, Reinhold [Vis alle 9 forfattere av denne artikkelen] (2015). Health-related Quality of Life in Inflammatory Bowel Disease in a European-wide Population-based Cohort 10 Years After Diagnosis. Inflammatory Bowel Diseases. ISSN 1078-0998. 21(2), s. 337–344. doi: 10.1097/MIB.0000000000000272.
• Hovde, Øistein; Huppertz-Hauss, Gert; Høivik, Marte & Moum, Bjørn (2014). Clinical course, treatment strategies, social and economic impact of Ulcerative Colitis: An overview. Austin Journal of Gastroenterology. ISSN 2381-9219. 1(4), s. 1–9.
• Moum, Bjørn; Hovde, Øistein & Høivik, Marte (2014). What have we learnt about the role of the environment and natural course of IBD in the new millennium? 20-year follow-up of the IBSEN cohort. Digestive Diseases. ISSN 0257-2753. 32, s. 2–9. doi: 10.1159/000367818. Vis sammendrag

  The incidence and prevalence of IBD, both Crohn's disease (CD) and ulcerative colitis (UC), have increased in recent years, especially in industrialized countries. Still, the etiology of IBD remains largely unknown. Most research on IBD before the 1990s was conducted on selected patient populations. Selected patient populations are likely to introduce important bias and limit the interpretation and generalizability. The inclusion of both incident and prevalent cases or the inclusion of incident cases over long periods of time (decades) might also introduce bias due to changes in treatment regimens and socioeconomic factors over timer (time-trend bias). Consequently, the choice of a well-characterized population-based inception cohort provides the best opportunity to describe the natural course of a disease. The IBSEN (Inflammatory Bowel Disease in South-Eastern Norway) study followed a large population-based cohort of newly diagnosed IBD patients for 20 years and has contributed significantly to the knowledge of the natural course of IBD.

• Høivik, Marte; Reinisch, Walter; Småstuen, Milada Cvancarova & Moum, Bjørn (2014). Anaemia in inflammatory bowel disease: a population-based 10-year follow-up. Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. 39(1), s. 69–76. doi: 10.1111/apt.12541.
• Høivik, Marte; Moum, Bjørn; Solberg, Inger Camilla; Henriksen, Magne; Småstuen, Milada C & Bernklev, Tomm (2013). Work disability in inflammatory bowel disease patiens 10 years after disease onset: results from the IBSEN Study. Gut. ISSN 0017-5749. 62(3), s. 368–375. doi: 10.1136/gutjnl-2012-302311.
• Opheim, Randi; Høivik, Marte; Solberg, Inger Camilla & Moum, Bjørn (2012). Complementary and alternative medicine in patients with inflammatory bowel disease: The results of a population-based inception cohort study (IBSEN). Journal - Crohn's and Colitis Foundation of Canada. ISSN 1197-4982. 6(3), s. 345–353. doi: 10.1016/j.crohns.2011.09.007.
• Høivik, Marte; Moum, Bjørn; Solberg, Inger Camilla; Småstuen, Milada C; Høie, Ole Ingebreth & Vatn, Morten H [Vis alle 7 forfattere av denne artikkelen] (2012). Health-related quality of life in patients with ulcerative colitis after a 10-year disease course: results from the IBSEN study. Inflammatory Bowel Diseases. ISSN 1078-0998. 18(8), s. 1540–1549. doi: 10.1002/ibd.21863.
• Høivik, Marte; Bernklev, Tomm; Solberg, Inger Camilla; Småstuen, Milada C; Lygren, Idar & Jahnsen, Jørgen [Vis alle 7 forfattere av denne artikkelen] (2012). Patients with Crohn's disease experience reduced general health and vitality in the chronic stage: Ten-year results from the IBSEN study. Journal - Crohn's and Colitis Foundation of Canada. ISSN 1197-4982. 6(4), s. 441–453. doi: 10.1016/j.crohns.2011.10.001.
• Høivik, Marte; Bernklev, Tomm & Moum, Bjørn (2010). Need for Standardization in Population-Based Quality of Life Studies: A Review of the Current Literature. Inflammatory Bowel Diseases. ISSN 1078-0998. 16(3), s. 525–536. doi: 10.1002/ibd.21032.

Se alle arbeider i Cristin

• Bazov, I.; Kruse, R.; Bergemalm, D.; Eriksson, C.; Hedin, C.R. & van Nieuwenhoven, M. [Vis alle 28 forfattere av denne artikkelen] (2023). A novel serum protein signature as biomarker for Inflammatory Bowel Disease: A diagnostic performance and prediction modelling study using data from two independent inception cohorts. Journal of Crohn's and Colitis. ISSN 1873-9946. 17, s. i314–i315. doi: 10.1093/ecco-jcc/jjac190.0284.
• Mathisen, Carl Magnus Bache Wiig; Nyström, N.; Bazov, I.; Andersen, S.; Olbjørn, Christine & Perminow, Gøri Margrete [Vis alle 22 forfattere av denne artikkelen] (2023). A novel diagnostic serum protein signature for paediatric Inflammatory Bowel Disease: A discovery and validation study in two independent inception cohorts. Journal of Crohn's and Colitis. ISSN 1873-9946. 17, s. i71– i71. doi: 10.1093/ecco-jcc/jjac190.0051.
• Tran, Trung; Vaage, Eline Benno; Mehta, Adi; Chopra, Adity; Tietze, Lisa & Kolderup, Heidi Anette [Vis alle 40 forfattere av denne artikkelen] (2023). Author Correction: Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants (npj Vaccines, (2022), 7, 1, (174), 10.1038/s41541-022-00586-7). npj Vaccines. ISSN 2059-0105. 8(1). doi: 10.1038/s41541-023-00600-6.
• Fossmark, Reidar; Lirhus, Sandre Svatun & Høivik, Marte Lie (2023). Protonpumpehemmere påvirker forløpet av ulcerøs colitt negativt - En kohortstudie av over 10000 nydiagnostiserte pasienter i Norge.
• Hansen, Simen Hyll; Gjerstad Maseng, M; Bjørkqvist, O; Halfvarsson, J; Bang, C & Detlie, Trond Espen [Vis alle 23 forfattere av denne artikkelen] (2023). Gut microbiota at diagnosis is associated with clinical features and future disease course in Inflammatory Bowel Disease: Data from IBSEN III, a new large Norwegian population-based inception cohort. Journal of Crohn's and Colitis. ISSN 1873-9946. 17, s. i1028–I2029. doi: 10.1093/ecco-jcc/jjac190.1050.
• Zerouga, Insaf; Sommer, Christine; Carlsen, Monica Hauger; Valeur, Jørgen; Kristensen, Vendel Ailin & Høivik, Marte Lie [Vis alle 8 forfattere av denne artikkelen] (2023). Kosthold og ernæringsstatus ved nydiagostisert IBD: resultater fra IBSEN III.
• Johansen, Ingunn; Småstuen, Milada Cvancarova; Løkkeberg, Stine Eileen Torp; Kristensen, Vendel Ailin; Høivik, Marte Lie & Lund, Charlotte [Vis alle 16 forfattere av denne artikkelen] (2022). Symptoms and symptom clusters in patients newly diagnosed with inflammtory bowel disease – results from the IBSEN III study .
• Strande, Vibeke; Småstuen, Milada C.; Lund, Charlotte; Bengtson, May-Bente; Høie, Ole & Boyar Cetinkaya, Raziye [Vis alle 26 forfattere av denne artikkelen] (2022). Klinisk karakteristika hos nydiagnostiserte pasienter med inflammatorisk tarmsykdom - resultater fra IBSEN III-studien.
• Strande, Vibeke; Småstuen, Milada C; Huppertz-Hauss, Gert; Perminow, Gøri ; Henriksen, Magne & Bengtson, May-Bente [Vis alle 17 forfattere av denne artikkelen] (2022). Fecal calprotectin at diagnosis is associated with oral steroid use first year of inflammatory bowel disease.
• Andersen, Svend; Bernklev, Tomm; Størdal, Ketil; Perminow, Gøri & Høivik, Marte Lie (2022). Paediatric IBD incidence increases in South-East Norway.
• Strande, Vibeke; Småstuen, Milada C.; Hasund, Audun; Huppertz-Hauss, Gert; Pallenschat, Jens & Bengtson, May-Bente [Vis alle 18 forfattere av denne artikkelen] (2021). Clinical characteristics associated with biochemical remission three months after diagnosis of Crohn's disease.
• Strande, Vibeke; Småstuen, Milada C.; Hasund, Audun; Huppertz-Hauss, Gert; Pallenschat, Jens & Bengtson, May-Bente [Vis alle 18 forfattere av denne artikkelen] (2021). Clinical characteristics associated with biochemical remission three months after diagnosis of ulcerative colitis.
• Høivik, Marte Lie (2020). Kvinner med IBD - utfordringer gjennom livsløpet.
• Kristensen, Vendel Ailin; Lund, Charlotte; Opheim, Randi; Ricanek, Petr; Huppertz-Hauss, Gert & Perminow, Gøri Margrete [Vis alle 37 forfattere av denne artikkelen] (2020). Inflammatory Bowel Disease in South-Eastern Norway III – IBSEN III.
• Mortensen, Joachim Høg; Lunder, Aida Kapic; Manon-Jensen, Tina; Karsdal, MA; Nielsen, Mette & Leeming, DJ [Vis alle 13 forfattere av denne artikkelen] (2020). P117 Biomarkers of extracellular matrix remodelling are associated with intestinal fibrosis assessed by magnetic resonance enterography and accumulated intestinal damage (Lémann index): the IBSEN study.
• Kristensen, Vendel Ailin; Småstuen, Milada Cvancarova; Høivik, Marte Lie; Moum, Bjørn & Vatn, Morten (2018). Long term stability of serological antibodies in a population-based inception cohort of inflammatory bowel disease - The IBSEN study.
• Kristensen, Vendel Ailin; Opheim, Randi; Ricanek, Petr; Detlie, Trond Espen; Perminow, Gøri Margrete & Høivik, Marte Lie (2018). IBSEN III—a new population-based inception cohort from South-Eastern Norway.
• Hovde, Øistein; Høivik, Marte Lie; Henriksen, Magne; Solberg, Inger Camilla; Småstuen, Milada Cvancarova & Moum, Bjørn Allan (2017). Corrigendum: Malignancies in Patients with Inflammatory Bowel Disease (IBD): Results from 20 Years of Follow-up in the IBSEN (Inflammatory Bowel South-Eastern Norway) Study. Journal of Crohn's and Colitis. ISSN 1873-9946. 11(12). doi: 10.1093/ecco-jcc/jjw218.
• Frigstad, Svein Oskar; Høivik, Marte Lie; Jahnsen, Jørgen; Dahl, Sandra Rinne; Cvancarova, Milada & Grimstad, Tore [Vis alle 13 forfattere av denne artikkelen] (2017). Vitamin D deficiency is not associated with depression in IBD patients. Journal of Crohn's and Colitis. ISSN 1873-9946. 11, s. 444–445. doi: 10.1093/ecco-jcc/jjx002.834.
• Frigstad, Svein Oskar; Høivik, Marte Lie; Jahnsen, Jørgen; Småstuen, Milada C; Grimstad, Tore & Berset, Ingrid Prytz [Vis alle 12 forfattere av denne artikkelen] (2017). Fatigue is not Associated with Vitamin D Deficiency in IBD Patients. Gastroenterology. ISSN 0016-5085. 152(5). doi: 10.1016/S0016-5085(17)33218-3.
• Frigstad, Svein Oskar; Høivik, Marte Lie; Småstuen, Milada C; Jahnsen, Jørgen; Dahl, Sandra Rinne & Berset, Ingrid Prytz [Vis alle 13 forfattere av denne artikkelen] (2017). Fatigue er ikke assosiert med vitamin D mangel hos IBD pasienter.
• Henriksen, Magne; Jelsness-Jørgensen, Lars-Petter; Høivik, Marte Lie & Moum, Bjørn (2017). Symptomer på irritabel tarmsyndrom (IBS)forekommer hyppig ved ulcerøs kolitt (UC) uavhengig av hvordan remisjon defineres. Resultater fra 20 års oppfølging i IBSEN studien.
• Frigstad, Svein Oskar; Høivik, Marte Lie; Moum, Bjørn; Dahl, Sandra Rinne; Jahnsen, Jørgen & Småstuen, Milada Cvancarova [Vis alle 12 forfattere av denne artikkelen] (2017). Vitamin D deficiency is not associated with depression in IBD patients.
• Bernklev, Tomm; Huppertz-Hauss, Gert; Opheim, Randi; Høivik, Marte; Moum, Bjørn & Jelsness-Jørgensen, Lars-Petter [Vis alle 7 forfattere av denne artikkelen] (2016). Co-existing Irritable Bowel Syndrome (IBS) in Inflammatory Bowel Disease (IBD) is associated with increased risk of chronic fatigue (CF), especially in females.
• Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas; Vesterhus, Mette; Høivik, Marte & Trøseid, Marius [Vis alle 12 forfattere av denne artikkelen] (2015). O082 : THE GUT MICROBIOTA IN PRIMARY SCLEROSING CHOLANGITIS DIFFERS FROM THAT OF HEALTHY CONTROLS AND ULCERATIVE COLITIS PATIENTS WITHOUT BILIARY DISEASE.
• Bernklev, Tomm; Huppertz-Hauss, Gert; Jelsness-Jørgensen, Lars-Petter; Høivik, Marte; Opheim, Randi & Jahnsen, Jørgen [Vis alle 7 forfattere av denne artikkelen] (2014). Chronic Fatigue Twenty Years After Diagnosis. Results from the IBSEN-Study. Inflammatory Bowel Diseases. ISSN 1078-0998. 20(12), s. 31–32. doi: 10.1097/01.MIB.0000456782.03905.38.

Se alle arbeider i Cristin