Nina Kathrine Aass

• Karlsson, Astrid Telhaug; Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Skovlund, Eva; Kaasa, Stein & Yri, Olav Erich (2024). Overall Survival after Radiotherapy for Brain Metastases According to ECOG Status—A Prospective Study of 294 NSCLC Patients. Cancers. ISSN 2072-6694. 16(8). doi: 10.3390/cancers16081486.
• Hjermstad, Marianne Jensen; Pirnat, Aleksandra; Aass, Nina Kathrine; Andersen, Sigve; Astrup, Guro Lindviksmoen & Dajani, Olav [Vis alle 19 forfattere av denne artikkelen] (2024). PALLiative care in ONcology (PALLiON): A cluster-randomised trial investigating the effect of palliative care on the use of anticancer treatment at the end of life. Palliative Medicine. ISSN 0269-2163. 38(2), s. 229–239. doi: 10.1177/02692163231222391. Vis sammendrag

  Background: Effects on anticancer therapy following the integration of palliative care and oncology are rarely investigated. Thus, its potential effect is unknown. Aim: To investigate the effects of the complex intervention PALLiON versus usual care on end-of-life anticancer therapy. Design: Cluster-randomised controlled trial (RCT), registered at ClinicalTrials.gov (No. NCT01362816). The complex intervention consisted of a physician education program enhancing theoretical, clinical and communication skills, a patient-centred care pathway and patient symptom reporting prior to all consultations. Primary outcome was overall use, start and cessation of anticancer therapy in the last 3 months before death. Secondary outcomes were patient-reported outcomes. Mixed effects logistic regression models and Cox proportional hazard were used. Setting: A total of 12 Norwegian hospitals (03/2017-02/2021). Participants: Patients ⩾18 years, advanced stage solid tumour, starting last line of anticancer therapy, estimated life expectancy ⩽12 months. Results: A total of 616 (93%) patients were included (intervention: 309/control:307); 63% males, median age 69, 77% had gastrointestinal cancers. Median survival time from inclusion was 8 (IQR 3-14) and 7 months (IQR 3-12), and days between anticancer therapy start and death were 204 (90-378) and 168 (69-351) (intervention/control). Overall, 78 patients (13%) received anticancer therapy in the last month (intervention: 33 [11%]/control: 45 [15%]). No differences were found in patient-reported outcomes. Conclusion: We found no significant differences in the probability of receiving end-of-life anticancer therapy. The intervention did not have the desired effect. It was probably too general and too focussed on communication skills to exert a substantial influence on conventional clinical practice.

• Bye, Asta; Bjerkeset, Ellen; Stensheim, Hanne; Loge, Jon Håvard; Hjermstad, Marianne Jensen & Klepstad, Pål [Vis alle 9 forfattere av denne artikkelen] (2022). Benefits of Study Participation for Patients with Advanced Cancer Receiving Radiotherapy: A Prospective Observational Study. Palliative Medicine Reports (PMR). 3(1), s. 264–271. doi: 10.1089/pmr.2022.0044. Fulltekst i vitenarkiv
• Habberstad, Ragnhild H; Aass, Nina Kathrine; Mollnes, Tom Eirik; Damås, Jan Kristian; Brunelli, Cinzia & Rossi, Romina [Vis alle 9 forfattere av denne artikkelen] (2022). Inflammatory Markers and Radiotherapy Response in Patients With Painful Bone Metastases. Journal of Pain and Symptom Management. ISSN 0885-3924. 64(4), s. 330–339. doi: 10.1016/j.jpainsymman.2022.06.018. Fulltekst i vitenarkiv
• Aass, Nina Kathrine & Kaasa, Stein (2022). Pasientsentrert behandling – er det mulig? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 142(3), s. 1–3. doi: 10.4045/tidsskr.22.0072.
• Lundeby, Tonje; Finset, Arnstein; Kaasa, Stein; Wester, Torunn Elin; Hjermstad, Marianne Jensen & Dajani, Olav [Vis alle 8 forfattere av denne artikkelen] (2022). A complex communication skills training program for physicians providing advanced cancer care–content development and barriers and solutions for implementation. Journal of Communication in Healthcare. ISSN 1753-8068. doi: 10.1080/17538068.2022.2039468. Fulltekst i vitenarkiv Vis sammendrag

  Background : Early integration of oncology and patient-centered palliative care is the recommended clinical practice model for patients with advanced cancer. General and specific communication skills are necessary to achieve integrated patient-centered care, but require organized training to be adequately mastered. Challenges and barriers on several levels, i.e. organizational, professional and individual may, however, hamper implementation. The development, implementation, and evaluation of such an educational program focusing on communication skills contain many steps, considerations and lessons learned, which are described in this article. Methods : A multi-professional faculty developed, implemented, and evaluated an educational program through a 5-step approach. The program was part of a Norwegian cluster-randomized controlled trial aiming to test the effect of early integration of oncology and palliative care for patients with advanced cancer. Results : The result is the PALLiON educational program; a multi-faceted, evidence-based, and learner-centered program with a specific focus on physicians’ communication skills. Four modules were developed: lectures, discussion groups, skills training, and coaching. These were implemented at the six intervention hospitals using different teaching strategies. Evaluation in a subgroup of participants showed a positive appraisal of the group discussions and skills training.

• Rootwelt, Rebecca; Hjermstad, Marianne Jensen; Skovlund, Eva; Aass, Nina Kathrine; Helseth, Eirik & Kaasa, Stein [Vis alle 8 forfattere av denne artikkelen] (2022). Surgery for brain metastases—impact of the extent of resection. Acta Neurochirurgica. ISSN 0001-6268. 164, s. 2773–2780. doi: 10.1007/s00701-021-05104-7. Fulltekst i vitenarkiv
• Rootwelt, Rebecca; Vik-Mo, Einar Osland; Yri, Olav Erich; Aass, Nina Kathrine; Kaasa, Stein & Skovlund, Eva [Vis alle 8 forfattere av denne artikkelen] (2021). Surgery for brain metastases – real-world prognostic factors’ association with survival. Acta Oncologica. ISSN 0284-186X. 60(9), s. 1161–1168. doi: 10.1080/0284186X.2021.1930150. Fulltekst i vitenarkiv
• Hjermstad, Marianne Jensen; Hamfjord, Julian; Aass, Nina Kathrine; Dajani, Olav; Lundeby, Tonje & Wester, Torunn Elin [Vis alle 7 forfattere av denne artikkelen] (2021). Using process indicators to monitor documentation of patient-centred variables in an integrated oncology and palliative care pathway—results from a cluster randomized trial. Cancers. ISSN 2072-6694. 13(9), s. 1–16. doi: 10.3390/cancers13092194. Fulltekst i vitenarkiv Vis sammendrag

  Background. Despite robust evidence from randomized controlled trials (RCTs) demonstrating clinical and patient-reported benefits of integrated oncology and palliative care, the tumour-centred focus is predominant. This single–centre process evaluation monitors documentation of required patient-centred variables during an RCT. Methods. Performance status, patient self-reported symptoms, weight and summaries to general practitioners were assessed from June 2017 to July 2020 in three consultation types: first oncological after study inclusion and palliative and oncological consultations during chemotherapy. Descriptive statistics were used to monitor if the pre-defined program fulfilment of ≥85% documentation was reached. Results. 435 consultations were monitored in 76 patients; 60.5% males, 86.8% with GI cancers; 76 (17.5%) were from the first oncological consultations, 87 (20.0%) and 272 (62.5%) from palliative or subsequent oncological consultations. Program fulfilment differed across consultation types with 94.8% in the palliative consultations (83.3–100%), relative to 65.8% (62.5–75.0%) and 69.2% (57.0–84.3%) for first and subsequent oncological consultations over time, respectively. Use of self-reported symptoms was consistently lower in the oncological consultations. Conclusions. The documentation level of required core variables was not satisfactory, notwithstanding their high clinical relevance and continuous reminders during study. Pre-trial optimization strategies are paramount to promote integration and reduce professional and personal barriers towards a more patient-centred focus.

• Habberstad, Ragnhild H; Frøseth, Trude Camilla Salvesen; Aass, Nina Kathrine; Bjerkeset, Ellen; Abramova, Tatiana Mikhailovna & Garcia-Alonso, Elena [Vis alle 13 forfattere av denne artikkelen] (2021). Clinical Predictors for Analgesic Response to Radiotherapy in Patients with Painful Bone Metastases. Journal of Pain and Symptom Management. ISSN 0885-3924. 62(4), s. 681–690. doi: 10.1016/j.jpainsymman.2021.03.022. Fulltekst i vitenarkiv Vis sammendrag

  Background Radiotherapy (RT) reduces pain in about 60% of patients with painful bone metastases, leaving many patients without clinical benefit. This study assesses predictors for RT effectiveness in patients with painful bone metastases. Materials and methods We included adult patients receiving RT for painful bone metastases in a multicenter, multinational longitudinal observational study. Pain response within 8 weeks was defined as ≥2-point decrease on a 0−10 pain score scale, without increase in analgesics; or a decrease in analgesics of ≥25% without increase in pain score. Potential predictors were related to patient demographics, RT administration, pain characteristics, tumor characteristics, depression and inflammation (C-reactive protein [CRP]). Multivariate logistic regression analysis with multiple imputation of missing data were applied to identify predictors of RT response. Results Of 513 eligible patients, 460 patients (90 %) were included in the regression model. 224 patients (44%, 95% confidence interval (CI) 39%−48%) responded to RT. Better Karnofsky performance status (Odds ratio (OR) 1.39, CI 1.15−1.68), breast cancer (OR 2.54, CI 1.12−5.73), prostate cancer (OR 2.83, CI 1.27−6.33) and soft tissue expansion (OR 2.00, CI 1.23−3.25) predicted RT response. Corticosteroids were a negative predictor (OR 0.57, CI 0.37−0.88). Single and multiple fraction RT had similar response. The discriminative ability of the model was moderate; C-statistic 0.69. Conclusion This study supports previous findings that better performance status and type of cancer diagnosis predicts analgesic RT response, and new data showing that soft tissue expansion predicts RT response and that corticosteroids is a negative predictor for RT response in patients with painful bone metastases.

• Karlsson, Astrid Telhaug; Hjermstad, Marianne Jensen; Omdahl, Therese; Aass, Nina Kathrine; Skovlund, Eva & Hellebust, Taran Paulsen [Vis alle 9 forfattere av denne artikkelen] (2021). Overall survival after initial radiotherapy for brain metastases; a population based study of 2140 patients with non-small cell lung cancer. Acta Oncologica. ISSN 0284-186X. 60(8), s. 1054–1060. doi: 10.1080/0284186X.2021.1924399.
• Gullhaug, Anna; Hjermstad, Marianne Jensen; Yri, Olav Erich; Svestad, Jørund Graadal; Aass, Nina Kathrine & Johansen, Safora (2021). Use of radiotherapy in breast cancer patients with brain metastases: a retrospective 11-year single center study. Journal of Medical Imaging and Radiation Sciences. ISSN 1939-8654. 52(2), s. 214–222. doi: 10.1016/j.jmir.2021.01.002. Fulltekst i vitenarkiv
• Jakobsen, Gunnhild; Engstrøm, Morten; Hjermstad, Marianne Jensen; Rosland, Jan Henrik; Aass, Nina Kathrine & Albert, Eva [Vis alle 10 forfattere av denne artikkelen] (2021). The short-term impact of methylprednisolone on patient-reported sleep in patients with advanced cancer in a randomized, placebo-controlled, double-blind trial. Supportive Care in Cancer. ISSN 0941-4355. 29(4), s. 2047–2055. doi: 10.1007/s00520-020-05693-6. Fulltekst i vitenarkiv Vis sammendrag

  Purpose: Although corticosteroids are frequently used in patients with advanced cancer, few studies have examined the impact of these drugs on patient-reported sleep. We aimed to examine the short-term impact of methylprednisolone on patient-reported sleep in patients with advanced cancer. Methods: Patient-reported sleep was a predefined secondary outcome in a prospective, randomized, placebo-controlled, double-blind trial that evaluated the analgesic efficacy of corticosteroids in advanced cancer patients (18+), using opioids, and having pain ≥ 4 past 24 h (NRS 0-10). Patients were randomized to the methylprednisolone group with methylprednisolone 16 mg × 2/day or placebo for 7 days. The EORTC QLQ-C30 (0-100) and the Pittsburgh Sleep Quality Index questionnaire (PSQI) (0-21) were used to assess the impact of corticosteroids on sleep at baseline and at day 7. Results: Fifty patients were randomized of which 25 were analyzed in the intervention group and 22 in the control group. Mean age was 64 years, mean Karnofsky performance status was 67 (SD 13.3), 51% were female, and the mean oral daily morphine equivalent dose was 223 mg (SD 222.77). Mean QLQ-C30 sleep score at baseline was 29.0 (SD 36.7) in the methylprednisolone group and 24.2 (SD 27.6) in the placebo group. At day 7, there was no difference between the groups on QLQ-C30 sleep score (methylprednisolone 20.3 (SD 32.9); placebo 28.8 (SD 33.0), p = 0.173). PSQI showed similar results. Conclusions: Methylprednisolone 16 mg twice daily for 7 days had no impact on patient-reported sleep in this cohort of patients with advanced cancer.

• Habberstad, Ragnhild H; Frøseth, Trude Camilla Salvesen; Aass, Nina Kathrine; Abramova, Tatiana Mikhailovna; Baas, Theo & Mørkeset, Siri Tessem [Vis alle 24 forfattere av denne artikkelen] (2018). The Palliative Radiotherapy and Inflammation Study (PRAIS) - Protocol for a longitudinal observational multicenter study on patients with cancer induced bone pain. BMC Palliative Care. ISSN 1472-684X. 17(110). doi: 10.1186/s12904-018-0362-9. Fulltekst i vitenarkiv
• Grønberg, Bjørn Henning; Sjøblom, Bjørg; Wentzel-Larsen, Tore; Baracos, Vickie Elaine; Hjermstad, Marianne Jensen & Aass, Nina Kathrine [Vis alle 10 forfattere av denne artikkelen] (2018). A comparison of CT based measures of skeletal muscle mass and density from the Th4 and L3 levels in patients with advanced non-small-cell lung cancer. European Journal of Clinical Nutrition. ISSN 0954-3007. s. 1–8. doi: 10.1038/s41430-018-0325-5. Fulltekst i vitenarkiv
• Grotmol, Kjersti Støen; Lie, Hanne Cathrine; Loge, Jon Håvard; Aass, Nina Kathrine; Haugen, Dagny Faksvåg & Stone, Patrick C [Vis alle 8 forfattere av denne artikkelen] (2018). Patients with advanced cancer and depression report a significantly higher symptom burden than non-depressed patients. Palliative & Supportive Care. ISSN 1478-9515. s. 1–7. doi: 10.1017/S1478951517001183. Fulltekst i vitenarkiv
• Grotmol, Kjersti Støen; Lie, Hanne Cathrine; Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Currow, David & Kaasa, Stein [Vis alle 9 forfattere av denne artikkelen] (2017). Depression-A Major Contributor to Poor Quality of Life in Patients With Advanced Cancer. Journal of Pain and Symptom Management. ISSN 0885-3924. 54(6), s. 889–897. doi: 10.1016/j.jpainsymman.2017.04.010. Fulltekst i vitenarkiv
• Bye, Asta; Sjøblom, Bjørg; Wentzel-Larsen, Tore; Grønberg, Bjørn Henning; Baracos, Vickie E. & Hjermstad, Marianne Jensen [Vis alle 10 forfattere av denne artikkelen] (2017). Muscle mass and association to quality of life in non-small cell lung cancer patients. Journal of Cachexia, Sarcopenia and Muscle. ISSN 2190-5991. 8, s. 759–767. doi: 10.1002/jcsm.12206. Fulltekst i vitenarkiv
• Jacobsen, Ellisiv Lærum; Bye, Asta; Aass, Nina Kathrine; Fosså, Sophie Dorothea; Grotmol, Kjersti Støen & Kaasa, Stein [Vis alle 9 forfattere av denne artikkelen] (2017). Norwegian reference values for the Short-Form Health Survey 36: development over time. Quality of Life Research. ISSN 0962-9343. s. 1–12. doi: 10.1007/s11136-017-1684-4. Fulltekst i vitenarkiv
• Paulsen, Ørnulf; Laird, Barry J; Aass, Nina Kathrine; Lea, Tor Erling; Fayers, Peter & Kaasa, Stein [Vis alle 7 forfattere av denne artikkelen] (2017). The relationship between pro-inflammatory cytokines and pain, appetite and fatigue in patients with advanced cancer. PLOS ONE. ISSN 1932-6203. 12(5). doi: 10.1371/journal.pone.0177620. Fulltekst i vitenarkiv
• Sjøblom, Bjørg; Saltyte Benth, Jurate; Grønberg, Bjørn Henning; Baracos, Vickie E.; Sawyer, Michael & Fløtten, Øystein [Vis alle 9 forfattere av denne artikkelen] (2017). Drug Dose Per Kilogram Lean Body Mass Predicts Hematologic Toxicity From Carboplatin-Doublet Chemotherapy in Advanced Non-Small-Cell Lung Cancer. Clinical Lung Cancer. ISSN 1525-7304. 18(2), s. e129–e136. doi: 10.1016/j.cllc.2016.09.008. Vis sammendrag

  Background Variations in lean body mass (LBM) have been suggested to explain variations in toxicity from systemic cancer treatment. We investigated if drug doses per kilogram of LBM were associated with severe hematologic toxicity (HT) in patients with stage IIIB/IV non–small-cell lung cancer (NSCLC) enrolled onto randomized trials comparing first-line carboplatin-doublets. Patients and Methods Patients received carboplatin (AUC [area under the plasma concentration vs. time curve] = 5) plus either pemetrexed 500 mg/m2, gemcitabine 1000 mg/m2, or vinorelbine 60 mg/m2. LBM was estimated from the cross-sectional muscle area at the third lumbar vertebra on computed tomographic scans. Administered doses on day 1, first cycle, were recalculated as milligram of drug per kilogram of LBM. Primary outcome was Common Terminology Criteria for Adverse Events version 3.0 grade 3/4 HT after cycle 1. Results Data from 424 patients were analyzed. Mean age was 65 years, 57% were men, and 78% had stage IV disease. Despite dose individualization by body surface area for the nonplatinum drugs, mean (range) doses expressed as mg/kg LBM showed ∼3-fold range: gemcitabine 38.0 (22.5-61.7) mg/kg LBM, pemetrexed 19.1 (8.1-27.9) mg/kg LBM, and vinorelbine 2.4 (1.4-3.6) mg/kg LBM. For these drugs, dose per kilogram of LBM was associated with HT in adjusted multivariate models (P = .004). Taking mean dose per kilogram LBM for each drug as reference, a 1% increase (odds ratio [OR] = 1.03; 95% confidence interval [CI], 1.01-1.06) or 1% decrease (OR = 0.97; 95% CI, 0.95-0.99) was associated with altered risk of grade 3/4 HT. For doses > 20% above and below mean (14% and 15% of patients, respectively) the risk of grade 3/4 HT was almost doubled (OR = 1.93, 95% CI, 1.21-3.10) and halved (OR = 0.52; 95% CI, 0.32-0.83), respectively. Conclusion Dose per kilogram of LBM varied considerably and was an independent predictor of HT. Computed tomography–defined LBM may provide a future basis for better dose individualization. Keywords Body composition; Chemotherapy dosing; Chemotherapy toxicity; Muscle wasting; Skeletal muscle

• Fredheim, Olav Magnus Søndenå; Brelin, Siri; Hjermstad, Marianne Jensen; Loge, Jon Håvard; Aass, Nina Kathrine & Johannessen, Tom Børge [Vis alle 7 forfattere av denne artikkelen] (2017). Prescriptions of analgesics during complete disease trajectories in patients who are diagnosed with and die from cancer within the five-year period 2005-2009. European Journal of Pain. ISSN 1090-3801. 21(3), s. 530–540. doi: 10.1002/ejp.956.
• Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Aielli, F; Bennett, Michael I.; Brunelli, Cinzia & Caraceni, Augusto [Vis alle 26 forfattere av denne artikkelen] (2016). Characteristics of the case mix, organization and delivery in cancer palliative care: a challenge for good-quality research. BMJ Supportive & Palliative Care. ISSN 2045-435X. 8(4), s. 456–467. doi: 10.1136/bmjspcare-2015-000997.
• Brelin, Siri; Fredheim, Olav Magnus; Loge, Jon Håvard; Skurtveit, Svetlana; Johannesen, Tom Børge & Aass, Nina Kathrine [Vis alle 8 forfattere av denne artikkelen] (2016). Opioids for outpatients with cancer in their last year of life: A nationwide pharmacoepidemiological study. Journal of Opioid Management. ISSN 1551-7489. 12(1), s. 25–36. doi: 10.5055/jom.2016.0309.
• Sjøblom, Bjørg; Grønberg, Bjørn Henning; Wentzel-Larsen, Tore; Baracos, Vickie E.; Hjermstad, Marianne Jensen & Aass, Nina Kathrine [Vis alle 10 forfattere av denne artikkelen] (2016). Skeletal muscle radiodensity is prognostic for survival in patients with advanced non-small cell lung cancer. Clinical Nutrition. ISSN 0261-5614. 35(6), s. 1386–1393. doi: 10.1016/j.clnu.2016.03.010.
• Hjermstad, Marianne Jensen; Kaasa, Stein; Caraceni, Augusto; Loge, Jon Håvard; Pedersen, Tore & Haugen, Dagny Faksvåg [Vis alle 7 forfattere av denne artikkelen] (2016). Characteristics of breakthrough cancer pain and its influence on quality of life in an international cohort of patients with cancer. BMJ Supportive & Palliative Care. ISSN 2045-435X. 6(3), s. 344–352. doi: 10.1136/bmjspcare-2015-000887. Vis sammendrag

  Objectives: Breakthrough cancer pain (BTP) represents a treatment challenge. Objectives were to examine the prevalence and characteristics of BTP in an international sample of patients with cancer, and to investigate the relationship between BTP and quality of life (QoL). Methods: This was an observational cross-sectional multicentre study. Participating patients completed self-report questionnaires on a touch-screen laptop computer, including the Brief Pain Inventory, Alberta Breakthrough Pain Assessment Tool (ABPAT) and European Organisation for Research and Treatment of Cancer 30-item Core Quality of Life Questionnaire (EORTC QLQ-C30). The study was performed in 17 centres in 8 countries and involved 4 languages (Norwegian, Italian, German and English). Results: Records from a convenience sample of 978 patients with advanced cancer were analysed; mean age was 62.2 years, 48.3% were women and 84.4% had metastatic disease. A total of 296 patients (30%) had no pain, defined as worst pain in the past 24 hours <1 on a 0–10 scale. Of the 682 patients with a pain score ≥1, 393 (58%) reported no BTP on the screening item, while 289 (30%) confirmed flare ups of BTP. Patients with BTP reported significantly higher pain intensity scores (<0.001) than patients without BTP; 57.1% of patients rated BTP at its worst as being severe: ≥7 on a 0–10 scale. Time from onset to peak intensity was <10 min for 42.9%, and average time to pain relief was 27.1 min. BTP was commonly triggered by medication wearing off (28%). Patients with BTP had significantly worse mean outcomes on 10 of 15 functional and symptom scales of the EORTC QLQ-C30 (<0.001). Severe pain intensity in the last week was a powerful predictor of BTP (OR 4.1) and poor QoL (OR 1.9). Conclusions: BTP is highly prevalent with prolonged episodes despite analgaesics, and has a pervasive impact on QoL. Patients reporting high pain intensity should be carefully evaluated for BTP and efficacy of analgaesic treatment, to provide optimal pain management and improve QoL.

• Sjøblom, Bjørg; Grønberg, Bjørn Henning; Saltyte Benth, Jurate; Baracos, Vickie E.; Fløtten, Øystein & Hjermstad, Marianne Jensen [Vis alle 8 forfattere av denne artikkelen] (2015). Low muscle mass is associated with chemotherapy-induced haematological toxicity in advanced non-small cell lung cancer. Lung Cancer. ISSN 0169-5002. 90(1), s. 85–91. doi: 10.1016/j.lungcan.2015.07.001.
• Paulsen, Ørnulf; Klepstad, Pål; Rosland, Jan Henrik; Aass, Nina Kathrine; Albert, Eva & Fayers, Peter [Vis alle 7 forfattere av denne artikkelen] (2014). Efficacy of methylprednisolone on pain, fatigue, and appetite loss in patients with advanced cancer using opioids: A randomized, placebo-controlled, double-blind trial. Journal of Clinical Oncology. ISSN 0732-183X. 32(29), s. 3221–3228. doi: 10.1200/JCO.2013.54.3926. Vis sammendrag

  Purpose Corticosteroids are frequently used in cancer pain management despite limited evidence. This study compares the analgesic efficacy of corticosteroid therapy with placebo. Patients and Methods Adult patients with cancer receiving opioids with average pain intensity ≥ 4 (numeric rating scale [NRS], 0 to 10) in the last 24 hours were eligible. Patients were randomly assigned to methylprednisolone (MP) 16 mg twice daily or placebo (PL) for 7 days. Primary outcome was average pain intensity measured at day 7 (NRS, 0 to 10); secondary outcomes were analgesic consumption (oral morphine equivalents), fatigue and appetite loss (European Organisation for Research and Treatment of Cancer–Quality of Life Questionnaire C30, 0 to 100), and patient satisfaction (NRS, 0 to 10). Results A total of 592 patients were screened; 50 were randomly assigned, and 47 were analyzed. Baseline opioid level was 269.9 mg in the MP arm and 160.4 mg in the PL arm. At day-7 evaluation, there was no difference between the groups in pain intensity (MP, 3.60 v PL, 3.68; P = .88) or relative analgesic consumption (MP, 1.19 v PL, 1.20; P = .95). Clinically and statistically significant improvements were found in fatigue (−17 v 3 points; P .003), appetite loss (−24 v 2 points; P = .003), and patient satisfaction (5.4 v 2.0 points; P = .001) in favor of the MP compared with the PL group, respectively. There were no differences in adverse effects between the groups. Conclusion MP 32 mg daily did not provide additional analgesia in patients with cancer receiving opioids, but it improved fatigue, appetite loss, and patient satisfaction. Clinical benefit beyond a short-term effect must be examined in a future study.

• Rayment, Clare; Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Kaasa, Stein; Caraceni, Augusto & Strasser, Florian [Vis alle 9 forfattere av denne artikkelen] (2013). Neuropathic cancer pain: Prevalence, severity, analgesics and impact from the European Palliative Care Research Collaborative-Computerised Symptom Assessment study. Palliative Medicine. ISSN 0269-2163. 27(8), s. 714–721. doi: 10.1177/0269216312464408.
• Paulsen, Ørnulf; Aass, Nina Kathrine; Kaasa, Stein & Dale, Ola (2013). Do Corticosteroids Provide Analgesic Effects in Cancer Patients? A Systematic Literature Review. Journal of Pain and Symptom Management. ISSN 0885-3924. 46(1), s. 96–105. doi: 10.1016/j.jpainsymman.2012.06.019.
• Brelin, Siri; Loge, Jon Håvard; Skurtveit, Svetlana; Johannesen, Tom Børge; Aass, Nina Kathrine & Ottesen, Stig [Vis alle 7 forfattere av denne artikkelen] (2013). Antidepressants to cancer patients during the last year of life - a population-based study. Psycho-Oncology. ISSN 1057-9249. 22(3), s. 506–514. doi: 10.1002/pon.3059.
• Hjermstad, Marianne Jensen; Kolflaath, Jan; Løkken, Aud Oddny; Hanssen, Sjur Bjørnar; Normann, Are Peder & Aass, Nina Kathrine (2013). Are emergency admissions in palliative cancer care always necessary? Results from a descriptive study. BMJ Open. ISSN 2044-6055. 3(5). doi: 10.1136/bmjopen-2012-002515. Fulltekst i vitenarkiv
• Paulsen, Ørnulf; Aass, Nina Kathrine; Kaasa, Stein & Dale, Ola (2013). Do coricosteroids provide anlgesic effects in cancer patients? A systeamtic literature review. Journal of Pain and Symptom Management. ISSN 0885-3924. 46(1), s. 96–105. doi: 10.1016/j.jpainsymman.2012.06.019.
• Nekolaichuk, Cheryl; Fainsinger, Robin; Aass, Nina Kathrine; Hjermstad, Marianne Jensen; Knudsen, Anne Kari & Klepstad, Pål [Vis alle 8 forfattere av denne artikkelen] (2013). The Edmonton Classification System for Cancer Pain: Comparison of Pain Classification Features and Pain Intensity Across Diverse Palliative Care Settings in Eight Countries. Journal of Palliative Medicine. ISSN 1096-6218. 16(5), s. 516–523. doi: 10.1089/jpm.2012.0390.
• de Wit, Ronald; Skoneczna, Iwona; Daugaard, Gedske; de Santis, Maria; Garin, August & Aass, Nina Kathrine [Vis alle 12 forfattere av denne artikkelen] (2012). Randomized Phase III Study Comparing Paclitaxel-Bleomycin, Etoposide, and Cisplatin (BEP) to Standard BEP in Intermediate-Prognosis Germ-Cell Cancer: Intergroup Study EORTC 30983. Journal of Clinical Oncology. ISSN 0732-183X. 30(8), s. 792–799. doi: 10.1200/JCO.2011.37.0171.
• Knudsen, Anne Kari; Aass, Nina Kathrine; Heitzer, Ellen; Klepstad, Pål; Hjermstad, Marianne Jensen & Schippinger, Walter [Vis alle 9 forfattere av denne artikkelen] (2012). Interviews with patients with advanced cancer-another step towards an international cancer pain classification system. Supportive Care in Cancer. ISSN 0941-4355. 20(10), s. 2491–2500. doi: 10.1007/s00520-011-1361-z.
• Knudsen, Anne Kari; Brunelli, C; Klepstad, Pål; Aass, Nina Kathrine; Apolone, Giovanni & Corli, Oscar [Vis alle 9 forfattere av denne artikkelen] (2012). Which domains should be included in a cancer pain classification system? Analyses of longitudinal data. Pain. ISSN 0304-3959. 153(3), s. 696–703. doi: 10.1016/j.pain.2011.12.005.
• Bennett, Michael I; Rayment, Clare; Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Caraceni, Augusto & Kaasa, Stein (2012). Prevalence and aetiology of neuropathic pain in cancer patients: a systematic review. Pain. ISSN 0304-3959. 153(2), s. 359–365. doi: 10.1016/j.pain.2011.10.028.
• Oliver, R. Timothy D.; Mead, Graham M.; Rustin, Gordon J.S.; Joffe, Johnathan K.; Aass, Nina & Coleman, Robert [Vis alle 9 forfattere av denne artikkelen] (2011). Randomized Trial of Carboplatin Versus Radiotherapy for Stage I Seminoma: Mature Results on Relapse and Contralateral Testis Cancer Rates in MRC TE19/EORTC 30982 Study (ISRCTN27163214). Journal of Clinical Oncology. ISSN 0732-183X. 29(8), s. 957–962. doi: 10.1200/JCO.2009.26.4655.
• Hjermstad, Marianne Jensen; Fayers, Peter; Haugen, Dagny R Faksvåg; Caraceni, Augusto; Hanks, Geoffrey & Loge, Jon Håvard [Vis alle 9 forfattere av denne artikkelen] (2011). Studies Comparing Numerical Rating Scales, Verbal Rating Scales, and Visual Analogue Scales for Assessment of Pain Intensity in Adults: A Systematic Literature Review. Journal of Pain and Symptom Management. ISSN 0885-3924. 41(6), s. 1073–1093. doi: 10.1016/j.jpainsymman.2010.08.016.
• Dausgaard, Gedske; Skoneczna, Iwona; Aass, Nina Kathrine; de Wit, Ronald; de Santis, Maria & Dumez, Herlinde [Vis alle 11 forfattere av denne artikkelen] (2011). A randomized phase III study comparing standard dose BEP with sequential high-dose cisplatin, etoposide, and ifosfamide (VIP) plus stem-cell support in males with poor-prognosis germ-cell cancer. An intergroup study of EORTC, GTCSG, and Grupo Germinal (EORTC 30974). Annals of Oncology. ISSN 0923-7534. 22(5), s. 1054–1061. doi: 10.1093/annonc/mdq575.
• Bergh, Irmelin; Kvalem, Ingela Lundin; Aass, Nina Kathrine & Hjermstad, Marianne Jensen (2011). What does the answer mean? A qualitative study of how palliative cancer patients interpret and respond to the Edmonton Symptom Assessment System. Palliative Medicine. ISSN 0269-2163. 25(7), s. 716–724. doi: 10.1177/0269216310395985.
• Knudsen, Anne Kari; Brunelli, C; Kaasa, Stein; Apolone, G.; Corli, O & Montanari, M [Vis alle 11 forfattere av denne artikkelen] (2011). Which variables are associated with pain intensity and treatment response in advanced cancer patients? - Implications for a future classification system for cancer pain. European Journal of Pain. ISSN 1090-3801. 15(3), s. 320–327. doi: 10.1016/j.ejpain.2010.08.001.
• Haugnes, Hege Sagstuen; Wethal, Torgeir; Aass, Nina Kathrine; Dahl, Olav; Klepp, Olbjørn & Langberg, Carl W. [Vis alle 9 forfattere av denne artikkelen] (2010). Cardiovascular risk factors and morbidity in long-term survivors of testicular cancer: a 20-year follow-up study. Journal of Clinical Oncology. ISSN 0732-183X. 28(30), s. 4649–4657. doi: 10.1200/JCO.2010.29.9362. Vis sammendrag

  Adressene er knyttet opp i samarbeid med korresponderende forfatter (tidsskriftet oppgir forfatterne og adressene hver for seg), og godkjent på grunnlag av dette./tøf

• Knudsen, Anne Kari; Aass, Nina; Fainsinger, Robin; Caraceni, Augusto; Klepstad, Pål & Jordhøy, Marit S [Vis alle 7 forfattere av denne artikkelen] (2009). Classification of pain in cancer patients - a systematic literature review. Palliative Medicine. ISSN 0269-2163. 23(4), s. 295–308. doi: 10.1177/0269216309103125.
• Haugen, Dagny Faksvåg; Kaasa, Stein & Aass, Nina (2009). Palliativ forskning i Norge i dag. Omsorg: Nordisk tidsskrift for Palliativ Medisin. ISSN 0800-7489. s. 3–7.
• Sagstuen, Hege; Aass, Nina Kathrine; Fosså, Sophie Dorothea; Klepp, Olbjørn; Wist, Erik & Dahl, Olav [Vis alle 8 forfattere av denne artikkelen] (2004). Blood pressure and body mass index (BMI) in testicular cancer survivors. Annals of Oncology. ISSN 0923-7534. 15, s. 112–112.
• Stensvold, E; Aass, Nina Kathrine; Gladhaug, Ivar Prydz; Stenwig, Anna Elisabeth; Clausen, Ole Petter Fraas & Fosså, Sophie Dorothea (2004). Erroneous diagnosis of pancreatic cancer after radiotherapy of testicular cancer. European Journal of Surgical Oncology. ISSN 0748-7983. 30(3), s. 352–355. doi: 10.1016/j.ejso.2003.09.003.
• Schmoll, H.J.; Souchon, R; Krege, S; Albers, P; Beyer, Jörg & Kollmannsberger, C [Vis alle 22 forfattere av denne artikkelen] (2004). European consensus on diagnosis and treatment of germ cell cancer: a report of the European Germ Cell Cancer Concensus Group (EGCCCG). Annals of Oncology. ISSN 0923-7534. 15(9), s. 1377–99.
• Fosså, Sophie Dorothea; Aass, Nina Kathrine; Harvei, Sverre & Tretli, Steinar (2004). Increased mortality rates in young and middle-aged patients with malignant germ cell tumours. British Journal of Cancer. ISSN 0007-0920. 90(3), s. 607–612.
• Rapley, Elizabeth A.; Hockley, S; Warren, W.; Johnson, L; Huddart, R & Crockford, Gillian P. [Vis alle 39 forfattere av denne artikkelen] (2004). Somatic mutations of KIT in familial testicular germ cell tumours. British Journal of Cancer. ISSN 0007-0920. 90(12), s. 2397–2401.

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• Halvorsen, Tarje Onsøien & Aass, Nina Kathrine (2016). Kvalme og oppkast. Gyldendal Akademisk. ISBN 9788205488403.
• Aass, Nina Kathrine & Kristensen, Are Korsnes (2016). Medikamentell tumorrettet behandling. Gyldendal Akademisk. ISBN 9788205488403.

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• Lillekroken, Daniela; Bye, Asta; Halvorsrud, Liv Torill; Yri, Olav Erich; Wester, Torunn Elin & Hjermstad, Marianne Jensen [Vis alle 9 forfattere av denne artikkelen] (2024). Living with brain metastases - A qualitative study about patient-and family members' coping strategies.
• Hjermstad, Marianne Jensen; Pirnat, Aleksandra; Aass, Nina Kathrine; Andersen, Sigve; Astrup, Guro Lindviksmoen & Dajani, Olav [Vis alle 19 forfattere av denne artikkelen] (2023). 1592MO Anticancer therapy at the end-of-life: A cluster-randomized trial. Annals of Oncology. ISSN 0923-7534. 34, s. S886–S886. doi: 10.1016/j.annonc.2023.09.789.
• Lundeby, Tonje; Aass, Nina Kathrine; Andersen, Sigve; Hanssen, Sjur Bjørnar; Hjermstad, Marianne Jensen & Kaasa, Stein [Vis alle 9 forfattere av denne artikkelen] (2023). Family carers' experiences with brain metastases: A longitudinal study.
• Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Gravli, Trine H.; Smeland, Sigbjørn & Kaasa, Stein (2023). Pasientsentrert kreftbehandling. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(1). doi: 10.4045/tidsskr.22.0668.
• Yri, Olav Erich; Astrup, Guro Lindviksmoen; Karlsson, Astrid Telhaug; Paulsen, Ørnulf; van Helvoirt, Rene & Lund, Jo-Åsmund [Vis alle 12 forfattere av denne artikkelen] (2022). Brain metastases: Real-life treatment patterns, survival and patient-reported outcomes – Results from a population-based, prospective study in 914 patients. Annals of Oncology. ISSN 0923-7534. 33, s. S668–S668. doi: 10.1016/j.annonc.2022.07.416.
• Urrizola, Amaia; Dajani, Olav; Aass, Nina Kathrine; Hjermstad, Marianne Jensen; Kaasa, Stein & Klepstad, Pål [Vis alle 9 forfattere av denne artikkelen] (2022). Nutrition Impact Symptoms in Oncology –Why should we address them?
• Lundeby, Tonje; Wester, Torunn Elin; Aass, Nina Kathrine; Hjermstad, Marianne Jensen; Yri, Olav Erich & Bye, Asta [Vis alle 7 forfattere av denne artikkelen] (2022). Living with brain metastases: A longitudinal qualitative study of patient experiences from time of diagnosis.
• Yri, Olav Erich; Aass, Nina Kathrine & Kaasa, Stein (2022). Helhjernebestråling bør begrenses. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 142(17). doi: 10.4045/tidsskr.22.0696.
• Raanes, Ida Ervik; Balstad, Trude Rakel; Martinez, Amaia; Rosendahl-Riis, Hanne; Dajani, Olav & Solheim, Tora S [Vis alle 12 forfattere av denne artikkelen] (2022). The role of inflammation in development of malnutrition in advanced cancer.
• Lundereng, Elias David; Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Lundeby, Tonje; Fallon, Marie & Velikova, Galina [Vis alle 9 forfattere av denne artikkelen] (2022). Developing Innovative Digital Patient Centered Care Pathways for Cancer Patients using Agile Design: A pre pilot study.
• Astrup, Guro Lindviksmoen; Kaasa, Stein; Aass, Nina Kathrine; Hjermstad, Marianne Jensen; Lundeby, Tonje & van Helvoirt, Rene [Vis alle 9 forfattere av denne artikkelen] (2021). Patient-reported outcomes in cancer patients newly diagnosed with brain metastases. Annals of Oncology. ISSN 0923-7534. 32, s. S1076–S1076. doi: 10.1016/j.annonc.2021.08.206.
• Yri, Olav Erich; Astrup, Guro Lindviksmoen; Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Lund, Jo-Åsmund & van Helvoirt, Rene [Vis alle 8 forfattere av denne artikkelen] (2021). Brain metastases: Extracranial disease status as a prognostic factor after whole brain radiotherapy. Results from a prospective, population-based study. Annals of Oncology. ISSN 0923-7534. 32, s. S526–S526. doi: 10.1016/j.annonc.2021.08.037.
• Jakobsen, Gunnhild; Kaasa, Stein; Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Klepstad, Pål & Paulsen, Ørnulf (2021). Kortikosteroider påvirker ikke søvn hos alvorlig syke kreftpasienter med smerte .
• Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Andersen, Sigve; Brunelli, Cinzia; Dajani, Olav & Ahmed, Herish [Vis alle 20 forfattere av denne artikkelen] (2020). PALLiON - PALLiative care Integrated in ONcology: Study protocol for a Norwegian national cluster-randomized control trial with a complex intervention of early integration of palliative care. Trials. ISSN 1745-6215. 21:303, s. 1–17. doi: 10.1186/s13063-020-4224-4. Fulltekst i vitenarkiv
• Habberstad, Ragnhild H; Frøseth, Trude Camilla Salvesen; Aass, Nina Kathrine; Bjerkeset, Ellen; Abramova, Tatiana Mikhailovna & Garcia-Alonso, Elena [Vis alle 13 forfattere av denne artikkelen] (2019). Clinical predictors for analgesic response to radiotherapy in patients with painful bone metastases. Annals of Oncology. ISSN 0923-7534. 30, s. v662–v662. doi: 10.1093/annonc/mdz261.003.
• Bjerkeset, Ellen; Aass, Nina Kathrine; Bye, Asta; Hamfjord, Julian; Hjermstad, Marianne Jensen & Loge, Jon Håvard [Vis alle 8 forfattere av denne artikkelen] (2018). Identified palliative care needs at start of radiotherapy for painful bone metastases.
• Bye, Asta; Seljelid, Berit; Aass, Nina Kathrine; Hjermstad, Marianne Jensen; Wester, Torunn & Loge, Jon Håvard (2018). Can we rely on reports on preferences for place of death? .
• Jacobsen, Ellisiv Lærum; Bye, Asta; Aass, Nina Kathrine; Fosså, Sophie Dorothea; Grotmol, Kjersti Støen & Kaasa, Stein [Vis alle 9 forfattere av denne artikkelen] (2017). Correction to: Norwegian reference values for the Short-Form Health Survey 36: development over time. Quality of Life Research. ISSN 0962-9343. s. 1–3. doi: 10.1007/s11136-017-1708-0. Fulltekst i vitenarkiv
• Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Grotmol, Kjersti Støen; Kaasa, Stein; Lundeby, Tonje & Seljelid, Berit [Vis alle 8 forfattere av denne artikkelen] (2017). Integration of oncology and palliative care - findings from the PALLiON pre-study survey.
• Haugen, Dagny Faksvåg & Aass, Nina Kathrine (2016). Organisering av palliative tilbud. I Kaasa, Stein & Loge, Jon Håvard (Red.), Palliasjon. Nordisk lærebok. 3. utgave. Gyldendal Akademisk. ISSN 9788205488403. s. 112–125.
• Paulsen, Ørnulf; Aass, Nina Kathrine; Klepstad, Pål & Kaasa, Stein (2015). Reply to A. Molfino et al. Journal of Clinical Oncology. ISSN 0732-183X. 33(13). doi: 10.1200/JCO.2014.60.6475.
• Kirkhus, Lene; Kristjansson, Siri Rostoft; Selbæk, Geir; Hjermstad, Marianne Jensen; Aass, Nina Kathrine & Bye, Asta [Vis alle 8 forfattere av denne artikkelen] (2013). Cancer in the elderly: prevalence and impact of age related symptoms on quality of life, treatment tolerance and survival.
• Knudsen, Anne Kari; Klepstad, Pål; Aass, Nina Kathrine; Brunelli, C; Caraceni, Augusto & Kaasa, Stein (2012). Classification and assessment of cancer pain. IASP Refresher Course Book.
• Knudsen, Anne Kari; Klepstad, Pål; Brunelli, C; Aass, Nina Kathrine; Caraceni, Augusto & Kaasa, Stein (2012). Cancer Pain Update: From Mechanisms to Treatment: Assessment & Classification.
• Knudsen, Anne Kari; Klepstad, Pål; Caraceni, Augusto; Kaasa, Stein; Brunelli, C & Aass, Nina Kathrine [Vis alle 9 forfattere av denne artikkelen] (2012). Cancer pain undertreatment and prognostic factors Response. Pain. ISSN 0304-3959. 153(8), s. 1771–1772. doi: 10.1016/j.pain.2012.03.033.
• Bergh, Irmelin; Aass, Nina Kathrine; Haugen, Dagny Faksvåg; Kaasa, Stein & Hjermstad, Marianne Jensen (2012). Symptomkartlegging i palliativ medisin. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 132, s. 18–19.
• Kolflaath, Jan; Løkken, A; Normann, Are Peder; Sætre, Liv; Hanssen, Sjur & Aass, Nina Kathrine [Vis alle 7 forfattere av denne artikkelen] (2011). Emergency admissions in palliative care may not always be appropriate. European Journal of Palliative Care. ISSN 1352-2779. s. 131–131.
• Rayment, Clare; Bennett, Michael; Aass, Nina Kathrine; Hjermstad, Marianne Jensen & Kaasa, Stein (2011). Cancer Neuropathic pain: prevalence and associated factors in the European Palliative Care Research Collaborative computerized symptom assessment study. European Journal of Palliative Care. ISSN 1352-2779. s. 230–230.
• Rayment, Clare; Bennett, Michael I; Aass, Nina Kathrine; Hjermstad, Marianne Jensen & Kaasa, Stein (2011). Performance of PainDetect for identifying cancer neuropathic pain in the European Palliative Care Research Collaborative computerized symptom assessment study. European Journal of Palliative Care. ISSN 1352-2779. s. 166–166.
• Nekolaichuk, Cheryl; Fainsinger, Robin; Aass, Nina Kathrine; Hjermstad, Marianne Jensen; Knudsen, Anne Kari & Klepstad, Pål [Vis alle 8 forfattere av denne artikkelen] (2011). The Edmonton Classification System for Cancer Pain: Comparison of Pain Classification Features Across Diverse Palliative Care Settings in Eight Countries. European Journal of Palliative Care. ISSN 1352-2779. s. 228–228.
• Bergh, Irmelin; Kvalem, Ingela Lundin; Aass, Nina Kathrine & Hjermstad, Marianne Jensen (2011). What does the answer mean? A qualitative study of how palliative cancer patients interpret and respond to the Edmonton Symptom Assessment System (ESAS). European Journal of Palliative Care. ISSN 1352-2779. s. 78–78.
• Knudsen, Anne Kari; Brunelli, C; Apolone, G.; Corli, O; Montanari, M & Fainsinger, Robin [Vis alle 11 forfattere av denne artikkelen] (2010). Content of a future classification system for cancer pain. Palliative Medicine. ISSN 0269-2163. 24(4), s. 22–23.
• Knudsen, Anne Kari; Brunelli, C; Apolone, G.; Corli, O; Montanari, M & Fainsinger, Robin [Vis alle 11 forfattere av denne artikkelen] (2010). Content of a future classification system for cancer pain.
• Knudsen, Anne Kari; Aass, Nina Kathrine; Klepstad, Pål; Heitzer, Ellen; Hjermstad, Marianne Jensen & Schippinger, Walter [Vis alle 9 forfattere av denne artikkelen] (2010). Advanced cancer patients' opinion on classification for cancer pain. Palliative Medicine. ISSN 0269-2163. 24(4).
• Knudsen, Anne Kari; Aass, Nina Kathrine; Klepstad, Pål; Heitzer, Ellen; Hjermstad, Marianne Jensen & Schippinger, Walter [Vis alle 9 forfattere av denne artikkelen] (2010). Advanced cancer patients' opinion on classification for cancer pain.
• Knudsen, Anne Kari; Brunelli, C; Apolone, G.; Corli, O; Montanari, M & Fayers, Peter [Vis alle 10 forfattere av denne artikkelen] (2010). Content of a future classification for pain.
• Hjermstad, Marianne Jensen; Fayers, Peter; Haugen, Dagny Faksvåg; Loge, Jon Håvard; Fainsinger, Robin & Hanks, Geoffrey [Vis alle 9 forfattere av denne artikkelen] (2010). Comparisons of Numerical Rating Scales (NRS), Verbal Rating Scales (VRS) and Visual Analogue Scales (VAS) for assessment of pain intensity - which is the preferred scale? Palliative Medicine. ISSN 0269-2163. 24(4).
• Knudsen, Anne Kari; Aass, Nina; Klepstad, Pål; Heitzer, Ellen; Hjermstad, Marianne Jensen & Schippinger, Walter [Vis alle 9 forfattere av denne artikkelen] (2009). Advanced cancer patients’ opinion on classification of cancer pain.
• Knudsen, Anne Kari; Aass, Nina; Fainsinger, Robin; Caraceni, Augusto; Klepstad, Pål & Jordhøy, Marit [Vis alle 8 forfattere av denne artikkelen] (2009). ”Improving assessment and classification of cancer pain - How can we improve?”.
• Sagstuen, Hege; Aass, Nina; Aass, Nina Kathrine; Fosså, Sophie D; Dahl, O & Klepp, Olbjørn [Vis alle 10 forfattere av denne artikkelen] (2005). Metabolic syndrome in long-term testicular cancer survivors. Journal of Clinical Oncology. ISSN 0732-183X. 23.

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