Pravesh Parekh

• Makowski, Carolina; Brown, Timothy T.; Zhao, Weiqi; Hagler Jr, Donald J.; Parekh, Pravesh & Garavan, Hugh [Vis alle 9 forfattere av denne artikkelen] (2024). Leveraging the adolescent brain cognitive development study to improve behavioral prediction from neuroimaging in smaller replication samples. Cerebral Cortex. ISSN 1047-3211. 34(6). doi: 10.1093/cercor/bhae223.
• Smith, Diana M.; Parekh, Pravesh; Kennedy, Joseph; Loughnan, Robert; Frei, Oleksandr & Nichols, Thomas E. [Vis alle 9 forfattere av denne artikkelen] (2024). Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components. Cerebral Cortex. ISSN 1047-3211. 34(6). doi: 10.1093/cercor/bhae234.
• Parekh, Pravesh; Fan, Chun Chieh; Frei, Oleksandr; Palmer, Clare E.; Smith, Diana M. & Makowski, Carolina [Vis alle 17 forfattere av denne artikkelen] (2024). FEMA: Fast and efficient mixed-effects algorithm for large sample whole-brain imaging data. Human Brain Mapping. ISSN 1065-9471. 45(2). doi: 10.1002/hbm.26579. Vis sammendrag

  The linear mixed-effects model (LME) is a versatile approach to account for dependence among observations. Many large-scale neuroimaging datasets with complex designs have increased the need for LME, however LME has seldom been used in whole-brain imaging analyses due to its heavy computational requirements. In this paper, we introduce a fast and efficient mixed-effects algorithm (FEMA) that makes whole-brain vertex-wise, voxel-wise, and connectome-wide LME analyses in large samples possible. We validate FEMA with extensive simulations, showing that the estimates of the fixed effects are equivalent to standard maximum likelihood estimates but obtained with orders of magnitude improvement in computational speed. We demonstrate the applicability of FEMA by studying the cross-sectional and longitudinal effects of age on region-of-interest level and vertex-wise cortical thickness, as well as connectome-wide functional connectivity values derived from resting state functional MRI, using longitudinal imaging data from the Adolescent Brain Cognitive DevelopmentSM Study release 4.0. Our analyses reveal distinct spatial patterns for the annualized changes in vertex-wise cortical thickness and connectome-wide connectivity values in early adolescence, highlighting a critical time of brain maturation. The simulations and application to real data show that FEMA enables advanced investigation of the relationships between large numbers of neuroimaging metrics and variables of interest while considering complex study designs, including repeated measures and family structures, in a fast and efficient manner. The source code for FEMA is available via: https://github.com/cmig-research-group/cmig_tools/.

• Bakken, Nora R.; Parker, Nadine; Hannigan, Laurie J.; Hagen, Espen; Parekh, Pravesh & Shadrin, Alexey [Vis alle 15 forfattere av denne artikkelen] (2023). Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders. medRxiv. doi: 10.1101/2023.11.21.23298804.
• Parker, Nadine; Cheng, Weiqiu; Hindley, Guy; Parekh, Pravesh; Shadrin, Alexey & Maximov, Ivan [Vis alle 12 forfattere av denne artikkelen] (2023). Psychiatric disorders and brain white matter exhibit genetic overlap implicating developmental and neural cell biology. Molecular Psychiatry. ISSN 1359-4184. doi: 10.1038/s41380-023-02264-z.
• Smith, Diana M.; Loughnan, Robert; Friedman, Naomi P.; Parekh, Pravesh; Frei, Oleksandr & Thompson, Wesley K. [Vis alle 10 forfattere av denne artikkelen] (2023). Heritability Estimation of Cognitive Phenotypes in the ABCD Study^® Using Mixed Models. Behavior Genetics. ISSN 0001-8244. 53(3), s. 169–188. doi: 10.1007/s10519-023-10141-2. Fulltekst i vitenarkiv
• Jaholkowski, Piotr; Shadrin, Alexey A.; Jangmo, Andreas; Frei, Evgeniia; Woldeyohannes, Markos Tesfaye & Hindley, Guy F. L. [Vis alle 23 forfattere av denne artikkelen] (2023). Associations Between Symptoms of Premenstrual Disorders and Polygenic Liability for Major Psychiatric Disorders. JAMA psychiatry. ISSN 2168-6238. 80(7), s. 738–742. doi: 10.1001/jamapsychiatry.2023.1137.
• Parekh, Pravesh; Bhalerao, Gaurav Vivek; Viswanath, Biju; Rao, Naren P.; Narayanaswamy, Janardhanan C. & Sivakumar, Palanimuthu T. [Vis alle 35 forfattere av denne artikkelen] (2022). Sample size requirement for achieving multisite harmonization using structural brain MRI features. NeuroImage. ISSN 1053-8119. 264. doi: 10.1016/j.neuroimage.2022.119768. Fulltekst i vitenarkiv

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• Birkenæs, Viktoria; Shadrin, Alexey; Parekh, Pravesh; Frei, Evgeniia; Havdahl, Alexandra & Andreassen, Ole [Vis alle 7 forfattere av denne artikkelen] (2023). Self-Reported Psychotic Experiences: Does an Unreliable Phenotypic Measure Introduce Bias in Genetic Associations?
• Birkenæs, Viktoria; Shadrin, Alexey; Frei, Evgeniia; Parekh, Pravesh; Jaholkowski, Piotr Pawel & Smeland, Olav Bjerkehagen [Vis alle 9 forfattere av denne artikkelen] (2023). Genome-Wide Analysis of Self-Reported Psychotic Experiences in the Norwegian Mother, Father, and Child study.

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