Sverre Heim

• Panagopoulos, Ioannis; Andersen, Kristin; Stavseth, Vidar; Torkildsen, Synne; Heim, Sverre & Tandsæther, Maren Randi (2024). Germline MYOF1::WNK4 and VPS25::MYOF1 Chimeras Generated by the Constitutional Translocation t(17;19)(q21;p13) in Two Siblings With Myelodysplastic Syndrome. Cancer Genomics & Proteomics. ISSN 1109-6535. 21(3), s. 272–284. doi: 10.21873/cgp.20446.
• Brunetti, Marta; Andersen, Kristin; Spetalen, Signe; Lenartova, Andrea; Osnes, Liv T. N. & Vålerhaugen, Helen [Vis alle 8 forfattere av denne artikkelen] (2024). NUP214 fusion genes in acute leukemias: genetic characterization of rare cases. Frontiers in Oncology. ISSN 2234-943X. 14. doi: 10.3389/fonc.2024.1371980.
• Panagopoulos, Ioannis; Andersen, Kristin; Johannsdottir, Inga Maria Rinvoll; Tandsæther, Maren Randi; Micci, Francesca & Heim, Sverre (2024). Genetic Characterization of Pediatric Mixed Phenotype Acute Leukemia (MPAL). Cancer Genomics & Proteomics. ISSN 1109-6535. 21(1), s. 1–11. doi: 10.21873/cgp.20424.
• Boye, Kjetil; Gorunova, Ludmila; Gunawan, Bastian; Hompland, Ivar; Sander, Bjoern & Panagopoulos, Ioannis [Vis alle 12 forfattere av denne artikkelen] (2023). Genomic Complexity as a Biomarker to De-Escalate Adjuvant Imatinib Treatment in High-Risk Gastrointestinal Stromal Tumor. JCO Precision Oncology (JCO PO). doi: 10.1200/PO.22.00351.
• Panagopoulos, Ioannis; Andersen, Kristin; Gorunova, Ludmila; Hognestad, Hanne Regine; Pedersen, Thomas Dahl & Lobmaier, Ingvild Victoria Koren [Vis alle 8 forfattere av denne artikkelen] (2023). Fusion of the Genes for Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2) and Caudal Type Homeobox 1 (CDX1) in a Chondrogenic Tumor. In Vivo. ISSN 0258-851X. 37(6), s. 2459–2463. doi: 10.21873/invivo.13352.
• Panagopoulos, Ioannis; Andersen, Kristin; Brunetti, Marta; Gorunova, Ludmila; Kostolomov, Ilya & Kildal, Wanja [Vis alle 10 forfattere av denne artikkelen] (2023). Pathogenetic Dichotomy in Angioleiomyoma. Cancer Genomics & Proteomics. ISSN 1109-6535. 20(6), s. 556–566. doi: 10.21873/cgp.20405.
• Panagopoulos, Ioannis; Andersen, Kristin; Brunetti, Marta; Gorunova, Ludmila; Davidson, Ben & Lund-Iversen, Marius [Vis alle 8 forfattere av denne artikkelen] (2023). Genetic Pathways in Peritoneal Mesothelioma Tumorigenesis. Cancer Genomics & Proteomics. ISSN 1109-6535. 20(4), s. 363–374. doi: 10.21873/cgp.20388. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Andersen, Kristin; Wik, Hilde Skuterud; Tandsæther, Maren Randi; Micci, Francesca & Heim, Sverre (2023). Acute Undifferentiated Leukemia With a Balanced t(5;10)(q35;p12) Resulting in Fusion of HNRNPH1 With MLLT10. Cancer Genomics & Proteomics. ISSN 1109-6535. 20(4), s. 354–362. doi: 10.21873/cgp.20387.
• Panagopoulos, Ioannis; Andersen, Kristin; Gorunova, Ludmila; Lund-Iversen, Marius; Lobmaier, Ingvild Victoria Koren & Micci, Francesca [Vis alle 7 forfattere av denne artikkelen] (2023). Recurrent 8q11-13 Aberrations Leading to PLAG1 Rearrangements, Including Novel Chimeras HNRNPA2B1::PLAG1 and SDCBP::PLAG1, in Lipomatous Tumors. Cancer Genomics & Proteomics. ISSN 1109-6535. 20(2), s. 171–181. doi: 10.21873/cgp.20372.
• Panagopoulos, Ioannis; Andersen, Kristin; Brunetti, Marta; Gorunova, Ludmila; Lund-Iversen, Marius & Micci, Francesca [Vis alle 7 forfattere av denne artikkelen] (2023). Fusion of the High-mobility Group AT-Hook 2 (HMGA2) and the Gelsolin (GSN) Genes in Lipomas with t(9;12)(q33;q14) Chromosomal Translocation. In Vivo. ISSN 0258-851X. 37(2), s. 524–530. doi: 10.21873/invivo.13110. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Andersen, Kristin; Gorunova, Ludmila; Hognestad, Hanne Regine; Pedersen, Thomas Dahl & Lobmaier, Ingvild Victoria Koren [Vis alle 8 forfattere av denne artikkelen] (2023). Chromosome Translocation t(10;19)(q26;q13) in a CIC-sarcoma. In Vivo. ISSN 0258-851X. 37(1), s. 57–69. doi: 10.21873/invivo.13054. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Andersen, Kristin; Johannsdottir, Inga Marie; Micci, Francesca & Heim, Sverre (2023). Novel MYCBP::EHD2 and RUNX1::ZNF780A Fusion Genes in T-cell Acute Lymphoblastic Leukemia. Cancer Genomics & Proteomics. ISSN 1109-6535. 20(1), s. 51–63. doi: 10.21873/cgp.20364.
• Panagopoulos, Ioannis; Andersen, Kristin; Gorunova, Ludmila; Davidson, Ben; Micci, Francesca & Heim, Sverre (2022). Fusion of the HMGA2 and BNC2 genes in uterine leiomyoma with t(9;12)(p22;q14). In Vivo. ISSN 0258-851X. 36(6), s. 2654–2661. doi: 10.21873/invivo.13000. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis & Heim, Sverre (2022). Neoplasia-associated Chromosome Translocations Resulting in Gene Truncation. Cancer Genomics & Proteomics. ISSN 1109-6535. 19(6), s. 647–672. doi: 10.21873/cgp.20349. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Andersen, Kristin; Gorunova, Ludmila; Davidson, Ben; Micci, Francesca & Heim, Sverre (2022). A Novel Cryptic t(2;3)(p21;q25) Translocation Fuses the WWTR1 and PRKCE Genes in Uterine Leiomyoma With 3q- as the Sole Visible Chromosome Abnormality. Cancer Genomics & Proteomics. ISSN 1109-6535. 19(5), s. 636–646. doi: 10.21873/cgp.20348. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Andersen, Kristin; Lobmaier, Ingvild Victoria Koren; Micci, Francesca & Heim, Sverre (2022). Fusion of High Mobility Group AT-hook 2 Gene (HMGA2) With the Chromosome 12 Open Reading Frame 42 Gene (C12orf42) in an Aggressive Angiomyxoma With del(12)(q14q23) as the Sole Cytogenetic Anomaly. Cancer Genomics & Proteomics. ISSN 1109-6535. 19(5), s. 576–583. doi: 10.21873/cgp.20342. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Andersen, Kristin; Gorunova, Ludmila; Eilert-Olsen, Martine; Lund-Iversen, Marius & Wessel-Aas, Trygve [Vis alle 9 forfattere av denne artikkelen] (2022). Presence of a t(12;18)(q14;q21) Chromosome Translocation and Fusion of the Genes for High-mobility Group AT-Hook 2 ( HMGA2 ) and WNT Inhibitory Factor 1 ( WIF1 ) in Infrapatellar Fat Pad Cells from a Patient With Hoffas Disease. Cancer Genomics & Proteomics. ISSN 1109-6535. 19(5), s. 584–590. doi: 10.21873/cgp.20343. Fulltekst i vitenarkiv
• Brunetti, Marta; Panagopoulos, Ioannis; Vitelli, Valeria; Andersen, Kristin; Hveem, Tarjei Sveinsgjerd & Davidson, Ben [Vis alle 10 forfattere av denne artikkelen] (2022). Endometrial Carcinoma: Molecular Cytogenetics and Transcriptomic Profile. Cancers. ISSN 2072-6694. 14:3536(14), s. 1–16. doi: 10.3390/cancers14143536. Fulltekst i vitenarkiv Vis sammendrag

  Simple Summary Endometrial carcinomas (ECs), the most frequent type of uterine body cancer, are highly heterogeneous with overlapping clinical, pathological, and molecular features. This study aimed to gain insights into these cancers’ chromosomal and genomic aberration patterns as well as their gene and miRNA expression profiles, all of which are both pathogenetically and clinically important disease features. We found that chromosome 1 was the most frequently rearranged chromosome, mostly leading to gain of 1q, that the genes PTEN, PDGFRA, PIK3CA, and KIT were the most frequent pathogenic variants, and that some other genes and miRNAs of known importance in carcinogenesis and the immune response showed consistent deregulation. This study confirms that a high degree of genetic heterogeneity characterizes EC tumors but highlights the nonrandom involvement of some loci. Abstract Endometrial carcinomas (ECs) are histologically classified as endometrioid and nonendometrioid tumors, with each subgroup displaying different molecular profiles and clinical outcomes. Considerable biological and clinical heterogeneity exists within this scheme, however, reflecting its imperfection. We aimed to gather additional data that might help clarify the tumors’ pathogenesis and contribute toward a more meaningful classification scheme. In total, 33 ECs were examined for the presence of chromosomal aberrations, genomic imbalances, pathogenic variants, microsatellite instability, and expression profiles at both gene and miRNA levels. Chromosome 1 was the most frequently rearranged chromosome, showing a gain of all or part of the long arm. Pathogenic variants were found for PTEN (53%), PDGFRA (37%), PIK3CA (34%), and KIT (31%). High microsatellite instability was identified in 15 ECs. Comparing tumors and controls, we identified 23 differentially expressed genes of known importance in carcinogenesis, 15 genes involved in innate and adaptative immune responses, and altered expression of 7 miRNAs. miR-32-5p was the most upregulated. Our series showed a high degree of heterogeneity. Tumors were well-separated from controls, but there was no clear-cut separation between endometrioid and nonendometrioid ECs. Whether this means that the current phenotypic classification is of little relevance or if one still has not detected which genomic parameters to enter into correlation analyses remains unknown. Keywords: endometrial carcinoma; karyotype; chromosome 1; mutation analysis; microsatellite instability; gene expression; cancer pathways; cancer immune profile; miRNA

• Panagopoulos, Ioannis; Gorunova, Ludmila; Andersen, Kristin; Lund-Iversen, Marius; Hognestad, Hanne Regine & Lobmaier, Ingvild Victoria Koren [Vis alle 8 forfattere av denne artikkelen] (2022). Chromosomal Translocation t(5;12)(p13;q14) Leading to Fusion of High-mobility Group AT-hook 2 Gene With Intergenic Sequences From Chromosome Sub-Band 5p13.2 in Benign Myoid Neoplasms of the Breast: A Second Case. Cancer Genomics & Proteomics. ISSN 1109-6535. 19(4), s. 445–455. doi: 10.21873/cgp.20331. Fulltekst i vitenarkiv
• Gorunova, Ludmila; Pedersen, Kjetil Boye; Panagopoulos, Ioannis; Berner, Jeanne-Marie; Bjerkehagen, Bodil & Hompland, Ivar [Vis alle 11 forfattere av denne artikkelen] (2022). Cytogenetic and molecular analyses of 291 gastrointestinal stromal tumors: site-specific cytogenetic evolution as evidence of pathogenetic heterogeneity. OncoTarget. ISSN 1949-2553. 13(1), s. 508–517. doi: 10.18632/ONCOTARGET.28209. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Andersen, Kristin; Gorunova, Ludmila; Lund-Iversen, Marius; Lobmaier, Ingvild Victoria Koren & Heim, Sverre (2022). Recurrent Fusion of the Genes for High-mobility Group AT-hook 2 (HMGA2) and Nuclear Receptor Co-repressor 2 (NCOR2) in Osteoclastic Giant Cell-rich Tumors of Bone. Cancer Genomics & Proteomics. ISSN 1109-6535. 19(2), s. 163–177. doi: 10.21873/cgp.20312.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Andersen, Kristin; Lobmaier, Ingvild Victoria Koren & Heim, Sverre (2021). Several fusion genes identified in a spermatic cord leiomyoma with rearrangements of chromosome arms 3p and 21q. Cancer Genomics & Proteomics. ISSN 1109-6535. 18(4), s. 531–532. doi: 10.21873/CGP.20278.
• Panagopoulos, Ioannis; Andersen, Kristin; Eilert-Olsen, Martine; Rognlien, Anne Gro Wesenberg; Munthe-Kaas, Monica Cheng & Micci, Francesca [Vis alle 7 forfattere av denne artikkelen] (2021). Rare KMT2A-ELL and novel ZNF56-KMT2A fusion genes in pediatric T-cell acute lymphoblastic leukemia. Cancer Genomics & Proteomics. ISSN 1109-6535. 18(2), s. 121–131. doi: 10.21873/CGP.20247.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Andersen, Kristin; Lund-Iversen, Marius; Tafjord, Svetlana & Micci, Francesca [Vis alle 7 forfattere av denne artikkelen] (2021). Fusion of the Paired Box 3 (PAX3) and Myocardin (MYOCD) Genes in Pediatric Rhabdomyosarcoma. Cancer Genomics & Proteomics. ISSN 1109-6535. 18(6), s. 723–734. doi: 10.21873/cgp.20293. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis & Heim, Sverre (2021). Interstitial deletions generating fusion genes. Cancer Genomics & Proteomics. ISSN 1109-6535. 18(3), s. 167–196. doi: 10.21873/CGP.20251. Fulltekst i vitenarkiv
• PANAGOPOULOS, IOANNIS; GORUNOVA, LUDMILA; Lund-Iversen, Marius & Heim, Sverre (2021). Monosomy 13 in mammary myofibroblastoma. Anticancer Research. ISSN 0250-7005. 41(8), s. 3747–3751. doi: 10.21873/anticanres.15166. Fulltekst i vitenarkiv Vis sammendrag

  Background/Aim: Myofibroblastoma of the breast is a rare benign mesenchymal tumor whose morphology is similar to that of spindle-cell lipoma. The few hitherto genetically investigated mammary myofibroblastomas have been shown to have had loss of material from chromosome 13, changes that are also common in spindle-cell lipoma. Our aim was to add to the existing knowledge of genetic aberrations in mammary myofibroblastoma by investigating another such tumor. Materials and Methods: Cytogenetic and array comparative genome hybridization (aCGH) analyses were performed on a surgically removed mammary myofibroblastoma from a 76-year-old man. Results: Short-term cultured cells from the tumor showed the karyotype 45,XY,-13[3]/44~45,idem,add(19)(q13)[cp2]. aCGH detected loss of one entire chromosome 13 and heterozygous loss from 19q between sub-band 19q13.12 and 19qter. Conclusion: These findings add to the evidence that loss of 13q material is typical of mammary myofibroblastomas.

• Panagopoulos, Ioannis; Andersen, Kristin; Ramslien, Lloyd Frode; Ikonomou, Ida Merete Münster; Micci, Francesca & Heim, Sverre (2021). Therapy-related myeloid leukemia with the translocation t(8;19)(p11;q13) leading to a KAT6A-LEUTX fusion gene. Anticancer Research. ISSN 0250-7005. 41(4), s. 1753–1760. doi: 10.21873/anticanres.14940. Fulltekst i vitenarkiv Vis sammendrag

  Background/aim: The chromosome translocation t(8;19)(p11;q13) has been reported in only six acute myeloid leukemia (AML) patients. We here present the genetic and clinical features of the seventh AML case with this aberration. Materials and methods: Cytogenetic and molecular genetic investigations were performed on leukemic bone marrow cells from a patient with therapy-related AML. Results: A t(8;19)(p11;q13) was found leading to an in-frame fusion of exon 16 of the lysine acetyltransferase 6A gene (KAT6A) from 8p11 with exon 2 of the leucine twenty homeobox gene (LEUTX) from 19q13 resulting in expression of the otherwise silent LEUTX gene in the leukemic cells. The KAT6A-LEUTX protein is predicted to act as a histone acetyltransferase at its amino-terminal-KAT6A moiety but as a homeobox transcription factor at the LEUTX-carboxyl-terminal moiety. Conclusion: The present case is the second therapy-related AML, and the third AML overall, in which both a t(8;19)(p11;q13) and its molecular result, a KAT6A-LEUTX fusion gene, are described. The t(8;19)(p11;q13)/KAT6A-LEUTX deregulates transcription and induces leukemogenesis.

• Micci, Francesca; Heim, Sverre & Panagopoulos, Ioannis (2021). Molecular pathogenesis and prognostication of "low-grade'' and "high-grade" endometrial stromal sarcoma. Genes, Chromosomes and Cancer. ISSN 1045-2257. 60(3), s. 160–167. doi: 10.1002/gcc.22907. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Andersen, Kristin; Eilert-Olsen, Martine; Zeller, Bernward; Munthe-Kaas, Monica Cheng & Buechner, Jochen [Vis alle 9 forfattere av denne artikkelen] (2021). Therapy-induced deletion in 11q23 leading to fusion of KMT2A with ARHGEF12 and development of B lineage acute lymphoplastic leukemia in a child treated for acute myeloid leukemia caused by t(9;11)(p21;q23)/ KMT2A-MLLT3. Cancer Genomics & Proteomics. ISSN 1109-6535. 18(1), s. 67–81. doi: 10.21873/CGP.20242. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Andersen, Kristin; Lund-Iversen, Marius; Lobmaier, Ingvild Victoria Koren & Micci, Francesca [Vis alle 7 forfattere av denne artikkelen] (2020). NDRG1-PLAG1 and TRPS1-PLAG1 fusion genes in chondroid syringoma. Cancer Genomics & Proteomics. ISSN 1109-6535. 17(3), s. 237–248. doi: 10.21873/cgp.20184. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Lobmaier, Ingvild Victoria Koren; Andersen, Kristin; Lund-Iversen, Marius & Micci, Francesca [Vis alle 7 forfattere av denne artikkelen] (2020). Fusion of the COL4A5 gene with NR2F2-AS1 in a hemangioma carrying a t(X;15)(q22;q26) chromosomal translocation. Cancer Genomics & Proteomics. ISSN 1109-6535. 17(4), s. 383–390. doi: 10.21873/cgp.20197. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Rise, Tor Vikan; Andersen, Kristin; Micci, Francesca & Heim, Sverre (2020). An Unbalanced Chromosome Translocation Between 7p22 and 12q13 Leads to ACTB-GLI1 Fusion in Pericytoma. Anticancer Research. ISSN 0250-7005. 40(3), s. 1239–1245. doi: 10.21873/anticanres.14065. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Lobmaier, Ingvild Victoria Koren; Andersen, Kristin; Kostolomov, Ilya & Lund-Iversen, Marius [Vis alle 8 forfattere av denne artikkelen] (2020). FOS-ANKH and FOS-RUNX2 fusion genes in osteoblastoma. Cancer Genomics & Proteomics. ISSN 1109-6535. 17(2), s. 161–168. doi: 10.21873/cgp.20176. Fulltekst i vitenarkiv
• Brunetti, Marta; Zeller, Bernward; Tierens, Anne; Heim, Sverre; Micci, Francesca & Panagopoulos, Ioannis (2020). TYRO3 truncation resulting from a t(10;15)(p11;q15) chromosomal translocation in pediatric acute myeloid leukemia. Anticancer Research. ISSN 0250-7005. 40(11), s. 6115–6121. doi: 10.21873/anticanres.14632. Fulltekst i vitenarkiv
• Jeanmougin, Marine; Håvik, Annette Bentsen; Cekaite, Lina; Brandal, Petter; Sveen, Anita & Meling, Torstein Ragnar [Vis alle 11 forfattere av denne artikkelen] (2020). Improved prognostication of glioblastoma beyond molecular subtyping by transcriptional profiling of the tumor microenvironment. Molecular Oncology. ISSN 1574-7891. s. 1016–1027. doi: 10.1002/1878-0261.12668. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Kostolomov, Ilya; Lobmaier, Ingvild Victoria Koren; Bjerkehagen, Bodil & Heim, Sverre (2020). Chronic expanding hematoma with a t(11;19)(q13;q13) chromosomal translocation. Anticancer Research. ISSN 0250-7005. 40(1), s. 97–100. doi: 10.21873/anticanres.13930. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Andersen, Kristin; Tafjord, Svetlana; Lund-Iversen, Marius & Lobmaier, Ingvild Victoria Koren [Vis alle 8 forfattere av denne artikkelen] (2020). Recurrent fusion of the GRB2 associated binding protein 1 (GAB1) gene with ABL proto-oncogene 1 (ABL1) in benign pediatric soft tissue tumors. Cancer Genomics & Proteomics. ISSN 1109-6535. 17(5), s. 499–508. doi: 10.21873/CGP.20206. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Andersen, Kristin; Lobmaier, Ingvild Victoria Koren; Lund-Iversen, Marius & Micci, Francesca [Vis alle 7 forfattere av denne artikkelen] (2020). Fusion of the Lumican (LUM) Gene with the Ubiquitin Specific Peptidase 6 (USP6) Gene in an Aneurysmal Bone Cyst Carrying a t(12;17)(q21;p13) Chromosome Translocation. Cancer Genomics & Proteomics. ISSN 1109-6535. 17(5), s. 555–561. doi: 10.21873/CGP.20211. Fulltekst i vitenarkiv
• Gorunova, Ludmila; Bjerkehagen, Bodil; Micci, Francesca; Heim, Sverre & Panagopoulos, Ioannis (2020). Cytogenetic and Molecular Study of an Adult Sclerosing Rhabdomyosarcoma of the Extremity: MYOD1-mutation and Clonal Evolution. Cancer Genomics & Proteomics. ISSN 1109-6535. 17(5), s. 563–569. doi: 10.21873/CGP.20212. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Johannsdottir, Inga Maria Rinvoll; Andersen, Kristin; Holth, Arild & Beiske, Klaus [Vis alle 7 forfattere av denne artikkelen] (2020). Chromosome Translocation t(14;21)(q11;q22) Activates Both OLIG1 and OLIG2 in Pediatric T-cell Lymphoblastic Malignancies and May Signify Adverse Prognosis. Cancer Genomics & Proteomics. ISSN 1109-6535. 17(1), s. 41–48. doi: 10.21873/cgp.20166. Fulltekst i vitenarkiv
• Brunetti, Marta; Panagopoulos, Ioannis; Kostolomov, Ilya; Davidson, Ben; Heim, Sverre & Micci, Francesca (2020). Mutation analysis and genomic imbalances of cells found in effusion fluids from patients with ovarian cancer. Oncology Letters. ISSN 1792-1074. 20(3), s. 2273–2279. doi: 10.3892/ol.2020.11782. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Andersen, Hege Kilen; Pedersen, Thomas Dahl; Lømo, Jon & Lund-Iversen, Marius [Vis alle 8 forfattere av denne artikkelen] (2019). Genetic characterization of myoid hamartoma of the breast. Cancer Genomics & Proteomics. ISSN 1109-6535. 16(6), s. 563–568. doi: 10.21873/cgp.20158. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Lund-Iversen, Marius; Bassarova, Assia Vassileva & Heim, Sverre (2019). Fusion of the genes PHF1 and TFE3 in malignant chondroid syringoma. Cancer Genomics & Proteomics. ISSN 1109-6535. 16(5), s. 345–351. doi: 10.21873/cgp.20139. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Lobmaier, Ingvild Victoria Koren; Lund-Iversen, Marius; Andersen, Kristin & Holth, Arild [Vis alle 8 forfattere av denne artikkelen] (2019). Fusion of the COL1A1 and Fyn genes in epithelioid osteoblastoma. Cancer Genomics & Proteomics. ISSN 1109-6535. 16(5), s. 361–368. doi: 10.21873/cgp.20141. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Lobmaier, Ingvild Victoria Koren; Gorunova, Ludmila & Heim, Sverre (2019). Fusion of the Genes WWTR1 and FOSB in Pseudomyogenic Hemangioendothelioma. Cancer Genomics & Proteomics. ISSN 1109-6535. 16(4), s. 293–298. doi: 10.21873/cgp.20134.
• Brunetti, Marta; Agostini, Antonio; Staurseth, Julie; Davidson, Ben; Heim, Sverre & Micci, Francesca (2019). Molecular characterization of carcinosarcomas arising in the uterus and ovaries. OncoTarget. ISSN 1949-2553. 10(38), s. 3614–3624. doi: 10.18632/oncotarget.26942. Fulltekst i vitenarkiv
• Torkildsen, Synne; Gorunova, Ludmila; Heim, Sverre; Tjønnfjord, Geir Erland; Spetalen, Signe & Risberg, Bente [Vis alle 8 forfattere av denne artikkelen] (2019). Molecular Genetic Characterization of Acute Myeloid Leukemia With Trisomy 4 as the Sole Chromosome Abnormality. Cancer Genomics & Proteomics. ISSN 1109-6535. 16(3), s. 175–178. doi: 10.21873/cgp.20123. Fulltekst i vitenarkiv
• Johannessen, Lene Elisabeth; Brandal, Petter; Myklebust, Tor Åge; Heim, Sverre; Micci, Francesca & Panagopoulos, Ioannis (2018). MGMT gene promoter methylation status - Assessment of two pyrosequencing kits and three methylation-specific PCR methods for their predictive capacity in glioblastomas. Cancer Genomics & Proteomics. ISSN 1109-6535. 15(6), s. 437–446. doi: 10.21873/cgp.20102. Fulltekst i vitenarkiv
• Agostini, Antonio; Brunetti, Marta; Davidson, Ben; Tropé, Claes Gøran; Heim, Sverre & Panagopoulos, Ioannis [Vis alle 7 forfattere av denne artikkelen] (2018). Identification of novel cyclin gene fusion transcripts in endometrioid ovarian carcinomas. International Journal of Cancer. ISSN 0020-7136. 143(6), s. 1379–1387. doi: 10.1002/ijc.31418. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Leske, Henning; Niehusmann, Pitt; Johannessen, Lene Elisabeth & Staurseth, Julie [Vis alle 11 forfattere av denne artikkelen] (2018). Pyrosequencing analysis of MGMT promoter methylation in meningioma. Cancer Genomics & Proteomics. ISSN 1109-6535. 15(5), s. 379–385. doi: 10.21873/cgp.20096. Fulltekst i vitenarkiv
• Agostini, Antonio; Brunetti, Marta; Davidson, Ben; Tropé, Claes Gøran; Eriksson, Ane Gerda Zahl & Heim, Sverre [Vis alle 8 forfattere av denne artikkelen] (2018). The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas. Scientific Reports. ISSN 2045-2322. 8. doi: 10.1038/s41598-018-29332-7. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Lund-Iversen, Marius; Andersen, Kristin; Andersen, Hege Kilen & Lobmaier, Ingvild Victoria Koren [Vis alle 8 forfattere av denne artikkelen] (2018). Cytogenetics of spindle cell/pleomorphic lipomas: Karyotyping and fish analysis of 31 tumors. Cancer Genomics & Proteomics. ISSN 1109-6535. 15(3), s. 193–200. doi: 10.21873/cgp.20077. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Andersen, Kristin; Lobmaier, Ingvild Victoria Koren; Bjerkehagen, Bodil & Heim, Sverre (2018). Consistent involvement of chromosome 13 in angiolipoma. Cancer Genomics & Proteomics. ISSN 1109-6535. 15(1), s. 61–65. doi: 10.21873/cgp.20065. Fulltekst i vitenarkiv
• Brunetti, Marta; Gorunova, Ludmila; Davidson, Ben; Heim, Sverre; Panagopoulos, Ioannis & Micci, Francesca (2018). Identification of an EPC2-PHF1 fusion transcript in low-grade endometrial stromal sarcoma. OncoTarget. ISSN 1949-2553. 9(27), s. 19203–19208. doi: 10.18632/oncotarget.24969. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Jacobsen, Eva-Marie; Andersen, Kristin; Micci, Francesca & Heim, Sverre (2018). RUNX1-PDCD6 fusion resulting from a novel t(5;21)(p15;q22) chromosome translocation in myelodysplastic syndrome secondary to chronic lymphocytic leukemia. PLOS ONE. ISSN 1932-6203. 13(4). doi: 10.1371/journal.pone.0196181. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Andersen, Hege Kilen; Bergrem, Astrid; Dahm, Anders Erik A & Andersen, Kristin [Vis alle 8 forfattere av denne artikkelen] (2018). PAN3-PSMA2 fusion resulting from a novel t(7;13)(p14;q12) chromosome translocation in a myelodysplastic syndrome that evolved into acute myeloid leukemia. Experimental hematology and oncology. ISSN 2162-3619. 7(7). doi: 10.1186/s40164-018-0099-4. Fulltekst i vitenarkiv
• Panagopoulos, Ioannis; Gorunova, Ludmila; Torkildsen, Synne; Tjønnfjord, Geir Erland; Micci, Francesca & Heim, Sverre (2017). DEK-NUP214-fusion identified by RNA-sequencing of an acute myeloid leukemia with t(9;12)(q34;q15). Cancer Genomics & Proteomics. ISSN 1109-6535. 14(6), s. 437–443. doi: 10.21873/CGP.20053.
• Brunetti, Marta; Panagopoulos, Ioannis; Gorunova, Ludmila; Davidson, Ben; Heim, Sverre & Micci, Francesca (2017). RNA-sequencing identifies novel GREB1-NCOA2 fusion gene in a uterine sarcoma with the chromosomal translocation t(2;8)(p25;q13). Genes, Chromosomes and Cancer. ISSN 1045-2257. 57(4), s. 176–181. doi: 10.1002/gcc.22518. Vis sammendrag

  Sarcomas account for 3% of all uterine malignancies and many of them are characterized by acquired, specific fusion genes whose detection has increased pathogenetic knowledge and diagnostic precision. We describe a novel fusion gene, GREB1-NCOA2, detected by transcriptome sequencing and validated by reverse transcriptase polymerase chain reaction and Sanger sequencing in an undifferentiated uterine sarcoma. The chimeric transcript was an in-frame fusion between exon 3 of GREB1 and exon 15 of NCOA2. The fusion is reported here for the first time, but it involves the GREB1 gene, an important promoter of tumor growth and progression, and NCOA2 which is known to be involved in transcriptional regulation. The alteration and recombination of these genes played a role in the tumorigenesis and/or progression of this sarcoma.

• Panagopoulos, Ioannis; Gorunova, Ludmila; Spetalen, Signe; Bassarova, Assia Vassileva; Beiske, Klaus & Micci, Francesca [Vis alle 7 forfattere av denne artikkelen] (2017). Fusion of the genes ataxin 2 like, ATXN2L, and Janus kinase 2, JAK2, in cutaneous CD4 positive T-cell lymphoma. OncoTarget. ISSN 1949-2553. 8(61), s. 103775–103784. doi: 10.18632/oncotarget.21790.
• Micci, Francesca; Brunetti, Marta; Dal Cin, Paola; Nucci, Marisa R.; Gorunova, Ludmila & Heim, Sverre [Vis alle 7 forfattere av denne artikkelen] (2017). Fusion of the genes BRD8 and PHF1 in endometrial stromal sarcoma. Genes, Chromosomes and Cancer. ISSN 1045-2257. 56(12), s. 841–845. doi: 10.1002/gcc.22485.
• Smebye, Marianne Lislerud; Agostini, Antonio; Johannessen, Bjarne; Thorsen, Jim; Davidson, Ben & Tropé, Claes Gøran [Vis alle 9 forfattere av denne artikkelen] (2017). Involvement of DPP9 in gene fusions in serous ovarian carcinoma. BMC Cancer. ISSN 1471-2407. 17(1). doi: 10.1186/s12885-017-3625-6.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Lobmaier, Ingvild Victoria Koren; Andersen, Hege Kilen; Bjerkehagen, Bodil & Heim, Sverre (2017). Cytogenetic analysis of a pseudoangiomatous pleomorphic/spindle cell lipoma. Anticancer Research. ISSN 0250-7005. 37(5), s. 2219–2223. doi: 10.21873/anticanres.11557.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Brunetti, Marta; Agostini, Antonio; Andersen, Hege Kilen & Lobmaier, Ingvild Victoria Koren [Vis alle 8 forfattere av denne artikkelen] (2017). Genetic heterogeneity in leiomyomas of deep soft tissue. OncoTarget. ISSN 1949-2553. 8(30), s. 48769–48781. doi: 10.18632/oncotarget.17953.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Lobmaier, Ingvild Victoria Koren; Bjerkehagen, Bodil & Heim, Sverre (2017). Identification of SETD2-NF1 fusion gene in a pediatric spindle cell tumor with the chromosomal translocation t(3;17)(p21;q12). Oncology Reports. ISSN 1021-335X. 37(6), s. 3181–3188. doi: 10.3892/or.2017.5628.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Lobmaier, Ingvild Victoria Koren; Bjerkehagen, Bodil & Heim, Sverre (2017). Karyotyping and analysis of GNAS locus in intramuscular myxomas. OncoTarget. ISSN 1949-2553. 8(13), s. 22086–22094. doi: 10.18632/oncotarget.14986.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Torkildsen, Synne; Tierens, Anne; Heim, Sverre & Micci, Francesca (2017). FAM53B truncation caused by t(10;19)(q26;q13) chromosome translocation in acute lymphoblastic leukemia. Oncology Letters. ISSN 1792-1074. 13(4), s. 2216–2220. doi: 10.3892/ol.2017.5705.
• Torkildsen, Synne; Brunetti, Marta; Gorunova, Ludmila; Spetalen, Signe; Beiske, Klaus & Heim, Sverre [Vis alle 7 forfattere av denne artikkelen] (2017). Rearrangement of the chromatin organizer special AT-rich binding protein 1 gene, SATB1, resulting from a t(3;5)(p24;q14) chromosomal translocation in acute myeloid leukemia. Anticancer Research. ISSN 0250-7005. 37(2), s. 693–698. doi: 10.21873/anticanres.11365.
• Agostini, Antonio; Brunetti, Marta; Davidson, Ben; Tropé, Claes Gøran; Heim, Sverre & Panagopoulos, Ioannis [Vis alle 7 forfattere av denne artikkelen] (2017). Genomic imbalances are involved in miR-30c and let-7a deregulation in ovarian tumors: Implications for HMGA2 expression. OncoTarget. ISSN 1949-2553. 8(13), s. 21554–21560. doi: 10.18632/oncotarget.15795.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Bjerkehagen, Bodil; Andersen, Kristin; Lund-Iversen, Marius & Heim, Sverre (2017). Loss of chromosome 13 material in cellular angiofibromas indicates pathogenetic similarity with spindle cell lipomas. Diagnostic Pathology. ISSN 1746-1596. 12:17, s. 1–5. doi: 10.1186/s13000-017-0607-6.
• Brunetti, Marta; Agostini, Antonio; Davidson, Ben; Tropé, Claes Gøran; Heim, Sverre & Panagopoulos, Ioannis [Vis alle 7 forfattere av denne artikkelen] (2017). Recurrent fusion transcripts in squamous cell carcinomas of the vulva. OncoTarget. ISSN 1949-2553. 8(10), s. 16843–16850. doi: 10.18632/oncotarget.15167.
• Smebye, Marianne Lislerud; Haugom, Lisbeth; Davidson, Ben; Tropé, Claes Gøran; Heim, Sverre & Skotheim, Rolf I. [Vis alle 7 forfattere av denne artikkelen] (2017). Bilateral ovarian carcinomas differ in the expression of metastasis-related genes. Oncology Letters. ISSN 1792-1074. 13(1), s. 184–190. doi: 10.3892/ol.2016.5384.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Lund-Iversen, Marius; Lobmaier, Ingvild Victoria Koren; Bjerkehagen, Bodil & Heim, Sverre (2016). Recurrent fusion of the genes FN1 and ALK in gastrointestinal leiomyomas. Modern Pathology. ISSN 0893-3952. 29(11), s. 1415–1423. doi: 10.1038/modpathol.2016.129.
• Agostini, Antonio; Brunetti, Marta; Davidson, Ben; Tropé, Claes Gøran; Heim, Sverre & Panagopoulos, Ioannis [Vis alle 7 forfattere av denne artikkelen] (2016). Expressions of miR-30c and let-7α are inversely correlated with HMGA2 expression in squamous cell carcinoma of the vulva. OncoTarget. ISSN 1949-2553. 7(51), s. 85058–85062. doi: 10.18632/oncotarget.13187.
• Olsen, Thale Kristin; Panagopoulos, Ioannis; Gorunova, Ludmila; Micci, Francesca; Andersen, Kristin & Andersen, Hege Kilen [Vis alle 11 forfattere av denne artikkelen] (2016). Novel fusion genes and chimeric transcripts in ependymal tumors. Genes, Chromosomes and Cancer. ISSN 1045-2257. 55(12), s. 944–953. doi: 10.1002/gcc.22392. Vis sammendrag

  We have previously identified two ALK rearrangements in a subset of ependymal tumors using a combination of cytogenetic data and RNA sequencing. The aim of this study was to perform an unbiased search for fusion transcripts in our entire series of ependymal tumors. Fusion analysis was performed using the FusionCatcher algorithm on 12 RNA-sequenced ependymal tumors. Candidate transcripts were prioritized based on the software's filtering and manual visualization using the BLAST (Basic Local Alignment Search Tool) and BLAT (BLAST-like alignment tool) tools. Genomic and reverse transcriptase PCR with subsequent Sanger sequencing was used to validate the potential fusions. Fluorescent in situ hybridization (FISH) using locus-specific probes was also performed. A total of 841 candidate chimeric transcripts were identified in the 12 tumors, with an average of 49 unique candidate fusions per tumor. After algorithmic and manual filtering, the final list consisted of 24 potential fusion events. Raw RNA-seq read sequences and PCR validation supports two novel fusion genes: a reciprocal fusion gene involving UQCR10 and C1orf194 in an adult spinal ependymoma and a TSPAN4-CD151 fusion gene in a pediatric infratentorial anaplastic ependymoma. Our previously reported ALK rearrangements and the RELA and YAP1 fusions found in supratentorial ependymomas were until now the only known fusion genes present in ependymal tumors. The chimeric transcripts presented here are the first to be reported in infratentorial or spinal ependymomas. Further studies are required to characterize the genomic rearrangements causing these fusion genes, as well as the frequency and functional importance of the fusions. © 2016 Wiley Periodicals, Inc

• Johannessen, Lene Elisabeth; Panagopoulos, Ioannis; Haugvik, Sven-Petter; Gladhaug, Ivar Prydz; Heim, Sverre & Micci, Francesca (2016). Upregulation of INS-IGF2 read-through expression and identification of a novel INS-IGF2 splice variant in insulinomas. Oncology Reports. ISSN 1021-335X. 36(5), s. 2653–2662. doi: 10.3892/or.2016.5132.
• Panagopoulos, Ioannis; Torkildsen, Synne; Gorunova, Ludmila; ULVMOEN, AINA; Tierens, Anne & Zeller, Bernward [Vis alle 7 forfattere av denne artikkelen] (2016). RUNX1 truncation resulting from a cryptic and novel t(6;21)(q25;q22) chromosome translocation in acute myeloid leukemia: A case report. Oncology Reports. ISSN 1021-335X. 36(5), s. 2481–2488. doi: 10.3892/or.2016.5119. Vis sammendrag

  Fluorescence in situ hybridization examination of a pediatric AML patient whose bone marrow cells carried trisomy 4 and FLT3-ITD mutation, demonstrated that part of the RUNX1 probe had unexpectedly moved to chromosome band 6q25 indicating a cryptic t(6;21)(q25;q22) translocation. RNA sequencing showed fusion of exon 7 of RUNX1 with an intergenic sequence of 6q25 close to the MIR1202 locus, something that was verified by RT-PCR together with Sanger sequencing. The RUNX1 fusion transcript encodes a truncated protein containing the Runt homology domain responsible for both heterodimerization with CBFB and DNA binding, but lacking the proline-, serine-, and threonine-rich (PST) region which is the transcription activation domain at the C terminal end. Which genetic event (+4, FLT3-ITD, t(6;21)-RUNX1 truncation or other, undetected acquired changes) was more pathogenetically important in the present case of AML, remains unknown. The case illustrates that submicroscopic chromosomal rearrangements may accompany visible numerical changes and perhaps should be actively looked for whenever a single trisomy is found. An active search for them may provide both pathogenetic and prognostic novel information.

• Panagopoulos, Ioannis; Gorunova, Ludmila; Viset, Trond & Heim, Sverre (2016). Gene fusions AHRR-NCOA2, NCOA2-ETV4, ETV4-AHRR, P4HA2-TBCK, and TBCK-P4HA2 resulting from the translocations t(5;8;17)(p15;q13;q21) and t(4;5)(q24;q31) in a soft tissue angiofibroma. Oncology Reports. ISSN 1021-335X. 36(5), s. 2455–2462. doi: 10.3892/or.2016.5096. Vis sammendrag

  We present an angiofibroma of soft tissue with the karyotype 46,XY,t(4;5)(q24;q31),t(5;8;17)(p15;q13;q21)[8]/46,XY,t(1;14)(p31;q32)[2]/46,XY[3]. RNA‑sequencing showed that the t(4;5)(q24;q31) resulted in recombination of the genes TBCK on 4q24 and P4HA2 on 5q31.1 with generation of an in‑frame TBCK‑P4HA2 and the reciprocal but out‑of‑frame P4HA2‑TBCK fusion transcripts. The putative TBCK‑P4HA2 protein would contain the kinase, the rhodanese‑like domain, and the Tre‑2/Bub2/Cdc16 (TBC) domains of TBCK together with the P4HA2 protein which is a component of the prolyl 4‑hydroxylase. The t(5;8;17)(p15;q13;q21) three‑way chromosomal translocation targeted AHRR (on 5p15), NCOA2 (on 8q13), and ETV4 (on 17q21) generating the in‑frame fusions AHRR‑NCOA2 and NCOA2‑ETV4 as well as an out‑of‑frame ETV4‑AHRR transcript. In the AHRR‑NCOA2 protein, the C‑terminal part of AHRR is replaced by the C‑terminal part of NCOA2 which contains two activation domains. The NCOA2‑ETV4 protein would contain the helix‑loop‑helix, PAS_9 and PAS_11, CITED domains, the SRC‑1 domain of NCOA2 and the ETS DNA‑binding domain of ETV4. No fusion gene corresponding to t(1;14)(p31;q32) was found. Our findings indicate that, in spite of the recurrence of AHRR‑NCOA2 in angiofibroma of soft tissue, additional genetic events (or fusion genes) might be required for the development of this tumor.

• Haugvik, Sven-Petter; Vodak, Daniel; Haugom, Lisbeth; Hovig, Johannes Eivind; Gladhaug, Ivar Prydz & Heim, Sverre [Vis alle 7 forfattere av denne artikkelen] (2016). Transcriptomic Profiling of Tumor Aggressiveness in Sporadic Nonfunctioning Pancreatic Neuroendocrine Neoplasms. Pancreas. ISSN 0885-3177. 45(8), s. 1196–1203. doi: 10.1097/MPA.0000000000000610.
• Micci, Francesca; Gorunova, Ludmila; Agostini, Antonio; Johannessen, Lene Elisabeth; Brunetti, Marta & Davidson, Ben [Vis alle 8 forfattere av denne artikkelen] (2016). Cytogenetic and molecular profile of endometrial stromal sarcoma. Genes, Chromosomes and Cancer. ISSN 1045-2257. 55(11), s. 834–846. doi: 10.1002/gcc.22380.
• Agostini, Antonio; Gorunova, Ludmila; Bjerkehagen, Bodil; Lobmaier, Ingvild Victoria Koren; Heim, Sverre & Panagopoulos, Ioannis (2016). Molecular characterization of the t(4;12)(q27~28;q14~15) chromosomal rearrangement in lipoma. Oncology Letters. ISSN 1792-1074. 12(3), s. 1701–1704. doi: 10.3892/ol.2016.4834.
• Hastings, Rosalind J.; Bown, Nick; Tibiletti, Maria G.; Debiec-Rychter, Maria; Vanni, Roberta & Espinet, Blanca [Vis alle 19 forfattere av denne artikkelen] (2016). Guidelines for cytogenetic investigations in tumours. European Journal of Human Genetics. ISSN 1018-4813. 24(1), s. 6–13. doi: 10.1038/ejhg.2015.35.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Kerndrup, Gitte; Spetalen, Signe; Tierens, Anne & Osnes, Liv T. N. [Vis alle 11 forfattere av denne artikkelen] (2016). Rare MLL-ELL fusion transcripts in childhood acute myeloid leukemia-association with young age and myeloid sarcomas? Experimental hematology and oncology. ISSN 2162-3619. 5:8. doi: 10.1186/s40164-016-0037-2. Vis sammendrag

  Background The chromosomal translocation t(11;19)(q23;p13) with a breakpoint within subband 19p13.1 is found mainly in acute myeloid leukemia (AML) and results in the MLL-ELL fusion gene. Variations in the structure of MLL-ELL seem to influence the leukemogenic potency of the fusion in vivo and may lie behind differences in clinical features. The number of cases reported so far is very limited and the addition of more information about MLL-ELL variants is essential if the possible clinical significance of rare fusions is to be determined. Case presentation Cytogenetic and molecular genetic analyses were done on the bone marrow cells of a 20-month-old boy with an unusual form of myelomonocytic AML with multiple myeloid sarcomas infiltrating bone and soft tissues. The G-banding analysis together with FISH yielded the karyotype 47,XY, +6,t(8;19;11)(q24;p13;q23). FISH analysis also demonstrated that MLL was split. RNA-sequencing showed that the translocation had generated an MLL-ELL chimera in which exon 9 of MLL (nt 4241 in sequence with accession number NM_005933.3) was fused to exon 6 of ELL (nt 817 in sequence with accession number NM_006532.3). RT-PCR together with Sanger sequencing verified the presence of the above-mentioned fusion transcript. Conclusions Based on our findings and information on a few previously reported patients, we speculate that young age, myelomonoblastic AML, and the presence of extramedullary disease may be typical of children with rare MLL-ELL fusion transcripts.

• Agostini, Antonio; Panagopoulos, Ioannis; Davidson, Ben; Tropé, Claes Gøran; Heim, Sverre & Micci, Francesca (2016). A novel truncated form of HMGA2 in tumors of the ovaries. Oncology Letters. ISSN 1792-1074. 12(2), s. 1559–1563. doi: 10.3892/ol.2016.4805.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Agostini, Antonio; Lobmaier, Ingvild Victoria Koren; Bjerkehagen, Bodil & Heim, Sverre (2016). Fusion of the HMGA2 and C9orf92 genes in myolipoma with t(9;12)(p22;q14). Diagnostic Pathology. ISSN 1746-1596. 11(22). doi: 10.1186/s13000-016-0472-8.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Bjerkehagen, Bodil; Lobmaier, Ingvild Victoria Koren & Heim, Sverre (2016). Fusion of the TBL1XR1 and HMGA1 genes in splenic hemangioma with t(3;6)(q26;p21). International Journal of Oncology. ISSN 1019-6439. 48(3), s. 1242–1250. doi: 10.3892/ijo.2015.3310.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Bjerkehagen, Bodil; Lobmaier, Ingvild Victoria Koren & Heim, Sverre (2015). LAMTOR1-PRKCD and NUMA1-SFMBT1 fusion genes identified by RNA sequencing in aneurysmal benign fibrous histiocytoma with t(3;11)(p21;q13). Cancer Genetics. ISSN 2210-7762. 208(11), s. 545–551. doi: 10.1016/j.cancergen.2015.07.007.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Bjerkehagen, Bodil; Lobmaier, Ingvild Victoria Koren & Heim, Sverre (2015). The recurrent chromosomal translocation t(12;18) (q14∼15;q12∼21) causes the fusion gene HMGA2-SETBP1 and HMGA2 expression in lipoma and osteochondrolipoma. International Journal of Oncology. ISSN 1019-6439. 47(3), s. 884–890. doi: 10.3892/ijo.2015.3099.
• Olsen, Thale Kristin; Panagopoulos, Ioannis; Meling, Torstein Ragnar; Micci, Francesca; Gorunova, Ludmila & Thorsen, Jim [Vis alle 13 forfattere av denne artikkelen] (2015). Fusion genes with ALK as recurrent partner in ependymoma-like gliomas: A new brain tumor entity? Neuro-Oncology. ISSN 1522-8517. 17(10), s. 1365–1373. doi: 10.1093/neuonc/nov039.
• Torkildsen, Synne; Gorunova, Ludmila; Beiske, Klaus; Tjønnfjord, Geir Erland; Heim, Sverre & Panagopoulos, Ioannis (2015). Novel ZEB2-BCL11B fusion gene identified by RNA-sequencing in acute myeloid leukemia with t(2;14)(q22;q32). PLOS ONE. ISSN 1932-6203. 10(7). doi: 10.1371/journal.pone.0132736.
• Panagopoulos, Ioannis; Bjerkehagen, Bodil; Gorunova, Ludmila; Taksdal, Ingeborg & Heim, Sverre (2015). Rearrangement of chromosome bands 12q14-15 causing HMGA2-SOX5 gene fusion and HMGA2 expression in extraskeletal osteochondroma. Oncology Reports. ISSN 1021-335X. 34(2), s. 577–584. doi: 10.3892/or.2015.4035.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Taksdal, Ingeborg ; Bjerkehagen, Bodil & Heim, Sverre (2015). Recurrent 12q13-15 chromosomal aberrations, high frequency of isocitrate dehydrogenase 1 mutations, and absence of high mobility group At-hook 2 expression in periosteal chondromas. Oncology Letters. ISSN 1792-1074. 10(1), s. 163–167. doi: 10.3892/ol.2015.3197.
• Agostini, Antonio; Panagopoulos, Ioannis; Andersen, Hege Kilen; Johannessen, Lene Elisabeth; Davidson, Ben & Tropé, Claes Gøran [Vis alle 8 forfattere av denne artikkelen] (2015). HMGA2 expression pattern and TERT mutations in tumors of the vulva. Oncology Reports. ISSN 1021-335X. 33(6), s. 2675–2680. doi: 10.3892/or.2015.3882.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Bjerkehagen, Bodil & Heim, Sverre (2015). Fusion of the genes EWSR1 and PBX3 in retroperitoneal leiomyoma with t(9;22)(q33;q12). PLOS ONE. ISSN 1932-6203. 10(4). doi: 10.1371/journal.pone.0124288.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Bjerkehagen, Bodil & Heim, Sverre (2015). Novel KAT6B-KANSL1 fusion gene identified by RNA sequencing in retroperitoneal Leiomyoma with t(10;17)(q22;q21). PLOS ONE. ISSN 1932-6203. 10(1). doi: 10.1371/journal.pone.0117010.
• Panagopoulos, Ioannis; Gorunova, Ludmila; Davidson, Ben & Heim, Sverre (2015). Novel TNS3-MAP3K3 and ZFPM2-ELF5 fusion genes identified by RNA sequencing in multicystic mesothelioma with t(7;17)(p12;q23) and t(8;11)(q23;p13). Cancer Letters. ISSN 0304-3835. 357(2), s. 502–509. doi: 10.1016/j.canlet.2014.12.002.
• Haugvik, Sven-Petter; Gorunova, Ludmila; Haugom, Lisbeth; Eibak, Anne Mette E.; Gladhaug, Ivar Prydz & Heim, Sverre [Vis alle 7 forfattere av denne artikkelen] (2014). Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms. Oncology Reports. ISSN 1021-335X. s. 906–912. doi: 10.3892/or.2014.3328.
• Heim, Sverre (2014). Boveri at 100: Boveri, chromosomes and cancer. Journal of Pathology. ISSN 0022-3417. 234(2), s. 138–141. doi: 10.1002/path.4406.

Se alle arbeider i Cristin

• Panagopoulos, Ioannis; Brunetti, Marta; Stoltenberg, Margrethe; Strandabø, Rønnaug; Staurseth, Julie & Andersen, Kristin [Vis alle 13 forfattere av denne artikkelen] (2019). Novel GTF2I-PDGFRB and IKZF1-TYW1 fusions in pediatric leukemia with normal karyotype. Experimental hematology and oncology. ISSN 2162-3619. 8:12, s. 1–8. doi: 10.1186/s40164-019-0136-y. Fulltekst i vitenarkiv
• Jeanmougin, M; Håvik, Annette Bentsen; Cekaite, Lina; Brandal, Petter; Sveen, Anders & Meling, Torstein Ragnar [Vis alle 11 forfattere av denne artikkelen] (2016). Primary and secondary glioblastomas: global expression analysis of two histologically indistinguishable tumor subtypes.
• Håvik, Annette Bentsen; Lind, Guro Elisabeth; Honne, Hilde; Meling, Torstein; Scheie, David & Hall, Kirsten Sundby [Vis alle 12 forfattere av denne artikkelen] (2014). Sequencing IDH1/2 glioma mutation hotspots in gliomas and malignant peripheral nerve sheath tumors. Neuro-Oncology. ISSN 1522-8517. 16(2), s. 320–322. doi: 10.1093/neuonc/not230.

Se alle arbeider i Cristin