Nicola Pietro Montaldo

• Bordin, Diana Lilian; Grooms, Kayla Mae; Montaldo, Nicola Pietro; Fordyce Martin, Sarah L.; Sætrom, Pål & Samson, Leona D. [Vis alle 8 forfattere av denne artikkelen] (2024). Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory. DNA Repair. ISSN 1568-7864. 135. doi: 10.1016/j.dnarep.2024.103632.
• Glærum, Ingvild Lynneberg; Dunville, Keagan; Moan, Kristian Magnus; Krause, Maike; Montaldo, Nicola Pietro & Kirikae, Hinaco [Vis alle 10 forfattere av denne artikkelen] (2024). Postnatal persistence of hippocampal Cajal-Retzius cells has a critical role in the establishment of the hippocampal circuit. Development. ISSN 0950-1991. 151(1). doi: 10.1242/dev.202236.
• Loevenich, Simon; Montaldo, Nicola Pietro; Wickenhagen, Arthur; Sherstova, Tatyana; van Loon, Barbara & Boyartchuk, Victor [Vis alle 7 forfattere av denne artikkelen] (2023). Human metapneumovirus driven IFN-β production antagonizes macrophage transcriptional induction of IL1-β in response to bacterial pathogens. Frontiers in Immunology. ISSN 1664-3224. 14. doi: 10.3389/fimmu.2023.1173605. Fulltekst i vitenarkiv
• Lirussi, Lisa; Ayyildiz, Dilara; Liu, Yan; Montaldo, Nicola Pietro; Carracedo Huroz, Sergio & Aure, Miriam Ragle [Vis alle 16 forfattere av denne artikkelen] (2022). A regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in ER+ breast tumours. Nucleic Acids Research (NAR). ISSN 0305-1048. 50(18), s. 10449–10468. doi: 10.1093/nar/gkac807. Fulltekst i vitenarkiv
• Akbari, Mansour; Nilsen, Hilde & Montaldo, Nicola Pietro (2022). Dynamic features of human mitochondrial DNA maintenance and transcription. Frontiers in Cell and Developmental Biology. ISSN 2296-634X. 10. doi: 10.3389/fcell.2022.984245. Fulltekst i vitenarkiv
• Aprigliano, Rossana; Aksu, Merdane Ezgi; Bradamante, Stefano; Mihaljevic, Boris; Wang, Wei & Rian, Kristin [Vis alle 19 forfattere av denne artikkelen] (2021). Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities. Cell Reports Medicine. ISSN 2666-3791. 2(4). doi: 10.1016/j.xcrm.2021.100240. Fulltekst i vitenarkiv Vis sammendrag

  Essential E3 ubiquitin ligase HUWE1 (HECT, UBA, and WWE domain containing 1) regulates key factors, such as p53. Although mutations in HUWE1 cause heterogenous neurodevelopmental X-linked intellectual disabilities (XLIDs), the disease mechanisms common to these syndromes remain unknown. In this work, we identify p53 signaling as the central process altered in HUWE1-promoted XLID syndromes. By focusing on Juberg-Marsidi syndrome (JMS), one of the severest XLIDs, we show that increased p53 signaling results from p53 accumulation caused by HUWE1 p.G4310R destabilization. This further alters cell-cycle progression and proliferation in JMS cells. Modeling of JMS neurodevelopment reveals majorly impaired neural differentiation accompanied by increased p53 signaling. The neural differentiation defects can be successfully rescued by reducing p53 levels and restoring the expression of p53 target genes, in particular CDKN1A/p21. In summary, our findings suggest that increased p53 signaling underlies HUWE1-promoted syndromes and impairs XLID JMS neural differentiation.

• Rolinski, Milosz; Montaldo, Nicola Pietro; Aksu, Merdane Ezgi; Martin, Sarah Fordyce; Brambilla, Alessandro & Kunath, Nicolas [Vis alle 13 forfattere av denne artikkelen] (2021). Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation. Nucleic Acids Research (NAR). ISSN 0305-1048. 49(3), s. 1470–1484. doi: 10.1093/nar/gkaa1289. Fulltekst i vitenarkiv
• Montaldo, Nicola Pietro; Bordin, Diana Lilian; Brambilla, Alessandro; Rösinger, Marcel; Martin, Sarah Fordyce & Bjørås, Karine Øian [Vis alle 16 forfattere av denne artikkelen] (2019). Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression. Nature Communications. ISSN 2041-1723. 10(1). doi: 10.1038/s41467-019-13394-w. Fulltekst i vitenarkiv

Se alle arbeider i Cristin

• Anthonsen, Marit Walbye; Boyartchuk, Victor; Loevenich, Simon; van Loon, Barbara; Montaldo, Nicola Pietro & Sherstova, Tatyana (2019). Human metapneumovirus impairs antibacterial transcription by introducing H3K27 trimethylation at the IL1B promoter.

Se alle arbeider i Cristin