Stian Foss

• Foss, Stian; Sakya, Siri Aastedatter; Aguinagalde, Leire; Lustig, Marta; Shaughnessy, Jutamas & Cruz, Ana Rita [Vis alle 25 forfattere av denne artikkelen] (2024). Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria. Nature Communications. ISSN 2041-1723. 15(1). doi: 10.1038/s41467-024-46321-9.
• Jørstad, Øystein Kalsnes; Foss, Stian; gjølberg, torleif; mester, simone; Nyquist-Andersen, Mari & Sivertsen, Magne S. [Vis alle 10 forfattere av denne artikkelen] (2023). Pharmaceutical compounding and storage of faricimab in a syringe for intravitreal injection do not impair stability and bi-specific binding properties. International Journal of Retina and Vitreous (IJRV). ISSN 2056-9920. 9(1). doi: 10.1186/s40942-023-00507-3. Fulltekst i vitenarkiv
• Lustig, Marta; Chan, Chilam; Jansen, J. H. Marco; Bräutigam, Maria; Kölling, Max A. & Gehlert, Carina Lynn [Vis alle 16 forfattere av denne artikkelen] (2023). Disruption of the sialic acid/Siglec-9 axis improves antibody-mediated neutrophil cytotoxicity towards tumor cells. Frontiers in Immunology. ISSN 1664-3224. 14, s. 1–15. doi: 10.3389/fimmu.2023.1178817. Fulltekst i vitenarkiv
• Mukadam, Aamir S.; Miller, Lauren V.C.; Smith, Annabel E.; Vaysburd, Marina; Sakya, Siri Aastedatter & Sanford, Sophie [Vis alle 24 forfattere av denne artikkelen] (2023). Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models. Science. ISSN 0036-8075. 379(6639), s. 1336–1341. doi: 10.1126/science.abn1366.
• gjølberg, torleif; Wik, Jonas Aakre; Johannessen, Hanna; Krüger, Stig; Bassi, Nicola & Christopoulos, Panagiotis [Vis alle 15 forfattere av denne artikkelen] (2023). Antibody blockade of Jagged1 attenuates choroidal neovascularization. Nature Communications. ISSN 2041-1723. 14(1). doi: 10.1038/s41467-023-38563-w. Fulltekst i vitenarkiv
• Mørtberg, Trude Victoria; Zhi, Huiying; Vidarsson, Gestur; Foss, Stian; Lissenberg-Thunnissen, Suzanne & Wuhrer, Manfred [Vis alle 12 forfattere av denne artikkelen] (2022). Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia in Mice: Biochemical and Cell Biological Characterization of Isoforms of a Human Monoclonal Antibody. ImmunoHorizons. ISSN 2573-7732. 6(1), s. 90–103. doi: 10.4049/immunohorizons.2100097. Fulltekst i vitenarkiv
• Foss, Stian; Jonsson, Alexandra; Bottermann, Maria; Watkinson, Ruth; Lode, Heidrun Elisabeth & McAdam, Martin Berner [Vis alle 10 forfattere av denne artikkelen] (2022). Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge. Science immunology. ISSN 2470-9468. 7(70). doi: 10.1126/sciimmunol.abj1640.
• Tollefsrud Gjølberg, Torleif; Frick, Rahel; Mester, Simone; Foss, Stian; Grevys, Algirdas & Høydahl, Lene Støkken [Vis alle 11 forfattere av denne artikkelen] (2022). Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life. Communications Biology. ISSN 2399-3642. 5(1), s. 1–17. doi: 10.1038/s42003-022-03787-x. Fulltekst i vitenarkiv
• Zakrzewicz, Anna; Würth, Celina; Beckert, Benedikt; Feldhoff, Simon; Vanderheyden, Katrien & Foss, Stian [Vis alle 11 forfattere av denne artikkelen] (2022). Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus? Cells. ISSN 2073-4409. 11:942(6), s. 1–23. doi: 10.3390/cells11060942. Fulltekst i vitenarkiv
• Grevys, Algirdas; Frick, Rahel; Mester, Simone; Flem-Karlsen, Karine; Nilsen, Jeannette & Foss, Stian [Vis alle 13 forfattere av denne artikkelen] (2022). Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life. iScience. ISSN 2589-0042. 25:103746(2), s. 1–22. doi: 10.1016/j.isci.2022.103746. Fulltekst i vitenarkiv
• Caddy, Sarah L.; Vaysburd, Marina; Papa, Guido; Wing, Mark; O'Connell, Kevin & Stoycheva, Diana [Vis alle 10 forfattere av denne artikkelen] (2020). Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity. EMBO Journal. ISSN 0261-4189. 40:e106228(5), s. 1–9. doi: 10.15252/embj.2020106228. Fulltekst i vitenarkiv
• Hubbard, Jonathan J.; Pyzik, Michal; Rath, Timo; Kozicky, Lisa K.; Sand, Kine Marita Knudsen & Gandhi, Amit K. [Vis alle 17 forfattere av denne artikkelen] (2020). FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 217(10). doi: 10.1084/jem.20200359.
• Caddy, Sarah L.; Vaysburd, Marina; Wing, Mark; Foss, Stian; Andersen, Jan Terje & O'Connell, Kevin [Vis alle 11 forfattere av denne artikkelen] (2020). Intracellular neutralisation of rotavirus by VP6-specific IgG. PLoS Pathogens. ISSN 1553-7366. 16(8), s. 1–18. doi: 10.1371/journal.ppat.1008732. Fulltekst i vitenarkiv
• Bern, Malin C.; Nilsen, Jeannette; Ferrarese, Mattia; Sand, Kine Marita Knudsen; Tollefsrud Gjølberg, Torleif & Lode, Heidrun Elisabeth [Vis alle 24 forfattere av denne artikkelen] (2020). An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics. Science Translational Medicine. ISSN 1946-6234. 12(565), s. 1–13. doi: 10.1126/scitranslmed.abb0580. Fulltekst i vitenarkiv
• Lode, Heidrun Elisabeth; Gjølberg, Torleif Tollefsrud ; Foss, Stian; Sivertsen, Magne S.; Brustugun, Jørgen & Andersson, Yvonne [Vis alle 9 forfattere av denne artikkelen] (2019). A new method for pharmaceutical compounding and storage of anti-VEGF biologics for intravitreal use in silicone oil-free prefilled plastic syringes. Scientific Reports. ISSN 2045-2322. 9:18021(1), s. 1–10. doi: 10.1038/s41598-019-54226-7. Fulltekst i vitenarkiv Vis sammendrag

  Intravitreal injections of antibody-based biologics targeting vascular endothelial growth factor (VEGF) are highly effective and have markedly decreased the risk of visual impairment associated with prevalent retinal diseases, such as neovascular age-related macular degeneration and diabetes macular oedema. The diseases are chronic in their nature, and most patients need long-term therapy to suppress disease activity. We previously reported a compounding method for repackaging and storage of aflibercept (Eylea), a commonly used anti-VEGF biologic, in silicone oil-coated plastic syringes without compromising drug stability or activity. In addition to improving safety and time spent per patient, compounding of anti-VEGF biologics enables single-dose vials to be split into multiple syringes, thereby considerably reducing waste and drug expenses. However, symptomatic silicone oil droplets may deposit in the eye's vitreous body after repetitive injections. To fully avoid this complication, we here report on a novel pharmaceutical compounding method using silicone oil-free syringes and a 33 G × 9 mm Low Dead Space Needle hub injection needle. We evaluate the method for three anti-VEGF biologics commonly used in ophthalmology: aflibercept, ranibizumab (Lucentis) and bevacizumab (Avastin). Our results show that compounding and storage for one week does not compromise the functional activity of the biologics and allows for safe and cost-effective compounding of anti-VEGF biologics for intravitreal injections in prefilled silicone oil-free syringes.

• Foss, Stian; Bottermann, Maria; Jonsson, Alexandra; Sandlie, Inger; James, Leo C. & Andersen, Jan Terje (2019). TRIM21-From intracellular immunity to therapy. Frontiers in Immunology. ISSN 1664-3224. 10:2049, s. 1–14. doi: 10.3389/fimmu.2019.02049. Fulltekst i vitenarkiv
• Labzin, LI; Bottermann, M; Rodriguez-Silvestre, P; Foss, Stian; Andersen, Jan Terje & Vaysburd, M [Vis alle 8 forfattere av denne artikkelen] (2019). Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection. EMBO Journal. ISSN 0261-4189. doi: 10.15252/embj.2018101365. Fulltekst i vitenarkiv
• Bottermann, Maria; Foss, Stian; Caddy, Sarah L.; Clift, Dean; van Tienen, Laurens M. & Vaysburd, Marina [Vis alle 16 forfattere av denne artikkelen] (2019). Complement C4 prevents viral infection through capsid inactivation. Cell Host and Microbe. ISSN 1931-3128. 25(4), s. 617–629. doi: 10.1016/j.chom.2019.02.016. Fulltekst i vitenarkiv
• Høydahl, Lene Støkken; Richter, Lisa Maria; Frick, Rahel; Snir, Omri; Gunnarsen, Kristin Støen & Landsverk, Ole J. B. [Vis alle 18 forfattere av denne artikkelen] (2019). Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease. Gastroenterology. ISSN 0016-5085. 156(5), s. 1428–1439.e10. doi: 10.1053/j.gastro.2018.12.013. Fulltekst i vitenarkiv
• Grevys, Algirdas; Nilsen, Jeannette; Sand, Kine Marita Knudsen; Daba, Muluneh Bekele; Øynebråten, Inger & Bern, Malin C. [Vis alle 15 forfattere av denne artikkelen] (2018). A human endothelial cell-based recycling assay for screening of FcRn targeted molecules. Nature Communications. ISSN 2041-1723. 9. doi: 10.1038/s41467-018-03061-x. Fulltekst i vitenarkiv
• Sivertsen, Magne S.; Jørstad, Øystein Kalsnes; Grevys, Algirdas; Foss, Stian; Moe, Morten Carsten & Andersen, Jan Terje (2018). Pharmaceutical compounding of aflibercept in prefilled syringes does not affect structural integrity, stability or VEGF and Fc binding properties. Scientific Reports. ISSN 2045-2322. 8(1). doi: 10.1038/s41598-018-20525-8. Fulltekst i vitenarkiv
• Bottermann, Maria; Lode, Heidrun Elisabeth; Watkinson, Ruth E; Foss, Stian; Sandlie, Inger & Andersen, Jan Terje [Vis alle 7 forfattere av denne artikkelen] (2016). Antibody-antigen kinetics constrain intracellular humoral immunity. Scientific Reports. ISSN 2045-2322. 6. doi: 10.1038/srep37457. Fulltekst i vitenarkiv
• Foss, Stian; Watkinson, Ruth E; Grevys, Algirdas; Mc, Adam Martin Berner; Bern, Malin C. & Høydahl, Lene Støkken [Vis alle 11 forfattere av denne artikkelen] (2016). TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity. Journal of Immunology. ISSN 0022-1767. 196(8), s. 3452–3459. doi: 10.4049/jimmunol.1502601. Fulltekst i vitenarkiv
• Foss, Stian; Grevys, Algirdas; Sand, Kine Marita Knudsen; Bern, Malin C.; Blundell, Pat & Michaelsen, Terje Einar [Vis alle 9 forfattere av denne artikkelen] (2016). Enhanced FcRn-dependent transepithelial delivery of IgG by Fc-engineering and polymerization. Journal of Controlled Release. ISSN 0168-3659. 223, s. 42–52. doi: 10.1016/j.jconrel.2015.12.033. Fulltekst i vitenarkiv
• Foss, Stian; Watkinson, Ruth; Sandlie, Inger; James, Leo C. & Andersen, Jan Terje (2015). TRIM21: A cytosolic Fc receptor with broad antibody isotype specificity. Immunological Reviews. ISSN 0105-2896. 268(1), s. 328–339. doi: 10.1111/imr.12363. Fulltekst i vitenarkiv
• Grevys, Algirdas; Bern, Malin C.; Foss, Stian; Bratlie, Diane Lynn Bryant; Moen, Anders & Gunnarsen, Kristin Støen [Vis alle 10 forfattere av denne artikkelen] (2015). Fc Engineering of Human IgG1 for Altered Binding to the Neonatal Fc Receptor Affects Fc Effector Functions. Journal of Immunology. ISSN 0022-1767. 194(11), s. 5497–5508. doi: 10.4049/jimmunol.1401218. Fulltekst i vitenarkiv
• Hallstensen, Randi; Bergseth, Grete; Foss, Stian; Jæger, Steinar; Gedde-Dahl, Thobias & Holt, jan [Vis alle 14 forfattere av denne artikkelen] (2015). Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn. Immunobiology. ISSN 0171-2985. 220(4), s. 452–459. doi: 10.1016/j.imbio.2014.11.003. Fulltekst i vitenarkiv
• Sand, Kine Marita Knudsen; Dalhus, Bjørn; Christianson, Gregory J.; Bern, Malin C.; Foss, Stian & Cameron, Jason [Vis alle 11 forfattere av denne artikkelen] (2014). Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies. Journal of Biological Chemistry. ISSN 0021-9258. doi: 10.1074/jbc.M113.522565.
• Sand, Kine Marita Knudsen; Dalhus, Bjørn; Christianson, Gregory J.; Bern, Malin C.; Foss, Stian & Cameron, Jason [Vis alle 11 forfattere av denne artikkelen] (2014). Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies. Journal of Biological Chemistry. ISSN 0021-9258. 289(24), s. 17228–17239. doi: 10.1074/jbc.M113.522565. Fulltekst i vitenarkiv
• Andersen, Jan Terje; Gonzalez-Pajuelo, Maria; Foss, Stian; Landsverk, Ole J. B.; Pinto, Debora & Szyroki, Alexander [Vis alle 10 forfattere av denne artikkelen] (2013). Selection of Nanobodies that Target Human Neonatal Fc Receptor. Scientific Reports. ISSN 2045-2322. 3. doi: 10.1038/srep01118. Fulltekst i vitenarkiv
• Andersen, Jan Terje; Foss, Stian; Kenanova, Vania E; Olafsen, Tove; Leikfoss, Ingvild Sørum & Roopenian, Derry C [Vis alle 8 forfattere av denne artikkelen] (2012). Anti-carcinoembryonic Antigen Single-chain Variable Fragment Antibody Variants Bind Mouse and Human Neonatal Fc Receptor with Different Affinities That Reveal Distinct Cross-species Differences in Serum Half-life. Journal of Biological Chemistry. ISSN 0021-9258. 287(27), s. 22927–22937. doi: 10.1074/jbc.M112.355131. Fulltekst i vitenarkiv

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• Zakrzewicz, Anna; Würth, Celina; Beckert, Benedikt; Feldhoff, Simon; Vanderheyden, Katrien & Foss, Stian [Vis alle 11 forfattere av denne artikkelen] (2022). Correction: Zakrzewicz et al. Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus? (Cells 2022, 11, 942). Cells. ISSN 2073-4409. 11(10). doi: 10.3390/cells11101700.
• Borowicz, Pawel; Gopalakrishnan, Ramakrishna Prabhu; Chan, Hanna; Granum, Stine; Abrahamsen, Greger & Foss, Stian [Vis alle 9 forfattere av denne artikkelen] (2022). How to investigate the function of a single amino acid? Using the example of a conserved pTyr motif in the unstructured C-terminus of TSAd.
• Foss, Stian (2020). Design of the next Generation of Biologics.
• Andersen, Jan Terje; Sakya, Siri Aastedatter; Foss, Stian; Sandlie, Inger & Voets, Ardi (2019). Is an HIV vaccine within reach? Vaksinebloggen.
• Andersen, Jan Terje; Sakya, Siri Aastedatter; Foss, Stian & Sandlie, Inger (2019). Hvordan kan moderne medisin forebygge HIV? Medisinbloggen.
• Borowicz, Pawel; Gopalakrishnan, Ramakrishna Prabhu; Chan, Hanna; Kjelstrup, Hanna; Foss, Stian & De Souza, Gustavo Antonio [Vis alle 8 forfattere av denne artikkelen] (2019). A conserved pTyr motif in the unstructured C-terminus regulates the function of the T cell specific adaptor TSAd.
• Foss, Stian; Michaelsen, Terje Einar; Sandlie, Inger & Andersen, Jan Terje (2011). The Influence of Removal of the IgG Fab Arms on Binding to FcRn. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), s. 350–351. doi: 10.1111/j.1365-3083.2011.02516.x.

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