Naveen Parmar

• Diez Sanchez, Alberto; Lindholm, Håvard Takle; Vornewald, Pia Magdalena; Ostrop, Jenny; Yao, Rouan & Single, Andrew Bruce [Vis alle 11 forfattere av denne artikkelen] (2024). LSD1 drives intestinal epithelial maturation and controls small intestinal immune cell composition independent of microbiota in a murine model. Nature Communications. ISSN 2041-1723. 15(1). doi: 10.1038/s41467-024-47815-2.
• Vornewald, Pia Magdalena; Forman, Ruth; Yao, Rouan; Parmar, Naveen; Lindholm, Håvard Takle & Lee, Lilith Sian Kaspersen [Vis alle 9 forfattere av denne artikkelen] (2023). Mmp17- deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection. Frontiers in Immunology. ISSN 1664-3224. 14:1243528, s. 1–16. doi: 10.3389/fimmu.2023.1243528. Fulltekst i vitenarkiv
• Das, Saykat; Stamnæs, Jorunn; Kemppainen, Esko; Hervonen, Kaisa; Lundin, Knut & Parmar, Naveen [Vis alle 12 forfattere av denne artikkelen] (2023). Separate Gut Plasma Cell Populations Produce Auto-Antibodies against Transglutaminase 2 and Transglutaminase 3 in Dermatitis Herpetiformis. Advanced Science. ISSN 2198-3844. 10:2300401(25), s. 1–10. doi: 10.1002/advs.202300401. Fulltekst i vitenarkiv
• Lindholm, Håvard Takle; Parmar, Naveen; Drurey, Claire; Poveda, Marta Campillo; Vornewald, Pia & Ostrop, Jenny [Vis alle 9 forfattere av denne artikkelen] (2022). BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia. Science immunology. ISSN 2470-9468. 7(71). doi: 10.1126/sciimmunol.abl6543.
• Parmar, Naveen; Burrows, Kyle; Vornewald, Pia; Lindholm, Håvard Takle; Zwiggelaar, Rosalie Theda Margien & Sanchez, Alberto Diez [Vis alle 12 forfattere av denne artikkelen] (2021). Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection. PLoS Pathogens. ISSN 1553-7366. 17(3). doi: 10.1371/JOURNAL.PPAT.1009476. Fulltekst i vitenarkiv
• Roberts, Luke B.; Schnoeller, Corinna; Berkachy, Rita; Darby, Matthew; Pillaye, Jamie & Oudhoff, Menno [Vis alle 17 forfattere av denne artikkelen] (2021). Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths. Science immunology. ISSN 2470-9468. 6(57), s. 1–14. doi: 10.1126/sciimmunol.abd0359.
• Ostrop, Jenny; Zwiggelaar, Rosalie Theda Margien; Terndrup Pedersen, Marianne; Gerbe, François; Bösl, Korbinian & Lindholm, Håvard Takle [Vis alle 14 forfattere av denne artikkelen] (2021). A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial differentiation. Frontiers in Cell and Developmental Biology. ISSN 2296-634X. 8:618552, s. 1–20. doi: 10.3389/fcell.2020.618552.
• Parmar, Naveen; Chandrakar, Pragya & Kar, Susanta (2020). Leishmania donovani Subverts Host Immune Response by Epigenetic Reprogramming of Macrophage M(Lipopolysaccharides + IFN-g)/M(IL-10) Polarization. Journal of Immunology. ISSN 0022-1767. 204(10), s. 2762–2778. doi: 10.4049/jimmunol.1900251.
• Zwiggelaar, Rosalie; Lindholm, Håvard Takle; Fosslie, Madeleine Lystad; Pedersen, Marianne Terndrup; Ohta, Yuki & Sanchez, Alberto Diez [Vis alle 20 forfattere av denne artikkelen] (2020). LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium. Science Advances. ISSN 2375-2548. 6(37). doi: 10.1126/sciadv.abc0367. Fulltekst i vitenarkiv Vis sammendrag

  Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial development by testing a small library of epigenetic modifier inhibitors in Paneth cell–skewed organoid cultures. We found that lysine-specific demethylase 1A (Kdm1a/Lsd1) is absolutely required for Paneth cell differentiation. Lsd1-deficient crypts, devoid of Paneth cells, are still able to form organoids without a requirement of exogenous or endogenous Wnt. Mechanistically, we find that LSD1 enzymatically represses genes that are normally expressed only in fetal and neonatal epithelium. This gene profile is similar to what is seen in repairing epithelium, and we find that Lsd1-deficient epithelium has superior regenerative capacities after irradiation injury. In summary, we found an important regulator of neonatal intestinal development and identified a druggable target to reprogram intestinal epithelium toward a reparative state.

Se alle arbeider i Cristin

• Parmar, Naveen (2019). Decoding the role of the H3K4 demethylase LSD1 in mediating host defense against intestinal pathogens.

Se alle arbeider i Cristin